Age at Autism Diagnosis in the Norwegian Mother, Father, and Child Cohort Study (MoBa): Exploring the Association With Family Well-Being / Bernt Damian GLASER in Autism, 30-10 (October 2026)  

Public ISBD [article]  inAutism > 30-10 (October 2026) . - p.2596-2609 Titre : Age at Autism Diagnosis in the Norwegian Mother, Father, and Child Cohort Study (MoBa): Exploring the Association With Family Well-Being Type de document : texte imprimé Auteurs : Bernt Damian GLASER, Auteur ; Meseret Mamo BAZEZEW, Auteur ; Daniela BRAGANTINI, Auteur ; Laura Elizabeth HEGEMANN, Auteur ; Stian ORM, Auteur ; Morgan James MORGAN, Auteur ; Somer L. BISHOP, Auteur ; Stian Barbo VALAND, Auteur ; Laurie John HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.2596-2609 Langues : Anglais (eng) Mots-clés : autism  diagnosis  well-being  family functioning and support  school-age children  adolescents  parents  MoBa  the Norwegian Mother  Father and Child Cohort Study Index. décimale : PER Périodiques Résumé : For many autistic individuals, close family members represent a crucial source of support throughout their lifetime. Early autism diagnosis is thought to benefit both autistic individuals and their family members by facilitating early access to services and information. However, little research has empirically studied the relationship between age at diagnosis and well-being among autistic individuals and their family members. In this study, we examined predictors of age at autism diagnosis and its relationship with family well-being using the population-based Norwegian Mother, Father, and Child Cohort Study (MoBa). We found that the most important factors associated with a later age at diagnosis were fewer social communication difficulties at age three, fewer maternal concerns about development in early childhood, absence of a co-occurring intellectual disability diagnosis, female sex, and having older siblings. While a later age at diagnosis was associated with higher well-being for mothers and children during childhood, it was associated with lower well-being for children during adolescence. All associations were substantially attenuated after adjustment for various clinical, demographic, and genetic factors – reflecting complex patterns of confounding. We argue that future research should aim to leverage public awareness campaigns, screening programmes, or changes in clinical practice to understand the causal mechanisms underlying these relationships.Lay abstract Family members of autistic people are often an important source of support for their well-being. An earlier autism diagnosis might be helpful for autistic individuals and their families, because families might receive professional support sooner. However, the impact of an earlier diagnosis is difficult to study, because many child and family characteristics that lead to an earlier autism diagnosis may have their own influence on well-being in autistic individuals and their families. In this study, we look at how age at diagnosis and family well-being are related and how they both relate to different child and family characteristics. We find that children, on average, receive a later autism diagnosis when they have fewer social communication difficulties and fewer maternal concerns in early childhood, do not also have an intellectual disability diagnosis, are a girl, or have older siblings. We also found that a later autism diagnosis was associated with higher well-being for children and mothers in childhood but with lower well-being for children in adolescence. When we compared families with similar child and family characteristics, we no longer saw such clear links between age at diagnosis and well-being. This might be because of the complex mixture of influences child and family characteristics have on both age at diagnosis and well-being and suggests that other types of study may be better for investigating the impact of age at diagnosis on well-being in families. En ligne : https://dx.doi.org/10.1177/13623613261474929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Age at Autism Diagnosis in the Norwegian Mother, Father, and Child Cohort Study (MoBa): Exploring the Association With Family Well-Being [texte imprimé] / Bernt Damian GLASER, Auteur ; Meseret Mamo BAZEZEW, Auteur ; Daniela BRAGANTINI, Auteur ; Laura Elizabeth HEGEMANN, Auteur ; Stian ORM, Auteur ; Morgan James MORGAN, Auteur ; Somer L. BISHOP, Auteur ; Stian Barbo VALAND, Auteur ; Laurie John HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur . - p.2596-2609. Langues : Anglais (eng) in Autism > 30-10 (October 2026) . - p.2596-2609 Mots-clés : autism  diagnosis  well-being  family functioning and support  school-age children  adolescents  parents  MoBa  the Norwegian Mother  Father and Child Cohort Study Index. décimale : PER Périodiques Résumé : For many autistic individuals, close family members represent a crucial source of support throughout their lifetime. Early autism diagnosis is thought to benefit both autistic individuals and their family members by facilitating early access to services and information. However, little research has empirically studied the relationship between age at diagnosis and well-being among autistic individuals and their family members. In this study, we examined predictors of age at autism diagnosis and its relationship with family well-being using the population-based Norwegian Mother, Father, and Child Cohort Study (MoBa). We found that the most important factors associated with a later age at diagnosis were fewer social communication difficulties at age three, fewer maternal concerns about development in early childhood, absence of a co-occurring intellectual disability diagnosis, female sex, and having older siblings. While a later age at diagnosis was associated with higher well-being for mothers and children during childhood, it was associated with lower well-being for children during adolescence. All associations were substantially attenuated after adjustment for various clinical, demographic, and genetic factors – reflecting complex patterns of confounding. We argue that future research should aim to leverage public awareness campaigns, screening programmes, or changes in clinical practice to understand the causal mechanisms underlying these relationships.Lay abstract Family members of autistic people are