Correction to: Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) / Anouck AMESTOY in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 4p. Titre : Correction to: Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) Type de document : texte imprimé Auteurs : Anouck AMESTOY, Auteur ; Etienne GUILLAUD, Auteur ; Giulia BUCCHIONI, Auteur ; Tiziana ZALLA, Auteur ; Daniel UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Josselin HOUENOU, Auteur ; Richard DELORME, Auteur ; Myriam Ly LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Manuel P. BOUVARD, Auteur ; Jean-René CAZALETS, Auteur Article en page(s) : 4p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-021-00479-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Correction to: Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) [texte imprimé] / Anouck AMESTOY, Auteur ; Etienne GUILLAUD, Auteur ; Giulia BUCCHIONI, Auteur ; Tiziana ZALLA, Auteur ; Daniel UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Josselin HOUENOU, Auteur ; Richard DELORME, Auteur ; Myriam Ly LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Manuel P. BOUVARD, Auteur ; Jean-René CAZALETS, Auteur . - 4p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 4p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-021-00479-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism / Charles LAIDI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Titre : Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism Type de document : texte imprimé Auteurs : Charles LAIDI, Auteur ; Jennifer BOISGONTIER, Auteur ; Amicie DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Federico BOLOGNANI, Auteur ; Christian CZECH, Auteur ; Céline BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; Julie PETIT, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Alexandru GAMAN, Auteur ; Elie TOLEDANO, Auteur ; Myriam Ly LE-MOAL, Auteur ; Isabelle SCHEID, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur Article en page(s) : p.1402-1409 Langues : Anglais (eng) Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism [texte imprimé] / Charles LAIDI, Auteur ; Jennifer BOISGONTIER, Auteur ; Amicie DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Federico BOLOGNANI, Auteur ; Christian CZECH, Auteur ; Céline BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; Julie PETIT, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Alexandru GAMAN, Auteur ; Elie TOLEDANO, Auteur ; Myriam Ly LE-MOAL, Auteur ; Isabelle SCHEID, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur . - p.1402-1409. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands / Aline LEFEBVRE in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2373-2382 Titre : Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands Type de document : texte imprimé Auteurs : Aline LEFEBVRE, Auteur ; Alicia COHEN, Auteur ; Anna MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; Myriam Ly LE-MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur Article en page(s) : p.2373-2382 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p < 10(-4) ), but poorly differentiated the ASD and OCD relatives (≈46%). The stepwise analysis reveals that five symptoms attributed to high-order RB and two related to low-order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro-developmental disorders. LAY SUMMARY: Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first-degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro-developmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands [texte imprimé] / Aline LEFEBVRE, Auteur ; Alicia COHEN, Auteur ; Anna MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; Myriam Ly LE-MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur . - p.2373-2382. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2373-2382 Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p < 10(-4) ), but poorly differentiated the ASD and OCD relatives (≈46%). The stepwise analysis reveals that five symptoms attributed to high-order RB and two related to low-order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro-developmental disorders. LAY SUMMARY: Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first-degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro-developmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications / Nicolas TRAUT ; Amandine PEDOUX ; Anna MARUANI ; Anita BEGGIATO ; Monique ELMALEH ; David GERMANAUD ; Anouck AMESTOY ; Myriam Ly LE-MOAL ; Christopher H. CHATHAM ; Lorraine MURTAGH ; Manuel P. BOUVARD ; Marianne ALISSON ; Marion LEBOYER ; Thomas BOURGERON ; Roberto TORO ; Guillaume DUMAS ; Clara MOREAU ; Richard DELORME in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 45 p. Titre : Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications Type de document : texte imprimé Auteurs : Nicolas TRAUT, Auteur ; Amandine PEDOUX, Auteur ; Anna MARUANI, Auteur ; Anita BEGGIATO, Auteur ; Monique ELMALEH, Auteur ; David GERMANAUD, Auteur ; Anouck AMESTOY, Auteur ; Myriam Ly LE-MOAL, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; Marianne ALISSON, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Roberto TORO, Auteur ; Guillaume DUMAS, Auteur ; Clara MOREAU, Auteur ; Richard DELORME, Auteur Article en page(s) : 45 p. Langues : Anglais (eng) Mots-clés : Humans  *Autistic Disorder/diagnostic imaging  *Autism Spectrum Disorder/diagnosis  Neuroanatomy  Magnetic Resonance Imaging  Principal Component Analysis  Cortico-striatal-thalamo-cortical loop  Phenotype  Rrb Index. décimale : PER Périodiques Résumé : BACKGROUND: Repetitive and restricted behaviors and interests (RRBI) are core symptoms of autism with a complex entity and are commonly categorized into 'motor-driven' and 'cognitively driven'. RRBI symptomatology depends on the individual's clinical environment limiting the understanding of RRBI physiology, particularly their associated neuroanatomical structures. The complex RRBI heterogeneity needs to explore the whole RRBI spectrum by integrating the clinical context [autistic individuals, their relatives and typical developing (TD) individuals]. We hypothesized that different RRBI dimensions would emerge by exploring the whole spectrum of RRBI and that these dimensions are associated with neuroanatomical signatures-involving cortical and subcortical areas. METHOD: A sample of 792 individuals composed of 267 autistic subjects, their 370 first-degree relatives and 155 TD individuals was enrolled in the study. We assessed the whole patterns of RRBI in each individual by using the Repetitive Behavior Scale-Revised and the Yale-Brown Obsessive Compulsive Scale. We estimated brain volumes using MRI scanner for a subsample of the subjects (n=152, 42 ASD, 89 relatives and 13 TD). We first investigated the dimensionality of RRBI by performing a principal component analysis on all items of these scales and included all the sampling population. We then explored the relationship between RRBI-derived factors with brain volumes using linear regression models. RESULTS: We identified 3 main factors (with 30.3% of the RRBI cumulative variance): Factor 1 (FA1, 12.7%) reflected mainly the 'motor-driven' RRBI symptoms; Factor 2 and 3 (respectively, 8.8% and 7.9%) gathered mainly Y-BOCS related items and represented the 'cognitively driven' RRBI symptoms. These three factors were significantly associated with the right/left putamen volumes but with opposite effects: FA1 was negatively associated with an increased volume of the right/left putamen conversely to FA2 and FA3 (all uncorrected p<0.05). FA1 was negatively associated with the left amygdala (uncorrected p<0.05), and FA2 was positively associated with the left parietal structure (uncorrected p=0.001). CONCLUSION: Our results suggested 3 coherent RRBI dimensions involving the putamen commonly and other structures according to the RRBI dimension. The exploration of the putamen's integrative role in RSBI needs to be strengthened in further studies. En ligne : https://dx.doi.org/10.1186/s13229-023-00576-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications [texte imprimé] / Nicolas TRAUT, Auteur ; Amandine PEDOUX, Auteur ; Anna MARUANI, Auteur ; Anita BEGGIATO, Auteur ; Monique ELMALEH, Auteur ; David GERMANAUD, Auteur ; Anouck AMESTOY, Auteur ; Myriam Ly LE-MOAL, Auteur ; Christopher H. CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; Marianne ALISSON, Auteur ; Marion LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; Roberto TORO, Auteur ; Guillaume DUMAS, Auteur ; Clara MOREAU, Auteur ; Richard DELORME, Auteur . - 45 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 45 p. Mots-clés : Humans  *Autistic Disorder/diagnostic imaging  *Autism Spectrum Disorder/diagnosis  Neuroanatomy  Magnetic Resonance Imaging  Principal Component Analysis  Cortico-striatal-thalamo-cortical loop  Phenotype  Rrb Index. décimale : PER Périodiques Résumé : BACKGROUND: Repetitive and restricted behaviors and interests (RRBI) are core symptoms of autism with a complex entity and are commonly categorized into 'motor-driven' and 'cognitively driven'. RRBI symptomatology depends on the individual's clinical environment limiting the understanding of RRBI physiology, particularly their associated neuroanatomical structures. The complex RRBI heterogeneity needs to explore the whole RRBI spectrum by integrating the clinical context [autistic individuals, their relatives and typical developing (TD) individuals]. We hypothesized that different RRBI dimensions would emerge by exploring the whole spectrum of RRBI and that these dimensions are associated with neuroanatomical signatures-involving cortical and subcortical areas. METHOD: A sample of 792 individuals composed of 267 autistic subjects, their 370 first-degree relatives and 155 TD individuals was enrolled in the study. We assessed the whole patterns of RRBI in each individual by using the Repetitive Behavior Scale-Revised and the Yale-Brown Obsessive Compulsive Scale. We estimated brain volumes using MRI scanner for a subsample of the subjects (n=152, 42 ASD, 89 relatives and 13 TD). We first investigated the dimensionality of RRBI by performing a principal component analysis on all items of these scales and included all the sampling population. We then explored the relationship between RRBI-derived factors with brain volumes using linear regression models. RESULTS: We identified 3 main factors (with 30.3% of the RRBI cumulative variance): Factor 1 (FA1, 12.7%) reflected mainly the 'motor-driven' RRBI symptoms; Factor 2 and 3 (respectively, 8.8% and 7.9%) gathered mainly Y-BOCS related items and represented the 'cognitively driven' RRBI symptoms. These three factors