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Auteur Susan B. PERLMAN |
Documents disponibles écrits par cet auteur (5)



Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder / Laura E. QUIÑONES-CAMACHO in Autism Research, 14-8 (August 2021)
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Titre : Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laura E. QUIÑONES-CAMACHO, Auteur ; F. A. FISHBURN, Auteur ; Katie BELARDI, Auteur ; D. L. WILLIAMS, Auteur ; T. J. HUPPERT, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.1585-1596 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Brain Brain Mapping Humans Mentalization Spectroscopy, Near-Infrared Asd Tpj neural synchrony social communication impairment social deficits Index. décimale : PER Périodiques Résumé : Social deficits in autism spectrum disorder (ASD) have been linked to atypical activation of the mentalizing network. This work, however, has been limited by a focus on the brain activity of a single person during computerized social tasks rather than exploring brain activity during in vivo interactions. The current study assessed neural synchronization during a conversation as a mechanism for social impairment in adults with ASD (n = 24) and matched controls (n = 26). Functional near-infrared spectroscopy (fNIRS) data were collected from the prefrontal cortex (PFC) and tempoparietal junction (TPJ). Participants self-reported on their social communication and videos of the interaction were coded for utterances and conversational turns. As expected, controls showed more neural synchrony than participants with ASD in the TPJ. Also as expected, controls showed less social communication impairment than participants with ASD. However, participants with ASD did not have fewer utterances compared with control subjects. Overall, less neural synchrony in the TPJ was associated with higher social impairment and marginally fewer utterances. Our findings advance our understanding of social difficulties in ASD by linking them to decreased neural synchronization of the TPJ. LAY SUMMARY: The coordination of brain responses is important for efficient social interactions. The current study explored the coordination of brain responses in neurotypical adults and adults with ASD to investigate if difficulties in social interactions are related to difficulties coordinating brain responses in ASD. We found that participants with ASD had more difficulties coordinating brain responses during a conversation with an interacting partner. Additionally, we found that the level of coordination in brain responses was linked to problems with social communication. En ligne : http://dx.doi.org/10.1002/aur.2513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1585-1596[article] Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder [Texte imprimé et/ou numérique] / Laura E. QUIÑONES-CAMACHO, Auteur ; F. A. FISHBURN, Auteur ; Katie BELARDI, Auteur ; D. L. WILLIAMS, Auteur ; T. J. HUPPERT, Auteur ; Susan B. PERLMAN, Auteur . - p.1585-1596.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1585-1596
Mots-clés : Adult Autism Spectrum Disorder Brain Brain Mapping Humans Mentalization Spectroscopy, Near-Infrared Asd Tpj neural synchrony social communication impairment social deficits Index. décimale : PER Périodiques Résumé : Social deficits in autism spectrum disorder (ASD) have been linked to atypical activation of the mentalizing network. This work, however, has been limited by a focus on the brain activity of a single person during computerized social tasks rather than exploring brain activity during in vivo interactions. The current study assessed neural synchronization during a conversation as a mechanism for social impairment in adults with ASD (n = 24) and matched controls (n = 26). Functional near-infrared spectroscopy (fNIRS) data were collected from the prefrontal cortex (PFC) and tempoparietal junction (TPJ). Participants self-reported on their social communication and videos of the interaction were coded for utterances and conversational turns. As expected, controls showed more neural synchrony than participants with ASD in the TPJ. Also as expected, controls showed less social communication impairment than participants with ASD. However, participants with ASD did not have fewer utterances compared with control subjects. Overall, less neural synchrony in the TPJ was associated with higher social impairment and marginally fewer utterances. Our findings advance our understanding of social difficulties in ASD by linking them to decreased neural synchronization of the TPJ. LAY SUMMARY: The coordination of brain responses is important for efficient social interactions. The current study explored the coordination of brain responses in neurotypical adults and adults with ASD to investigate if difficulties in social interactions are related to difficulties coordinating brain responses in ASD. We found that participants with ASD had more difficulties coordinating brain responses during a conversation with an interacting partner. Additionally, we found that the level of coordination in brain responses was linked to problems with social communication. En ligne : http://dx.doi.org/10.1002/aur.2513 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Getting in synch: Unpacking the role of parent–child synchrony in the development of internalizing and externalizing behaviors / Laura E. QUIÑONES-CAMACHO in Development and Psychopathology, 34-5 (December 2022)