often an important source of support for their well-being. An earlier autism diagnosis might be helpful for autistic individuals and their families, because families might receive professional support sooner. However, the impact of an earlier diagnosis is difficult to study, because many child and family characteristics that lead to an earlier autism diagnosis may have their own influence on well-being in autistic individuals and their families. In this study, we look at how age at diagnosis and family well-being are related and how they both relate to different child and family characteristics. We find that children, on average, receive a later autism diagnosis when they have fewer social communication difficulties and fewer maternal concerns in early childhood, do not also have an intellectual disability diagnosis, are a girl, or have older siblings. We also found that a later autism diagnosis was associated with higher well-being for children and mothers in childhood but with lower well-being for children in adolescence. When we compared families with similar child and family characteristics, we no longer saw such clear links between age at diagnosis and well-being. This might be because of the complex mixture of influences child and family characteristics have on both age at diagnosis and well-being and suggests that other types of study may be better for investigating the impact of age at diagnosis on well-being in families. En ligne : https://dx.doi.org/10.1177/13623613261474929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study / Alexandra HAVDAHL in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1070-1078 Titre : Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study Type de document : texte imprimé Auteurs : Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; Synnve SCHJØLBERG, Auteur ; Anne-Siri ØYEN, Auteur ; PÃ¥l SUREN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Per MAGNUS, Auteur ; Michaeline BRESNAHAN, Auteur ; Mady HORNIG, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Catherine LORD, Auteur ; Camilla STOLTENBERG, Auteur ; Audrey THURM, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.1070-1078 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Child  Cohort Studies  Humans  Intellectual Disability/epidemiology  Neurodevelopmental Disorders/epidemiology  Walking  Intellectual disability  MoBa  epidemiology  gross motor milestones  late walking  All profits from their research are donated to charity. The other authors report no  conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. OBJECTIVE: To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). METHODS: Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. RESULTS: The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, χ(2)  = 13.93, p = .0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio = 0.79, 95% CI: 0.78-0.85) in the NDD group compared to 8% (hazard ratio = 0.92, 95% CI: 0.86-0.98) in the ASD group. CONCLUSIONS: The finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs. En ligne : http://dx.doi.org/10.1111/jcpp.13369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study [texte imprimé] / Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; Synnve SCHJØLBERG, Auteur ; Anne-Siri ØYEN, Auteur ; PÃ¥l SUREN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Per MAGNUS, Auteur ; Michaeline BRESNAHAN, Auteur ; Mady HORNIG, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Catherine LORD, Auteur ; Camilla STOLTENBERG, Auteur ; Audrey THURM, Auteur ; Somer L. BISHOP, Auteur . - p.1070-1078. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1070-1078 Mots-clés : Autism Spectrum Disorder/epidemiology  Child  Cohort Studies  Humans  Intellectual Disability/epidemiology  Neurodevelopmental Disorders/epidemiology  Walking  Intellectual disability  MoBa  epidemiology  gross motor milestones  late walking  All profits from their research are donated to charity. The other authors report no  conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. OBJECTIVE: To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). METHODS: Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n = 212 vs. NDD n = 354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. RESULTS: The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group × nonverbal IQ interaction, χ(2)  = 13.93, p = .0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio = 0.79, 95% CI: 0.78-0.85) in the NDD group compared to 8% (hazard ratio = 0.92, 95% CI: 0.86-0.98) in the ASD group. CONCLUSIONS: The finding that age of walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs. En ligne : http://dx.doi.org/10.1111/jcpp.13369 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study / Alexandra HAVDAHL in Journal of Child Psychology and Psychiatry, 65-5 (May 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.610-619 Titre : Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study Type de document : texte imprimé Auteurs : Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; PÃ¥l SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Per MAGNUS, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur ; Somer L. BISHOP, Auteur ; Audrey THURM, Auteur Article en page(s) : p.610-619 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Delays and loss of early-emerging social-communication skills are often discussed as unique to autism. However, most studies of regression have relied on retrospective recall and clinical samples. Here, we examine attainment and loss of social-communication skills in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa). Methods Mothers rated their child's attainment of 10 early-emerging social-communication skills at ages 18 and 36 months (N = 40,613, 50.9% male). Prospectively reported loss was defined as skill presence at 18 months but absence at 36 months. At 36 months, mothers also recalled whether the child had lost social-communication skills. The Norwegian Patient Registry was used to capture diagnoses of Autism Spectrum Disorder (autism) and other neurodevelopmental disabilities (NDDs). Results Delay in at least one skill was observed in 14% of the sample and loss in 5.4%. Recalled loss of social-communication skills was rare (0.86%) and showed low convergence with prospectively reported loss. Delay and especially loss were associated with elevated odds