Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder / Nico BAST in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1609-1620 Titre : Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder Type de document : texte imprimé Auteurs : Nico BAST, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur ; Veit ROESSNER, Auteur ; Christine M. FREITAG, Auteur ; Melanie RING, Auteur Article en page(s) : p.1609-1620 Langues : Anglais (eng) Mots-clés : Adult  Arousal/physiology  Autism Spectrum Disorder/complications  Humans  Locus Coeruleus  Pupil/physiology  Recognition, Psychology  Asd  locus coeruleus-norepinephrine system  memory  pupillometry Index. décimale : PER Périodiques Résumé : Recently, we have shown that pupil dilation during a recognition memory task can serve as an index of memory retrieval difficulties in autism. At the time of publication, we were unaware of specific data-analysis methods that can be used to shed further light on the origins of such memory related pupil dilation. Specifically, by distinguishing "tonic" from "phasic" changes in pupil dilation and considering their temporal progression, it is possible to draw inferences about the functional integrity of a locus coeruleus-norepinephrine system (LC-NE) that is known to play a key role in regulating memory encoding and retrieval processes. We therefore apply these analyses to our previously published eye-tracking data of adults with ASD (N = 24) and neurotypical development (TD, N = 30) during the recognition memory task. In this re-analysis, we related pupil dilation during encoding and retrieval to recognition accuracy in a per-trial analysis of linear mixed models. In ASD, we replicated attenuated recognition accuracy, which was accompanied by attenuated pupil dilation during encoding and retrieval. Group differences in pupil dilation during retrieval occurred late during the trial (after 1.75s) and indicated an altered top-down processing like attenuated attribution of semantic salience in response to previously encoded stimuli. In addition, only in the ASD group were higher pupil dilation during encoding and lower pupil dilation during retrieval associated with decreased recognition accuracy. This supports altered modulation of memory encoding and retrieval in ASD, with LC-NE phasic activity as promising underlying mechanism. LAY SUMMARY: We investigated the changes of pupil size during memory testing in autism spectrum disorder. Adults with ASD remembered fewer items correctly than neurotypical individuals (TD). This reduced memory was related to increased pupillary responses at study and decreased pupil dilation at test only for adults with ASD indicating a different modulation of memory by the locus coeruleus. En ligne : http://dx.doi.org/10.1002/aur.2784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder [texte imprimé] / Nico BAST, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur ; Veit ROESSNER, Auteur ; Christine M. FREITAG, Auteur ; Melanie RING, Auteur . - p.1609-1620. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1609-1620 Mots-clés : Adult  Arousal/physiology  Autism Spectrum Disorder/complications  Humans  Locus Coeruleus  Pupil/physiology  Recognition, Psychology  Asd  locus coeruleus-norepinephrine system  memory  pupillometry Index. décimale : PER Périodiques Résumé : Recently, we have shown that pupil dilation during a recognition memory task can serve as an index of memory retrieval difficulties in autism. At the time of publication, we were unaware of specific data-analysis methods that can be used to shed further light on the origins of such memory related pupil dilation. Specifically, by distinguishing "tonic" from "phasic" changes in pupil dilation and considering their temporal progression, it is possible to draw inferences about the functional integrity of a locus coeruleus-norepinephrine system (LC-NE) that is known to play a key role in regulating memory encoding and retrieval processes. We therefore apply these analyses to our previously published eye-tracking data of adults with ASD (N = 24) and neurotypical development (TD, N = 30) during the recognition memory task. In this re-analysis, we related pupil dilation during encoding and retrieval to recognition accuracy in a per-trial analysis of linear mixed models. In ASD, we replicated attenuated recognition accuracy, which was accompanied by attenuated pupil dilation during encoding and retrieval. Group differences in pupil dilation during retrieval occurred late during the trial (after 1.75s) and indicated an altered top-down processing like attenuated attribution of semantic salience in response to previously encoded stimuli. In addition, only in the ASD group were higher pupil dilation during encoding and lower pupil dilation during retrieval associated with decreased recognition accuracy. This supports altered modulation of memory encoding and retrieval in ASD, with LC-NE phasic activity as promising underlying mechanism. LAY SUMMARY: We investigated the changes of pupil size during memory testing in autism spectrum disorder. Adults with ASD remembered fewer items correctly than neurotypical individuals (TD). This reduced memory was related to increased pupillary responses at study and decreased pupil dilation at test only for adults with ASD indicating a