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Titre : Getting in synch: Unpacking the role of parent–child synchrony in the development of internalizing and externalizing behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Laura E. QUIÑONES-CAMACHO, Auteur ; Caroline P. HOYNIAK, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.1901-1913 Langues : Anglais (eng) Mots-clés : externalizing internalizing neural synchrony parent–child synchrony prefrontal cortex (PFC) Index. décimale : PER Périodiques Résumé : While substantial research supports the role of parent “child interactions on the emergence of psychiatric symptoms, few studies have explored biological mechanisms for this association. The current study explored behavioral and neural parent “child synchronization during frustration and play as predictors of internalizing and externalizing behaviors across a span of 1.5 years. Parent “child dyads first came to the laboratory when the child was 4 “5 years old and completed the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB-DOS: BioSync) task while functional near-infrared spectroscopy (fNIRS) data were recorded. Parents reported on their child's internalizing and externalizing behaviors using the Child Behavior Checklist (CBCL) four times over 1.5 years. Latent growth curve (LGC) modeling was conducted to assess neural and behavioral synchrony as predictors of internalizing and externalizing trajectories. Consistent with previous investigations in this age range, on average, internalizing and externalizing behaviors decreased over the four time points. Parent “child neural synchrony during a period of play predicted rate of change in internalizing but not externalizing behaviors such that higher parent “child neural synchrony was associated with a more rapid decrease in internalizing behaviors. Our results suggest that a parent “child dyad's ability to coordinate neural activation during positive interactions might serve as a protective mechanism in the context of internalizing behaviors. En ligne : http://dx.doi.org/10.1017/S0954579421000468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Development and Psychopathology > 34-5 (December 2022) . - p.1901-1913[article] Getting in synch: Unpacking the role of parent–child synchrony in the development of internalizing and externalizing behaviors [Texte imprimé et/ou numérique] / Laura E. QUIÑONES-CAMACHO, Auteur ; Caroline P. HOYNIAK, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Susan B. PERLMAN, Auteur . - p.1901-1913.
Langues : Anglais (eng)
in Development and Psychopathology > 34-5 (December 2022) . - p.1901-1913
Mots-clés : externalizing internalizing neural synchrony parent–child synchrony prefrontal cortex (PFC) Index. décimale : PER Périodiques Résumé : While substantial research supports the role of parent “child interactions on the emergence of psychiatric symptoms, few studies have explored biological mechanisms for this association. The current study explored behavioral and neural parent “child synchronization during frustration and play as predictors of internalizing and externalizing behaviors across a span of 1.5 years. Parent “child dyads first came to the laboratory when the child was 4 “5 years old and completed the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB-DOS: BioSync) task while functional near-infrared spectroscopy (fNIRS) data were recorded. Parents reported on their child's internalizing and externalizing behaviors using the Child Behavior Checklist (CBCL) four times over 1.5 years. Latent growth curve (LGC) modeling was conducted to assess neural and behavioral synchrony as predictors of internalizing and externalizing trajectories. Consistent with previous investigations in this age range, on average, internalizing and externalizing behaviors decreased over the four time points. Parent “child neural synchrony during a period of play predicted rate of change in internalizing but not externalizing behaviors such that higher parent “child neural synchrony was associated with a more rapid decrease in internalizing behaviors. Our results suggest that a parent “child dyad's ability to coordinate neural activation during positive interactions might serve as a protective mechanism in the context of internalizing behaviors. En ligne : http://dx.doi.org/10.1017/S0954579421000468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 A network approach to the investigation of childhood irritability: probing frustration using social stimuli / Clayton J. SCHNEIDER ; Justin A. LOPEZ-ROQUE ; Lauren S. WAKSCHLAG ; Helmet T. KARIM ; Susan B. PERLMAN in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)
