Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts / Lucy THOMPSON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290 Titre : Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts Type de document : texte imprimé Auteurs : Lucy THOMPSON, Auteur ; Christopher GILLBERG, Auteur ; Sara LANDBERG, Auteur ; Anne-Katrin KANTZER, Auteur ; Carmela MINISCALCO, Auteur ; Martina BARNEVIK OLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Elisabeth FERNELL, Auteur Article en page(s) : p.2281-2290 Langues : Anglais (eng) Mots-clés : Asd  Autism  Developmental language disorder  Intellectual developmental disorder  Non-regressive autism  Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts [texte imprimé] / Lucy THOMPSON, Auteur ; Christopher GILLBERG, Auteur ; Sara LANDBERG, Auteur ; Anne-Katrin KANTZER, Auteur ; Carmela MINISCALCO, Auteur ; Martina BARNEVIK OLSSON, Auteur ; Mats A. ERIKSSON, Auteur ; Elisabeth FERNELL, Auteur . - p.2281-2290. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2281-2290 Mots-clés : Asd  Autism  Developmental language disorder  Intellectual developmental disorder  Non-regressive autism  Regressive autism Index. décimale : PER Périodiques Résumé : Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n = 301) and subdivided according to history of regression. Those with regression (n = 62), 20.5% of the combined cohort, were contrasted with those without regression (n = 241) at first assessment (age range 19-60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p < .001), language development (p < .001), and to severity of autism (p < .01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed 'from normal' and those who had regressed 'from low' functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-03871-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? / KatieLynne RYAN in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1184-1191 Titre : Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? Type de document : texte imprimé Auteurs : KatieLynne RYAN, Auteur ; Lucy THOMPSON, Auteur ; Patricia A. MENDOZA, Auteur ; Kathryn K. CHADMAN, Auteur Article en page(s) : p.1184-1191 Langues : Anglais (eng) Mots-clés : Asd  Btbr  C57bl/6j  female  male  mice  social behavior  social preference Index. décimale : PER Périodiques Résumé : BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. In the first test, the subject mice had a choice between a stranger mouse of the same strain or from a strain with a different level of sociability. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice, although more moderately with sniff time only. The C57BL/6J female mice showed a moderate preference, sniff time only, for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference. The second experiment examined whether the subject mouse preferred a stranger mouse or bedding from the stranger mouse home cage. Male BTBR mice always preferred bedding, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but not when the stranger mouse was the same strain. Therefore, the stranger mouse strain seems to influence the preference of the female mice more than the male mice. The mice preferred spending time in the chamber with the social smell but not the actual stranger mouse although not always significantly. This suggests that contact with a stranger mouse is more stressful or anxiety provoking than the smell. Autism Res 2019, 12: 1184-1191. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. These experiments examined how the sociability level of the stranger mouse affected the subject mouse's preference and if social odor was preferable to a social situation in the BTBR mice. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice. The C57BL/6J female mice showed a moderate preference for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference for either stranger mouse. The second modification let the subject mouse have a choice between a stranger mouse or bedding. Male BTBR mice preferred bedding, regardless of the strain of the stranger mouse, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but showed no preference when the stranger mouse was from the same strain. The stranger mouse strain seems to influence the female mice more. Male BTBR mice preferred spending time in the chamber with the social smell but not the actual mouse, suggesting that actual contact with a stranger mouse is more stressful or anxiety provoking. En ligne : http://dx.doi.org/10.1002/aur.2158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? [texte imprimé] / KatieLynne RYAN, Auteur ; Lucy THOMPSON, Auteur ; Patricia A. MENDOZA, Auteur ; Kathryn K. CHADMAN, Auteur . - p.1184-1191. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1184-1191 Mots-clés : Asd  Btbr  C57bl/6j  female  male  mice  social behavior  social preference Index. décimale : PER Périodiques Résumé : BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. In the first test, the subject mice had a choice between a stranger mouse of the same strain or from a strain with a different level of sociability. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice, although more moderately with sniff time only. The C57BL/6J female mice showed a moderate preference, sniff time only, for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference. The second experiment examined whether the subject mouse preferred a stranger mouse or bedding from the stranger mouse home cage. Male BTBR mice always preferred bedding, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but not when the stranger mouse was the same strain. Therefore, the stranger mouse strain seems to influence the preference of the female mice more than the male mice. The mice preferred spending time in the chamber with the social smell but not the actual stranger mouse although not always significantly. This suggests that contact with a stranger mouse is more stressful or anxiety provoking than the smell. Autism Res 2019, 12: 1184-1191. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. These experiments examined how the sociability level of the stranger mouse affected the subject mouse's preference and if social odor was preferable to a social situation in the BTBR mice. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice. The C57BL/6J female mice showed a moderate preference for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference for either stranger mouse. The second modification let the subject mouse have a choice between a stranger mouse or bedding. Male BTBR mice preferred bedding, regardless of the strain of the stranger mouse, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but showed no preference when the stranger mouse was from the same strain. The stranger mouse strain seems to influence the female mice more. Male BTBR mice preferred spending time in the chamber with the social smell but not the actual mouse, suggesting that actual contact with a stranger mouse is more stressful or anxiety provoking. En ligne : http://dx.doi.org/10.1002/aur.2158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Prenatal maternal infections and early childhood developmental outcomes: analysis of linked administrative health data for Greater Glasgow & Clyde, Scotland / Iain HARDIE in Journal of Child Psychology and Psychiatry, 66-1 (January 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-1 (January 2025) . - p.30-40 Titre : Prenatal maternal infections and early childhood developmental outcomes: analysis of linked administrative health data for Greater Glasgow & Clyde, Scotland Type de document : texte imprimé Auteurs : Iain HARDIE, Auteur ; Aja Louise MURRAY, Auteur ; Josiah KING, Auteur ; Hildigunnur Anna HALL, Auteur ; Emily LUEDECKE, Auteur ; Louise MARRYAT, Auteur ; Lucy THOMPSON, Auteur ; Helen MINNIS, Auteur ; Philip WILSON, Auteur ; Bonnie AUYEUNG, Auteur Article en page(s) : p.30-40 Langues : Anglais (eng) Mots-clés : Child development  maternal factors  prenatal  infection  CNS Index. décimale : PER Périodiques Résumé : Background Previous research has linked prenatal maternal infections to later childhood developmental outcomes and socioemotional difficulties. However, existing studies have relied on retrospectively self-reported survey data, or data on hospital-recorded infections only, resulting in gaps in data collection. Methods This study used a large linked administrative health dataset, bringing together data from birth records, hospital records, prescriptions and routine child health reviews for 55,856 children born in Greater Glasgow 95% CI: 1.19 1.42). This was broadly consistent across all developmental outcome types and appeared to be specifically linked to infections occurring in pregnancy trimesters 2 (OR: 1.34; 95% CI: 1.07 1.67) and 3 (OR: 1.33; 95% CI: 1.21 1.47), that is the trimesters in which foetal brain myelination occurs. Infection-related prescriptions were not associated with any clear increase in odds of having at least one developmental concern after confounder/covariate adjustment (OR: 1.03; 95% CI: 0.98 1.08), but were associated with slightly increased odds of concerns specifically related to personal-social (OR: 1.12; 95% CI: 1.03 1.22) and emotional-behavioural-attention (OR: 1.15; 95% CI: 1.08 1.22) development. Conclusions Prenatal infections, particularly those which are hospital-diagnosed (and likely more severe), are associated with early childhood developmental outcomes. Prevention of prenatal infections, and monitoring of support needs of affected children, may improve childhood development, but causality remains to be established. En ligne : https://dx.doi.org/10.1111/jcpp.14028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Prenatal maternal infections and early childhood developmental outcomes: analysis of linked administrative health data for Greater Glasgow & Clyde, Scotland [texte imprimé] / Iain HARDIE, Auteur ; Aja Louise MURRAY, Auteur ; Josiah KING, Auteur ; Hildigunnur Anna HALL, Auteur ; Emily LUEDECKE, Auteur ; Louise MARRYAT, Auteur ; Lucy THOMPSON, Auteur ; Helen MINNIS, Auteur ; Philip WILSON, Auteur ; Bonnie AUYEUNG, Auteur . - p.30-40. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-1 (January 2025) . - p.30-40 Mots-clés : Child development  maternal factors  prenatal  infection  CNS Index. décimale : PER Périodiques Résumé : Background Previous research has linked prenatal maternal infections to later childhood developmental outcomes and socioemotional difficulties. However, existing studies have relied on retrospectively self-reported survey data, or data on hospital-recorded infections only, resulting in gaps in data collection. Methods This study used a large linked administrative health dataset, bringing together data from birth records, hospital records, prescriptions and routine child health reviews for 55,856 children born in Greater Glasgow 95% CI: 1.19 1.42). This was broadly consistent across all developmental outcome types and appeared to be specifically linked to infections occurring in pregnancy trimesters 2 (OR: 1.34; 95% CI: 1.07 1.67) and 3 (OR: 1.33; 95% CI: 1.21 1.47), that is the trimesters in which foetal brain myelination occurs. Infection-related prescriptions were not associated with any clear increase in odds of having at least one developmental concern after confounder/covariate adjustment (OR: 1.03; 95% CI: 0.98 1.08), but were associated with slightly increased odds of concerns specifically related to personal-social (OR: 1.12; 95% CI: 1.03 1.22) and emotional-behavioural-attention (OR: 1.15; 95% CI: 1.08 1.22) development. Conclusions Prenatal infections, particularly those which are hospital-diagnosed (and likely more severe), are associated with early childhood developmental outcomes. Prevention of prenatal infections, and monitoring of support needs of affected children, may improve childhood development, but causality remains to be established. En ligne : https://dx.doi.org/10.1111/jcpp.14028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper / Christopher GILLBERG in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1022-1044 Titre : The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper Type de document : texte imprimé Auteurs : Christopher GILLBERG, Auteur ; Elisabeth FERNELL, Auteur ; Eva KOCOVSKA, Auteur ; Helen MINNIS, Auteur ; Thomas BOURGERON, Auteur ; Lucy THOMPSON, Auteur ; Clare S. ALLELY, Auteur Article en page(s) : p.1022-1044 Langues : Anglais (eng) Mots-clés : autism  cholesterol  cortisol  estrogens  steroid hormones  testosterone  vitamin D Index. décimale : PER Périodiques Résumé : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. En ligne : http://dx.doi.org/10.1002/aur.1777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper [texte imprimé] / Christopher GILLBERG, Auteur ; Elisabeth FERNELL, Auteur ; Eva KOCOVSKA, Auteur ; Helen MINNIS, Auteur ; Thomas BOURGERON, Auteur ; Lucy THOMPSON, Auteur ; Clare S. ALLELY, Auteur . - p.1022-1044. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1022-1044 Mots-clés : autism  cholesterol  cortisol  estrogens  steroid hormones  testosterone  vitamin D Index. décimale : PER Périodiques Résumé : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. En ligne : http://dx.doi.org/10.1002/aur.1777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

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