Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder / Laura E. QUIÑONES-CAMACHO in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1585-1596 Titre : Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder Type de document : texte imprimé Auteurs : Laura E. QUIÑONES-CAMACHO, Auteur ; Frank A. FISHBURN, Auteur ; Katie BELARDI, Auteur ; Diane L. WILLIAMS, Auteur ; Theodore J. HUPPERT, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.1585-1596 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Brain  Brain Mapping  Humans  Mentalization  Spectroscopy, Near-Infrared  Asd  Tpj  neural synchrony  social communication impairment  social deficits Index. décimale : PER Périodiques Résumé : Social deficits in autism spectrum disorder (ASD) have been linked to atypical activation of the mentalizing network. This work, however, has been limited by a focus on the brain activity of a single person during computerized social tasks rather than exploring brain activity during in vivo interactions. The current study assessed neural synchronization during a conversation as a mechanism for social impairment in adults with ASD (n = 24) and matched controls (n = 26). Functional near-infrared spectroscopy (fNIRS) data were collected from the prefrontal cortex (PFC) and tempoparietal junction (TPJ). Participants self-reported on their social communication and videos of the interaction were coded for utterances and conversational turns. As expected, controls showed more neural synchrony than participants with ASD in the TPJ. Also as expected, controls showed less social communication impairment than participants with ASD. However, participants with ASD did not have fewer utterances compared with control subjects. Overall, less neural synchrony in the TPJ was associated with higher social impairment and marginally fewer utterances. Our findings advance our understanding of social difficulties in ASD by linking them to decreased neural synchronization of the TPJ. LAY SUMMARY: The coordination of brain responses is important for efficient social interactions. The current study explored the coordination of brain responses in neurotypical adults and adults with ASD to investigate if difficulties in social interactions are related to difficulties coordinating brain responses in ASD. We found that participants with ASD had more difficulties coordinating brain responses during a conversation with an interacting partner. Additionally, we found that the level of coordination in brain responses was linked to problems with social communication. En ligne : http://dx.doi.org/10.1002/aur.2513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder [texte imprimé] / Laura E. QUIÑONES-CAMACHO, Auteur ; Frank A. FISHBURN, Auteur ; Katie BELARDI, Auteur ; Diane L. WILLIAMS, Auteur ; Theodore J. HUPPERT, Auteur ; Susan B. PERLMAN, Auteur . - p.1585-1596. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1585-1596 Mots-clés : Adult  Autism Spectrum Disorder  Brain  Brain Mapping  Humans  Mentalization  Spectroscopy, Near-Infrared  Asd  Tpj  neural synchrony  social communication impairment  social deficits Index. décimale : PER Périodiques Résumé : Social deficits in autism spectrum disorder (ASD) have been linked to atypical activation of the mentalizing network. This work, however, has been limited by a focus on the brain activity of a single person during computerized social tasks rather than exploring brain activity during in vivo interactions. The current study assessed neural synchronization during a conversation as a mechanism for social impairment in adults with ASD (n = 24) and matched controls (n = 26). Functional near-infrared spectroscopy (fNIRS) data were collected from the prefrontal cortex (PFC) and tempoparietal junction (TPJ). Participants self-reported on their social communication and videos of the interaction were coded for utterances and conversational turns. As expected, controls showed more neural synchrony than participants with ASD in the TPJ. Also as expected, controls showed less social communication impairment than participants with ASD. However, participants with ASD did not have fewer utterances compared with control subjects. Overall, less neural synchrony in the TPJ was associated with higher social impairment and marginally fewer utterances. Our findings advance our understanding of social difficulties in ASD by linking them to decreased neural synchronization of the TPJ. LAY SUMMARY: The coordination of brain responses is important for efficient social interactions. The current study explored the coordination of brain responses in neurotypical adults and adults with ASD to investigate if difficulties in social interactions are related to difficulties coordinating brain responses in ASD. We found that participants with ASD had more difficulties coordinating brain responses