Childhood psychopathology mediates associations between childhood adversities and multiple health risk behaviours in adolescence: analysis using the ALSPAC birth cohort / D. TROY in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1100-1109 Titre : Childhood psychopathology mediates associations between childhood adversities and multiple health risk behaviours in adolescence: analysis using the ALSPAC birth cohort Type de document : texte imprimé Auteurs : D. TROY, Auteur ; A. RUSSELL, Auteur ; J. KIDGER, Auteur ; C. WRIGHT, Auteur Article en page(s) : p.1100-1109 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Child  Health Risk Behaviors  Humans  Longitudinal Studies  Mental Disorders/epidemiology/etiology  Parents  Risk Factors  Self-Injurious Behavior  Alspac  Adverse childhood experiences  UK birth cohort study  adolescence  mediation analysis  multiple health risk behaviours  psychosocial attributes  structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood adversity strongly predicts adolescent multiple health risk behaviours (MRBs) such as alcohol/tobacco use, self-harm and physical inactivity, and both adversities and MRBs are associated with premature mortality and several chronic health conditions that are among the leading causes of death in adults. It is therefore important to understand the relationship between adversities and MRBs and what could mediate any association. The aim of this study was to explore whether childhood psychopathology mediates associations between adversities and MRBs. METHODS: Participants were young people in the Avon Longitudinal Study of Parents and Children (ALSPAC) (N = 5,799). Using structural equation modelling, we explored the associations between adversities before 9 years and MRBs at age 16 years. We also explored potential mediating pathways through dimensional psychopathology measured by the Strength and Difficulties Questionnaire subscales at age 12 years. RESULTS: There were strong positive associations between adversities and MRBs (β .25, 95% CI 0.20, 0.31, p < .001) suggesting that each additional adversity is associated with a 0.25 increase in number of MRBs out of 13 total risk behaviours. We found robust evidence of mediating pathways from adversities through conduct problems (β .05, 95% CI 0.03, 0.06, p < .001), hyperactivity/inattention (β .02, 95% CI 0.01, 0.03, p < .001) and peer relationship problems (β -.02, 95% CI -0.03, -0.02, p < .001) to MRBs. CONCLUSIONS: Increased conduct problems and hyperactivity/inattention appear to partially explain the relationship between adversities and MRBs. Peer relationship problems also appear to reduce the association between adversities and MRBs, and further research is needed to understand how to encourage peer connectivity without increasing risk of MRBs. These results suggest that interventions aimed at reducing MRBs among those exposed to childhood adversities could focus on prevention of behavioural problems. En ligne : http://dx.doi.org/10.1111/jcpp.13379 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Childhood psychopathology mediates associations between childhood adversities and multiple health risk behaviours in adolescence: analysis using the ALSPAC birth cohort [texte imprimé] / D. TROY, Auteur ; A. RUSSELL, Auteur ; J. KIDGER, Auteur ; C. WRIGHT, Auteur . - p.1100-1109. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1100-1109 Mots-clés : Adolescent  Adult  Child  Health Risk Behaviors  Humans  Longitudinal Studies  Mental Disorders/epidemiology/etiology  Parents  Risk Factors  Self-Injurious Behavior  Alspac  Adverse childhood experiences  UK birth cohort study  adolescence  mediation analysis  multiple health risk behaviours  psychosocial attributes  structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood adversity strongly predicts adolescent multiple health risk behaviours (MRBs) such as alcohol/tobacco use, self-harm and physical inactivity, and both adversities and MRBs are associated with premature mortality and several chronic health conditions that are among the leading causes of death in adults. It is therefore important to understand the relationship between adversities and MRBs and what could mediate any association. The aim of this study was to explore whether childhood psychopathology mediates associations between adversities and MRBs. METHODS: Participants were young people in the Avon Longitudinal Study of Parents and Children (ALSPAC) (N = 5,799). Using structural equation modelling, we explored the associations between adversities before 9 years and MRBs at age 16 years. We also explored potential mediating pathways through dimensional psychopathology measured by the Strength and Difficulties Questionnaire subscales at age 12 years. RESULTS: There were strong positive associations between adversities and MRBs (β .25, 95% CI 0.20, 0.31, p < .001) suggesting that each additional adversity is associated with a 0.25 increase in number of MRBs out of 13 total risk behaviours. We found robust evidence of mediating pathways from adversities through conduct problems (β .05, 95% CI 0.03, 0.06, p < .001), hyperactivity/inattention (β .02, 95% CI 0.01, 0.03, p < .001) and peer relationship problems (β -.02, 95% CI -0.03, -0.02, p < .001) to MRBs. CONCLUSIONS: Increased conduct problems and hyperactivity/inattention appear to partially explain the relationship between adversities and MRBs. Peer relationship problems also appear to reduce the association between adversities and MRBs, and further research is needed to understand how to encourage peer connectivity without increasing risk of MRBs. These results suggest that interventions aimed at reducing MRBs among those exposed to childhood adversities could focus on prevention of behavioural problems. En ligne : http://dx.doi.org/10.1111/jcpp.13379 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum / S. ESPENHAHN in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 26 p. Titre : Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum Type de document : texte imprimé Auteurs : S. ESPENHAHN, Auteur ; K. J. GODFREY, Auteur ; S. KAUR, Auteur ; M. ROSS, Auteur ; N. NATH, Auteur ; O. DMITRIEVA, Auteur ; C. MCMORRIS, Auteur ; F. CORTESE, Auteur ; C. WRIGHT, Auteur ; K. MURIAS, Auteur ; Deborah DEWEY, Auteur ; A. B. PROTZNER, Auteur ; A. MCCRIMMON, Auteur ; S. BRAY, Auteur ; A. D. HARRIS, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/physiopathology  Child  Child, Preschool  Electroencephalography  Evoked Potentials, Somatosensory  Female  Humans  Male  Somatosensory Cortex/physiopathology  Touch  Adaptation  Autism  Children  Eeg  Erp  Somatosensory-evoked potentials  Tactile sensitivities  Tactile stimulation Index. décimale : PER Périodiques Résumé : BACKGROUND: Unusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features (< age 3) and their potential impact on development and quality of life, little is known about the neural mechanisms underlying sensory reactivity in early childhood autism. METHODS: Here, we used electroencephalography (EEG) to investigate tactile cortical processing in young children aged 3-6 years with autism and in neurotypical (NT) children. Scalp EEG was recorded from 33 children with autism, including those with low cognitive and/or verbal abilities, and 45 age- and sex-matched NT children during passive tactile fingertip stimulation. We compared properties of early and later somatosensory-evoked potentials (SEPs) and their adaptation with repetitive stimulation between autistic and NT children and assessed whether these neural measures are linked to "real-world" parent-reported tactile reactivity. RESULTS: As expected, we found elevated tactile reactivity in children on the autism spectrum. Our findings indicated no differences in amplitude or latency of early and mid-latency somatosensory-evoked potentials (P50, N80, P100), nor adaptation between autistic and NT children. However, latency of later processing of tactile information (N140) was shorter in young children with autism compared to NT children, suggesting faster processing speed in young autistic children. Further, correlational analyses and exploratory analyses using tactile reactivity as a grouping variable found that enhanced early neural responses were associated with greater tactile reactivity in autism. LIMITATIONS: The relatively small sample size and the inclusion of a broad range of autistic children (e.g., with low cognitive and/or verbal abilities) may have limited our power to detect subtle group differences and associations. Hence, replications are needed to verify these results. CONCLUSIONS: Our findings suggest that electrophysiological somatosensory cortex processing measures may be indices of "real-world" tactile reactivity in early childhood autism. Together, these findings advance our understanding of the neurophysiological mechanisms underlying tactile reactivity in early childhood autism and, in the clinical context, may have therapeutic implications. En ligne : http://dx.doi.org/10.1186/s13229-021-00435-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum [texte imprimé] / S. ESPENHAHN, Auteur ; K. J. GODFREY, Auteur ; S. KAUR, Auteur ; M. ROSS, Auteur ; N. NATH, Auteur ; O. DMITRIEVA, Auteur ; C. MCMORRIS, Auteur ; F. CORTESE, Auteur ; C. WRIGHT, Auteur ; K. MURIAS, Auteur ; Deborah DEWEY, Auteur ; A. B. PROTZNER, Auteur ; A. MCCRIMMON, Auteur ; S. BRAY, Auteur ; A. D. HARRIS, Auteur . - 26 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 26 p. Mots-clés : Autistic Disorder/physiopathology  Child  Child, Preschool  Electroencephalography  Evoked Potentials, Somatosensory  Female  Humans  Male  Somatosensory Cortex/physiopathology  Touch  Adaptation  Autism  Children  Eeg  Erp  Somatosensory-evoked potentials  Tactile sensitivities  Tactile stimulation Index. décimale : PER Périodiques Résumé : BACKGROUND: Unusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features (< age 3) and their potential impact on development and quality of life, little is known about the neural mechanisms underlying sensory reactivity in early childhood autism. METHODS: Here, we used electroencephalography (EEG) to investigate tactile cortical processing in young children aged 3-6 years with autism and in neurotypical (NT) children. Scalp