Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data / A. S. DICRISCIO in Research in Autism Spectrum Disorders, 108 (October 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 108 (October 2023) . - p.102234 Titre : Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data Type de document : Texte imprimé et/ou numérique Auteurs : A. S. DICRISCIO, Auteur ; D. BEILER, Auteur ; J. SMITH, Auteur ; P. ASDELL, Auteur ; S. DICKEY, Auteur ; M. DISTEFANO, Auteur ; V. TROIANI, Auteur Article en page(s) : p.102234 Mots-clés : Autonomic function  Chart review  Autism spectrum disorder  Developmental brain dysfunction  Individual differences Index. décimale : PER Périodiques Résumé : Background Sleep disturbances, gastrointestinal problems, and atypical heart rate are commonly observed in patients with autism spectrum disorder (ASD) and may relate to underlying function of the autonomic nervous system (ANS). The overall objective of the current study was to quantitatively characterize features of ANS function using symptom scales and available electronic health record (EHR) data in a clinically and genetically characterized pediatric cohort. Methods We assessed features of ANS function via chart review of patient records adapted from items drawn from a clinical research questionnaire of autonomic symptoms. This procedure coded for the presence and/or absence of targeted symptoms and was completed in 3 groups of patients, including patients with a clinical neurodevelopmental diagnosis and identified genetic etiology (NPD, n = 244), those with an ASD diagnosis with no known genetic cause (ASD, n = 159), and age and sex matched controls (MC, n = 213). Symptoms were assessed across four main categories: (1) Mood, Behavior, and Emotion; (2) Secretomotor, Sensory Integration; (3) Urinary, Gastrointestinal, and Digestion; and (4) Circulation, Thermoregulation, Circadian function, and Sleep/Wake cycles. Results Chart review scores indicate an increased rate of autonomic symptoms across all four sections in our NPD group as compared to scores with ASD and/or MC. Additionally, we note several significant relationships between individual differences in autonomic symptoms and quantitative ASD traits. Conclusion These results highlight EHR review as a potentially useful method for quantifying variance in symptoms adapted from a questionnaire or survey. Further, using this method indicates that autonomic features are more prevalent in children with genetic disorders conferring risk for ASD and other neurodevelopmental diagnoses. En ligne : https://doi.org/10.1016/j.rasd.2023.102234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514 [article] Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data [Texte imprimé et/ou numérique] / A. S. DICRISCIO, Auteur ; D. BEILER, Auteur ; J. SMITH, Auteur ; P. ASDELL, Auteur ; S. DICKEY, Auteur ; M. DISTEFANO, Auteur ; V. TROIANI, Auteur . - p.102234. in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102234 Mots-clés : Autonomic function  Chart review  Autism spectrum disorder  Developmental brain dysfunction  Individual differences Index. décimale : PER Périodiques Résumé : Background Sleep disturbances, gastrointestinal problems, and atypical heart rate are commonly observed in patients with autism spectrum disorder (ASD) and may relate to underlying function of the autonomic nervous system (ANS). The overall objective of the current study was to quantitatively characterize features of ANS function using symptom scales and available electronic health record (EHR) data in a clinically and genetically characterized pediatric cohort. Methods We assessed features of ANS function via chart review of patient records adapted from items drawn from a clinical research questionnaire of autonomic symptoms. This procedure coded for the presence and/or absence of targeted symptoms and was completed in 3 groups of patients, including patients with a clinical neurodevelopmental diagnosis and identified genetic etiology (NPD, n = 244), those with an ASD diagnosis with no known genetic cause (ASD, n = 159), and age and sex matched controls (MC, n = 213). Symptoms were assessed across four main categories: (1) Mood, Behavior, and Emotion; (2) Secretomotor, Sensory Integration; (3) Urinary, Gastrointestinal, and Digestion; and (4) Circulation, Thermoregulation, Circadian function, and Sleep/Wake cycles. Results Chart review scores indicate an increased rate of autonomic symptoms across all four sections in our NPD group as compared to scores with ASD and/or MC. Additionally, we note several significant relationships between individual differences in autonomic symptoms and quantitative ASD traits. Conclusion These results highlight EHR review as a potentially useful method for quantifying variance in symptoms adapted from a questionnaire or survey. Further, using this method indicates that autonomic features are more prevalent in children with genetic disorders conferring risk for ASD and other neurodevelopmental diagnoses. En ligne : https://doi.org/10.1016/j.rasd.2023.102234 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514

Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm / A. S. DICRISCIO in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.5086-5099 Titre : Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm Type de document : Texte imprimé et/ou numérique Auteurs : A. S. DICRISCIO, Auteur ; Y. HU, Auteur ; V. TROIANI, Auteur Article en page(s) : p.5086-5099 Langues : Anglais (eng) Mots-clés : Attention  Autism  Eye tracking  Pupillometry  Visual perception Index. décimale : PER Périodiques Résumé : We assessed the association between dynamic changes in pupil response in the context of visual perception and quantitative measures of the autism phenotype in healthy adults. Using Navon stimuli in a task-switching paradigm, participants were instructed to identify global or local information based on a cue. Multiple pupil response trajectories across conditions were identified. We combined trajectory patterns for global and local conditions and used data-driven methods to identify three distinct pupil trajectory sub-groups. We report higher scores on quantitative measures of autism features in individuals who demonstrated an increased change in pupil diameter across both conditions. Results demonstrate the use of individualized pupil response trajectories in order to quantitatively characterize visual perception associated with the broader autism phenotype (BAP). En ligne : http://dx.doi.org/10.1007/s10803-019-04213-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm [Texte imprimé et/ou numérique] / A. S. DICRISCIO, Auteur ; Y. HU, Auteur ; V. TROIANI, Auteur . - p.5086-5099. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.5086-5099 Mots-clés : Attention  Autism  Eye tracking  Pupillometry  Visual perception Index. décimale : PER Périodiques Résumé : We assessed the association between dynamic changes in pupil response in the context of visual perception and quantitative measures of the autism phenotype in healthy adults. Using Navon stimuli in a task-switching paradigm, participants were instructed to identify global or local information based on a cue. Multiple pupil response trajectories across conditions were identified. We combined trajectory patterns for global and local conditions and used data-driven methods to identify three distinct pupil trajectory sub-groups. We report higher scores on quantitative measures of autism features in individuals who demonstrated an increased change in pupil diameter across both conditions. Results demonstrate the use of individualized pupil response trajectories in order to quantitatively characterize visual perception associated with the broader autism phenotype (BAP). En ligne : http://dx.doi.org/10.1007/s10803-019-04213-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children / A. S. DICRISCIO in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3016-3030 Titre : Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children Type de document : Texte imprimé et/ou numérique Auteurs : A. S. DICRISCIO, Auteur ; Y. HU, Auteur ; V. TROIANI, Auteur Article en page(s) : p.3016-3030 Langues : Anglais (eng) Mots-clés : Autism  Eye tracking  Global-local processing  Perception  Pupillometry Index. décimale : PER Périodiques Résumé : We applied a trajectory-based analysis to eye tracking data in order to quantify individualized patterns of pupil response in the context of global-local processing that may be associated with autism spectrum disorder (ASD) features. Multiple pupil response trajectories across both global and local conditions were identified. Using the combined trajectory patterns for global and local conditions for each individual, we were able to identify three groups based on trajectory group membership that were thought to reflect perceptual strategy. Results indicated that the proportion of children with ASD was significantly greater in the group demonstrating a local-focus response. This research presents a novel analytic approach to the objective characterization of individualized pupil response patterns that are associated with ASD features. En ligne : http://dx.doi.org/10.1007/s10803-019-04028-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children [Texte imprimé et/ou numérique] / A. S. DICRISCIO, Auteur ; Y. HU, Auteur ; V. TROIANI, Auteur . - p.3016-3030. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3016-3030 Mots-clés : Autism  Eye tracking  Global-local processing  Perception  Pupillometry Index. décimale : PER Périodiques Résumé : We applied a trajectory-based analysis to eye tracking data in order to quantify individualized patterns of pupil response in the context of global-local processing that may be associated with autism spectrum disorder (ASD) features. Multiple pupil response trajectories across both global and local conditions were identified. Using the combined trajectory patterns for global and local conditions for each individual, we were able to identify three groups based on trajectory group membership that were thought to reflect perceptual strategy. Results indicated that the proportion of children with ASD was significantly greater in the group demonstrating a local-focus response. This research presents a novel analytic approach to the objective characterization of individualized pupil response patterns that are associated with ASD features. En ligne : http://dx.doi.org/10.1007/s10803-019-04028-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children / A. S. DICRISCIO in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2416-2435 Titre : Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children Type de document : Texte imprimé et/ou numérique Auteurs : A. S. DICRISCIO, Auteur ; V. TROIANI, Auteur Article en page(s) : p.2416-2435 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/physiopathology/psychology  Benchmarking  Biological Variation, Population  Child  Child, Preschool  Female  Humans  Individuality  Intelligence  Logistic Models  Male  Punishment/psychology  Pupil/physiology  Rest  Reward  Sex Factors  Autism spectrum disorder  Individual differences  Motivation  Punishment sensitivity  Pupillometry Index. décimale : PER Périodiques Résumé : The current study examined the relationship between quantitative measures of reward and punishment sensitivity, features of autism spectrum disorder (ASD), and resting and functional pupil response metrics across a clinically heterogeneous sample. Scores on a parent-report measure of punishment and reward sensitivity were correlated with ASD features. We also assessed whether pupil measurements could be used as a physiologic correlate of reward sensitivity and predictor of ASD diagnosis. In a logistic regression model, pupil dilation metrics, sex, and IQ, correctly classified 86.3% of participants as having an ASD diagnosis versus not. This research highlights individual differences of reward sensitivity associated with ASD features. Results support the use of pupil metrics and other patient-level variables as predictors of ASD diagnostic status. En ligne : http://dx.doi.org/10.1007/s10803-020-04721-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children [Texte imprimé et/ou numérique] / A. S. DICRISCIO, Auteur ; V. TROIANI, Auteur . - p.2416-2435. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2416-2435 Mots-clés : Adolescent  Autism Spectrum Disorder/physiopathology/psychology  Benchmarking  Biological Variation, Population  Child  Child, Preschool  Female  Humans  Individuality  Intelligence  Logistic Models  Male  Punishment/psychology  Pupil/physiology  Rest  Reward  Sex Factors  Autism spectrum disorder  Individual differences  Motivation  Punishment sensitivity  Pupillometry Index. décimale : PER Périodiques Résumé : The current study examined the relationship between quantitative measures of reward and punishment sensitivity, features of autism spectrum disorder (ASD), and resting and functional pupil response metrics across a clinically heterogeneous sample. Scores on a parent-report measure of punishment and reward sensitivity were correlated with ASD features. We also assessed whether pupil measurements could be used as a physiologic correlate of reward sensitivity and predictor of ASD diagnosis. In a logistic regression model, pupil dilation metrics, sex, and IQ, correctly classified 86.3% of participants as having an ASD diagnosis versus not. This research highlights individual differences of reward sensitivity associated with ASD features. Results support the use of pupil metrics and other patient-level variables as predictors of ASD diagnostic status. En ligne : http://dx.doi.org/10.1007/s10803-020-04721-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

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