An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder / Alice GARRICK in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2046-2060 Titre : An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alice GARRICK, Auteur ; Marie L. LEE, Auteur ; Carrington SCARFFE, Auteur ; Tony ATTWOOD, Auteur ; Kirsten FURLEY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur Article en page(s) : p.2046-2060 Langues : Anglais (eng) Mots-clés : Australia/epidemiology  Autism Spectrum Disorder/epidemiology  Child  Cross-Sectional Studies  Emergency Service, Hospital  Humans  Parents  Attention deficit hyperactivity disorder  Autism spectrum disorders  Comorbidity  Emergency department  Survey Index. décimale : PER Périodiques Résumé : Parents of children with ASD who had attended an Australian emergency department (ED; n=421) completed a questionnaire relating to their experiences in the ED, including (1) child's reason for presentation and existing comorbidities, (2) quality of care during the visit (3) child's behaviour during visit, e.g. sensory responses to the ED environment, and disruptive behaviours. Children with comorbid ASD and intellectual disability were more likely to present with gastrointestinal issues and seizures, while those with comorbid ASD and oppositional defiant disorder were more likely to present with self-injury. ED staff awareness of ASD-related issues, including communication and expression of pain, were common difficulties for parents. The ED environment (e.g. lights, sounds, waiting areas), exacerbated child anxiety and led to disruptive behaviour. En ligne : http://dx.doi.org/10.1007/s10803-021-05091-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder [texte imprimé] / Alice GARRICK, Auteur ; Marie L. LEE, Auteur ; Carrington SCARFFE, Auteur ; Tony ATTWOOD, Auteur ; Kirsten FURLEY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur . - p.2046-2060. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2046-2060 Mots-clés : Australia/epidemiology  Autism Spectrum Disorder/epidemiology  Child  Cross-Sectional Studies  Emergency Service, Hospital  Humans  Parents  Attention deficit hyperactivity disorder  Autism spectrum disorders  Comorbidity  Emergency department  Survey Index. décimale : PER Périodiques Résumé : Parents of children with ASD who had attended an Australian emergency department (ED; n=421) completed a questionnaire relating to their experiences in the ED, including (1) child's reason for presentation and existing comorbidities, (2) quality of care during the visit (3) child's behaviour during visit, e.g. sensory responses to the ED environment, and disruptive behaviours. Children with comorbid ASD and intellectual disability were more likely to present with gastrointestinal issues and seizures, while those with comorbid ASD and oppositional defiant disorder were more likely to present with self-injury. ED staff awareness of ASD-related issues, including communication and expression of pain, were common difficulties for parents. The ED environment (e.g. lights, sounds, waiting areas), exacerbated child anxiety and led to disruptive behaviour. En ligne : http://dx.doi.org/10.1007/s10803-021-05091-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis / Kirsten FURLEY in Journal of Autism and Developmental Disorders, 56-7 (July 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-7 (July 2026) . - p.2721-2734 Titre : The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis Type de document : texte imprimé Auteurs : Kirsten FURLEY, Auteur ; Audrey TEO, Auteur ; Katrina WILLIAMS, Auteur ; Mohammed ALSHAWSH, Auteur ; Amanda BRIGNELL, Auteur Article en page(s) : p.2721-2734 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This systematic review evaluates the diagnostic yield of investigations requested for children with developmental regression. Online databases MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane were searched to identify published records that reported a diagnostic yield for children with developmental regression. Random effects meta-analyses were performed using R software with meta package. Our search identified 11,283 published records, of which 347 were assessed for eligibility, and 15 (596 children) were included in the final systematic review and meta-analysis. Subgroup analysis assessed the diagnostic yield for investigating children with different presentations and developmental regression. Diagnostic yield results were 68% for children with neurological symptoms (two records, six children, 95%CI 32–100) and children with epileptic symptoms (two records, 56 children, 95%CI 15–100); 40% for children with neurodevelopmental delay (six records, 294 children, 95%CI 3–78); 9% for autistic children (three records, 138 children, 95%CI 0–26). Pooled analysis could not be completed for metabolic (one record, 29 children) or genetic presentations (one record, 73 children). The diagnostic yield for genetic/genomic investigations (six records, 142 children, 95%CI, 47–92) was 70%, compared with 28% for metabolic (five records, 286 children, 95%CI 0–64), 13% for neurophysiological (two records, 127 children, 95%CI 0–39) and 6% for neuroimaging (two records, 41 children, 95%CI 0–20). Investigations for children with developmental regression and neurological or epileptic symptoms resulted in the highest diagnostic yield. These results are clinically meaningful and will inform future research to advance towards an agreed investigative approach yet lack statistical significance due to small samples. En ligne : https://doi.org/10.1007/s10803-025-06749-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis [texte imprimé] / Kirsten FURLEY, Auteur ; Audrey TEO, Auteur ; Katrina WILLIAMS, Auteur ; Mohammed ALSHAWSH, Auteur ; Amanda BRIGNELL, Auteur . - p.2721-2734. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-7 (July 2026) . - p.2721-2734 Index. décimale : PER Périodiques Résumé : This systematic review evaluates the diagnostic yield of investigations requested for children with developmental regression. Online databases MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane were searched to identify published records that reported a diagnostic yield for children with developmental regression. Random effects meta-analyses were performed using R software with meta package. Our search identified 11,283 published records, of which 347 were assessed for eligibility, and 15 (596 children) were included in the final systematic review and meta-analysis. Subgroup analysis assessed the diagnostic yield for investigating children with different presentations and developmental regression. Diagnostic yield results were 68% for children with neurological symptoms (two records, six children, 95%CI 32–100) and children with epileptic symptoms (two records, 56 children, 95%CI 15–100); 40% for children with neurodevelopmental delay (six records, 294 children, 95%CI 3–78); 9% for autistic children (three records, 138 children, 95%CI 0–26). Pooled analysis could not be completed for metabolic (one record, 29 children) or genetic presentations (one record, 73 children). The diagnostic yield for genetic/genomic investigations (six records, 142 children, 95%CI, 47–92) was 70%, compared with 28% for metabolic (five records, 286 children, 95%CI 0–64), 13% for neurophysiological (two records, 127 children, 95%CI 0–39) and 6% for neuroimaging (two records, 41 children, 95%CI 0–20). Investigations for children with developmental regression and neurological or epileptic symptoms resulted in the highest diagnostic yield. These results are clinically meaningful and will inform future research to advance towards an agreed investigative approach yet lack statistical significance due to small samples. En ligne : https://doi.org/10.1007/s10803-025-06749-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology / Rachael KNOTT in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 55 p. Titre : The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology Type de document : texte imprimé Auteurs : Rachael KNOTT, Auteur ; Beth P. JOHNSON, Auteur ; Jeggan TIEGO, Auteur ; Olivia MELLAHN, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Maria KOUSPOS, Auteur ; Vishnu Priya MOHANAKUMAR SINDHU, Auteur ; Ziarih HAWI, Auteur ; Aurina ARNATKEVICIUTE, Auteur ; Tracey CHAU, Auteur ; Dalia MARON, Auteur ; Emily-Clare MERCIECA, Auteur ; Kirsten FURLEY, Auteur ; Katrina HARRIS, Auteur ; Katrina WILLIAMS, Auteur ; Alexandra URE, Auteur ; Alex FORNITO, Auteur ; Kylie M. GRAY, Auteur ; David COGHILL, Auteur ; Ann NICHOLSON, Auteur ; Dinh PHUNG, Auteur ; Eva LOTH, Auteur ; Luke MASON, Auteur ; Dennis MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Mark A. BELLGROVE, Auteur Article en page(s) : 55 p. Langues : Anglais (eng) Mots-clés : Adhd  Asd  Cognition  Eye-tracking  Genetics  HiTOP  Neuroimaging  RDoC Index. décimale : PER Périodiques Résumé : BACKGROUND: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. METHODS: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. CONCLUSION: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. En ligne : http://dx.doi.org/10.1186/s13229-021-00457-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology [texte imprimé] / Rachael KNOTT, Auteur ; Beth P. JOHNSON, Auteur ; Jeggan TIEGO, Auteur ; Olivia MELLAHN, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Maria KOUSPOS, Auteur ; Vishnu Priya MOHANAKUMAR SINDHU, Auteur ; Ziarih HAWI, Auteur ; Aurina ARNATKEVICIUTE, Auteur ; Tracey CHAU, Auteur ; Dalia MARON, Auteur ; Emily-Clare MERCIECA, Auteur ; Kirsten FURLEY, Auteur ; Katrina HARRIS, Auteur ; Katrina WILLIAMS, Auteur ; Alexandra URE, Auteur ; Alex FORNITO, Auteur ; Kylie M. GRAY, Auteur ; David COGHILL, Auteur ; Ann NICHOLSON, Auteur ; Dinh PHUNG, Auteur ; Eva LOTH, Auteur ; Luke MASON, Auteur ; Dennis MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Mark A. BELLGROVE, Auteur . - 55 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 55 p. Mots-clés : Adhd  Asd  Cognition  Eye-tracking  Genetics  HiTOP  Neuroimaging  RDoC Index. décimale : PER Périodiques Résumé : BACKGROUND: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. METHODS: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. CONCLUSION: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. En ligne : http://dx.doi.org/10.1186/s13229-021-00457-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

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