Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission / Rosemarie E. PERRY in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1696-1714 Titre : Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission Type de document : texte imprimé Auteurs : Rosemarie E. PERRY, Auteur ; Stephen H. BRAREN, Auteur ; Maya OPENDAK, Auteur ; Annie BRANDES-AITKEN, Auteur ; Divija CHOPRA, Auteur ; Joyce WOO, Auteur ; Regina SULLIVAN, Auteur ; Clancy BLAIR, Auteur Article en page(s) : p.1696-1714 Langues : Anglais (eng) Mots-clés : Corticosterone  Female  Humans  *Hydrocortisone  Infant  Mother-Child Relations  *Mothers  Parenting  Stress, Psychological  *corticosterone  *cortisol  *early-life adversity  *early-life stress  *mother–infant  *social transmission Index. décimale : PER Périodiques Résumé : Environmental adversity increases child susceptibility to disrupted developmental outcomes, but the mechanisms by which adversity can shape development remain unclear. A translational cross-species approach was used to examine stress-mediated pathways by which poverty-related adversity can influence infant social development. Findings from a longitudinal sample of low-income mother-infant dyads indicated that infant cortisol (CORT) on its own did not mediate relations between early-life scarcity-adversity exposure and later infant behavior in a mother-child interaction task. However, maternal CORT through infant CORT served as a mediating pathway, even when controlling for parenting behavior. Findings using a rodent "scarcity-adversity" model indicated that pharmacologically blocking pup corticosterone (CORT, rodent equivalent to cortisol) in the presence of a stressed mother causally prevented social transmission of scarcity-adversity effects on pup social behavior. Furthermore, pharmacologically increasing pup CORT without the mother present was not sufficient to disrupt pup social behavior. Integration of our cross-species results suggests that elevated infant CORT may be necessary, but without elevated caregiver CORT, may not be sufficient in mediating the effects of environmental adversity on development. These findings underscore the importance of considering infant stress physiology in relation to the broader social context, including caregiver stress physiology, in research and interventional efforts. En ligne : http://dx.doi.org/10.1017/s0954579420001455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission [texte imprimé] / Rosemarie E. PERRY, Auteur ; Stephen H. BRAREN, Auteur ; Maya OPENDAK, Auteur ; Annie BRANDES-AITKEN, Auteur ; Divija CHOPRA, Auteur ; Joyce WOO, Auteur ; Regina SULLIVAN, Auteur ; Clancy BLAIR, Auteur . - p.1696-1714. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1696-1714 Mots-clés : Corticosterone  Female  Humans  *Hydrocortisone  Infant  Mother-Child Relations  *Mothers  Parenting  Stress, Psychological  *corticosterone  *cortisol  *early-life adversity  *early-life stress  *mother–infant  *social transmission Index. décimale : PER Périodiques Résumé : Environmental adversity increases child susceptibility to disrupted developmental outcomes, but the mechanisms by which adversity can shape development remain unclear. A translational cross-species approach was used to examine stress-mediated pathways by which poverty-related adversity can influence infant social development. Findings from a longitudinal sample of low-income mother-infant dyads indicated that infant cortisol (CORT) on its own did not mediate relations between early-life scarcity-adversity exposure and later infant behavior in a mother-child interaction task. However, maternal CORT through infant CORT served as a mediating pathway, even when controlling for parenting behavior. Findings using a rodent "scarcity-adversity" model indicated that pharmacologically blocking pup corticosterone (CORT, rodent equivalent to cortisol) in the presence of a stressed mother causally prevented social transmission of scarcity-adversity effects on pup social behavior. Furthermore, pharmacologically increasing pup CORT without the mother present was not sufficient to disrupt pup social behavior. Integration of our cross-species results suggests that elevated infant CORT may be necessary, but without elevated caregiver CORT, may not be sufficient in mediating the effects of environmental adversity on development. These findings underscore the importance of considering infant stress physiology in relation to the broader social context, including caregiver stress physiology, in research and interventional efforts. En ligne : http://dx.doi.org/10.1017/s0954579420001455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Sensory over-responsivity: parent report, direct assessment measures, and neural architecture / Teresa TAVASSOLI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 4 p. Titre : Sensory over-responsivity: parent report, direct assessment measures, and neural architecture Type de document : texte imprimé Auteurs : Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Lisa PORTER, Auteur ; Sarah SCHOEN, Auteur ; Lucy Jane MILLER, Auteur ; Molly Rae GERDES, Auteur ; Julia OWEN, Auteur ; Pratik MUKHERJEE, Auteur ; Elysa J. MARCO, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : *Assessment  *Diffusion Tensor Imaging  *Neurodevelopmental disorder  *Sensory over-responsivity  *Sensory processing disorder  *autism  of California, San Francisco (10-01940). Written consent was collected from  parents of the participants.All recruited participants/parents have given consent  for publication during the recruitment process.The authors declare that they have  no competing interests.Springer Nature remains neutral with regard to  jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Sensory over-responsivity: parent report, direct assessment measures, and neural architecture [texte imprimé] / Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Lisa PORTER, Auteur ; Sarah SCHOEN, Auteur ; Lucy Jane MILLER, Auteur ; Molly Rae GERDES, Auteur ; Julia OWEN, Auteur ; Pratik MUKHERJEE, Auteur ; Elysa J. MARCO, Auteur . - 4 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 4 p. Mots-clés : *Assessment  *Diffusion Tensor Imaging  *Neurodevelopmental disorder  *Sensory over-responsivity  *Sensory processing disorder  *autism  of California, San Francisco (10-01940). Written consent was collected from  parents of the participants.All recruited participants/parents have given consent  for publication during the recruitment process.The authors declare that they have  no competing interests.Springer Nature remains neutral with regard to  jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