of an autism diagnosis (n = 383) versus no autism diagnosis (n = 40,230; 3 skills delayed: OR = 7.09[4.15,12.11]; 3 skills lost: OR = 30.66[17.30,54.33]). They were also associated with an increased likelihood of autism compared to some other NDDs. Delay (relative risk [RR] = 4.16[2.08, 8.33]) and loss (RR = 10.00[3.70, 25.00]) associated with increased likelihood of autism versus ADHD, and loss (RR = 4.35[1.28,14.29]), but not delay (RR = 2.00[0.78,5.26]), associated with increased likelihood of autism compared to language disability. Conversely, delay conferred decreased likelihood of autism versus intellectual disability (RR = 0.11[0.06,0.21]), and loss was not reliably associated with likelihood of autism versus intellectual disability (RR = 1.89[0.44,8.33]). Conclusions This population-based study suggests that loss of early social communication skills is more common than studies using retrospective reports have indicated and is observed across several NDD diagnoses (not just autism). Nevertheless, most children with NDD diagnoses showed no reported delay or loss in these prospectively measured skills. En ligne : https://doi.org/10.1111/jcpp.13792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study [texte imprimé] / Alexandra HAVDAHL, Auteur ; Cristan FARMER, Auteur ; PÃ¥l SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Per MAGNUS, Auteur ; Ezra SUSSER, Auteur ; W. Ian LIPKIN, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur ; Somer L. BISHOP, Auteur ; Audrey THURM, Auteur . - p.610-619. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.610-619 Index. décimale : PER Périodiques Résumé : Background Delays and loss of early-emerging social-communication skills are often discussed as unique to autism. However, most studies of regression have relied on retrospective recall and clinical samples. Here, we examine attainment and loss of social-communication skills in the population-based Norwegian Mother, Father and Child Cohort Study (MoBa). Methods Mothers rated their child's attainment of 10 early-emerging social-communication skills at ages 18 and 36 months (N = 40,613, 50.9% male). Prospectively reported loss was defined as skill presence at 18 months but absence at 36 months. At 36 months, mothers also recalled whether the child had lost social-communication skills. The Norwegian Patient Registry was used to capture diagnoses of Autism Spectrum Disorder (autism) and other neurodevelopmental disabilities (NDDs). Results Delay in at least one skill was observed in 14% of the sample and loss in 5.4%. Recalled loss of social-communication skills was rare (0.86%) and showed low convergence with prospectively reported loss. Delay and especially loss were associated with elevated odds of an autism diagnosis (n = 383) versus no autism diagnosis (n = 40,230; 3 skills delayed: OR = 7.09[4.15,12.11]; 3 skills lost: OR = 30.66[17.30,54.33]). They were also associated with an increased likelihood of autism compared to some other NDDs. Delay (relative risk [RR] = 4.16[2.08, 8.33]) and loss (RR = 10.00[3.70, 25.00]) associated with increased likelihood of autism versus ADHD, and loss (RR = 4.35[1.28,14.29]), but not delay (RR = 2.00[0.78,5.26]), associated with increased likelihood of autism compared to language disability. Conversely, delay conferred decreased likelihood of autism versus intellectual disability (RR = 0.11[0.06,0.21]), and loss was not reliably associated with likelihood of autism versus intellectual disability (RR = 1.89[0.44,8.33]). Conclusions This population-based study suggests that loss of early social communication skills is more common than studies using retrospective reports have indicated and is observed across several NDD diagnoses (not just autism). Nevertheless, most children with NDD diagnoses showed no reported delay or loss in these prospectively measured skills. En ligne : https://doi.org/10.1111/jcpp.13792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood / Laura SCHELLHAS in Journal of Child Psychology and Psychiatry, 67-11 (November 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-11 (November 2026) . - p.1868-1882 Titre : Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood Type de document : texte imprimé Auteurs : Laura SCHELLHAS, Auteur ; Mannan LUO, Auteur ; Janine F. FELIX, Auteur ; Christian M. PAGE, Auteur ; Mona BEKKHUS, Auteur ; Marcus R. MUNAFO, Auteur ; Luisa ZUCCOLO, Auteur ; Alexandra HAVDAHL, Auteur ; Charlotte A. M. CECIL, Auteur ; Gemma C. SHARP, Auteur Article en page(s) : p.1868-1882 Langues : Anglais (eng) Mots-clés : PACE consortium  internalising problems  DNA methylation Index. décimale : PER Périodiques Résumé : Background Pre- and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems. Methods We meta-analysed probe and region-level epigenome-wide association studies using data from 3 European birth cohorts (ALSPAC, MoBa, Generation R; analytic N?=?1,121?3,011) from the Pregnancy And Childhood Epigenetics (PACE) Consortium. DNAm was assessed at birth (cord blood) and age 6?years (peripheral blood). Internalising problems (ages 3 and 6) were reported by mothers using the Child Behaviour Checklist or Strengths and Difficulties Questionnaire. Models were adjusted for age at DNAm assessment, 20 surrogate variables, estimated cell proportions, maternal education, age, smoking and, in secondary analysis, maternal anxiety and depression. Public databases were searched for mental health associations with top CpG sites and regions. Results No significant probe-level associations were found between cord- or peripheral-blood DNAm and internalising problems. In region-level analyses, two differentially methylated regions (DMRs) in cord blood were associated with internalising problems at age 3 (annotated to STK32C, MIR886) and one at age 6 (PFKFB2). At age 6, peripheral-blood analyses identified two DMRs (C10orf26 (WBP1L), FAM125A). Several genes showed prior associations with psychiatric phenotypes, including depression. Conclusions The higher-powered regional-level analyses revealed more associations than probe-level. Among others, we identified a region annotated to STK32C that has previously been linked to adolescent depression. Larger samples and refined phenotyping are needed to clarify the role of DNAm in internalising problems. En ligne : https://doi.org/10.1111/jcpp.