Autism spectrum disorder is associated with an increased risk of development of underweight in children and adolescents: A systematic review and meta-analysis / Chanaka N. KAHATHUDUWA in Research in Autism Spectrum Disorders, 94 (June 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 94 (June 2022) . - 101969 Titre : Autism spectrum disorder is associated with an increased risk of development of underweight in children and adolescents: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Chanaka N. KAHATHUDUWA, Auteur ; Chathurika S. DHANASEKARA, Auteur ; Sarah WAKEFIELD, Auteur ; Naima MOUSTAID-MOUSSA, Auteur ; Ann MASTERGEORGE, Auteur Article en page(s) : 101969 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Underweight  Systematic review  Meta-analysis  Meta-regression Index. décimale : PER Périodiques Résumé : Background & Aims Multiple observational studies have examined the association between autism spectrum disorder (ASD) and underweight, yet the evidence remains ambiguous. We examined the pooled prevalence and relative risk of developing underweight among children with ASD in a systematic review and meta-analysis and examined the effects of potential risk factors in a meta-regression. Methods ProQuest, PubMed, Scopus and Web of Science databases were systematically searched and screened per the PRISMA guidelines. DerSimonian?Laird random-effects meta-analyses were performed using the ?meta? package in R to determine the pooled prevalence and the relative risk of underweight among children with ASD. Meta-regression analyses examined the moderator effects of risk factors. Results Underweight had a prevalence of 6.5% (95% CI, 5.1?8.2) among children with ASD overall (29 study groups). Children with ASD possessed a 28.5% (8 studies) greater risk of being underweight vs. neurotypical controls. Meta-regression analyses revealed that non-Caucasian origin and male sex may increase the risk of being underweight in children with ASD. Conclusions Children with ASD seem to be at an increased risk of being underweight, which may further impair the clinical outcomes and quality of life. Clinicians need to vigilantly monitor weight and height among children with ASD to prevent underweight and associated complications. Future studies should aim to establish factors that may contribute to the development of underweight among children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101969 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Autism spectrum disorder is associated with an increased risk of development of underweight in children and adolescents: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Chanaka N. KAHATHUDUWA, Auteur ; Chathurika S. DHANASEKARA, Auteur ; Sarah WAKEFIELD, Auteur ; Naima MOUSTAID-MOUSSA, Auteur ; Ann MASTERGEORGE, Auteur . - 101969. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101969 Mots-clés : Autism spectrum disorder  Underweight  Systematic review  Meta-analysis  Meta-regression Index. décimale : PER Périodiques Résumé : Background & Aims Multiple observational studies have examined the association between autism spectrum disorder (ASD) and underweight, yet the evidence remains ambiguous. We examined the pooled prevalence and relative risk of developing underweight among children with ASD in a systematic review and meta-analysis and examined the effects of potential risk factors in a meta-regression. Methods ProQuest, PubMed, Scopus and Web of Science databases were systematically searched and screened per the PRISMA guidelines. DerSimonian?Laird random-effects meta-analyses were performed using the ?meta? package in R to determine the pooled prevalence and the relative risk of underweight among children with ASD. Meta-regression analyses examined the moderator effects of risk factors. Results Underweight had a prevalence of 6.5% (95% CI, 5.1?8.2) among children with ASD overall (29 study groups). Children with ASD possessed a 28.5% (8 studies) greater risk of being underweight vs. neurotypical controls. Meta-regression analyses revealed that non-Caucasian origin and male sex may increase the risk of being underweight in children with ASD. Conclusions Children with ASD seem to be at an increased risk of being underweight, which may further impair the clinical outcomes and quality of life. Clinicians need to vigilantly monitor weight and height among children with ASD to prevent underweight and associated complications. Future studies should aim to establish factors that may contribute to the development of underweight among children with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101969 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Central Executive and Default Mode Networks: An Appraisal of Executive Function and Social Skill Brain-Behavior Correlates in Youth with Autism Spectrum Disorder / Jessica BLUME in Journal of Autism and Developmental Disorders, 54-5 (May 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-5 (May 2024) . - p.1882-1896 Titre : Central Executive and Default Mode Networks: An Appraisal of Executive Function and Social Skill Brain-Behavior Correlates in Youth with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BLUME, Auteur ; Chathurika S. DHANASEKARA, Auteur ; Chanaka N. KAHATHUDUWA, Auteur ; Ann M. MASTERGEORGE, Auteur Article en page(s) : p.1882-1896 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Atypical connectivity patterns have been observed for individuals with autism spectrum disorders (ASD), particularly across the triple-network model. The current study investigated brain-behavior relationships in the context of social skills and executive function profiles for ASD youth. We calculated connectivity measures from diffusion tensor imaging using Bayesian estimation and probabilistic tractography. We replicated prior structural equation modeling of behavioral measures with total default mode network (DMN) connectivity to include comparisons with central executive network (CEN) connectivity and CEN-DMN connectivity. Increased within-CEN connectivity was related to metacognitive strengths. Our findings indicate behavior regulation difficulties in youth with ASD may be attributable to impaired connectivity between the CEN and DMN and social skill difficulties may be exacerbated by impaired within-DMN connectivity. En ligne : https://doi.org/10.1007/s10803-023-05961-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 [article] Central Executive and Default Mode Networks: An Appraisal of Executive Function and Social Skill Brain-Behavior Correlates in Youth with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jessica BLUME, Auteur ; Chathurika S. DHANASEKARA, Auteur ; Chanaka N. KAHATHUDUWA, Auteur ; Ann M. MASTERGEORGE, Auteur . - p.1882-1896. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-5 (May 2024) . - p.1882-1896 Index. décimale : PER Périodiques Résumé : Atypical connectivity patterns have been observed for individuals with autism spectrum disorders (ASD), particularly across the triple-network model. The current study investigated brain-behavior relationships in the context of social skills and executive function profiles for ASD youth. We calculated connectivity measures from diffusion tensor imaging using Bayesian estimation and probabilistic tractography. We replicated prior structural equation modeling of behavioral measures with total default mode network (DMN) connectivity to include comparisons with central executive network (CEN) connectivity and CEN-DMN connectivity. Increased within-CEN connectivity was related to metacognitive strengths. Our findings indicate behavior regulation difficulties in youth with ASD may be attributable to impaired connectivity between the CEN and DMN and social skill difficulties may be exacerbated by impaired within-DMN connectivity. En ligne : https://doi.org/10.1007/s10803-023-05961-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530

Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder / Chanaka N. KAHATHUDUWA in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4751-4760 Titre : Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chanaka N. KAHATHUDUWA, Auteur ; B. WEST, Auteur ; A. MASTERGEORGE, Auteur Article en page(s) : p.4751-4760 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain  Connectome  Functional neuroimaging  Magnetic resonance imaging  Obesity  Overweight Index. décimale : PER Périodiques Résumé : Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. En ligne : http://dx.doi.org/10.1007/s10803-019-04187-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Chanaka N. KAHATHUDUWA, Auteur ; B. WEST, Auteur ; A. MASTERGEORGE, Auteur . - p.4751-4760. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4751-4760 Mots-clés : Autism spectrum disorder  Brain  Connectome  Functional neuroimaging  Magnetic resonance imaging  Obesity  Overweight Index. décimale : PER Périodiques Résumé : Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. En ligne : http://dx.doi.org/10.1007/s10803-019-04187-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

Eye-Tracking in Infants and Young Children at Risk for Autism Spectrum Disorder: A Systematic Review of Visual Stimuli in Experimental Paradigms / A. M. MASTERGEORGE in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2578-2599 Titre : Eye-Tracking in Infants and Young Children at Risk for Autism Spectrum Disorder: A Systematic Review of Visual Stimuli in Experimental Paradigms Type de document : Texte imprimé et/ou numérique Auteurs : A. M. MASTERGEORGE, Auteur ; Chanaka N. KAHATHUDUWA, Auteur ; Jessica BLUME, Auteur Article en page(s) : p.2578-2599 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  Diagnostic Techniques, Ophthalmological  Eye Movements  Eye-Tracking Technology  Humans  Infant  Infant, Newborn  Male  Research Design  Visual Perception  Eye-tracking  Gaze behavior  Infants  Screening  Young children Index. décimale : PER Périodiques Résumé : Eye-tracking represents a sensitive, direct measure of gaze allocation and goal-directed looking behaviors that correspond to visual information processing. Clear definitions and standardization of research protocols to document the utility and feasibility of these methods are warranted. This systematic review provides an account of stimuli dimensions and experimental paradigms used in eye-tracking research for young children at risk for ASD published from 2005 through 2019. This review identifies variability in eye-tracking protocols and heterogeneity of stimuli used for eye-tracking as factors that undermine the value of eye-tracking as an objective, reliable screening tool. We underscore the importance of sharing eye-tracking stimuli to enhance replicability of findings and more importantly the need to develop a bank of publicly available, validated stimuli. En ligne : http://dx.doi.org/10.1007/s10803-020-04731-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Eye-Tracking in Infants and Young Children at Risk for Autism Spectrum Disorder: A Systematic Review of Visual Stimuli in Experimental Paradigms [Texte imprimé et/ou numérique] / A. M. MASTERGEORGE, Auteur ; Chanaka N. KAHATHUDUWA, Auteur ; Jessica BLUME, Auteur . - p.2578-2599. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2578-2599 Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Child, Preschool  Diagnostic Techniques, Ophthalmological  Eye Movements  Eye-Tracking Technology  Humans  Infant  Infant, Newborn  Male  Research Design  Visual Perception  Eye-tracking  Gaze behavior  Infants  Screening  Young children Index. décimale : PER Périodiques Résumé : Eye-tracking represents a sensitive, direct measure of gaze allocation and goal-directed looking behaviors that correspond to visual information processing. Clear definitions and standardization of research protocols to document the utility and feasibility of these methods are warranted. This systematic review provides an account of stimuli dimensions and experimental paradigms used in eye-tracking research for young children at risk for ASD published from 2005 through 2019. This review identifies variability in eye-tracking protocols and heterogeneity of stimuli used for eye-tracking as factors that undermine the value of eye-tracking as an objective, reliable screening tool. We underscore the importance of sharing eye-tracking stimuli to enhance replicability of findings and more importantly the need to develop a bank of publicly available, validated stimuli. En ligne : http://dx.doi.org/10.1007/s10803-020-04731-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

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