Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories / Elysia Poggi DAVIS in Journal of Child Psychology and Psychiatry, 65-4 (April 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.508-534 Titre : Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.508-534 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant impacts of patterns of signals on child development. We begin with an overview of the existing unpredictability literature, which has focused primarily on longer patterns of unpredictability (e.g. years, months, and days). We then describe our work testing the impact of patterns of parental signals on a moment-to-moment timescale, providing evidence that patterns of these signals during sensitive windows of development influence neurocircuit formation across species and thus may be an evolutionarily conserved process that shapes the developing brain. Next, attention is drawn to emerging themes which provide a framework for future directions of research including the evaluation of functions, such as effortful control, that may be particularly vulnerable to unpredictability, sensitive periods, sex differences, cross-cultural investigations, addressing causality, and unpredictability as a pathway by which other forms of ELA impact development. Finally, we provide suggestions for prevention and intervention, including the introduction of a screening instrument for the identification of children exposed to unpredictable experiences. En ligne : https://doi.org/10.1111/jcpp.13958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories [Texte imprimé et/ou numérique] / Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.508-534. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.508-534 Index. décimale : PER Périodiques Résumé : The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant impacts of patterns of signals on child development. We begin with an overview of the existing unpredictability literature, which has focused primarily on longer patterns of unpredictability (e.g. years, months, and days). We then describe our work testing the impact of patterns of parental signals on a moment-to-moment timescale, providing evidence that patterns of these signals during sensitive windows of development influence neurocircuit formation across species and thus may be an evolutionarily conserved process that shapes the developing brain. Next, attention is drawn to emerging themes which provide a framework for future directions of research including the evaluation of functions, such as effortful control, that may be particularly vulnerable to unpredictability, sensitive periods, sex differences, cross-cultural investigations, addressing causality, and unpredictability as a pathway by which other forms of ELA impact development. Finally, we provide suggestions for prevention and intervention, including the introduction of a screening instrument for the identification of children exposed to unpredictable experiences. En ligne : https://doi.org/10.1111/jcpp.13958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

