Chronic oxytocin improves neural decoupling at rest in children with autism: an exploratory RCT / Matthijs MOERKERKE ; Nicky DANIELS ; Qianqian ZHANG ; Ricchiuti GRAZIA ; Jean STEYAERT ; Jellina PRINSEN ; Bart BOETS in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1311-1326 Titre : Chronic oxytocin improves neural decoupling at rest in children with autism: an exploratory RCT Type de document : texte imprimé Auteurs : Matthijs MOERKERKE, Auteur ; Nicky DANIELS, Auteur ; Qianqian ZHANG, Auteur ; Ricchiuti GRAZIA, Auteur ; Jean STEYAERT, Auteur ; Jellina PRINSEN, Auteur ; Bart BOETS, Auteur Article en page(s) : p.1311-1326 Langues : Anglais (eng) Mots-clés : Oxytocin  autism spectrum disorder  electroencephalography  heart rate variability  neural rhythms  alpha  theta  signal to noise Index. décimale : PER Périodiques Résumé : Background Shifts in peak frequencies of oscillatory neural rhythms are put forward as a principal mechanism by which cross-frequency coupling/decoupling is implemented in the brain. During active neural processing, functional integration is facilitated through transitory formations of ?harmonic? cross-frequency couplings, whereas ?nonharmonic? decoupling among neural oscillatory rhythms is postulated to characterize the resting, default state of the brain, minimizing the occurrence of spurious, noisy, background couplings. Methods Within this exploratory, randomized, placebo-controlled trial, we assessed whether the transient occurrence of nonharmonic and harmonic relationships between peak-frequencies in the alpha (8 14 Hz) and theta (4 8 Hz) bands is impacted by intranasal administration of oxytocin, a neuromodulator implicated in improving homeostasis and reducing stress/anxiety. To do so, resting-state electroencephalography was acquired before and after 4 weeks of oxytocin administration (12 IU twice-daily) in children with autism spectrum disorder (8 12 years, n 33 oxytocin; n 34 placebo). At the baseline, neural assessments of children with autism were compared with those of a matched cohort of children without autism (n 40). Results Compared to nonautistic peers, autistic children displayed a lower incidence of nonharmonic alpha-theta cross-frequency decoupling, indicating a higher incidence of spurious ?noisy? coupling in their resting brain (p .001). Dimensionally, increased neural coupling was associated with more social difficulties (p .002) and lower activity of the parasympathetic ?rest & digest? branch of the autonomic nervous system (p .018), indexed with high-frequency heart-rate-variability. Notably, after oxytocin administration, the transient formation of nonharmonic cross-frequency configurations was increased in the cohort of autistic children (p < .001), indicating a beneficial effect of oxytocin on reducing spurious cross-frequency-interactions. Furthermore, parallel epigenetics changes of the oxytocin receptor gene indicated that the neural effects were likely mediated by changes in endogenous oxytocinergic signaling (p .006). Conclusions Chronic oxytocin induced important homeostatic changes in the resting-state intrinsic neural frequency architecture, reflective of reduced noisy oscillatory couplings and improved signal-to-noise properties. En ligne : https://doi.org/10.1111/jcpp.13966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Chronic oxytocin improves neural decoupling at rest in children with autism: an exploratory RCT [texte imprimé] / Matthijs MOERKERKE, Auteur ; Nicky DANIELS, Auteur ; Qianqian ZHANG, Auteur ; Ricchiuti GRAZIA, Auteur ; Jean STEYAERT, Auteur ; Jellina PRINSEN, Auteur ; Bart BOETS, Auteur . - p.1311-1326. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1311-1326 Mots-clés : Oxytocin  autism spectrum disorder  electroencephalography  heart rate variability  neural rhythms  alpha  theta  signal to noise Index. décimale : PER Périodiques Résumé : Background Shifts in peak frequencies of oscillatory neural rhythms are put forward as a principal mechanism by which cross-frequency coupling/decoupling is implemented in the brain. During active neural processing, functional integration is facilitated through transitory formations of ?harmonic? cross-frequency couplings, whereas ?nonharmonic? decoupling among neural oscillatory rhythms is postulated to characterize the resting, default state of the brain, minimizing the occurrence of spurious, noisy, background couplings. Methods Within this exploratory, randomized, placebo-controlled trial, we assessed whether the transient occurrence of nonharmonic and