Associations Among Symptoms of Autism, Symptoms of Depression and Executive Functions in Children with High-Functioning Autism: A 2 Year Follow-Up Study / Per NORMANN ANDERSEN in Journal of Autism and Developmental Disorders, 45-8 (August 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2497-2507 Titre : Associations Among Symptoms of Autism, Symptoms of Depression and Executive Functions in Children with High-Functioning Autism: A 2 Year Follow-Up Study Type de document : texte imprimé Auteurs : Per NORMANN ANDERSEN, Auteur ; Erik Winther SKOGLI, Auteur ; Kjell TORE HOVIK, Auteur ; Jens EGELAND, Auteur ; Merete Glenne ØIE, Auteur Année de publication : 2015 Article en page(s) : p.2497-2507 Langues : Anglais (eng) Mots-clés : Asperger’s syndrome  Autism spectrum disorder  Depressive symptoms  Executive function  Follow-up  Self-report Index. décimale : PER Périodiques Résumé : This study investigated the course of and association among changes in autism symptoms, depression symptoms and executive functions (EF) in children with high-functioning autism (HFA). Thirty-four children with HFA and 45 typically developing children (age 9–16) were assessed at baseline and after 2 years. Children with HFA had impaired scores on all measures at both time points. According to parent reports, depressive symptoms decreased over time, while EF improved and autism symptoms were stable. Children’s reports did not reveal less depressive symptoms over time. A positive association was found only between changes in autism symptoms and changes in symptoms of depression. A possible implication is that interventions aimed at either autism symptoms or symptoms of depression may improve the other. En ligne : http://dx.doi.org/10.1007/s10803-015-2415-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Associations Among Symptoms of Autism, Symptoms of Depression and Executive Functions in Children with High-Functioning Autism: A 2 Year Follow-Up Study [texte imprimé] / Per NORMANN ANDERSEN, Auteur ; Erik Winther SKOGLI, Auteur ; Kjell TORE HOVIK, Auteur ; Jens EGELAND, Auteur ; Merete Glenne ØIE, Auteur . - 2015 . - p.2497-2507. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2497-2507 Mots-clés : Asperger’s syndrome  Autism spectrum disorder  Depressive symptoms  Executive function  Follow-up  Self-report Index. décimale : PER Périodiques Résumé : This study investigated the course of and association among changes in autism symptoms, depression symptoms and executive functions (EF) in children with high-functioning autism (HFA). Thirty-four children with HFA and 45 typically developing children (age 9–16) were assessed at baseline and after 2 years. Children with HFA had impaired scores on all measures at both time points. According to parent reports, depressive symptoms decreased over time, while EF improved and autism symptoms were stable. Children’s reports did not reveal less depressive symptoms over time. A positive association was found only between changes in autism symptoms and changes in symptoms of depression. A possible implication is that interventions aimed at either autism symptoms or symptoms of depression may improve the other. En ligne : http://dx.doi.org/10.1007/s10803-015-2415-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment / Tonje TORSKE in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.207-220 Titre : Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment Type de document : texte imprimé Auteurs : Tonje TORSKE, Auteur ; Terje NAERLAND, Auteur ; Francesco BETTELLA, Auteur ; Thomas BJELLA, Auteur ; Eva MALT, Auteur ; Anne Lise HOYLAND, Auteur ; Nina STENBERG, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.207-220 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  behavior rating inventory of executive function  executive function  polygenic score Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R(2) = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. En ligne : http://dx.doi.org/10.1002/aur.2207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment [texte imprimé] / Tonje TORSKE, Auteur ; Terje NAERLAND, Auteur ; Francesco BETTELLA, Auteur ; Thomas BJELLA, Auteur ; Eva MALT, Auteur ; Anne Lise HOYLAND, Auteur ; Nina STENBERG, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur . - p.207-220. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.207-220 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  behavior rating inventory of executive function  executive function  polygenic score Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R(2) = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. En ligne : http://dx.doi.org/10.1002/aur.2207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Brief report: Autism spectrum disorder diagnostic persistence in a 10-year longitudinal study / Stian ORM in Research in Autism Spectrum Disorders, 97 (September 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 97 (September 2022) . - 102007 Titre : Brief report: Autism spectrum disorder diagnostic persistence in a 10-year longitudinal study Type de document : texte imprimé Auteurs : Stian ORM, Auteur ; Per Normann ANDERSEN, Auteur ; Ingrid Nesdal FOSSUM, Auteur ; Merete Glenne ØIE, Auteur ; Erik Winther SKOGLI, Auteur Article en page(s) : 102007 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Longitudinal study  Diagnostic stability  Diagnostic persistence  Childhood predictors Index. décimale : PER Périodiques Résumé : Background The aim was to examine diagnostic persistence of Autism Spectrum Disorder (ASD) in individuals without intellectual disability from childhood to emerging adulthood. Method We assessed 38 children with estimated full-scale intelligence quotient (IQ)70 who were diagnosed with ASD at baseline (Mage=12.0, SD=2.3, 84% male), and re-assessed two (n=37, Mage=14.2, SD=2.4, 84% male) and 10 years (n=23, Mage=21.7, SD=2.4, 78% male) later. Results At two-year follow-up, all participants still