Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study / A.L. HOYLAND in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 10 p. Titre : Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study Type de document : texte imprimé Auteurs : A.L. HOYLAND, Auteur ; Terje NAERLAND, Auteur ; M. ENGSTROM, Auteur ; Tonje TORSKE, Auteur ; Stian LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : 10 p. Langues : Anglais (eng) Mots-clés : *asd  *erp  *n1  *P3a  *Passive condition  Research Ethics South East (2013/1236/REK South-East). Written informed consent  was obtained from participants and/ or parents necessary due to age.The authors  declare that they have no competing interests.Springer Nature remains neutral  with regard to jurisdictional claims in published maps and institutional  affiliations. Index. décimale : PER Périodiques Résumé : Background: The core features of autism spectrum disorder (ASD) are easily recognizable in non-structured clinical and real-life situations. The features are often difficult to capture in structured laboratory settings, and the results from tests do not necessarily reflect symptom severity. We investigated neurophysiological processing in the passive parts of a cued Go-NoGo task, using the active parts of the test as a comparator. Methods: Forty-nine adolescents diagnosed with ASD and 49 typically developing (TD) adolescents (age 12-21 years) were included. Daily life executive function was assessed with the Behavior Rating Inventory of Executive Function (BRIEF). We applied a visual cued Go-NoGo task and recorded event-related potentials (ERPs). We investigated occipital N1, a component related to early perception of visual stimuli, and P3a, a fronto-central component related to switching of attention, in the passive and active parts of the test. Results: During the passive parts, the ASD group had statistically significantly longer N1 latency (p < 0.001, Cohens d = 0.75) and enhanced amplitude of P3a (p = 0.002, Cohens d = 0.64) compared to the TD, while no significant differences were observed in the active parts. Both components correlated significantly with the Behavioral Regulation Index of the BRIEF (partial correlation r = 0.35, p = 0.003). Conclusion: Delayed N1 response, indicating altered visual perception, and enhanced P3a response, indicating increased neural activation related to attention allocation, were found during the passive parts of a Go-NoGo task in ASD participants. These abnormal ERP signals in the non-structured settings were associated with everyday executive function, suggesting that neurophysiolocal measures related to atypical control of alertness and "hyper-awareness" underlie daily life dysfunction in ASD. Assessments during passive settings have a potential to reveal core neurobiological substrates of ASD. En ligne : https://dx.doi.org/10.1186/s13229-019-0259-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study [texte imprimé] / A.L. HOYLAND, Auteur ; Terje NAERLAND, Auteur ; M. ENGSTROM, Auteur ; Tonje TORSKE, Auteur ; Stian LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur . - 10 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 10 p. Mots-clés : *asd  *erp  *n1  *P3a  *Passive condition  Research Ethics South East (2013/1236/REK South-East). Written informed consent  was obtained from participants and/ or parents necessary due to age.The authors  declare that they have no competing interests.Springer Nature remains neutral  with regard to jurisdictional claims in published maps and institutional  affiliations. Index. décimale : PER Périodiques Résumé : Background: The core features of autism spectrum disorder (ASD) are easily recognizable in non-structured clinical and real-life situations. The features are often difficult to capture in structured laboratory settings, and the results from tests do not necessarily reflect symptom severity. We investigated neurophysiological processing in the passive parts of a cued Go-NoGo task, using the active parts of the test as a comparator. Methods: Forty-nine adolescents diagnosed with ASD and 49 typically developing (TD) adolescents (age 12-21 years) were included. Daily life executive function was assessed with the Behavior Rating Inventory of Executive Function (BRIEF). We applied a visual cued Go-NoGo task and recorded event-related potentials (ERPs). We investigated occipital N1, a component related to early perception of visual stimuli, and P3a, a fronto-central component related to switching of attention, in the passive and active parts of the test. Results: During the passive parts, the ASD group had statistically significantly longer N1 latency (p < 0.001, Cohens d = 0.75) and enhanced amplitude of P3a (p = 0.002, Cohens d = 0.64) compared to the TD, while no significant differences were observed in the active parts. Both components correlated significantly with the Behavioral Regulation Index of the BRIEF (partial correlation r = 0.35, p = 0.003). Conclusion: Delayed N1 response, indicating altered visual perception, and enhanced P3a response, indicating increased neural activation related to attention allocation, were found during the passive parts of a Go-NoGo task in ASD participants. These abnormal ERP signals in the non-structured settings were associated with everyday executive function, suggesting that neurophysiolocal measures related to atypical control of alertness and "hyper-awareness" underlie daily life dysfunction in ASD. Assessments during passive settings have a