harmonic relationships between peak-frequencies in the alpha (8 14 Hz) and theta (4 8 Hz) bands is impacted by intranasal administration of oxytocin, a neuromodulator implicated in improving homeostasis and reducing stress/anxiety. To do so, resting-state electroencephalography was acquired before and after 4 weeks of oxytocin administration (12 IU twice-daily) in children with autism spectrum disorder (8 12 years, n 33 oxytocin; n 34 placebo). At the baseline, neural assessments of children with autism were compared with those of a matched cohort of children without autism (n 40). Results Compared to nonautistic peers, autistic children displayed a lower incidence of nonharmonic alpha-theta cross-frequency decoupling, indicating a higher incidence of spurious ?noisy? coupling in their resting brain (p .001). Dimensionally, increased neural coupling was associated with more social difficulties (p .002) and lower activity of the parasympathetic ?rest & digest? branch of the autonomic nervous system (p .018), indexed with high-frequency heart-rate-variability. Notably, after oxytocin administration, the transient formation of nonharmonic cross-frequency configurations was increased in the cohort of autistic children (p < .001), indicating a beneficial effect of oxytocin on reducing spurious cross-frequency-interactions. Furthermore, parallel epigenetics changes of the oxytocin receptor gene indicated that the neural effects were likely mediated by changes in endogenous oxytocinergic signaling (p .006). Conclusions Chronic oxytocin induced important homeostatic changes in the resting-state intrinsic neural frequency architecture, reflective of reduced noisy oscillatory couplings and improved signal-to-noise properties. En ligne : https://doi.org/10.1111/jcpp.13966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder / Shuxia YAO in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1609-1620 Titre : Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Shuxia YAO, Auteur ; Menghan ZHOU, Auteur ; Yuan ZHANG, Auteur ; Feng ZHOU, Auteur ; Qianqian ZHANG, Auteur ; Zhongbo ZHAO, Auteur ; Xi JIANG, Auteur ; Xiu XU, Auteur ; Benjamin BECKER, Auteur ; Keith M. KENDRICK, Auteur Année de publication : 2021 Article en page(s) : p.1609-1620 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Child  Child, Preschool  Corpus Callosum/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  autism spectrum disorder  children  corpus callosum  homotopic interhemispheric functional connectivity  resting-state Index. décimale : PER Périodiques Résumé : While several functional and structural changes occur in large-scale brain networks in autism spectrum disorder (ASD), reduced interhemispheric resting-state functional connectivity (rsFC) between homotopic regions may be of particular importance as a biomarker. ASD is an early-onset developmental disorder and neural alterations are often age-dependent. Although there is some evidence for homotopic interhemispheric rsFC alterations in language processing regions in ASD children, wider analyses using large data sets have not been performed. The present study, therefore, conducted a voxel-based homotopic interhemispheric rsFC analysis in 146 ASD and 175 typically developing children under-age 10 and examined associations with symptom severity in the autism brain imaging data exchange data sets. Given the role of corpus callosum (CC) in interhemispheric connectivity and reported CC volume changes in ASD we additionally examined whether there were parallel volumetric changes. Results demonstrated decreased homotopic rsFC in ASD children in the posterior cingulate cortex (PCC) and precuneus of the default mode network, the precentral gyrus of the mirror neuron system, and the caudate of the reward system. Homotopic rsFC of the PCC was associated with symptom severity. Furthermore, although no significant CC volume changes were found in ASD children, there was a significant negative correlation between the anterior CC volumes and homotopic rsFC strengths in the caudate. The present study shows that a reduced pattern of homotopic interhemispheric rsFC in ASD adults/adolescents is already present in children of 5-10 years old and further supports their potential use as a general ASD biomarker. LAY SUMMARY: Homotopic interhemispheric functional connectivity plays an important role in synchronizing activity between the two hemispheres and is altered in adults and adolescents with autism spectrum disorder (ASD). In the present study focused on children with ASD, we have observed a similar pattern of decreased homotopic connectivity, suggesting that alterations in homotopic interhemispheric connectivity may occur early in ASD and be a useful general biomarker across ages. En ligne : http://dx.doi.org/10.1002/aur.2523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder [texte imprimé] / Shuxia YAO, Auteur ; Menghan ZHOU, Auteur ; Yuan ZHANG, Auteur ; Feng ZHOU, Auteur ; Qianqian ZHANG, Auteur ; Zhongbo ZHAO, Auteur ; Xi JIANG, Auteur ; Xiu XU, Auteur ; Benjamin BECKER, Auteur ; Keith M. KENDRICK, Auteur . - 2021 . - p.1609-1620. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1609-1620 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Child  Child, Preschool  Corpus Callosum/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  autism spectrum disorder  children  corpus callosum  homotopic interhemispheric functional connectivity  resting-state Index. décimale : PER Périodiques Résumé : While several functional and structural changes occur in large-scale brain networks in autism spectrum disorder (ASD), reduced interhemispheric resting-state functional connectivity (rsFC) between homotopic regions may be of particular importance as a biomarker. ASD is an early-onset developmental disorder and neural alterations are often age-dependent. Although there is some evidence for homotopic interhemispheric rsFC alterations in language processing regions in ASD children, wider analyses using large data sets have not been performed. The present study, therefore, conducted a voxel-based homotopic interhemispheric rsFC analysis in 146 ASD and 175 typically developing children under-age 10 and examined associations with symptom severity in the autism brain imaging data exchange data sets. Given the role of corpus callosum (CC) in interhemispheric connectivity and reported CC volume changes in ASD we additionally examined whether there were parallel volumetric changes. Results demonstrated decreased homotopic rsFC in ASD children in the posterior cingulate cortex (PCC) and precuneus of the default mode network, the precentral gyrus of the mirror neuron system, and the caudate of the reward system. Homotopic rsFC of the PCC was associated with symptom severity. Furthermore, although no significant CC volume changes were found in ASD children, there was a significant negative correlation between the anterior CC volumes and homotopic rsFC strengths in the caudate. The present study shows that a reduced pattern of homotopic interhemispheric rsFC in ASD adults/adolescents is already present in children of 5-10 years old and further supports their potential use as a general ASD biomarker. LAY SUMMARY: Homotopic interhemispheric functional connectivity plays an important role in synchronizing activity between the two hemispheres and is altered in adults and adolescents with autism spectrum disorder (ASD). In the present study focused on children with ASD, we have observed a similar pattern of decreased homotopic connectivity, suggesting that alterations in homotopic interhemispheric connectivity may occur early in ASD and be a useful general biomarker across ages. En ligne : http://dx.doi.org/10.1002/aur.2523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Facial emotion training as an intervention in autism spectrum disorder: A meta-analysis of randomized controlled trials / Qianqian ZHANG in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2169-2182 Titre : Facial emotion training as an intervention in autism spectrum disorder: A meta-analysis of randomized controlled trials Type de document : texte imprimé Auteurs : Qianqian ZHANG, Auteur ; Renjing WU, Auteur ; Siyu ZHU, Auteur ; Jiao LE, Auteur ; Yuanshu CHEN, Auteur ; Chunmei LAN, Auteur ; Shuxia YAO, Auteur ; Weihua ZHAO, Auteur ; Keith M. KENDRICK, Auteur Année de publication : 2021 Article en page(s) : p.2169-2182 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Emotions  Facial Recognition  Humans  Randomized Controlled Trials as Topic  Social Skills  autism spectrum disorder  emotion expression  emotion recognition  emotion understanding  facial emotion training  meta-analysis  social skills Index. décimale : PER Périodiques Résumé : A large number of computer-based training programs have been developed as an intervention to help individuals with autism spectrum disorders (ASD) improve their facial emotion recognition ability, as well as social skills. However, it is unclear to what extent these facial emotion training programs can produce beneficial, long-lasting, and generalizable