DHEA: a neglected biological signal that may affect fetal and child development / Elysia Poggi DAVIS ; Curt A. SANDMAN ; Laura M. GLYNN in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1145-1155 Titre : DHEA: a neglected biological signal that may affect fetal and child development Type de document : Texte imprimé et/ou numérique Auteurs : Elysia Poggi DAVIS, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.1145-1155 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background The stress-sensitive maternal hypothalamic-pituitary-adrenal (HPA) axis through the end-product cortisol, represents a primary pathway through which maternal experience shapes fetal development with long-term consequences for child neurodevelopment. However, there is another HPA axis end-product that has been widely ignored in the study of human pregnancy. The synthesis and release of dehydroepiandosterone (DHEA) is similar to cortisol, so it is a plausible, but neglected, biological signal that may influence fetal neurodevelopment. DHEA also may interact with cortisol to determine developmental outcomes. Surprisingly, there is virtually nothing known about human fetal exposure to prenatal maternal DHEA and offspring neurodevelopment. The current study examined, for the first time, the joint impact of fetal exposure to prenatal maternal DHEA and cortisol on infant emotional reactivity. Methods Participants were 124 mother-infant dyads. DHEA and cortisol were measured from maternal hair at 15?weeks (early gestation) and 35?weeks (late gestation). Observational assessments of positive and negative emotional reactivity were obtained in the laboratory when the infants were 6?months old. Pearson correlations were used to examine the associations between prenatal maternal cortisol, prenatal maternal DHEA, and infant positive and negative emotional reactivity. Moderation analyses were conducted to investigate whether DHEA might modify the association between cortisol and emotional reactivity. Results Higher levels of both early and late gestation maternal DHEA were linked to greater infant positive emotional reactivity. Elevated late gestation maternal cortisol was associated with greater negative emotional reactivity. Finally, the association between fetal cortisol exposure and infant emotional reactivity was only observed when DHEA was low. Conclusions These new observations indicate that DHEA is a potential maternal biological signal involved in prenatal programming. It appears to act both independently and jointly with cortisol to determine a child's emotional reactivity. Its role as a primary end-product of the HPA axis, coupled with the newly documented associations with prenatal development shown here, strongly calls for the inclusion of DHEA in future investigations of fetal programming. En ligne : https://doi.org/10.1111/jcpp.13952 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] DHEA: a neglected biological signal that may affect fetal and child development [Texte imprimé et/ou numérique] / Elysia Poggi DAVIS, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur . - p.1145-1155. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1145-1155 Index. décimale : PER Périodiques Résumé : Background The stress-sensitive maternal hypothalamic-pituitary-adrenal (HPA) axis through the end-product cortisol, represents a primary pathway through which maternal experience shapes fetal development with long-term consequences for child neurodevelopment. However, there is another HPA axis end-product that has been widely ignored in the study of human pregnancy. The synthesis and release of dehydroepiandosterone (DHEA) is similar to cortisol, so it is a plausible, but neglected, biological signal that may influence fetal neurodevelopment. DHEA also may interact with cortisol to determine developmental outcomes. Surprisingly, there is virtually nothing known about human fetal exposure to prenatal maternal DHEA and offspring neurodevelopment. The current study examined, for the first time, the joint impact of fetal exposure to prenatal maternal DHEA and cortisol on infant emotional reactivity. Methods Participants were 124 mother-infant dyads. DHEA and cortisol were measured from maternal hair at 15?weeks (early gestation) and 35?weeks (late gestation). Observational assessments of positive and negative emotional reactivity were obtained in the laboratory when the infants were 6?months old. Pearson correlations were used to examine the associations between prenatal maternal cortisol, prenatal maternal DHEA, and infant positive and negative emotional reactivity. Moderation analyses were conducted to investigate whether DHEA might modify the association between cortisol and emotional reactivity. Results Higher levels of both early and late gestation maternal DHEA were linked to greater infant positive emotional reactivity. Elevated late gestation maternal cortisol was associated with greater negative emotional reactivity. Finally, the association between fetal cortisol exposure and infant emotional reactivity was only observed when DHEA was low. Conclusions These new observations indicate that DHEA is a potential maternal biological signal involved in prenatal programming. It appears to act both independently and jointly with cortisol to determine a child's emotional reactivity. Its role as a primary end-product of the HPA axis, coupled with the newly documented associations with prenatal development shown here, strongly calls for the inclusion of DHEA in future investigations of fetal programming. En ligne : https://doi.org/10.1111/jcpp.13952 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Exposure to prenatal maternal distress and infant white matter neurodevelopment / Catherine H. DEMERS in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1526-1538 Titre : Exposure to prenatal maternal distress and infant white matter neurodevelopment Type de document : Texte imprimé et/ou numérique Auteurs : Catherine H. DEMERS, Auteur ; Maria M. BAGONIS, Auteur ; Khalid