Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum / Stephanie PEDRAHITA in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70208 Titre : Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum Type de document : texte imprimé Auteurs : Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur Article en page(s) : e70208 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum [texte imprimé] / Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur . - e70208. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70208 Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Factors Associated with Confirmed and Unconfirmed Autism Spectrum Disorder Diagnosis in Children Volunteering for Research / Rachel K. GREENE ; Randi A. PHELPS ; Tara M. RUTTER ; Sheila MARKWARDT ; Julia GRIESER PAINTER ; Michaela CORDOVA ; Beth CALAME ; Olivia DOYLE ; Joel T. NIGG ; Eric FOMBONNE ; Damien A. FAIR in Journal of Autism and Developmental Disorders, 55-5 (May 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1660-1672 Titre : Factors Associated with Confirmed and Unconfirmed Autism Spectrum Disorder Diagnosis in Children Volunteering for Research Type de document : texte imprimé Auteurs : Rachel K. GREENE, Auteur ; Randi A. PHELPS, Auteur ; Tara M. RUTTER, Auteur ; Sheila MARKWARDT, Auteur ; Julia GRIESER PAINTER, Auteur ; Michaela CORDOVA, Auteur ; Beth CALAME, Auteur ; Olivia DOYLE, Auteur ; Joel T. NIGG, Auteur ; Eric FOMBONNE, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.1660-1672 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Diagnostic accuracy of autism spectrum disorder (ASD) is crucial to track and characterize ASD, as well as to guide appropriate interventions at the individual level. However, under-diagnosis, over-diagnosis, and misdiagnosis of ASD are still prevalent. En ligne : https://doi.org/10.1007/s10803-024-06329-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Factors Associated with Confirmed and Unconfirmed Autism Spectrum Disorder Diagnosis in Children Volunteering for Research [texte imprimé] / Rachel K. GREENE, Auteur ; Randi A. PHELPS, Auteur ; Tara M. RUTTER, Auteur ; Sheila MARKWARDT, Auteur ; Julia GRIESER PAINTER, Auteur ; Michaela CORDOVA, Auteur ; Beth CALAME, Auteur ; Olivia DOYLE, Auteur ; Joel T. NIGG, Auteur ; Eric FOMBONNE, Auteur ; Damien A. FAIR, Auteur . - p.1660-1672. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-5 (May 2025) . - p.1660-1672 Index. décimale : PER Périodiques Résumé : Diagnostic accuracy of autism spectrum disorder (ASD) is crucial to track and characterize ASD, as well as to guide appropriate interventions at the individual level. However, under-diagnosis, over-diagnosis, and misdiagnosis of ASD are still prevalent. En ligne : https://doi.org/10.1007/s10803-024-06329-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism / Alex BOXBERGER in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism Type de document : texte imprimé Auteurs : Alex BOXBERGER, Auteur ; Bosi CHEN, Auteur ; Lindsay OLSON, Auteur ; Michaela CORDOVA, Auteur ; Judy MAHMALJI, Auteur ; Adriana RIOS, Auteur ; Annika C. LINKE, Auteur ; Inna FISHMAN, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child, Preschool  Male  Female  Autism Spectrum Disorder/physiopathology/diagnostic imaging/complications  Attention Deficit Disorder with Hyperactivity/physiopathology/diagnostic  imaging/complications/epidemiology  Magnetic Resonance Imaging  Infant  Connectome  Brain/physiopathology/diagnostic imaging  Nerve Net/physiopathology/diagnostic imaging  Child Development/physiology  Attention  Autism spectrum  Early development  Functional MRI  Network connectivity  was approved by the institutional review boards of the University of California  San Diego and San Diego State University (Joint Review IRB #151091). Informed  consent was obtained from caregivers of all children included in the study.  Consent for publication: Not applicable. Competing interests: The authors declare  no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Symptoms of attention-deficit/hyperactivity disorder (ADHD) are common in children with autism spectrum disorder (ASD), and are associated with greater developmental challenges, poorer clinical outcomes, and alterations in functional connectivity (FC) of the brain. However, despite the consensus that ASD and other neurodevelopmental conditions emerge early in life, little is known about the trajectories of brain and behavioral development during the first years of life in children with ASD and co-occurring attention problems (AP). METHODS: In a sample of 122 young children (ages 1.5-5 years) with and without ASD, we examined whether toddlers and preschoolers with ASD and co-occurring AP already differ from peers with ASD without co-occurring AP on adaptive and developmental skills, ASD symptoms, and FC of the frontoparietal and salience networks, which have been previously linked to ADHD symptoms in older children with ASD and ADHD. RESULTS: Results of general linear model analyses revealed lower developmental