met diagnostic criteria for ASD according to the Diagnostic and Statistical Manual for Mental Disorders “ fourth version (DSM-IV). At 10-year follow-up, 65% met diagnostic criteria for ASD according to DSM-IV, 48% met diagnostic criteria according to the Diagnostic and Statistical Manual for Mental Disorders “ fifth version (DSM-5), 57% met the ASD cut-off on the Autism Spectrum Quotient 10-item (AQ-10), and 78% met either DSM-IV criteria or cut-off on the AQ-10. Higher IQ in childhood predicted loss of ASD diagnosis according to DSM-IV criteria (Hedges g = 1.30). A higher proportion of girls compared to boys displayed loss of ASD diagnosis according to DSM-IV criteria. Conclusions These findings suggest that ASD traits among individuals without intellectual disability may wane into emerging adulthood and that loss of ASD diagnosis is associated with higher IQ and being a girl. Diagnostic re-evaluations may be warranted for some individuals diagnosed with ASD as children or adolescents. En ligne : https://doi.org/10.1016/j.rasd.2022.102007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Brief report: Autism spectrum disorder diagnostic persistence in a 10-year longitudinal study [texte imprimé] / Stian ORM, Auteur ; Per Normann ANDERSEN, Auteur ; Ingrid Nesdal FOSSUM, Auteur ; Merete Glenne ØIE, Auteur ; Erik Winther SKOGLI, Auteur . - 102007. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 97 (September 2022) . - 102007 Mots-clés : Autism Spectrum Disorder  Longitudinal study  Diagnostic stability  Diagnostic persistence  Childhood predictors Index. décimale : PER Périodiques Résumé : Background The aim was to examine diagnostic persistence of Autism Spectrum Disorder (ASD) in individuals without intellectual disability from childhood to emerging adulthood. Method We assessed 38 children with estimated full-scale intelligence quotient (IQ)70 who were diagnosed with ASD at baseline (Mage=12.0, SD=2.3, 84% male), and re-assessed two (n=37, Mage=14.2, SD=2.4, 84% male) and 10 years (n=23, Mage=21.7, SD=2.4, 78% male) later. Results At two-year follow-up, all participants still met diagnostic criteria for ASD according to the Diagnostic and Statistical Manual for Mental Disorders “ fourth version (DSM-IV). At 10-year follow-up, 65% met diagnostic criteria for ASD according to DSM-IV, 48% met diagnostic criteria according to the Diagnostic and Statistical Manual for Mental Disorders “ fifth version (DSM-5), 57% met the ASD cut-off on the Autism Spectrum Quotient 10-item (AQ-10), and 78% met either DSM-IV criteria or cut-off on the AQ-10. Higher IQ in childhood predicted loss of ASD diagnosis according to DSM-IV criteria (Hedges g = 1.30). A higher proportion of girls compared to boys displayed loss of ASD diagnosis according to DSM-IV criteria. Conclusions These findings suggest that ASD traits among individuals without intellectual disability may wane into emerging adulthood and that loss of ASD diagnosis is associated with higher IQ and being a girl. Diagnostic re-evaluations may be warranted for some individuals diagnosed with ASD as children or adolescents. En ligne : https://doi.org/10.1016/j.rasd.2022.102007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

"I have to charge my social battery": Perspectives from autistic young adults on Quality of Life / Elisabeth ØVERLAND in Autism, 28-6 (June 2024)  

Public ISBD [article]  inAutism > 28-6 (June 2024) . - p.1369-1381 Titre : "I have to charge my social battery": Perspectives from autistic young adults on Quality of Life Type de document : texte imprimé Auteurs : Elisabeth ØVERLAND, Auteur ; Ã…shild Lappegard HAUGE, Auteur ; Stian ORM, Auteur ; Merete Glenne ØIE, Auteur ; Erik Winther SKOGLI, Auteur ; Elizabeth PELLICANO, Auteur ; Per Normann ANDERSEN, Auteur Article en page(s) : p.1369-1381 Langues : Anglais (eng) Mots-clés : autism  emerging adulthood  quality of life  reflexive thematic analysis Index. décimale : PER Périodiques Résumé : Several studies report on lower quality of life for autistic people when compared to non-autistic people. However, there are ongoing discussions about the conceptualization of quality of life for the autistic population. This qualitative study investigated self-perceived quality of life in the context of autistic young adults' everyday lives. Participants (age range 21-29 years) were recruited from a 10-year follow-up study, Lillehammer Neurodevelopmental Follow-up Study, all diagnosed in childhood and adolescence. Fourteen individual in-depth interviews were conducted. When asked about what was important for having a good quality of life, our autistic participants described relationships to people and pets as important, as well as having meaningful activities. Specific interests had guided many to their choice of both academic and work career. Many also described obstacles in their environment that had influenced their quality of life negatively, such as being misunderstood by teachers and other professionals, being bullied, and sensory and emotional overload. Our findings indicate that those in supportive roles should provide help with establishing connections to activities and people/animals, as this seems to be essential for creating a good quality of life. Taking advantage of passions and interests can create opportunities for autistic people. Findings suggest that future research should address the communication barriers between autistic people and professionals that can lead to misunderstandings. Lay abstract In this study we have asked a group of autistic young adults to describe what is important for their quality of life. The 14 participants (aged 21-29 years) were recruited from a 10-year follow-up study of autistic people. During interviews, our participants described the importance of having relationships with family, friends and pets. Having meaningful activities and being able to immerse themselves in particular interests was also reported to