potential to reveal core neurobiological substrates of ASD. En ligne : https://dx.doi.org/10.1186/s13229-019-0259-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment / Tonje TORSKE in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.207-220 Titre : Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment Type de document : texte imprimé Auteurs : Tonje TORSKE, Auteur ; Terje NAERLAND, Auteur ; Francesco BETTELLA, Auteur ; Thomas BJELLA, Auteur ; Eva MALT, Auteur ; Anne Lise HOYLAND, Auteur ; Nina STENBERG, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.207-220 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  behavior rating inventory of executive function  executive function  polygenic score Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R(2) = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. En ligne : http://dx.doi.org/10.1002/aur.2207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment [texte imprimé] / Tonje TORSKE, Auteur ; Terje NAERLAND, Auteur ; Francesco BETTELLA, Auteur ; Thomas BJELLA, Auteur ; Eva MALT, Auteur ; Anne Lise HOYLAND, Auteur ; Nina STENBERG, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur . - p.207-220. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.207-220 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  behavior rating inventory of executive function  executive function  polygenic score Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R(2) = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. En ligne : http://dx.doi.org/10.1002/aur.2207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Individual characteristics of students with autism spectrum disorders and school refusal behavior / Ellen Kathrine MUNKHAUGEN in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.413-423 Titre : Individual characteristics of students with autism spectrum disorders and school refusal behavior Type de document : texte imprimé Auteurs : Ellen Kathrine MUNKHAUGEN, Auteur ; Tonje TORSKE, Auteur ; Elen GJEVIK, Auteur ; Terje NAERLAND, Auteur ; Are Hugo PRIPP, Auteur ; Trond H. DISETH, Auteur Article en page(s) : p.413-423 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  individual characteristics  school refusal behavior Index. décimale : PER Périodiques Résumé : This study compared social, executive, emotional, and behavioral characteristics of students with autism spectrum disorder who did and did not display school refusal behavior. The participants were 62 students with autism spectrum disorder without intellectual disability aged 9-16 years attending inclusive schools. Parents first completed questionnaires assessing social and executive functioning as well as emotional and behavioral problems. They then documented their child's school refusal behavior for a period of 20 days. Compared to students without school refusal behavior (n = 29), students with school refusal behavior (n = 33) were significantly less socially motivated; displayed more deficits in initiating tasks or activities, in generating ideas, responses, or problem-solving strategies; and displayed more withdrawn and depressive symptoms. Assessing social and executive functioning, as well as emotional problems, may help professionals provide tailored interventions for students with autism spectrum disorder and school refusal behavior, which will further be valuable in recognizing characteristics associated with school refusal behavior. En ligne : http://dx.doi.org/10.1177/1362361317748619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Individual characteristics of students with autism spectrum disorders and school refusal behavior [texte imprimé] / Ellen Kathrine MUNKHAUGEN, Auteur ; Tonje TORSKE, Auteur ; Elen GJEVIK, Auteur ; Terje NAERLAND, Auteur ; Are Hugo PRIPP, Auteur ; Trond H. DISETH, Auteur . - p.413-423. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.413-423 Mots-clés : autism spectrum disorder  individual characteristics  school refusal behavior Index. décimale : PER Périodiques Résumé : This study compared social, executive, emotional, and behavioral characteristics of students with autism spectrum disorder who did and did not display school refusal behavior. The participants were 62 students with autism spectrum disorder without intellectual disability aged 9-16 years attending inclusive schools. Parents first completed questionnaires assessing social and executive functioning as well as emotional and behavioral problems. They then documented their child's school refusal behavior for a period of 20 days. Compared to students without school refusal behavior (n = 29), students with school refusal behavior (n = 33) were significantly less socially motivated; displayed more deficits in initiating tasks or activities, in generating ideas, responses, or problem-solving strategies; and displayed more withdrawn and depressive symptoms. Assessing social and executive functioning, as well as emotional problems, may help professionals provide tailored interventions for students with autism spectrum disorder and school refusal behavior, which will further be valuable in recognizing characteristics associated with school refusal behavior. En ligne : http://dx.doi.org/10.1177/1362361317748619 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder / Tonje TORSKE in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3847-3859 Titre : Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Tonje TORSKE, Auteur ; Terje NÆRLAND, Auteur ; Daniel S. QUINTANA, Auteur ; Ruth Elizabeth HYPHER, Auteur ; Anett KAALE, Auteur ; Anne Lise HØYLAND, Auteur ; Sigrun HOPE, Auteur ; Jarle JOHANNESSEN, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.3847-3859 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p<0.001) and communication (p=0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. En ligne : https://doi.org/10.1007/s10803-022-05629-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder [texte imprimé] / Tonje TORSKE, Auteur ; Terje NÆRLAND, Auteur ; Daniel S. QUINTANA, Auteur ; Ruth Elizabeth HYPHER, Auteur ; Anett KAALE, Auteur ; Anne Lise HØYLAND, Auteur ; Sigrun HOPE, Auteur ; Jarle JOHANNESSEN, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur . - p.3847-3859. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3847-3859 Index. décimale : PER Périodiques Résumé : Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p<0.001) and communication (p=0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. En ligne : https://doi.org/10.1007/s10803-022-05629-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT / Synnve SCHJØLBERG in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.296-304 Titre : What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT Type de document : texte imprimé Auteurs : Synnve SCHJØLBERG, Auteur ; Frederick SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anders NORDAHL-HANSEN, Auteur ; Nina STENBERG, Auteur ; Tonje TORSKE, Auteur ; Kenneth LARSEN, Auteur ; Katherine RILEY, Auteur ; Denis G. SUKHODOLSKY, Auteur ; James F. LECKMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Roald A. ØIEN, Auteur Article en page(s) : p.296-304 Langues : Anglais (eng) Mots-clés : children  early detection  psychometrics  (includes financial disclosures): None Index. décimale : PER Périodiques Résumé : The present study objectives were to examine the performance of the new M-CHAT-R algorithm to the original M-CHAT algorithm. The main purpose was to examine if the algorithmic changes increase identification of children later diagnosed with ASD, and to examine if there is a trade-off when changing algorithms. We included 54,463 screened cases from the Norwegian Mother and Child Cohort Study. Children were screened using the 23 items of the M-CHAT at 18 months. Further, the performance of the M-CHAT-R algorithm was compared to the M-CHAT algorithm on the 23-items. In total, 337 individuals were later diagnosed with ASD. Using M-CHAT-R algorithm decreased the number of correctly identified ASD children by 12 compared to M-CHAT, with no children with ASD screening negative on the M-CHAT criteria subsequently screening positive utilizing the M-CHAT-R algorithm. A nonparametric McNemar's test determined a statistically significant difference in identifying ASD utilizing the M-CHAT-R algorithm. The present study examined the application of 20-item MCHAT-R scoring criterion to the 23-item MCHAT. We found that this resulted in decreased sensitivity and increased specificity for identifying children with ASD, which is a trade-off that needs further investigation in terms of cost-effectiveness. However, further research is needed to optimize screening for ASD in the early developmental period to increase identification of false negatives. En ligne : http://dx.doi.org/10.1002/aur.2643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT [texte imprimé] / Synnve SCHJØLBERG, Auteur ; Frederick SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anders NORDAHL-HANSEN, Auteur ; Nina STENBERG, Auteur ; Tonje TORSKE, Auteur ; Kenneth LARSEN, Auteur ; Katherine RILEY, Auteur ; Denis G. SUKHODOLSKY, Auteur ; James F. LECKMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Roald A. ØIEN, Auteur . - p.296-304. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.296-304 Mots-clés : children  early detection  psychometrics  (includes financial disclosures): None Index. décimale : PER Périodiques Résumé : The present study objectives were to examine the performance of the new M-CHAT-R algorithm to the original M-CHAT algorithm. The main purpose was to examine if the algorithmic changes increase identification of children later diagnosed with ASD, and to examine if there is a trade-off when changing algorithms. We included 54,463 screened cases from the Norwegian Mother and Child Cohort Study. Children were screened using the 23 items of the M-CHAT at 18 months. Further, the performance of the M-CHAT-R algorithm was compared to the M-CHAT algorithm on the 23-items. In total, 337 individuals were later diagnosed with ASD. Using M-CHAT-R algorithm decreased the number of correctly identified ASD children by 12 compared to M-CHAT, with no children with ASD screening negative on the M-CHAT criteria subsequently screening positive utilizing the M-CHAT-R algorithm. A nonparametric McNemar's test determined a statistically significant difference in identifying ASD utilizing the M-CHAT-R algorithm. The present study examined the application of 20-item MCHAT-R scoring criterion to the 23-item MCHAT. We found that this resulted in decreased sensitivity and increased specificity for identifying children with ASD, which is a trade-off that needs further investigation in terms of cost-effectiveness. However, further research is needed to optimize screening for ASD in the early developmental period to increase identification of false negatives. En ligne : http://dx.doi.org/10.1002/aur.2643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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