results. Using standard meta-analytic techniques, we investigated the effects of facial emotion training including generalization and maintenance restricted to randomized control trial studies comprising a total of 595 individuals with ASD. Our findings revealed that the intervention resulted in a robust improvement in emotion recognition for individuals receiving training compared with controls. However, while there was also some evidence for generalization of training effects, the small number of studies which conducted follow-ups and assessed social skills reported that improvements were not maintained and there was no evidence for general improvement in social skills. Overall, the analysis revealed a medium effect size in training improvement indicating that facial emotion training may be an effective method for enhancing emotion recognition skills in ASD although more studies are required to assess maintenance of effects and possible general improvements in social skills. LAY SUMMARY: Facial emotion training as an intervention may be a potential way to help improve emotion recognition in autism spectrum disorder (ASD), however robust empirical support for its efficacy has not been sufficiently established. Here, we conducted a meta-analysis of previous studies to summarize the effects of facial emotion training on ASD. Our results show that the training produces a robust improvement in subsequent emotion recognition, while maintenance and generalization effects still need further investigation. To date, no experimentally verified improvements in social skills have been reported. En ligne : http://dx.doi.org/10.1002/aur.2565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Facial emotion training as an intervention in autism spectrum disorder: A meta-analysis of randomized controlled trials [texte imprimé] / Qianqian ZHANG, Auteur ; Renjing WU, Auteur ; Siyu ZHU, Auteur ; Jiao LE, Auteur ; Yuanshu CHEN, Auteur ; Chunmei LAN, Auteur ; Shuxia YAO, Auteur ; Weihua ZHAO, Auteur ; Keith M. KENDRICK, Auteur . - 2021 . - p.2169-2182. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2169-2182 Mots-clés : Autism Spectrum Disorder/therapy  Emotions  Facial Recognition  Humans  Randomized Controlled Trials as Topic  Social Skills  autism spectrum disorder  emotion expression  emotion recognition  emotion understanding  facial emotion training  meta-analysis  social skills Index. décimale : PER Périodiques Résumé : A large number of computer-based training programs have been developed as an intervention to help individuals with autism spectrum disorders (ASD) improve their facial emotion recognition ability, as well as social skills. However, it is unclear to what extent these facial emotion training programs can produce beneficial, long-lasting, and generalizable results. Using standard meta-analytic techniques, we investigated the effects of facial emotion training including generalization and maintenance restricted to randomized control trial studies comprising a total of 595 individuals with ASD. Our findings revealed that the intervention resulted in a robust improvement in emotion recognition for individuals receiving training compared with controls. However, while there was also some evidence for generalization of training effects, the small number of studies which conducted follow-ups and assessed social skills reported that improvements were not maintained and there was no evidence for general improvement in social skills. Overall, the analysis revealed a medium effect size in training improvement indicating that facial emotion training may be an effective method for enhancing emotion recognition skills in ASD although more studies are required to assess maintenance of effects and possible general improvements in social skills. LAY SUMMARY: Facial emotion training as an intervention may be a potential way to help improve emotion recognition in autism spectrum disorder (ASD), however robust empirical support for its efficacy has not been sufficiently established. Here, we conducted a meta-analysis of previous studies to summarize the effects of facial emotion training on ASD. Our results show that the training produces a robust improvement in subsequent emotion recognition, while maintenance and generalization effects still need further investigation. To date, no experimentally verified improvements in social skills have been reported. En ligne : http://dx.doi.org/10.1002/aur.2565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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