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood [texte imprimé] / Laura SCHELLHAS, Auteur ; Mannan LUO, Auteur ; Janine F. FELIX, Auteur ; Christian M. PAGE, Auteur ; Mona BEKKHUS, Auteur ; Marcus R. MUNAFO, Auteur ; Luisa ZUCCOLO, Auteur ; Alexandra HAVDAHL, Auteur ; Charlotte A. M. CECIL, Auteur ; Gemma C. SHARP, Auteur . - p.1868-1882. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-11 (November 2026) . - p.1868-1882 Mots-clés : PACE consortium  internalising problems  DNA methylation Index. décimale : PER Périodiques Résumé : Background Pre- and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems. Methods We meta-analysed probe and region-level epigenome-wide association studies using data from 3 European birth cohorts (ALSPAC, MoBa, Generation R; analytic N?=?1,121?3,011) from the Pregnancy And Childhood Epigenetics (PACE) Consortium. DNAm was assessed at birth (cord blood) and age 6?years (peripheral blood). Internalising problems (ages 3 and 6) were reported by mothers using the Child Behaviour Checklist or Strengths and Difficulties Questionnaire. Models were adjusted for age at DNAm assessment, 20 surrogate variables, estimated cell proportions, maternal education, age, smoking and, in secondary analysis, maternal anxiety and depression. Public databases were searched for mental health associations with top CpG sites and regions. Results No significant probe-level associations were found between cord- or peripheral-blood DNAm and internalising problems. In region-level analyses, two differentially methylated regions (DMRs) in cord blood were associated with internalising problems at age 3 (annotated to STK32C, MIR886) and one at age 6 (PFKFB2). At age 6, peripheral-blood analyses identified two DMRs (C10orf26 (WBP1L), FAM125A). Several genes showed prior associations with psychiatric phenotypes, including depression. Conclusions The higher-powered regional-level analyses revealed more associations than probe-level. Among others, we identified a region annotated to STK32C that has previously been linked to adolescent depression. Larger samples and refined phenotyping are needed to clarify the role of DNAm in internalising problems. En ligne : https://doi.org/10.1111/jcpp.70186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders / Nadine PARKER ; Laurie J. HANNIGAN ; Espen HAGEN ; Pravesh PAREKH ; Alexey SHADRIN ; Piotr JAHOLKOWSKI ; Evgeniia FREI ; Viktoria BIRKENÆS ; Guy HINDLEY ; Laura HEGEMANN ; Elizabeth C. CORFIELD ; Martin TESLI ; Alexandra HAVDAHL ; Ole A. ANDREASSEN in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.350-365 Titre : Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders Type de document : texte imprimé Auteurs : Nadine PARKER, Auteur ; Laurie J. HANNIGAN, Auteur ; Espen HAGEN, Auteur ; Pravesh PAREKH, Auteur ; Alexey SHADRIN, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Evgeniia FREI, Auteur ; Viktoria BIRKENÆS, Auteur ; Guy HINDLEY, Auteur ; Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Martin TESLI, Auteur ; Alexandra HAVDAHL, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.350-365 Langues : Anglais (eng) Mots-clés : Emotional problems  behavioral problems  polygenic risk (PRS)  mood disorder  anxiety disorder  development  MoBa  MBRN Index. décimale : PER Périodiques Résumé : Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders. Methods This study uses data from a genotyped sample of children (n 54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5 5 years) and latent profile analyses (1.5 8 years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGSBD), anxiety (PGSANX), depression (PGSDEP), and neuroticism (PGSNEUR). Results Associations between PGSDEP, PGSANX, and PGSNEUR, and emotional and behavioral difficulties in childhood were more persistent than age-specific across early childhood (1.5 5 years). Higher PGSANX and PGSDEP were associated with steeper increases in behavioral difficulties across early childhood. Latent profile analyses identified five profiles with different associations with emotional disorder diagnosis. All PGS were associated with the probability of classification into profiles characterized by some form of difficulties (vs. a normative reference profile), but only PGSBD was uniquely associated with a single developmental profile. Conclusions Genetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention. En ligne : https://doi.org/10.1111/jcpp.14063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders [texte imprimé] / Nadine PARKER, Auteur ; Laurie J. HANNIGAN, Auteur ; Espen HAGEN, Auteur ; Pravesh PAREKH, Auteur ; Alexey SHADRIN, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Evgeniia FREI, Auteur ; Viktoria BIRKENÆS, Auteur ; Guy HINDLEY, Auteur ; Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Martin TESLI, Auteur ; Alexandra HAVDAHL, Auteur ; Ole A. ANDREASSEN, Auteur . - p.350-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.350-365 Mots-clés : Emotional problems  behavioral problems  polygenic risk (PRS)  mood disorder  anxiety disorder  development  MoBa  MBRN Index. décimale : PER Périodiques Résumé : Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders. Methods This study uses data from a genotyped sample of children (n 54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5 5 years) and latent profile analyses (1.5 8 years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGSBD), anxiety (PGSANX), depression (PGSDEP), and neuroticism (PGSNEUR). Results Associations between PGSDEP, PGSANX, and PGSNEUR, and emotional and behavioral difficulties in childhood were more persistent than age-specific across early childhood (1.5 5 years). Higher PGSANX and PGSDEP were associated with steeper increases in behavioral difficulties across early childhood. Latent profile analyses identified five profiles with different associations with emotional disorder diagnosis. All PGS were associated with the probability of classification into profiles characterized by some form of difficulties (vs. a normative reference profile), but only PGSBD was uniquely associated with a single developmental profile. Conclusions Genetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention. En ligne : https://doi.org/10.1111/jcpp.14063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder / Hugo PEYRE in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