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Titre : A network approach to the investigation of childhood irritability: probing frustration using social stimuli Type de document : Texte imprimé et/ou numérique Auteurs : Clayton J. SCHNEIDER, Auteur ; Justin A. LOPEZ-ROQUE, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Helmet T. KARIM, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.959-972 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Self-regulation in early childhood develops within a social context. Variations in such development can be attributed to inter-individual behavioral differences, which can be captured both as facets of temperament and across a normal:abnormal dimensional spectrum. With increasing emphasis on irritability as a robust early-life transdiagnostic indicator of broad psychopathological risk, linkage to neural mechanisms is imperative. Currently, there is inconsistency in the identification of neural circuits that underlie irritability in children, especially in social contexts. This study aimed to address this gap by utilizing a functional magnetic resonance imaging (fMRI) paradigm to investigate pediatric anger/frustration using social stimuli. Methods Seventy-three children (M = 6?years, SD = 0.565) were recruited from a larger longitudinal study on irritability development. Caregivers completed questionnaires assessing irritable temperament and clinical symptoms of irritability. Children participated in a frustration task during fMRI scanning that was designed to induce frustration through loss of a desired prize to an animated character. Data were analyzed using both general linear modeling (GLM) and independent components analysis (ICA) and examined from the temperament and clinical perspectives. Results ICA results uncovered an overarching network structure above and beyond what was revealed by traditional GLM analyses. Results showed that greater temperamental irritability was associated with significantly diminished spatial extent of activation and low-frequency power in a network comprised of the posterior superior temporal sulcus (pSTS) and the precuneus (p <.05, FDR-corrected). However, greater severity along the spectrum of clinical expression of irritability was associated with significantly increased extent and intensity of spatial activation as well as low- and high-frequency neural signal power in the right caudate (p <.05, FDR-corrected). Conclusions Our findings point to specific neural circuitry underlying pediatric irritability in the context of frustration using social stimuli. Results suggest that a deliberate focus on the construction of network-based neurodevelopmental profiles and social interaction along the normal:abnormal irritability spectrum is warranted to further identify comprehensive transdiagnostic substrates of the irritability. En ligne : https://doi.org/10.1111/jcpp.13937 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532
in Journal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.959-972[article] A network approach to the investigation of childhood irritability: probing frustration using social stimuli [Texte imprimé et/ou numérique] / Clayton J. SCHNEIDER, Auteur ; Justin A. LOPEZ-ROQUE, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Helmet T. KARIM, Auteur ; Susan B. PERLMAN, Auteur . - p.959-972.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.959-972
Index. décimale : PER Périodiques Résumé : Background Self-regulation in early childhood develops within a social context. Variations in such development can be attributed to inter-individual behavioral differences, which can be captured both as facets of temperament and across a normal:abnormal dimensional spectrum. With increasing emphasis on irritability as a robust early-life transdiagnostic indicator of broad psychopathological risk, linkage to neural mechanisms is imperative. Currently, there is inconsistency in the identification of neural circuits that underlie irritability in children, especially in social contexts. This study aimed to address this gap by utilizing a functional magnetic resonance imaging (fMRI) paradigm to investigate pediatric anger/frustration using social stimuli. Methods Seventy-three children (M = 6?years, SD = 0.565) were recruited from a larger longitudinal study on irritability development. Caregivers completed questionnaires assessing irritable temperament and clinical symptoms of irritability. Children participated in a frustration task during fMRI scanning that was designed to induce frustration through loss of a desired prize to an animated character. Data were analyzed using both general linear modeling (GLM) and independent components analysis (ICA) and examined from the temperament and clinical perspectives. Results ICA results uncovered an overarching network structure above and beyond what was revealed by traditional GLM analyses. Results showed that greater temperamental irritability was associated with significantly diminished spatial extent of activation and low-frequency power in a network comprised of the posterior superior temporal sulcus (pSTS) and the precuneus (p <.05, FDR-corrected). However, greater severity along the spectrum of clinical expression of irritability