and adaptive skills across multiple domains in children with ASD and elevated AP compared with their peers with lower AP, despite equivalent levels of ASD symptoms. Further, children with ASD and elevated AP showed reduced FC within the frontoparietal network (p = .027), between the frontoparietal and language networks (p = .004), and the frontoparietal and default mode networks (p = .046) in comparison to their peers with lower AP. No group differences in FC of the salience network were observed (all p > .05). CONCLUSIONS: These findings provide evidence that neurodevelopmental and behavioral differences in children with ASD and co-occurring AP emerge very early in life, before a reliable diagnosis of ADHD is typically made. Specifically, these results demonstrate that early inattention symptoms are associated with unique connectivity patterns in executive circuitry as early as the first years of life in toddlers and preschoolers with ASD, likely contributing to the phenotypic and neural heterogeneity recognized in autism. Thus, our results underscore the importance of considering co-occurring conditions early in developmental research and clinical care, as further understanding these trajectories can inform early interventions during the critical time period when they have the greatest potential for positive impact. En ligne : https://dx.doi.org/10.1186/s11689-025-09650-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism [texte imprimé] / Alex BOXBERGER, Auteur ; Bosi CHEN, Auteur ; Lindsay OLSON, Auteur ; Michaela CORDOVA, Auteur ; Judy MAHMALJI, Auteur ; Adriana RIOS, Auteur ; Annika C. LINKE, Auteur ; Inna FISHMAN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Child, Preschool  Male  Female  Autism Spectrum Disorder/physiopathology/diagnostic imaging/complications  Attention Deficit Disorder with Hyperactivity/physiopathology/diagnostic  imaging/complications/epidemiology  Magnetic Resonance Imaging  Infant  Connectome  Brain/physiopathology/diagnostic imaging  Nerve Net/physiopathology/diagnostic imaging  Child Development/physiology  Attention  Autism spectrum  Early development  Functional MRI  Network connectivity  was approved by the institutional review boards of the University of California  San Diego and San Diego State University (Joint Review IRB #151091). Informed  consent was obtained from caregivers of all children included in the study.  Consent for publication: Not applicable. Competing interests: The authors declare  no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Symptoms of attention-deficit/hyperactivity disorder (ADHD) are common in children with autism spectrum disorder (ASD), and are associated with greater developmental challenges, poorer clinical outcomes, and alterations in functional connectivity (FC) of the brain. However, despite the consensus that ASD and other neurodevelopmental conditions emerge early in life, little is known about the trajectories of brain and behavioral development during the first years of life in children with ASD and co-occurring attention problems (AP). METHODS: In a sample of 122 young children (ages 1.5-5 years) with and without ASD, we examined whether toddlers and preschoolers with ASD and co-occurring AP already differ from peers with ASD without co-occurring AP on adaptive and developmental skills, ASD symptoms, and FC of the frontoparietal and salience networks, which have been previously linked to ADHD symptoms in older children with ASD and ADHD. RESULTS: Results of general linear model analyses revealed lower developmental and adaptive skills across multiple domains in children with ASD and elevated AP compared with their peers with lower AP, despite equivalent levels of ASD symptoms. Further, children with ASD and elevated AP showed reduced FC within the frontoparietal network (p = .027), between the frontoparietal and language networks (p = .004), and the frontoparietal and default mode networks (p = .046) in comparison to their peers with lower AP. No group differences in FC of the salience network were observed (all p > .05). CONCLUSIONS: These findings provide evidence that neurodevelopmental and behavioral differences in children with ASD and co-occurring AP emerge very early in life, before a reliable diagnosis of ADHD is typically made. Specifically, these results demonstrate that early inattention symptoms are associated with unique connectivity patterns in executive circuitry as early as the first years of life in toddlers and preschoolers with ASD, likely contributing to the phenotypic and neural heterogeneity recognized in autism. Thus, our results underscore the importance of considering co-occurring conditions early in developmental research and clinical care, as further understanding these trajectories can inform early interventions during the critical time period when they have the greatest potential for positive impact. En ligne : https://dx.doi.org/10.1186/s11689-025-09650-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

---

1 (1 - 3 / 3) Par page : 25 50 100 200