were significantly associated with the right/left putamen volumes but with opposite effects: FA1 was negatively associated with an increased volume of the right/left putamen conversely to FA2 and FA3 (all uncorrected p<0.05). FA1 was negatively associated with the left amygdala (uncorrected p<0.05), and FA2 was positively associated with the left parietal structure (uncorrected p=0.001). CONCLUSION: Our results suggested 3 coherent RRBI dimensions involving the putamen commonly and other structures according to the RRBI dimension. The exploration of the putamen's integrative role in RSBI needs to be strengthened in further studies. En ligne : https://dx.doi.org/10.1186/s13229-023-00576-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? / Meriem BENNABI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 22p. Titre : Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? Type de document : texte imprimé Auteurs : Meriem BENNABI, Auteur ; Nadine TARANTINO, Auteur ; Alexandru GAMAN, Auteur ; Isabelle SCHEID, Auteur ; Rajagopal KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; Arthur BOULEAU, Auteur ; Mireille CARALP, Auteur ; Sonia GUEGUEN, Auteur ; Myriam Ly LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; Richard DELORME, Auteur ; Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Vincent VIEILLARD, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events? [texte imprimé] / Meriem BENNABI, Auteur ; Nadine TARANTINO, Auteur ; Alexandru GAMAN, Auteur ; Isabelle SCHEID, Auteur ; Rajagopal KRISHNAMOORTHY, Auteur ; P. DEBRE, Auteur ; Arthur BOULEAU, Auteur ; Mireille CARALP, Auteur ; Sonia GUEGUEN, Auteur ; Myriam Ly LE-MOAL, Auteur ; Manuel P. BOUVARD, Auteur ; Anouck AMESTOY, Auteur ; Richard DELORME, Auteur ; Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Vincent VIEILLARD, Auteur . - 22p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 22p. Mots-clés : Autism spectrum disorders  High-functioning autism  Natural killer cells  Pathogens Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) are characterized by abnormal neurodevelopment, genetic, and environmental risk factors, as well as immune dysfunctions. Several lines of evidence suggest alterations in innate immune responses in children with ASD. To address this question in adults with high-functioning ASD (hf-ASD), we sought to investigate the role of natural killer (NK) cells in the persistence of ASD. Methods: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy controls (HC), selected for the absence of any immune dysfunctions, at different time-points, and over a 2-year follow-up period for four patients. The phenotype and polyfunctional capacities of NK cells were explored according to infectious stigma and clinical parameters (IQ, social, and communication scores). Results: As compared to HC, NK cells from patients with hf-ASD showed a high level of cell activation (p < 0.0001), spontaneous degranulation (p < 0.0001), and interferon-gamma production (p = 0.0004), whereas they were exhausted after in vitro stimulations (p = 0.0006). These data yielded a specific HLA-DR(+)KIR2DL1(+)NKG2C(+) NK-cell signature. Significant overexpression of NKG2C in hf-ASD patients (p = 0.0005), indicative of viral infections, was inversely correlated with the NKp46 receptor level (r = - 0.67; p < 0.0001), regardless of the IgG status of tested pathogens. Multivariate linear regression analysis also revealed that expression of the late-activating HLA-DR marker was both associated with structural language (r = 0.48; p = 0.007) and social awareness (r = 0.60; p = 0.0007) scores in adult patients with hf-ASD, while KIR2DL1 expression correlated with IQ scores (p = 0.0083). Conclusions: This study demonstrates that adults with hf-ASD have specific NK-cell profile. Presence of NKG2C overexpression together with high-level activation of NK cells suggest an association with underlying pathogens, a hypothesis warranting further exploration in future studies. En ligne : http://dx.doi.org/10.1186/s13229-019-0269-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder / Nathan NEU ; Aurélie WATILLIAUX ; Axelle MARTINEZ-TERUEL ; Mihoby RAZAFINIMANANA ; Jennifer BOISGONTIER ; Sevan HOTIER ; Marc-Antoine D'ALBIS ; Richard DELORME ; Anouck AMESTOY ; Stefan HOLIGA ; Myriam Ly LE-MOAL ; Pierrick COUPÃ ; Marion LEBOYER ; Josselin HOUENOU ; Laure RONDI-REIG ; Anne-Lise PARADIS in Autism Research, 16-2 (February 2023)  

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"Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study / Matias BALTAZAR in Autism Research, 14-2 (February 2021)  

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Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways / Julian TILLMANN ; Freddy CLIQUET ; Frédérique AMSELLEM ; Anna MARUANI ; Claire S. LEBLOND ; Anita BEGGIATO ; David GERMANAUD ; Anouck AMESTOY ; Myriam Ly LE-MOAL ; Daniel UMBRICHT ; Christopher H. CHATHAM ; Lorraine MURTAGH ; Manuel P. BOUVARD ; Marion LEBOYER ; Tony CHARMAN ; Thomas BOURGERON ; Richard DELORME ; Guillaume DUMAS ; EU-AIMS LEAP GROUP in Autism Research, 16-2 (February 2023)  

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Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR) / Anouck AMESTOY in Molecular Autism, 12 (2021)  

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