AL-ALI, Auteur ; Sarah E. GARCIA, Auteur ; Martin A. STYNER, Auteur ; John H. GILMORE, Auteur ; M. Camille HOFFMAN, Auteur ; Benjamin L. HANKIN, Auteur ; Elysia Poggi DAVIS, Auteur Article en page(s) : p.1526-1538 Langues : Anglais (eng) Mots-clés : pregnancy  white matter microstructure  magnetic resonance imaging (MRI)  diffusion tensor imaging (DTI)  anxiety Index. décimale : PER Périodiques Résumé : The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ postconceptional age. Findings demonstrated that higher prenatal maternal distress at 29 weeks’ GA was associated with increased fractional anisotropy, b = .283, t(64) = 2.319, p = .024, and with increased axial diffusivity, b = .254, t(64) = 2.067, p = .043, within the right anterior cingulate white matter tract. No other significant associations were found with prenatal distress exposure and tract fractional anisotropy or axial diffusivity at 29 weeks’ GA, or earlier in gestation. En ligne : http://dx.doi.org/10.1017/S0954579421000742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Exposure to prenatal maternal distress and infant white matter neurodevelopment [Texte imprimé et/ou numérique] / Catherine H. DEMERS, Auteur ; Maria M. BAGONIS, Auteur ; Khalid AL-ALI, Auteur ; Sarah E. GARCIA, Auteur ; Martin A. STYNER, Auteur ; John H. GILMORE, Auteur ; M. Camille HOFFMAN, Auteur ; Benjamin L. HANKIN, Auteur ; Elysia Poggi DAVIS, Auteur . - p.1526-1538. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1526-1538 Mots-clés : pregnancy  white matter microstructure  magnetic resonance imaging (MRI)  diffusion tensor imaging (DTI)  anxiety Index. décimale : PER Périodiques Résumé : The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ postconceptional age. Findings demonstrated that higher prenatal maternal distress at 29 weeks’ GA was associated with increased fractional anisotropy, b = .283, t(64) = 2.319, p = .024, and with increased axial diffusivity, b = .254, t(64) = 2.067, p = .043, within the right anterior cingulate white matter tract. No other significant associations were found with prenatal distress exposure and tract fractional anisotropy or axial diffusivity at 29 weeks’ GA, or earlier in gestation. En ligne : http://dx.doi.org/10.1017/S0954579421000742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health / Sabrina R. LIU in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.899-911 Titre : Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health Type de document : Texte imprimé et/ou numérique Auteurs : Sabrina R. LIU, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.899-911 Langues : Anglais (eng) Mots-clés : acculturative stress  discrimination  infant emotion  parenting  prenatal Index. décimale : PER Périodiques Résumé : Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers' exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M = 12.6, SD = .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience. En ligne : http://dx.doi.org/10.1017/S0954579422000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health [Texte imprimé et/ou numérique] / Sabrina R. LIU, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.899-911. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.899-911 Mots-clés : acculturative stress  discrimination  infant emotion  parenting  prenatal Index. décimale : PER Périodiques Résumé : Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers' exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M = 12.6, SD = .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience. En ligne : http://dx.doi.org/10.1017/S0954579422000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development / Leah A. GRANDE in Development and Psychopathology, 34-4 (October 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-4 (October 2022) . - p.1376-1385 Titre : Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development Type de document : Texte imprimé et/ou numérique Auteurs : Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur Article en page(s) : p.1376-1385 Langues : Anglais (eng) Mots-clés : Child Development  Child, Preschool  Depression/psychology  Female  Humans  Mothers/psychology  Pregnancy  Prenatal Exposure Delayed Effects/psychology  Psychological Distress  Stress, Psychological/psychology  cognitive function  depression  fetal programming  maternal care  parenting  prenatal stress  resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development [Texte imprimé et/ou numérique] / Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur . - p.1376-1385. Langues : Anglais (eng) in Development and Psychopathology > 34-4 (October 2022) . - p.1376-1385 Mots-clés : Child Development  Child, Preschool  Depression/psychology  Female  Humans  Mothers/psychology  Pregnancy  Prenatal Exposure Delayed Effects/psychology  Psychological Distress  Stress, Psychological/psychology  cognitive function  depression  fetal programming  maternal care  parenting  prenatal stress  resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Preconception maternal posttraumatic stress and child negative affectivity: Prospectively evaluating the intergenerational impact of trauma / Danielle A. SWALES in Development and Psychopathology, 35-2 (May 2023)  

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Pregnancy as a period of risk, adaptation, and resilience for mothers and infants / Elysia Poggi DAVIS in Development and Psychopathology, 32-5 (December 2020)  

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Prenatal maternal psychological distress and fetal developmental trajectories: associations with infant temperament / Mariann A. HOWLAND in Development and Psychopathology, 32-5 (December 2020)  

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Risk and resilience factors for psychopathology during pregnancy: An application of the Hierarchical Taxonomy of Psychopathology (HiTOP) / Benjamin L. HANKIN ; Angela J. NARAYAN ; Elysia Poggi DAVIS in Development and Psychopathology, 36-2 (May 2024)  

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