different modulation of memory by the locus coeruleus. En ligne : http://dx.doi.org/10.1002/aur.2784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Capturing change in restricted and repetitive behaviour in preschoolers with ASD: A comparison of direct behavioural observation and parent report / Naisan RAJI in Journal of Child Psychology and Psychiatry, 66-11 (November 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1736-1747 Titre : Capturing change in restricted and repetitive behaviour in preschoolers with ASD: A comparison of direct behavioural observation and parent report Type de document : texte imprimé Auteurs : Naisan RAJI, Auteur ; Janina KITZEROW-CLEVEN, Auteur ; Ziyon KIM, Auteur ; Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Christian LEMLER, Auteur ; Melanie RING, Auteur ; Regina TAURINES, Auteur ; Julia GEIßLER, Auteur ; Ulrike FRÖHLICH, Auteur ; Michele NOTERDAEME, Auteur ; Nico BAST, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.1736-1747 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  longitudinal studies  development  behavioural measures  stereotyped behaviour Index. décimale : PER Périodiques Résumé : Background Restricted and repetitive behaviour (RRB) in autism spectrum disorder (ASD) can be assessed by different measures, which diverge in item quantity, dimensionality or source of information. However, change sensitivity has not been systematically investigated among commonly used measures, albeit its importance for clinical trials and longitudinal studies. Methods Longitudinal data resulting from behavioural observation (Autism Diagnostic Observation Schedule-2, ADOS-2; Brief Observation of Social Communication Change, BOSCC) and parent report (Restricted Behaviour Scale-Revised, RBS-R) was collected for 134 toddlers and preschoolers aged 25?65?months diagnosed with ASD by the Autism Diagnostic Interview-Revised (ADI-R) and ADOS-2. Change sensitivity was estimated using the reliable-change index and developmental trajectories of RRB by linear mixed models and k-means clustering. Results The RBS-R identified significantly more reliable change in RRB severity compared to ADOS-2 and BOSCC. For all measures, except the RBS-R self-injurious behaviour subscale, three distinct RRB trajectories were found as follows: increasing, stable and decreasing RRB severity. Overlap was low between trajectory group assignment across measures, as were cross-sectional correlations between ADI-R, ADOS-2, BOSCC and RBS-R. Trajectory group comparisons among measures mostly showed lower baseline RRB severity in the increasing trajectory groups and higher baseline RRB severity in the decreasing trajectory groups. The trajectory groups did not differ in age or nonverbal IQ across RRB measures, except for the RBS-R compulsive behaviour subscale, which had higher nonverbal IQ in the decreasing trajectory group. Conclusions The dimensional questionnaire RBS-R compared to ADOS-2 and BOSCC is superior in capturing subtle changes in RRB during preschool age. En ligne : https://doi.org/10.1111/jcpp.70009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Capturing change in restricted and repetitive behaviour in preschoolers with ASD: A comparison of direct behavioural observation and parent report [texte imprimé] / Naisan RAJI, Auteur ; Janina KITZEROW-CLEVEN, Auteur ; Ziyon KIM, Auteur ; Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Christian LEMLER, Auteur ; Melanie RING, Auteur ; Regina TAURINES, Auteur ; Julia GEIßLER, Auteur ; Ulrike FRÖHLICH, Auteur ; Michele NOTERDAEME, Auteur ; Nico BAST, Auteur ; Christine M. FREITAG, Auteur . - p.1736-1747. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-11 (November 2025) . - p.1736-1747 Mots-clés : Autism spectrum disorders  longitudinal studies  development  behavioural measures  stereotyped behaviour Index. décimale : PER Périodiques Résumé : Background Restricted and repetitive behaviour (RRB) in autism spectrum disorder (ASD) can be assessed by different measures, which diverge in item quantity, dimensionality or source of information. However, change sensitivity has not been systematically investigated among commonly used measures, albeit its importance for clinical trials and longitudinal studies. Methods Longitudinal data resulting from behavioural observation (Autism Diagnostic Observation Schedule-2, ADOS-2; Brief Observation of Social Communication Change, BOSCC) and parent report (Restricted Behaviour Scale-Revised, RBS-R) was collected for 134 toddlers and preschoolers aged 25?65?months diagnosed with ASD by the Autism Diagnostic Interview-Revised (ADI-R) and ADOS-2. Change sensitivity was estimated using the reliable-change index and developmental trajectories of RRB by linear mixed models and k-means clustering. Results The RBS-R identified significantly more reliable change in RRB severity compared to ADOS-2 and BOSCC. For all measures, except the RBS-R self-injurious behaviour subscale, three distinct RRB trajectories were found as follows: increasing, stable and decreasing RRB severity. Overlap was low between trajectory group assignment across measures, as were cross-sectional correlations between ADI-R, ADOS-2, BOSCC and RBS-R. Trajectory group comparisons among measures mostly showed lower baseline RRB severity in the increasing trajectory groups