was associated with significantly increased extent and intensity of spatial activation as well as low- and high-frequency neural signal power in the right caudate (p <.05, FDR-corrected). Conclusions Our findings point to specific neural circuitry underlying pediatric irritability in the context of frustration using social stimuli. Results suggest that a deliberate focus on the construction of network-based neurodevelopmental profiles and social interaction along the normal:abnormal irritability spectrum is warranted to further identify comprehensive transdiagnostic substrates of the irritability. En ligne : https://doi.org/10.1111/jcpp.13937 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 Parent-child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability / Laura E. QUIÑONES-CAMACHO in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)
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Titre : Parent-child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability Type de document : Texte imprimé et/ou numérique Auteurs : Laura E. QUIÑONES-CAMACHO, Auteur ; Frank A. FISHBURN, Auteur ; M. Catalina CAMACHO, Auteur ; Christina O. HLUTKOWSKY, Auteur ; Theodore J. HUPPERT, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Susan B. PERLMAN, Auteur Article en page(s) : p.1213-1223 Langues : Anglais (eng) Mots-clés : Neural synchrony irritability parent-child synchrony prefrontal cortex recovery Index. décimale : PER Périodiques Résumé : BACKGROUND: Research to date has largely conceptualized irritability in terms of intraindividual differences. However, the role of interpersonal dyadic processes has received little consideration. Nevertheless, difficulties in how parent-child dyads synchronize during interactions may be an important correlate of irritably in early childhood. Innovations in developmentally sensitive neuroimaging methods now enable the use of measures of neural synchrony to quantify synchronous responses in parent-child dyads and can help clarify the neural underpinnings of these difficulties. We introduce the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB-DOS:BioSync) as a paradigm for exploring parent-child neural synchrony as a potential biological mechanism for interpersonal difficulties in preschool psychopathology. METHODS: Using functional near-infrared spectroscopy (fNIRS) 4- to 5-year-olds (N = 116) and their mothers completed the DB-DOS:BioSync while assessing neural synchrony during mild frustration and recovery. Child irritability was measured using a latent irritability factor that was calculated from four developmentally sensitive indicators. RESULTS: Both the mild frustration and the recovery contexts resulted in neural synchrony. However, less neural synchrony during the recovery context only was associated with more child irritability. CONCLUSIONS: Our results suggest that recovering after a frustrating period might be particularly challenging for children high in irritability and offer support for the use of the DB-DOS:BioSync task to elucidate interpersonal neural mechanisms of developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1213-1223[article] Parent-child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability [Texte imprimé et/ou numérique] / Laura E. QUIÑONES-CAMACHO, Auteur ; Frank A. FISHBURN, Auteur ; M. Catalina CAMACHO, Auteur ; Christina O. HLUTKOWSKY, Auteur ; Theodore J. HUPPERT, Auteur ; Lauren S. WAKSCHLAG, Auteur ; Susan B. PERLMAN, Auteur . - p.1213-1223.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1213-1223
Mots-clés : Neural synchrony irritability parent-child synchrony prefrontal cortex recovery Index. décimale : PER Périodiques Résumé : BACKGROUND: Research to date has largely conceptualized irritability in terms of intraindividual differences. However, the role of interpersonal dyadic processes has received little consideration. Nevertheless, difficulties in how parent-child dyads synchronize during interactions may be an important correlate of irritably in early childhood. Innovations in developmentally sensitive neuroimaging methods now enable the use of measures of neural synchrony to quantify synchronous responses in parent-child dyads and can help clarify the neural underpinnings of these difficulties. We introduce the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB-DOS:BioSync) as a paradigm for exploring parent-child neural synchrony as a potential biological mechanism for interpersonal difficulties in preschool psychopathology. METHODS: Using functional near-infrared spectroscopy (fNIRS) 4- to 5-year-olds (N = 116) and their mothers completed the DB-DOS:BioSync while assessing neural synchrony during mild frustration and recovery. Child irritability was measured using a latent irritability factor that was calculated from four developmentally sensitive indicators. RESULTS: Both the mild frustration and the recovery contexts resulted in neural synchrony. However, less neural synchrony during the recovery context only was associated with more child irritability. CONCLUSIONS: Our results suggest that recovering after a frustrating period might be particularly challenging for children high in irritability and offer support for the use of the DB-DOS:BioSync task to elucidate interpersonal neural mechanisms of developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 Trajectory of emotion dysregulation in positive and negative affect across childhood predicts adolescent emotion dysregulation and overall functioning / Alecia C. VOGEL in Development and Psychopathology, 33-5 (December 2021)
