A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study / Kensuke NOMURA ; Kenji SANADA ; Katsuma MIYAHO ; Chiharu ISHII ; Shinji FUKUDA ; Chiaki IWAMOTO ; Minori NARAOKA ; Shintaro YONEDA ; Masahiro IMAFUKU ; Juntaro MATSUZAKI ; Yoshimasa SAITO ; Masaru MIMURA ; Taishiro KISHIMOTO in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1184-1195 Titre : A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study Type de document : texte imprimé Auteurs : Kensuke NOMURA, Auteur ; Kenji SANADA, Auteur ; Katsuma MIYAHO, Auteur ; Chiharu ISHII, Auteur ; Shinji FUKUDA, Auteur ; Chiaki IWAMOTO, Auteur ; Minori NARAOKA, Auteur ; Shintaro YONEDA, Auteur ; Masahiro IMAFUKU, Auteur ; Juntaro MATSUZAKI, Auteur ; Yoshimasa SAITO, Auteur ; Masaru MIMURA, Auteur ; Taishiro KISHIMOTO, Auteur Article en page(s) : p.1184-1195 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Previous research has shown a significant link between gut microbiota in children with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). However, much remains unknown because of the heterogeneity of disorders and the potential confounders such as dietary patterns and control group variations. Methods Children aged 6-12 years who had been clinically diagnosed with ASD and/or ADHD, their unaffected neurotypical siblings, and non-related neurotypical volunteers were recruited cross-sectionally. The ASD diagnosis was confirmed using the Autism Diagnostic Observation Schedule-2 (ADOS-2) in all patients, including those with ADHD. Standardized DNA extraction and sequencing methods were used to compare gut microbial alpha-diversity among the groups. Dietary diversity was calculated from a standardized dietary questionnaire form. We compared the difference in gut microbiome between patients with ASD and/or ADHD with neurotypical siblings and non-related neurotypical controls. Results Ninety-eight subjects were included in the study (18 with ASD, 19 with ADHD, 20 with both ASD and ADHD, 13 neurotypical siblings, and 28 non-related neurotypical controls). The alpha-diversity indices, such as Chao 1 and Shannon index, showed a significant difference between the groups in a Linear mixed-effect model (F(4, 93) = 4.539, p = .02), (F(4, 93) = 3.185, p = .017), respectively. In a post-hoc pairwise comparison, patients with ASD had lower alpha-diversity compared with non-related controls after Bonferroni correction. Dietary diversity shown in Shannon index did not differ among the groups (F(4, 84) = 1.494, p = .211). Conclusions Our study indicates disorder-specific microbiome differences in patients with ASD. In future research on gut microbiota in neurodevelopmental disorders, it is necessary to consider the impact of ASD and ADHD co-occurrence, and strictly control for background information such as diet, to elucidate the gut-microbiota interaction in ASD and ADHD for exploring the potential of therapeutic interventions. En ligne : https://doi.org/10.1111/jcpp.13962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study [texte imprimé] / Kensuke NOMURA, Auteur ; Kenji SANADA, Auteur ; Katsuma MIYAHO, Auteur ; Chiharu ISHII, Auteur ; Shinji FUKUDA, Auteur ; Chiaki IWAMOTO, Auteur ; Minori NARAOKA, Auteur ; Shintaro YONEDA, Auteur ; Masahiro IMAFUKU, Auteur ; Juntaro MATSUZAKI, Auteur ; Yoshimasa SAITO, Auteur ; Masaru MIMURA, Auteur ; Taishiro KISHIMOTO, Auteur . - p.1184-1195. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1184-1195 Index. décimale : PER Périodiques Résumé : Background Previous research has shown a significant link between gut microbiota in children with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). However, much remains unknown because of the heterogeneity of disorders and the potential confounders such as dietary patterns and control group variations. Methods Children aged 6-12 years who had been clinically diagnosed with ASD and/or ADHD, their unaffected neurotypical siblings, and non-related neurotypical volunteers were recruited cross-sectionally. The ASD diagnosis was confirmed using the Autism Diagnostic Observation Schedule-2 (ADOS-2) in all patients, including those with ADHD. Standardized DNA extraction and sequencing methods were used to compare gut microbial alpha-diversity among the groups. Dietary diversity was calculated from a standardized dietary questionnaire form. We compared the difference in gut microbiome between patients with ASD and/or ADHD with neurotypical siblings and non-related neurotypical controls. Results Ninety-eight subjects were included in the study (18 with ASD, 19 with ADHD, 20 with both ASD and ADHD, 13 neurotypical siblings, and 28 non-related neurotypical controls). The alpha-diversity indices, such as Chao 1 and Shannon index, showed a significant difference between the groups in a Linear mixed-effect model (F(4, 93) = 4.539, p = .02), (F(4, 93) = 3.185, p = .017), respectively. In a post-hoc pairwise comparison, patients with ASD had lower alpha-diversity compared with non-related controls after Bonferroni correction. Dietary diversity shown in Shannon index did not differ among the groups (F(4, 84) = 1.494, p = .211). Conclusions Our study indicates disorder-specific microbiome differences in patients with ASD. In future research on gut microbiota in neurodevelopmental disorders, it is necessary to consider the impact of ASD and ADHD co-occurrence, and strictly control for background information such as diet, to elucidate the gut-microbiota interaction in ASD and ADHD for exploring the potential of therapeutic interventions. En ligne : https://doi.org/10.1111/jcpp.13962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders / S. KUROKAWA in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1996-2001 Titre : Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders Type de document : texte imprimé Auteurs : S. KUROKAWA, Auteur ; Kensuke NOMURA, Auteur ; Katsuma MIYAHO, Auteur ; Kenji SANADA, Auteur ; Chiaki IWAMOTO, Auteur ; Minori NARAOKA, Auteur ; Shintaro YONEDA, Auteur ; Yoshihiro TOMIZAWA, Auteur ; Yukinori SAWAE, Auteur ; Ryoichiro IWANAGA, Auteur ; Masaru MIMURA, Auteur ; Taishiro KISHIMOTO, Auteur Année de publication : 2021 Article en page(s) : p.1996-2001 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/complications  Autism Spectrum Disorder/complications  Child  Cross-Sectional Studies  Humans  Problem Behavior  Quality of Life  Autism spectrum disorders  attention-deficit/hyperactivity disorder  behavioral problems  gastrointestinal symptoms  sensory abnormalities Index. décimale : PER Périodiques Résumé : Behavioral problems directly affect the quality of life of caregivers and children with autism spectrum disorder (ASD) and/or attention-deficit/hyperactivity disorder (ADHD), and is known to be associated with clinical factors such as gastrointestinal (GI) symptoms, sensory abnormalities, intellectual abilities, and use of medication. However, previous studies have not considered these relationships comprehensively. We conducted a cross-sectional study of 6-12-year-old children with diagnoses of ASD and/or ADHD at two hospitals in Japan. Scores for the aberrant behavior checklist (ABC), autism-spectrum quotient (AQ), and Conners 3, as well as information on daily sleep and exercise, GI symptoms, and Short Sensory Profile, were collected. Each factor was subjected to a correlation analysis to investigate its effect on ABC scores. A stepwise multiple linear regression analysis for the factors with p < 0.05 was performed. Data were obtained from 60 patients with a mean age of 8.3 years; 21 had ASD alone, 18 had ADHD alone, and 21 had ASD + ADHD. The correlation analyses identified six factors associated with ABC severity: (a) methylphenidate use, (b) Conners hyperactivity score, (c) Conners inattention score, (d) AQ score, (e) SSP score, and (f) GI symptom score. The multiple regression showed that "GI symptoms" and "sensory abnormalities" were independently associated with ABC severity. Although further studies are needed to show a causal relationship, appropriate assessment of GI symptoms and sensory abnormalities may help alleviate some problematic behaviors and improve the quality of life of children with neurodevelopmental disorders and their families. LAY SUMMARY: Behavioral problems in children with neurodevelopmental disorders are known to be associated with many factors. This study aimed to comprehensively investigate the known factors. We have discovered that "gastrointestinal symptoms" and "sensory abnormalities" were independently associated with Behavioral problems. Our results suggest that it is important for clinicians and caregivers to pay more attention to children's GI symptoms and sensory abnormalities that may not present as obvious symptoms or complaints. En ligne : http://dx.doi.org/10.1002/aur.2549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders [texte imprimé] / S. KUROKAWA, Auteur ; Kensuke NOMURA, Auteur ; Katsuma MIYAHO, Auteur ; Kenji SANADA, Auteur ; Chiaki IWAMOTO, Auteur ; Minori NARAOKA, Auteur ; Shintaro YONEDA, Auteur ; Yoshihiro TOMIZAWA, Auteur ; Yukinori SAWAE, Auteur ; Ryoichiro IWANAGA, Auteur ; Masaru MIMURA, Auteur ; Taishiro KISHIMOTO, Auteur . - 2021 . - p.1996-2001. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1996-2001 Mots-clés : Attention Deficit Disorder with Hyperactivity/complications  Autism Spectrum Disorder/complications  Child  Cross-Sectional Studies  Humans  Problem Behavior  Quality of Life  Autism spectrum disorders  attention-deficit/hyperactivity disorder  behavioral problems  gastrointestinal symptoms  sensory abnormalities Index. décimale : PER Périodiques Résumé : Behavioral problems directly affect the quality of life of caregivers and children with autism spectrum disorder (ASD) and/or attention-deficit/hyperactivity disorder (ADHD), and is known to be associated with clinical factors such as gastrointestinal (GI) symptoms, sensory abnormalities, intellectual abilities, and use of medication. However, previous studies have not considered these relationships comprehensively. We conducted a cross-sectional study of 6-12-year-old children with diagnoses of ASD and/or ADHD at two hospitals in Japan. Scores for the aberrant behavior checklist (ABC), autism-spectrum quotient (AQ), and Conners 3, as well as information on daily sleep and exercise, GI symptoms, and Short Sensory Profile, were collected. Each factor was subjected to a correlation analysis to investigate its effect on ABC scores. A stepwise multiple linear regression analysis for the factors with p < 0.05 was performed. Data were obtained from 60 patients with a mean age of 8.3 years; 21 had ASD alone, 18 had ADHD alone, and 21 had ASD + ADHD. The correlation analyses identified six factors associated with ABC severity: (a) methylphenidate use, (b) Conners hyperactivity score, (c) Conners inattention score, (d) AQ score, (e) SSP score, and (f) GI symptom score. The multiple regression showed that "GI symptoms" and "sensory abnormalities" were independently associated with ABC severity. Although further studies are needed to show a causal relationship, appropriate assessment of GI symptoms and sensory abnormalities may help alleviate some problematic behaviors and improve the quality of life of children with neurodevelopmental disorders and their families. LAY SUMMARY: Behavioral problems in children with neurodevelopmental disorders are known to be associated with many factors. This study aimed to comprehensively investigate the known factors. We have discovered that "gastrointestinal symptoms" and "sensory abnormalities" were independently associated with Behavioral problems. Our results suggest that it is important for clinicians and caregivers to pay more attention to children's GI symptoms and sensory abnormalities that may not present as obvious symptoms or complaints. En ligne : http://dx.doi.org/10.1002/aur.2549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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