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Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021) / Laurie J. HANNIGAN in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)  

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Direct and indirect genetic effects on early neurodevelopmental traits / Laura HEGEMANN in Journal of Child Psychology and Psychiatry, 66-7 (July 2025)  

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Early manifestations of genetic risk for neurodevelopmental disorders / Ragna Bugge ASKELAND in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

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Evocative effects of children's education-associated genetics on maternal parenting: results from the Norwegian mother, father and child cohort study / Chloe AUSTERBERRY in Journal of Child Psychology and Psychiatry, 67-2 (February 2026)  

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Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study / Laura HEGEMANN in Molecular Autism, 15 (2024)  

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Indirect genetic effects of siblings / Mathias VALSTAD in Journal of Child Psychology and Psychiatry, 67-8 (August 2026)  

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Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study / Paul MADLEY-DOWD in Molecular Autism, 13 (2022)  

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Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire / Ragna BUGGE ASKELAND ; Stian BARBO VALAND ; Anne-Siri ØYEN ; Synnve SCHJØLBERG ; Vanessa H. BAL ; Somer L. BISHOP ; Camilla STOLTENBERG ; Tilmann VON SOEST ; Laurie J. HANNIGAN ; Alexandra HAVDAHL in Autism, 28-8 (August 2024)  

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Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study / Fartein Ask TORVIK in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

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