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Titre : Trajectory of emotion dysregulation in positive and negative affect across childhood predicts adolescent emotion dysregulation and overall functioning Type de document : Texte imprimé et/ou numérique Auteurs : Alecia C. VOGEL, Auteur ; Rebecca TILLMAN, Auteur ; Nourhan M. EL-SAYED, Auteur ; Joshua J. JACKSON, Auteur ; Susan B. PERLMAN, Auteur ; Deanna M. BARCH, Auteur ; Joan L. LUBY, Auteur Article en page(s) : p.1722-1733 Langues : Anglais (eng) Mots-clés : excitability irritability fMRI neuroimaging emotion lability Index. décimale : PER Périodiques Résumé : Emotion dysregulation is cross-diagnostic and impairing. Most research has focused on dysregulated expressions of negative affect, often measured as irritability, which is associated with multiple forms of psychopathology and predicts negative outcomes. However, the Research Domain Criteria (RDoC) include both negative and positive valence systems. Emerging evidence suggests that dysregulated expressions of positive affect, or excitability, in early childhood predict later psychopathology and impairment above and beyond irritability. Typically, irritability declines from early through middle childhood; however, the developmental trajectory of excitability is unknown. The impact of excitability across childhood on later emotion dysregulation is also yet unknown. In a well-characterized, longitudinal sample of 129 children studied from ages 3 to 5.11 years through 14 to 19 years, enriched for early depression and disruptive symptoms, we assessed the trajectory of irritability and excitability using multilevel modeling and how components of these trajectories impact later emotion dysregulation. While irritability declines across childhood, excitability remains remarkably stable both within and across the group. Overall levels of excitability (excitability intercept) predict later emotion dysregulation as measured by parent and self-report and predict decreased functional magnetic resonance imaging activity in cognitive emotion regulation regions during an emotion regulation task. Irritability was not related to any dysregulation outcome above and beyond excitability. En ligne : http://dx.doi.org/10.1017/S0954579421000705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Development and Psychopathology > 33-5 (December 2021) . - p.1722-1733[article] Trajectory of emotion dysregulation in positive and negative affect across childhood predicts adolescent emotion dysregulation and overall functioning [Texte imprimé et/ou numérique] / Alecia C. VOGEL, Auteur ; Rebecca TILLMAN, Auteur ; Nourhan M. EL-SAYED, Auteur ; Joshua J. JACKSON, Auteur ; Susan B. PERLMAN, Auteur ; Deanna M. BARCH, Auteur ; Joan L. LUBY, Auteur . - p.1722-1733.
Langues : Anglais (eng)
in Development and Psychopathology > 33-5 (December 2021) . - p.1722-1733
Mots-clés : excitability irritability fMRI neuroimaging emotion lability Index. décimale : PER Périodiques Résumé : Emotion dysregulation is cross-diagnostic and impairing. Most research has focused on dysregulated expressions of negative affect, often measured as irritability, which is associated with multiple forms of psychopathology and predicts negative outcomes. However, the Research Domain Criteria (RDoC) include both negative and positive valence systems. Emerging evidence suggests that dysregulated expressions of positive affect, or excitability, in early childhood predict later psychopathology and impairment above and beyond irritability. Typically, irritability declines from early through middle childhood; however, the developmental trajectory of excitability is unknown. The impact of excitability across childhood on later emotion dysregulation is also yet unknown. In a well-characterized, longitudinal sample of 129 children studied from ages 3 to 5.11 years through 14 to 19 years, enriched for early depression and disruptive symptoms, we assessed the trajectory of irritability and excitability using multilevel modeling and how components of these trajectories impact later emotion dysregulation. While irritability declines across childhood, excitability remains remarkably stable both within and across the group. Overall levels of excitability (excitability intercept) predict later emotion dysregulation as measured by parent and self-report and predict decreased functional magnetic resonance imaging activity in cognitive emotion regulation regions during an emotion regulation task. Irritability was not related to any dysregulation outcome above and beyond excitability. En ligne : http://dx.doi.org/10.1017/S0954579421000705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457