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Auteur Laura M. GLYNN |
Documents disponibles écrits par cet auteur (5)
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Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories / Elysia Poggi DAVIS in Journal of Child Psychology and Psychiatry, 65-4 (April 2024)
[article]
Titre : Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.508-534 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant impacts of patterns of signals on child development. We begin with an overview of the existing unpredictability literature, which has focused primarily on longer patterns of unpredictability (e.g. years, months, and days). We then describe our work testing the impact of patterns of parental signals on a moment-to-moment timescale, providing evidence that patterns of these signals during sensitive windows of development influence neurocircuit formation across species and thus may be an evolutionarily conserved process that shapes the developing brain. Next, attention is drawn to emerging themes which provide a framework for future directions of research including the evaluation of functions, such as effortful control, that may be particularly vulnerable to unpredictability, sensitive periods, sex differences, cross-cultural investigations, addressing causality, and unpredictability as a pathway by which other forms of ELA impact development. Finally, we provide suggestions for prevention and intervention, including the introduction of a screening instrument for the identification of children exposed to unpredictable experiences. En ligne : https://doi.org/10.1111/jcpp.13958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Journal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.508-534[article] Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories [Texte imprimé et/ou numérique] / Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.508-534.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.508-534
Index. décimale : PER Périodiques Résumé : The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant impacts of patterns of signals on child development. We begin with an overview of the existing unpredictability literature, which has focused primarily on longer patterns of unpredictability (e.g. years, months, and days). We then describe our work testing the impact of patterns of parental signals on a moment-to-moment timescale, providing evidence that patterns of these signals during sensitive windows of development influence neurocircuit formation across species and thus may be an evolutionarily conserved process that shapes the developing brain. Next, attention is drawn to emerging themes which provide a framework for future directions of research including the evaluation of functions, such as effortful control, that may be particularly vulnerable to unpredictability, sensitive periods, sex differences, cross-cultural investigations, addressing causality, and unpredictability as a pathway by which other forms of ELA impact development. Finally, we provide suggestions for prevention and intervention, including the introduction of a screening instrument for the identification of children exposed to unpredictable experiences. En ligne : https://doi.org/10.1111/jcpp.13958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 Development of the infant gut microbiome predicts temperament across the first year of life / Molly FOX in Development and Psychopathology, 34-5 (December 2022)
[article]
Titre : Development of the infant gut microbiome predicts temperament across the first year of life Type de document : Texte imprimé et/ou numérique Auteurs : Molly FOX, Auteur ; S. Melanie LEE, Auteur ; Kyle S. WILEY, Auteur ; Venu LAGISHETTY, Auteur ; Curt A. SANDMAN, Auteur ; Jonathan P. JACOBS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.1914-1925 Langues : Anglais (eng) Mots-clés : emotion regulation gut–brain axis infant development microbiome temperament Index. décimale : PER Périodiques Résumé : Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the microbiome may influence neurodevelopment remain understudied. We investigated relationships between gut microbiome composition across infancy and temperament at 12 months of age. In 67 infants, we examined if gut microbiome composition assessed at 1 “3 weeks, 2, 6, and 12 months of age was associated with temperament at age 12 months. Stool samples were sequenced using the 16S Illumina MiSeq platform. Temperament was assessed using the Infant Behavior Questionnaire-Revised (IBQ-R). Beta diversity at age 1 “3 weeks was associated with surgency/extraversion at age 12 months. Bifidobacterium and Lachnospiraceae abundance at 1 “3 weeks of age was positively associated with surgency/extraversion at age 12 months. Klebsiella abundance at 1 “3 weeks was negatively associated with surgency/extraversion at 12 months. Concurrent composition was associated with negative affectivity at 12 months, including a positive association with Ruminococcus-1 and a negative association with Lactobacillus. Our findings support a relationship between gut microbiome composition and infant temperament. While exploratory due to the small sample size, these results point to early and late infancy as sensitive periods during which the gut microbiome may exert effects on neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579421000456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Development and Psychopathology > 34-5 (December 2022) . - p.1914-1925[article] Development of the infant gut microbiome predicts temperament across the first year of life [Texte imprimé et/ou numérique] / Molly FOX, Auteur ; S. Melanie LEE, Auteur ; Kyle S. WILEY, Auteur ; Venu LAGISHETTY, Auteur ; Curt A. SANDMAN, Auteur ; Jonathan P. JACOBS, Auteur ; Laura M. GLYNN, Auteur . - p.1914-1925.
Langues : Anglais (eng)
in Development and Psychopathology > 34-5 (December 2022) . - p.1914-1925
Mots-clés : emotion regulation gut–brain axis infant development microbiome temperament Index. décimale : PER Périodiques Résumé : Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the microbiome may influence neurodevelopment remain understudied. We investigated relationships between gut microbiome composition across infancy and temperament at 12 months of age. In 67 infants, we examined if gut microbiome composition assessed at 1 “3 weeks, 2, 6, and 12 months of age was associated with temperament at age 12 months. Stool samples were sequenced using the 16S Illumina MiSeq platform. Temperament was assessed using the Infant Behavior Questionnaire-Revised (IBQ-R). Beta diversity at age 1 “3 weeks was associated with surgency/extraversion at age 12 months. Bifidobacterium and Lachnospiraceae abundance at 1 “3 weeks of age was positively associated with surgency/extraversion at age 12 months. Klebsiella abundance at 1 “3 weeks was negatively associated with surgency/extraversion at 12 months. Concurrent composition was associated with negative affectivity at 12 months, including a positive association with Ruminococcus-1 and a negative association with Lactobacillus. Our findings support a relationship between gut microbiome composition and infant temperament. While exploratory due to the small sample size, these results point to early and late infancy as sensitive periods during which the gut microbiome may exert effects on neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579421000456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health / Sabrina R. LIU in Development and Psychopathology, 35-2 (May 2023)
[article]
Titre : Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health Type de document : Texte imprimé et/ou numérique Auteurs : Sabrina R. LIU, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.899-911 Langues : Anglais (eng) Mots-clés : acculturative stress discrimination infant emotion parenting prenatal Index. décimale : PER Périodiques Résumé : Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers' exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M = 12.6, SD = .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience. En ligne : http://dx.doi.org/10.1017/S0954579422000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504
in Development and Psychopathology > 35-2 (May 2023) . - p.899-911[article] Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health [Texte imprimé et/ou numérique] / Sabrina R. LIU, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.899-911.