be important for a good quality of life. Interests had also guided their choice of what to study and what to do for work. They also spoke of how communication problems with professionals, bullying and sensory and emotional overload could have a negative impact on quality of life. Future interventions should focus on how professionals can help autistic people to connect to people/animals and meaningful activities, as the participants described this as important for having a good quality of life. These findings may be helpful in enhancing how passions and interests can be seen as opportunities for both academic and work careers for autistic people. Future research and interventions should also look at the communication barriers between autistic people and professionals, and how two-way understanding can be improved. En ligne : https://dx.doi.org/10.1177/13623613241245578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] "I have to charge my social battery": Perspectives from autistic young adults on Quality of Life [texte imprimé] / Elisabeth ØVERLAND, Auteur ; Ã…shild Lappegard HAUGE, Auteur ; Stian ORM, Auteur ; Merete Glenne ØIE, Auteur ; Erik Winther SKOGLI, Auteur ; Elizabeth PELLICANO, Auteur ; Per Normann ANDERSEN, Auteur . - p.1369-1381. Langues : Anglais (eng) in Autism > 28-6 (June 2024) . - p.1369-1381 Mots-clés : autism  emerging adulthood  quality of life  reflexive thematic analysis Index. décimale : PER Périodiques Résumé : Several studies report on lower quality of life for autistic people when compared to non-autistic people. However, there are ongoing discussions about the conceptualization of quality of life for the autistic population. This qualitative study investigated self-perceived quality of life in the context of autistic young adults' everyday lives. Participants (age range 21-29 years) were recruited from a 10-year follow-up study, Lillehammer Neurodevelopmental Follow-up Study, all diagnosed in childhood and adolescence. Fourteen individual in-depth interviews were conducted. When asked about what was important for having a good quality of life, our autistic participants described relationships to people and pets as important, as well as having meaningful activities. Specific interests had guided many to their choice of both academic and work career. Many also described obstacles in their environment that had influenced their quality of life negatively, such as being misunderstood by teachers and other professionals, being bullied, and sensory and emotional overload. Our findings indicate that those in supportive roles should provide help with establishing connections to activities and people/animals, as this seems to be essential for creating a good quality of life. Taking advantage of passions and interests can create opportunities for autistic people. Findings suggest that future research should address the communication barriers between autistic people and professionals that can lead to misunderstandings. Lay abstract In this study we have asked a group of autistic young adults to describe what is important for their quality of life. The 14 participants (aged 21-29 years) were recruited from a 10-year follow-up study of autistic people. During interviews, our participants described the importance of having relationships with family, friends and pets. Having meaningful activities and being able to immerse themselves in particular interests was also reported to be important for a good quality of life. Interests had also guided their choice of what to study and what to do for work. They also spoke of how communication problems with professionals, bullying and sensory and emotional overload could have a negative impact on quality of life. Future interventions should focus on how professionals can help autistic people to connect to people/animals and meaningful activities, as the participants described this as important for having a good quality of life. These findings may be helpful in enhancing how passions and interests can be seen as opportunities for both academic and work careers for autistic people. Future research and interventions should also look at the communication barriers between autistic people and professionals, and how two-way understanding can be improved. En ligne : https://dx.doi.org/10.1177/13623613241245578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder / Tonje TORSKE in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3847-3859 Titre : Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Tonje TORSKE, Auteur ; Terje NÆRLAND, Auteur ; Daniel S. QUINTANA, Auteur ; Ruth Elizabeth HYPHER, Auteur ; Anett KAALE, Auteur ; Anne Lise HØYLAND, Auteur ; Sigrun HOPE, Auteur ; Jarle JOHANNESSEN, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.3847-3859 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p<0.001) and communication (p=0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. En ligne : https://doi.org/10.1007/s10803-022-05629-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder [texte imprimé] / Tonje TORSKE, Auteur ; Terje NÆRLAND, Auteur ; Daniel S. QUINTANA, Auteur ; Ruth Elizabeth HYPHER, Auteur ; Anett KAALE, Auteur ; Anne Lise HØYLAND, Auteur ; Sigrun HOPE, Auteur ; Jarle JOHANNESSEN, Auteur ; Merete Glenne ØIE, Auteur ; Ole A. ANDREASSEN, Auteur . - p.3847-3859. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3847-3859 Index. décimale : PER Périodiques Résumé : Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p<0.001) and communication (p=0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. En ligne : https://doi.org/10.1007/s10803-022-05629-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Working memory arrest in children with high-functioning autism compared to children with attention-deficit/hyperactivity disorder: Results from a 2-year longitudinal study / Per Normann ANDERSEN in Autism, 19-4 (May 2015)  

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