White matter microstructure of children with sensory over-responsivity is associated with affective behavior / Jamie WREN-JARVIS in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : White matter microstructure of children with sensory over-responsivity is associated with affective behavior Type de document : texte imprimé Auteurs : Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Langues : Anglais (eng) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] White matter microstructure of children with sensory over-responsivity is associated with affective behavior [texte imprimé] / Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Within-person changes in basal cortisol and caregiving modulate executive attention across infancy / Annie BRANDES-AITKEN in Development and Psychopathology, 34-4 (October 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-4 (October 2022) . - p.1386-1399 Titre : Within-person changes in basal cortisol and caregiving modulate executive attention across infancy Type de document : texte imprimé Auteurs : Annie BRANDES-AITKEN, Auteur ; Stephen H. BRAREN, Auteur ; Sarah C. VOGEL, Auteur ; Rosemarie E. PERRY, Auteur ; Natalie H. BRITO, Auteur ; Clancy BLAIR, Auteur Article en page(s) : p.1386-1399 Langues : Anglais (eng) Mots-clés : Attention  Humans  Hydrocortisone/metabolism  Hypothalamo-Hypophyseal System/metabolism  Infant  Pituitary-Adrenal System/metabolism  Saliva/metabolism  Stress, Psychological/metabolism  caregiving  cortisol Index. décimale : PER Périodiques Résumé : One pathway by which environments of socioeconomic risk are thought to affect cognitive development is through stress physiology. The biological systems underpinning stress and attention undergo a sensitive period of development during infancy. Psychobiological theory emphasizes a dynamic pattern of context-dependent development, however, research has yet to examine how basal cortisol and attention dynamically covary across infancy in ecologically valid contexts. Thus, to address these gaps, we leveraged longitudinal, multilevel analytic methods to disentangle between- from within-person associations of hypothalamic-pituitary-adrenal (HPA) axis activity and executive attention behaviors across infancy. We use data from a large longitudinal sample (N = 1,292) of infants in predominantly low-income, nonurban communities at 7-, 15-, and 24-months of age. Using multilevel models, we investigated longitudinal associations of infant attention and basal cortisol levels and examined caregiving behaviors as moderators of this relationship. Results indicated a negative between- and within-person association between attention and cortisol across infancy and a within-person moderation by caregiver responsiveness. In other words, on the within-person level, higher levels of cortisol were concomitantly associated with lower infant attention across the first 2 years of life. However, variation in the caregiver's level of responsiveness either buffered or sensitized the executive attention system to the negative effects of physiological stress. En ligne : http://dx.doi.org/10.1017/s0954579421000262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Within-person changes in basal cortisol and caregiving modulate executive attention across infancy [texte imprimé] / Annie BRANDES-AITKEN, Auteur ; Stephen H. BRAREN, Auteur ; Sarah C. VOGEL, Auteur ; Rosemarie E. PERRY, Auteur ; Natalie H. BRITO, Auteur ; Clancy BLAIR, Auteur . - p.1386-1399. Langues : Anglais (eng) in Development and Psychopathology > 34-4 (October 2022) . - p.1386-1399 Mots-clés : Attention  Humans  Hydrocortisone/metabolism  Hypothalamo-Hypophyseal System/metabolism  Infant  Pituitary-Adrenal System/metabolism  Saliva/metabolism  Stress, Psychological/metabolism  caregiving  cortisol Index. décimale : PER Périodiques Résumé : One pathway by which environments of socioeconomic risk are thought to affect cognitive development is through stress physiology. The biological systems underpinning stress and attention undergo a sensitive period of development during infancy. Psychobiological theory emphasizes a dynamic pattern of context-dependent development, however, research has yet to examine how basal cortisol and attention dynamically covary across infancy in ecologically valid contexts. Thus, to address these gaps, we leveraged longitudinal, multilevel analytic methods to disentangle between- from within-person associations of hypothalamic-pituitary-adrenal (HPA) axis activity and executive attention behaviors across infancy. We use data from a large longitudinal sample (N = 1,292) of infants in predominantly low-income, nonurban communities at 7-, 15-, and 24-months of age. Using multilevel models, we investigated longitudinal associations of infant attention and basal cortisol levels and examined caregiving behaviors as moderators of this relationship. Results indicated a negative between- and within-person association between attention and cortisol across infancy and a within-person moderation by caregiver responsiveness. In other words, on the within-person level, higher levels of cortisol were concomitantly associated with lower infant attention across the first 2 years of life. However, variation in the caregiver's level of responsiveness either buffered or sensitized the executive attention system to the negative effects of physiological stress. En ligne : http://dx.doi.org/10.1017/s0954579421000262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

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