Langues : Anglais (eng)
in Development and Psychopathology > 35-2 (May 2023) . - p.899-911
Mots-clés : acculturative stress discrimination infant emotion parenting prenatal Index. décimale : PER Périodiques Résumé : Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers' exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M = 12.6, SD = .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience. En ligne : http://dx.doi.org/10.1017/S0954579422000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development / Leah A. GRANDE in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development Type de document : Texte imprimé et/ou numérique Auteurs : Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur Article en page(s) : p.1376-1385 Langues : Anglais (eng) Mots-clés : Child Development Child, Preschool Depression/psychology Female Humans Mothers/psychology Pregnancy Prenatal Exposure Delayed Effects/psychology Psychological Distress Stress, Psychological/psychology cognitive function depression fetal programming maternal care parenting prenatal stress resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Development and Psychopathology > 34-4 (October 2022) . - p.1376-1385[article] Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development [Texte imprimé et/ou numérique] / Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur . - p.1376-1385.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1376-1385
Mots-clés : Child Development Child, Preschool Depression/psychology Female Humans Mothers/psychology Pregnancy Prenatal Exposure Delayed Effects/psychology Psychological Distress Stress, Psychological/psychology cognitive function depression fetal programming maternal care parenting prenatal stress resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Prenatal maternal stress programs infant stress regulation / Elysia POGGI DAVIS in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)
[article]
Titre : Prenatal maternal stress programs infant stress regulation Type de document : Texte imprimé et/ou numérique Auteurs : Elysia POGGI DAVIS, Auteur ; Laura M. GLYNN, Auteur ; Feizal WAFFARN, Auteur ; Curt A. SANDMAN, Auteur Année de publication : 2011 Article en page(s) : p.119-129 Langues : Anglais (eng) Mots-clés : Pregnancy stress cortisol development glucocorticoids prenatal anxiety depression infancy fetal programming Index. décimale : PER Périodiques Résumé : Objective: Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming of later health outcomes. The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress.
Methods: The study sample comprised 116 women and their full term infants. Maternal plasma cortisol and report of stress, anxiety and depression were assessed at 15, 19, 25, 31 and 36 + weeks’ gestational age. Infant cortisol and behavioral responses to the painful stress of a heel-stick blood draw were evaluated at 24 hours after birth. The association between prenatal maternal measures and infant cortisol and behavioral stress responses was examined using hierarchical linear growth curve modeling.
Results: A larger infant cortisol response to the heel-stick procedure was associated with exposure to elevated concentrations of maternal cortisol during the late second and third trimesters. Additionally, a slower rate of behavioral recovery from the painful stress of a heel-stick blood draw was predicted by elevated levels of maternal cortisol early in pregnancy as well as prenatal maternal psychosocial stress throughout gestation. These associations could not be explained by mode of delivery, prenatal medical history, socioeconomic status or child race, sex or birth order.
Conclusions: These data suggest that exposure to maternal cortisol and psychosocial stress exerts programming influences on the developing fetus with consequences for infant stress regulation.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02314.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.119-129[article] Prenatal maternal stress programs infant stress regulation [Texte imprimé et/ou numérique] / Elysia POGGI DAVIS, Auteur ; Laura M. GLYNN, Auteur ; Feizal WAFFARN, Auteur ; Curt A. SANDMAN, Auteur . - 2011 . - p.119-129.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.119-129
Mots-clés : Pregnancy stress cortisol development glucocorticoids prenatal anxiety depression infancy fetal programming Index. décimale : PER Périodiques Résumé : Objective: Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming of later health outcomes. The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress.
Methods: The study sample comprised 116 women and their full term infants. Maternal plasma cortisol and report of stress, anxiety and depression were assessed at 15, 19, 25, 31 and 36 + weeks’ gestational age. Infant cortisol and behavioral responses to the painful stress of a heel-stick blood draw were evaluated at 24 hours after birth. The association between prenatal maternal measures and infant cortisol and behavioral stress responses was examined using hierarchical linear growth curve modeling.
Results: A larger infant cortisol response to the heel-stick procedure was associated with exposure to elevated concentrations of maternal cortisol during the late second and third trimesters. Additionally, a slower rate of behavioral recovery from the painful stress of a heel-stick blood draw was predicted by elevated levels of maternal cortisol early in pregnancy as well as prenatal maternal psychosocial stress throughout gestation. These associations could not be explained by mode of delivery, prenatal medical history, socioeconomic status or child race, sex or birth order.
Conclusions: These data suggest that exposure to maternal cortisol and psychosocial stress exerts programming influences on the developing fetus with consequences for infant stress regulation.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02314.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115