and higher baseline RRB severity in the decreasing trajectory groups. The trajectory groups did not differ in age or nonverbal IQ across RRB measures, except for the RBS-R compulsive behaviour subscale, which had higher nonverbal IQ in the decreasing trajectory group. Conclusions The dimensional questionnaire RBS-R compared to ADOS-2 and BOSCC is superior in capturing subtle changes in RRB during preschool age. En ligne : https://doi.org/10.1111/jcpp.70009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study / Nico BAST in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 41 Titre : Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study Type de document : texte imprimé Auteurs : Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Gráinne M. MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Gráinne M. MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : 41 Langues : Anglais (eng) Mots-clés : Humans  Male  Electroencephalography/methods  Female  Autistic Disorder/physiopathology  Adult  Locus Coeruleus/physiopathology/metabolism  Young Adult  Pupil/physiology  Auditory Perception  Adolescent  Acoustic Stimulation  Up-Regulation  Case-Control Studies  Arousal  Auditory oddball paradigm  Autism spectrum condition  Mismatch negativity  Predictive coding  Pupillometry  (where appropriate) and their parent/legal guardian provided written informed  consent. Ethical approval for this study was obtained through ethics committees  at each site (King’s College London—London Queen Square Health Research Authority  Research Ethics Committee: 13/LO/1156  Autism Research Centre, University of  Cambridge—London Queen Square Health Research Authority Research Ethics  Committee: 13/LO/1156  Radboud University Medical Centre—Quality and Safety  Committee on Research Involving Human Subjects Arnhem-Nijmegen: 2013/455,  University Medical Centre Utrecht—- Quality and Safety Committee on Research  Involving Human Subjects Arnhem-Nijmegen: 2013/455  Central Insitute of Mental  Health—University Medical Mannheim, Medical Ethics Commission II: 2014-540N-MA  Universita Campus Bio-Medica De Roma—Medical Ethics Committee: 18/14 PAR ComET  CBM  Karolinska Intitute – Central Ethical Review Board: 32–2010). Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing requires selectivity to salient sensory input. Many autistic individuals report different sensory processing, which has been associated with altered sensory selectivity. The locus-coeruleus norepinephrine (LC-NE) system modulates the neuronal gain of sensory input, which represents a neurophysiological mechanism of sensory selectivity. In autistic individuals, we hypothesized that LC-NE tonic upregulation reduces sensory selectivity and underlies different sensory processing. METHODS: Autistic (n = 139) and non-autistic (n = 98) individuals were assessed during a passive auditory oddball task with pupillometry and electroencephalography. For every trial, a baseline pupil size (BPS) assessed LC-NE tonic activity that coincides with current arousal, while a stimulus-evoked pupillary response (SEPR) assessed LC-NE phasic activity that estimated sensory selectivity. Electroencephalography assessed amplitudes of mismatch negativity (MMN-amp) that estimated pre-attentive change detection as a brain-activity readout of sensory selectivity. Measures were modeled between groups within the task by combining Frequentist and Bayesian approaches. RESULTS: Across groups, higher BPS was associated with more negative MMN-amp to standards and oddballs. A more negative MMN-amp to standards was associated with a higher SEPR to standards. Controlling for these associations, autistic versus non-autistic individuals showed a higher SEPR in response to standards. In addition, a positive association of BPS and SEPR to standards was specific to autistic individuals. With task progression, autistic versus non-autistic individuals showed a higher initial increase and subsequently steeper decrease of BPS. This was supported by Bayesian posterior distribution estimates. LIMITATIONS: A short trial duration required concatenating trials to epochs and applying a linear-time invariant filter to capture the slow pupil changes. Without an LC-NE manipulation, we cannot rule out that pupil changes are evoked by other cortical pathways than the LC-NE. CONCLUSIONS: Across groups, LC-NE tonic upregulation is emphasized as a general mechanism that un-specifically increases pre-attentive change detection to all sensory stimuli, which then increases sensory selectivity to frequent stimuli. In autistic individuals, different sensory processing is characterized by increased sensory selectivity to frequent stimuli. This is likely caused by an LC-NE tonic upregulation. It associates autistic sensory processing with increased arousal upregulation that increases sensory selectivity to inconspicuous auditory information. En ligne : https://dx.doi.org/10.1186/s13229-025-00678-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study [texte imprimé] / Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Gráinne M. MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Gráinne M. MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur . - 41. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 41 Mots-clés : Humans  Male  Electroencephalography/methods  Female  Autistic Disorder/physiopathology  Adult  Locus Coeruleus/physiopathology/metabolism  Young Adult  Pupil/physiology  Auditory Perception  Adolescent  Acoustic Stimulation  Up-Regulation  Case-Control Studies  Arousal  Auditory oddball paradigm  Autism spectrum condition  Mismatch negativity  Predictive coding  Pupillometry  (where appropriate) and their parent/legal guardian provided written informed  consent. Ethical approval for this study was obtained through ethics committees  at each site (King’s College London—London Queen Square Health Research Authority  Research Ethics Committee: 13/LO/1156  Autism Research Centre, University of  Cambridge—London Queen Square Health Research Authority Research Ethics  Committee: 13/LO/1156  Radboud University Medical Centre—Quality and Safety  Committee on Research Involving Human Subjects Arnhem-Nijmegen: 2013/455,  University Medical Centre Utrecht—- Quality and Safety Committee on Research  Involving Human Subjects Arnhem-Nijmegen: 2013/455  Central Insitute of Mental  Health—University Medical Mannheim, Medical Ethics Commission II: 2014-540N-MA  Universita Campus Bio-Medica De Roma—Medical Ethics Committee: 18/14 PAR ComET  CBM  Karolinska Intitute – Central Ethical Review Board: 32–2010). Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing requires selectivity to salient sensory input. Many autistic individuals report different sensory processing, which has been associated with altered sensory selectivity. The locus-coeruleus norepinephrine (LC-NE) system modulates the neuronal gain of sensory input, which represents a neurophysiological mechanism of sensory selectivity. In autistic individuals, we hypothesized that LC-NE tonic upregulation reduces sensory selectivity and underlies different sensory processing. METHODS: Autistic (n = 139) and non-autistic (n = 98) individuals were assessed during a passive auditory oddball task with pupillometry and electroencephalography. For every trial, a baseline pupil size (BPS) assessed LC-NE tonic activity that coincides with current arousal, while a stimulus-evoked pupillary response (SEPR) assessed LC-NE phasic activity that estimated sensory selectivity. Electroencephalography assessed amplitudes of mismatch negativity (MMN-amp) that estimated pre-attentive change detection as a brain-activity readout of sensory selectivity. Measures were modeled between groups within the task by combining Frequentist and Bayesian approaches. RESULTS: Across groups, higher BPS was associated with more negative MMN-amp to standards and oddballs. A more negative MMN-amp to standards was associated with a higher SEPR to standards. Controlling for these associations, autistic versus non-autistic individuals showed a higher SEPR in response to standards. In addition, a positive association of BPS and SEPR to standards was specific to autistic individuals. With task progression, autistic versus non-autistic individuals showed a higher initial increase and subsequently steeper decrease of BPS. This was supported by Bayesian posterior distribution estimates. LIMITATIONS: A short trial duration required concatenating trials to epochs and applying a linear-time invariant filter to capture the slow pupil changes. Without an LC-NE manipulation, we cannot rule out that pupil changes are evoked by other cortical pathways than the LC-NE. CONCLUSIONS: Across groups, LC-NE tonic upregulation is emphasized as a general mechanism that un-specifically increases pre-attentive change detection to all sensory stimuli, which then increases sensory selectivity to frequent stimuli. In autistic individuals, different sensory processing is characterized by increased sensory selectivity to frequent stimuli. This is likely caused by an LC-NE tonic upregulation. It associates autistic sensory processing with increased arousal upregulation that increases sensory selectivity to inconspicuous auditory information. En ligne : https://dx.doi.org/10.1186/s13229-025-00678-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder / Sara BOXHOORN in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.614-624 Titre : Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Sara BOXHOORN, Auteur ; Nico BAST, Auteur ; Hans SUPER, Auteur ; Leonie POLZER, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.614-624 Langues : Anglais (eng) Mots-clés : Attention  LC-NE system  attention-deficit/hyperactivity disorder  autism spectrum disorder  pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research demonstrated atypical attention in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets in ASD, and atypical processing of alerting cues in ADHD. The locus coeruleus-norepinephrine (LC-NE) system plays an important role in exploiting alerting cues to increase attention and task performance. The present study's aim was to examine differential subcortical processes underlying visual orienting in ASD and ADHD with pupil dilation (PD) as index of LC activity. METHODS: Pupil dilation (PD) progression metrics during visual orienting were calculated for task-evoked PD locked to cue, stimulus onset, and behavioral response. Group differences in PD and reaction time (RT) were compared between children with ASD without ADHD (ASD-) (N = 18), ADHD without ASD (ADHD-) (N = 28), both disorders (ASD + ADHD) (N = 14), and typically developing children (TD) (N = 31) using linear mixed models (LMM). To further explore the modulatory role of the LC-NE system group differences in the effect of task-evoked PD metrics on RT were examined exploratively. RESULTS: ASD (+ADHD) showed slower orienting responses to relatively unexpected spatial target stimuli as compared to TD, which was accompanied by higher PD amplitudes relative to ADHD- and TD. In ADHD-, shorter cue-evoked PD latencies relative to ASD-, ASD + ADHD, and TD were found. Group differences in the effect of cue- and stimulus-evoked PD amplitudes on RT were found in ASD- relative to TD. CONCLUSIONS: Study findings provide new evidence for a specific role of the LC-NE system in impaired reflexive orienting responses in ASD, and atypical visual processing of alerting cues in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder [texte imprimé] / Sara BOXHOORN, Auteur ; Nico BAST, Auteur ; Hans SUPER, Auteur ; Leonie POLZER, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur . - p.614-624. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.614-624 Mots-clés : Attention  LC-NE system  attention-deficit/hyperactivity disorder  autism spectrum disorder  pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research demonstrated atypical attention in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets in ASD, and atypical processing of alerting cues in ADHD. The locus coeruleus-norepinephrine (LC-NE) system plays an important role in exploiting alerting cues to increase attention and task performance. The present study's aim was to examine differential subcortical processes underlying visual orienting in ASD and ADHD with pupil dilation (PD) as index of LC activity. METHODS: Pupil dilation (PD) progression metrics during visual orienting were calculated for task-evoked PD locked to cue, stimulus onset, and behavioral response. Group differences in PD and reaction time (RT) were compared between children with ASD without ADHD (ASD-) (N = 18), ADHD without ASD (ADHD-) (N = 28), both disorders (ASD + ADHD) (N = 14), and typically developing children (TD) (N = 31) using linear mixed models (LMM). To further explore the modulatory role of the LC-NE system group differences in the effect of task-evoked PD metrics on RT were examined exploratively. RESULTS: ASD (+ADHD) showed slower orienting responses to relatively unexpected spatial target stimuli as compared to TD, which was accompanied by higher PD amplitudes relative to ADHD- and TD. In ADHD-, shorter cue-evoked PD latencies relative to ASD-, ASD + ADHD, and TD were found. Group differences in the effect of cue- and stimulus-evoked PD amplitudes on RT were found in ASD- relative to TD. CONCLUSIONS: Study findings provide new evidence for a specific role of the LC-NE system in impaired reflexive orienting responses in ASD, and atypical visual processing of alerting cues in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder / Nico BAST in Autism Research, 12-11 (November 2019)  

Public ISBD [article]  inAutism Research > 12-11 (November 2019) . - p.1680-1692 Titre : Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Nico BAST, Auteur ; Tobias BANASCHEWSKI, Auteur ; Isabel DZIOBEK, Auteur ; Daniel BRANDEIS, Auteur ; Luise POUSTKA, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.1680-1692 Langues : Anglais (eng) Mots-clés : attention modulation  biomarker  eye tracking  pupillary reactivity  sensory processing Index. décimale : PER Périodiques Résumé : Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism. En ligne : http://dx.doi.org/10.1002/aur.2178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder [texte imprimé] / Nico BAST, Auteur ; Tobias BANASCHEWSKI, Auteur ; Isabel DZIOBEK, Auteur ; Daniel BRANDEIS, Auteur ; Luise POUSTKA, Auteur ; Christine M. FREITAG, Auteur . - p.1680-1692. Langues : Anglais (eng) in Autism Research > 12-11 (November 2019) . - p.1680-1692 Mots-clés : attention modulation  biomarker  eye tracking  pupillary reactivity  sensory processing Index. décimale : PER Périodiques Résumé : Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism. En ligne : http://dx.doi.org/10.1002/aur.2178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder / Leonie POLZER in Autism Research, 15-11 (November 2022)  

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Repetitive Behavior in Children and Adolescents: Psychometric Properties of the German Version of the Repetitive Behavior Scale-Revised / Isabella S. KÄSTEL in Journal of Autism and Developmental Disorders, 51-4 (April 2021)  

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Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder / Nico BAST in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

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Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking / Solvejg K. KLEBER ; Leonie POLZER ; Naisan RAJI ; Janina KITZEROW-CLEVEN ; Ziyon KIM ; Simeon PLATTE ; Christine M. FREITAG ; Nico BAST in Autism Research, 18-4 (April 2025)  

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The Revised Children's Communication Checklist-2 (CCC-R): Factor Structure and Psychometric Evaluation / Sophia A.C. WELLNITZ in Autism Research, 14-4 (April 2021)  

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