EEG was recorded from 33 children with autism, including those with low cognitive and/or verbal abilities, and 45 age- and sex-matched NT children during passive tactile fingertip stimulation. We compared properties of early and later somatosensory-evoked potentials (SEPs) and their adaptation with repetitive stimulation between autistic and NT children and assessed whether these neural measures are linked to "real-world" parent-reported tactile reactivity. RESULTS: As expected, we found elevated tactile reactivity in children on the autism spectrum. Our findings indicated no differences in amplitude or latency of early and mid-latency somatosensory-evoked potentials (P50, N80, P100), nor adaptation between autistic and NT children. However, latency of later processing of tactile information (N140) was shorter in young children with autism compared to NT children, suggesting faster processing speed in young autistic children. Further, correlational analyses and exploratory analyses using tactile reactivity as a grouping variable found that enhanced early neural responses were associated with greater tactile reactivity in autism. LIMITATIONS: The relatively small sample size and the inclusion of a broad range of autistic children (e.g., with low cognitive and/or verbal abilities) may have limited our power to detect subtle group differences and associations. Hence, replications are needed to verify these results. CONCLUSIONS: Our findings suggest that electrophysiological somatosensory cortex processing measures may be indices of "real-world" tactile reactivity in early childhood autism. Together, these findings advance our understanding of the neurophysiological mechanisms underlying tactile reactivity in early childhood autism and, in the clinical context, may have therapeutic implications. En ligne : http://dx.doi.org/10.1186/s13229-021-00435-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Towards a Treatment for Intolerance of Uncertainty in Young People with Autism Spectrum Disorder: Development of the Coping with Uncertainty in Everyday Situations (CUES(c)) Programme / J. RODGERS in Journal of Autism and Developmental Disorders, 47-12 (December 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3959-3966 Titre : Towards a Treatment for Intolerance of Uncertainty in Young People with Autism Spectrum Disorder: Development of the Coping with Uncertainty in Everyday Situations (CUES(c)) Programme Type de document : texte imprimé Auteurs : J. RODGERS, Auteur ; A. HODGSON, Auteur ; K. SHIELDS, Auteur ; C. WRIGHT, Auteur ; E. HONEY, Auteur ; M. FREESTON, Auteur Année de publication : 2017 Article en page(s) : p.3959-3966 Langues : Anglais (eng) Mots-clés : Anxiety  Intervention  Intolerance of uncertainty  Parent group Index. décimale : PER Périodiques Résumé : Intolerance of uncertainty (IU) is indicated as an important transdiagnostic process variable in a range of anxiety disorders. Anxiety is very common in children with autism spectrum disorders (ASD). This study aimed to develop a parent group based manualised treatment programme for young people with ASD, which focused on IU. An eight session programme was developed and then delivered to 11 parents across three treatment groups, two recruited via a research data base and one via clinical services. Data regarding retention, acceptability and feasibility indicate that the parents valued the programme. Effect size analyses of outcome measures for potential use in larger trial indicate that the programme has promise as a treatment option of your people with ASD and IU. En ligne : http://dx.doi.org/10.1007/s10803-016-2924-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Towards a Treatment for Intolerance of Uncertainty in Young People with Autism Spectrum Disorder: Development of the Coping with Uncertainty in Everyday Situations (CUES(c)) Programme [texte imprimé] / J. RODGERS, Auteur ; A. HODGSON, Auteur ; K. SHIELDS, Auteur ; C. WRIGHT, Auteur ; E. HONEY, Auteur ; M. FREESTON, Auteur . - 2017 . - p.3959-3966. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3959-3966 Mots-clés : Anxiety  Intervention  Intolerance of uncertainty  Parent group Index. décimale : PER Périodiques Résumé : Intolerance of uncertainty (IU) is indicated as an important transdiagnostic process variable in a range of anxiety disorders. Anxiety is very common in children with autism spectrum disorders (ASD). This study aimed to develop a parent group based manualised treatment programme for young people with ASD, which focused on IU. An eight session programme was developed and then delivered to 11 parents across three treatment groups, two recruited via a research data base and one via clinical services. Data regarding retention, acceptability and feasibility indicate that the parents valued the programme. Effect size analyses of outcome measures for potential use in larger trial indicate that the programme has promise as a treatment option of your people with ASD and IU. En ligne : http://dx.doi.org/10.1007/s10803-016-2924-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

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