during a conversation with an interacting partner. Additionally, we found that the level of coordination in brain responses was linked to problems with social communication. En ligne : http://dx.doi.org/10.1002/aur.2513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Parent-child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability / Laura E. QUIÑONES-CAMACHO in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1213-1223 Titre : Parent-child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability Type de document : texte imprimé Auteurs : Laura E. QUIÑONES-CAMACHO, Auteur ; Frank A. FISHBURN, Auteur ; M. Catalina CAMACHO, Auteur ; Christina O. HLUTKOWSKY, Auteur ; Theodore J. HUPPERT, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.1213-1223 Langues : Anglais (eng) Mots-clés : Neural synchrony  irritability  parent-child synchrony  prefrontal cortex  recovery Index. décimale : PER Périodiques Résumé : BACKGROUND: Research to date has largely conceptualized irritability in terms of intraindividual differences. However, the role of interpersonal dyadic processes has received little consideration. Nevertheless, difficulties in how parent-child dyads synchronize during interactions may be an important correlate of irritably in early childhood. Innovations in developmentally sensitive neuroimaging methods now enable the use of measures of neural synchrony to quantify synchronous responses in parent-child dyads and can help clarify the neural underpinnings of these difficulties. We introduce the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB-DOS:BioSync) as a paradigm for exploring parent-child neural synchrony as a potential biological mechanism for interpersonal difficulties in preschool psychopathology. METHODS: Using functional near-infrared spectroscopy (fNIRS) 4- to 5-year-olds (N = 116) and their mothers completed the DB-DOS:BioSync while assessing neural synchrony during mild frustration and recovery. Child irritability was measured using a latent irritability factor that was calculated from four developmentally sensitive indicators. RESULTS: Both the mild frustration and the recovery contexts resulted in neural synchrony. However, less neural synchrony during the recovery context only was associated with more child irritability. CONCLUSIONS: Our results suggest that recovering after a frustrating period might be particularly challenging for children high in irritability and offer support for the use of the DB-DOS:BioSync task to elucidate interpersonal neural mechanisms of developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Parent-child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability [texte imprimé] / Laura E. QUIÑONES-CAMACHO, Auteur ; Frank A. FISHBURN, Auteur ; M. Catalina CAMACHO, Auteur ; Christina O. HLUTKOWSKY, Auteur ; Theodore J. HUPPERT, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Susan B. PERLMAN, Auteur . - p.1213-1223. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1213-1223 Mots-clés : Neural synchrony  irritability  parent-child synchrony  prefrontal cortex  recovery Index. décimale : PER Périodiques Résumé : BACKGROUND: Research to date has largely conceptualized irritability in terms of intraindividual differences. However, the role of interpersonal dyadic processes has received little consideration. Nevertheless, difficulties in how parent-child dyads synchronize during interactions may be an important correlate of irritably in early childhood. Innovations in developmentally sensitive neuroimaging methods now enable the use of measures of neural synchrony to quantify synchronous responses in parent-child dyads and can help clarify the neural underpinnings of these difficulties. We introduce the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB-DOS:BioSync) as a paradigm for exploring parent-child neural synchrony as a potential biological mechanism for interpersonal difficulties in preschool psychopathology. METHODS: Using functional near-infrared spectroscopy (fNIRS) 4- to 5-year-olds (N = 116) and their mothers completed the DB-DOS:BioSync while assessing neural synchrony during mild frustration and recovery. Child irritability was measured using a latent irritability factor that was calculated from four developmentally sensitive indicators. RESULTS: Both the mild frustration and the recovery contexts resulted in neural synchrony. However, less neural synchrony during the recovery context only was associated with more child irritability. CONCLUSIONS: Our results suggest that recovering after a frustrating period might be particularly challenging for children high in irritability and offer support for the use of the DB-DOS:BioSync task to elucidate interpersonal neural mechanisms of developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

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