CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes / Catherine FRICANO-KUGLER in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 25p. Titre : CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes Type de document : texte imprimé Auteurs : Catherine FRICANO-KUGLER, Auteur ; Aaron GORDON, Auteur ; Grace SHIN, Auteur ; Kun GAO, Auteur ; Jenny NGUYEN, Auteur ; Jamee BERG, Auteur ; Mary STARKS, Auteur ; Daniel H. GESCHWIND, Auteur Article en page(s) : 25p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Cyfip1  Dup15q  Fear conditioning  Mouse behavior  Neurodevelopmental disorders  RNA sequencing Index. décimale : PER Périodiques Résumé : Background: CYFIP1, a protein that interacts with FMRP and regulates protein synthesis and actin dynamics, is overexpressed in Dup15q syndrome as well as autism spectrum disorder (ASD). While CYFIP1 heterozygosity has been rigorously studied due to its loss in 15q11.2 deletion, Prader-Willi and Angelman syndrome, the effects of CYFIP1 overexpression, as is observed in patients with CYFIP1 duplication, are less well understood. Methods: We developed and validated a mouse model of human CYFIP1 overexpression (CYFIP1 OE) using qPCR and western blot analysis. We performed a large battery of behavior testing on these mice, including ultrasonic vocalizations, three-chamber social assay, home-cage behavior, Y-maze, elevated plus maze, open field test, Morris water maze, fear conditioning, prepulse inhibition, and the hot plate assay. We also performed RNA sequencing and analysis on the basolateral amygdala. Results: Extensive behavioral testing in CYFIP1 OE mice reveals no changes in the core behaviors related to ASD: social interactions and repetitive behaviors. However, we did observe mild learning deficits and an exaggerated fear response. Using RNA sequencing of the basolateral amygdala, a region associated with fear response, we observed changes in pathways related to cytoskeletal regulation, oligodendrocytes, and myelination. We also identified GABA-A subunit composition changes in basolateral amygdala neurons, which are essential components of the neural fear conditioning circuit. Conclusion: Overall, this research identifies the behavioral and molecular consequences of CYFIP1 overexpression and how they contribute to the variable phenotype seen in Dup15q syndrome and in ASD patients with excess CYFIP1. En ligne : http://dx.doi.org/10.1186/s13229-019-0278-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes [texte imprimé] / Catherine FRICANO-KUGLER, Auteur ; Aaron GORDON, Auteur ; Grace SHIN, Auteur ; Kun GAO, Auteur ; Jenny NGUYEN, Auteur ; Jamee BERG, Auteur ; Mary STARKS, Auteur ; Daniel H. GESCHWIND, Auteur . - 25p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 25p. Mots-clés : Autism spectrum disorder (ASD)  Cyfip1  Dup15q  Fear conditioning  Mouse behavior  Neurodevelopmental disorders  RNA sequencing Index. décimale : PER Périodiques Résumé : Background: CYFIP1, a protein that interacts with FMRP and regulates protein synthesis and actin dynamics, is overexpressed in Dup15q syndrome as well as autism spectrum disorder (ASD). While CYFIP1 heterozygosity has been rigorously studied due to its loss in 15q11.2 deletion, Prader-Willi and Angelman syndrome, the effects of CYFIP1 overexpression, as is observed in patients with CYFIP1 duplication, are less well understood. Methods: We developed and validated a mouse model of human CYFIP1 overexpression (CYFIP1 OE) using qPCR and western blot analysis. We performed a large battery of behavior testing on these mice, including ultrasonic vocalizations, three-chamber social assay, home-cage behavior, Y-maze, elevated plus maze, open field test, Morris water maze, fear conditioning, prepulse inhibition, and the hot plate assay. We also performed RNA sequencing and analysis on the basolateral amygdala. Results: Extensive behavioral testing in CYFIP1 OE mice reveals no changes in the core behaviors related to ASD: social interactions and repetitive behaviors. However, we did observe mild learning deficits and an exaggerated fear response. Using RNA sequencing of the basolateral amygdala, a region associated with fear response, we observed changes in pathways related to cytoskeletal regulation, oligodendrocytes, and myelination. We also identified GABA-A subunit composition changes in basolateral amygdala neurons, which are essential components of the neural fear conditioning circuit. Conclusion: Overall, this research identifies the behavioral and molecular consequences of CYFIP1 overexpression and how they contribute to the variable phenotype seen in Dup15q syndrome and in ASD patients with excess CYFIP1. En ligne : http://dx.doi.org/10.1186/s13229-019-0278-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Examining the effect of a wearable, anxiety detection technology on improving the awareness of anxiety signs in autism spectrum disorder: a pilot randomized controlled trial / Jenny NGUYEN in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 72 p. Titre : Examining the effect of a wearable, anxiety detection technology on improving the awareness of anxiety signs in autism spectrum disorder: a pilot randomized controlled trial Type de document : texte imprimé Auteurs : Jenny NGUYEN, Auteur ; Robyn E. CARDY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jessica BRIAN, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : 72 p. Langues : Anglais (eng) Mots-clés : Asd  Anxiety  Autism  Intervention  Wearables  commercialization, and will benefit financially from its sales. Index. décimale : PER Périodiques Résumé : BACKGROUND: Anxiety is prevalent in autism spectrum disorder (ASD) and can negatively impact physical and mental health. Self-awareness of anxiety signs is a key barrier to success of anxiety interventions for many children. METHODS: To address this, we conducted a randomized controlled trial to assess whether the Anxiety Meter, a wearable, real-time anxiety detection technology, can improve awareness of anxiety symptoms and the initiation of relaxation techniques in children with ASD. Twenty-eight children with ASD were trained on the use of the Anxiety Meter and taught a diaphragmatic breathing relaxation technique over three visits. On the fourth visit, participants were randomized to either receive feedback of their anxiety level or no feedback from the Anxiety Meter while completing a stress-eliciting task (public speaking) and asked to engage in deep breathing if anxious. RESULTS: Feedback from the Anxiety Meter was associated with increased likelihood of initiating deep breathing in response to anxiety. LIMITATIONS: Limitations include the small sample size, imbalanced group matching for IQ and sex, and the controlled-laboratory settings which limit the statistical power and generalizability of the results to real-world settings. CONCLUSIONS: Although these results are limited by the relatively small sample size, they support the feasibility of using a wearable device and real-time feedback to improve anxiety symptom awareness. Trial Registration ClinicalTrials.gov Identifier: NCT02160691, registration date: 06/05/2014. En ligne : http://dx.doi.org/10.1186/s13229-021-00477-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Examining the effect of a wearable, anxiety detection technology on improving the awareness of anxiety signs in autism spectrum disorder: a pilot randomized controlled trial [texte imprimé] / Jenny NGUYEN, Auteur ; Robyn E. CARDY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jessica BRIAN, Auteur ; Azadeh KUSHKI, Auteur . - 72 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 72 p. Mots-clés : Asd  Anxiety  Autism  Intervention  Wearables  commercialization, and will benefit financially from its sales. Index. décimale : PER Périodiques Résumé : BACKGROUND: Anxiety is prevalent in autism spectrum disorder (ASD) and can negatively impact physical and mental health. Self-awareness of anxiety signs is a key barrier to success of anxiety interventions for many children. METHODS: To address this, we conducted a randomized controlled trial to assess whether the Anxiety Meter, a wearable, real-time anxiety detection technology, can improve awareness of anxiety symptoms and the initiation of relaxation techniques in children with ASD. Twenty-eight children with ASD were trained on the use of the Anxiety Meter and taught a diaphragmatic breathing relaxation technique over three visits. On the fourth visit, participants were randomized to either receive feedback of their anxiety level or no feedback from the Anxiety Meter while completing a stress-eliciting task (public speaking) and asked to engage in deep breathing if anxious. RESULTS: Feedback from the Anxiety Meter was associated with increased likelihood of initiating deep breathing in response to anxiety. LIMITATIONS: Limitations include the small sample size, imbalanced group matching for IQ and sex, and the controlled-laboratory settings which limit the statistical power and generalizability of the results to real-world settings. CONCLUSIONS: Although these results are limited by the relatively small sample size, they support the feasibility of using a wearable device and real-time feedback to improve anxiety symptom awareness. Trial Registration ClinicalTrials.gov Identifier: NCT02160691, registration date: 06/05/2014. En ligne : http://dx.doi.org/10.1186/s13229-021-00477-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Short report: Evaluating the safety and usability of head-mounted virtual reality compared to monitor-displayed video for children with autism spectrum disorder / Mahan MALIHI in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1924-1929 Titre : Short report: Evaluating the safety and usability of head-mounted virtual reality compared to monitor-displayed video for children with autism spectrum disorder Type de document : texte imprimé Auteurs : Mahan MALIHI, Auteur ; Jenny NGUYEN, Auteur ; Robyn E. CARDY, Auteur ; Salina ELDON, Auteur ; Catharine PETTA, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.1924-1929 Langues : Anglais (eng) Mots-clés : *anxiety  *autism spectrum disorder  *autistic disorder  *children  *technology  *virtual reality Index. décimale : PER Périodiques Résumé : This study investigated the safety and usability of a virtual reality experience for children with autism spectrum disorder in a laboratory setting. In our study, the negative effects of head-mounted display-virtual reality were similar to monitor-displayed video watching. At the same time, the participants indicated that the head-mounted display-virtual reality experience provided improved realism and sense of presence. This study is a first step in understanding the impact of head-mounted display on children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361320934214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Short report: Evaluating the safety and usability of head-mounted virtual reality compared to monitor-displayed video for children with autism spectrum disorder [texte imprimé] / Mahan MALIHI, Auteur ; Jenny NGUYEN, Auteur ; Robyn E. CARDY, Auteur ; Salina ELDON, Auteur ; Catharine PETTA, Auteur ; Azadeh KUSHKI, Auteur . - p.1924-1929. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1924-1929 Mots-clés : *anxiety  *autism spectrum disorder  *autistic disorder  *children  *technology  *virtual reality Index. décimale : PER Périodiques Résumé : This study investigated the safety and usability of a virtual reality experience for children with autism spectrum disorder in a laboratory setting. In our study, the negative effects of head-mounted display-virtual reality were similar to monitor-displayed video watching. At the same time, the participants indicated that the head-mounted display-virtual reality experience provided improved realism and sense of presence. This study is a first step in understanding the impact of head-mounted display on children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361320934214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Understanding the Use of the Term "Weaponized Autism" in An Alt-Right Social Media Platform / Christie WELCH in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4035-4046 Titre : Understanding the Use of the Term "Weaponized Autism" in An Alt-Right Social Media Platform Type de document : texte imprimé Auteurs : Christie WELCH, Auteur ; Lili SENMAN, Auteur ; Rachel LOFTIN, Auteur ; Christian PICCIOLINI, Auteur ; John Elder ROBISON, Auteur ; Alexander WESTPHAL, Auteur ; Barbara PERRY, Auteur ; Jenny NGUYEN, Auteur ; Patrick JACHYRA, Auteur ; Suzanne STEVENSON, Auteur ; Jai AGGARWAL, Auteur ; Sachindri WIJEKOON, Auteur ; Simon BARON-COHEN, Auteur ; Melanie PENNER, Auteur Article en page(s) : p.4035-4046 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The term "weaponized autism" is frequently used on extremist platforms. To better understand this, we conducted a discourse analysis of posts on Gab, an alt-right social media platform. En ligne : https://doi.org/10.1007/s10803-022-05701-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Understanding the Use of the Term "Weaponized Autism" in An Alt-Right Social Media Platform [texte imprimé] / Christie WELCH, Auteur ; Lili SENMAN, Auteur ; Rachel LOFTIN, Auteur ; Christian PICCIOLINI, Auteur ; John Elder ROBISON, Auteur ; Alexander WESTPHAL, Auteur ; Barbara PERRY, Auteur ; Jenny NGUYEN, Auteur ; Patrick JACHYRA, Auteur ; Suzanne STEVENSON, Auteur ; Jai AGGARWAL, Auteur ; Sachindri WIJEKOON, Auteur ; Simon BARON-COHEN, Auteur ; Melanie PENNER, Auteur . - p.4035-4046. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4035-4046 Index. décimale : PER Périodiques Résumé : The term "weaponized autism" is frequently used on extremist platforms. To better understand this, we conducted a discourse analysis of posts on Gab, an alt-right social media platform. En ligne : https://doi.org/10.1007/s10803-022-05701-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

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