Affective–motivational brain responses to direct gaze in children with autism spectrum disorder / Anneli KYLLIAINEN in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.790-797 Titre : Affective–motivational brain responses to direct gaze in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anneli KYLLIAINEN, Auteur ; Simon WALLACE, Auteur ; Marc N. COUTANCHE, Auteur ; Jukka M. LEPPANEN, Auteur ; James CUSACK, Auteur ; Anthony J. BAILEY, Auteur ; Jari K. HIETANEN, Auteur Année de publication : 2012 Article en page(s) : p.790-797 Langues : Anglais (eng) Mots-clés : Direct gaze  eye contact  autism spectrum disorders  frontal EEG asymmetry  skin conductance Index. décimale : PER Périodiques Résumé : Background:  It is unclear why children with autism spectrum disorders (ASD) tend to be inattentive to, or even avoid eye contact. The goal of this study was to investigate affective–motivational brain responses to direct gaze in children with ASD. To this end, we combined two measurements: skin conductance responses (SCR), a robust arousal measure, and asymmetry in frontal electroencephalography (EEG) activity which is associated with motivational approach and avoidance tendencies. We also explored whether degree of eye openness and face familiarity modulated these responses. Methods:  Skin conductance responses and frontal EEG activity were recorded from 14 children with ASD and 15 typically developing children whilst they looked at familiar and unfamiliar faces with eyes shut, normally open or wide-open. Stimuli were presented in such a way that they appeared to be looming towards the children. Results:  In typically developing children, there were no significant differences in SCRs between the different eye conditions, whereas in the ASD group the SCRs were attenuated to faces with closed eyes and increased as a function of the degree of eye openness. In both groups, familiar faces elicited marginally greater SCRs than unfamiliar faces. In typically developing children, normally open eyes elicited greater relative left-sided frontal EEG activity (associated with motivational approach) than shut eyes and wide-open eyes. In the ASD group, there were no significant differences between the gaze conditions in frontal EEG activity. Conclusions:  Collectively, the results replicate previous finding in showing atypical modulation of arousal in response to direct gaze in children with ASD but do not support the assumption that this response is associated with an avoidant motivational tendency. Instead, children with ASD may lack normative approach-related motivational response to eye contact. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02522.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Affective–motivational brain responses to direct gaze in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Anneli KYLLIAINEN, Auteur ; Simon WALLACE, Auteur ; Marc N. COUTANCHE, Auteur ; Jukka M. LEPPANEN, Auteur ; James CUSACK, Auteur ; Anthony J. BAILEY, Auteur ; Jari K. HIETANEN, Auteur . - 2012 . - p.790-797. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.790-797 Mots-clés : Direct gaze  eye contact  autism spectrum disorders  frontal EEG asymmetry  skin conductance Index. décimale : PER Périodiques Résumé : Background:  It is unclear why children with autism spectrum disorders (ASD) tend to be inattentive to, or even avoid eye contact. The goal of this study was to investigate affective–motivational brain responses to direct gaze in children with ASD. To this end, we combined two measurements: skin conductance responses (SCR), a robust arousal measure, and asymmetry in frontal electroencephalography (EEG) activity which is associated with motivational approach and avoidance tendencies. We also explored whether degree of eye openness and face familiarity modulated these responses. Methods:  Skin conductance responses and frontal EEG activity were recorded from 14 children with ASD and 15 typically developing children whilst they looked at familiar and unfamiliar faces with eyes shut, normally open or wide-open. Stimuli were presented in such a way that they appeared to be looming towards the children. Results:  In typically developing children, there were no significant differences in SCRs between the different eye conditions, whereas in the ASD group the SCRs were attenuated to faces with closed eyes and increased as a function of the degree of eye openness. In both groups, familiar faces elicited marginally greater SCRs than unfamiliar faces. In typically developing children, normally open eyes elicited greater relative left-sided frontal EEG activity (associated with motivational approach) than shut eyes and wide-open eyes. In the ASD group, there were no significant differences between the gaze conditions in frontal EEG activity. Conclusions:  Collectively, the results replicate previous finding in showing atypical modulation of arousal in response to direct gaze in children with ASD but do not support the assumption that this response is associated with an avoidant motivational tendency. Instead, children with ASD may lack normative approach-related motivational response to eye contact. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02522.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Benefits and harms of interventions to improve anxiety, depression, and other mental health outcomes for autistic people: A systematic review and network meta-analysis of randomised controlled trials / Audrey LINDEN in Autism, 27-1 (January 2023)  

Public ISBD [article]  inAutism > 27-1 (January 2023) . - p.7-30 Titre : Benefits and harms of interventions to improve anxiety, depression, and other mental health outcomes for autistic people: A systematic review and network meta-analysis of randomised controlled trials Type de document : Texte imprimé et/ou numérique Auteurs : Audrey LINDEN, Auteur ; Lawrence BEST, Auteur ; Freya ELISE, Auteur ; Danielle ROBERTS, Auteur ; Aoife BRANAGAN, Auteur ; Yong Boon Ernest TAY, Auteur ; Laura CRANE, Auteur ; James CUSACK, Auteur ; Brian DAVIDSON, Auteur ; Ian DAVIDSON, Auteur ; Caroline HEARST, Auteur ; William MANDY, Auteur ; Dheeraj RAI, Auteur ; Edward SMITH, Auteur ; Kurinchi GURUSAMY, Auteur Article en page(s) : p.7-30 Langues : Anglais (eng) Mots-clés : adolescents  adults  anxiety  autism spectrum disorders  depression  interventions - pharmacologic  interventions - psychosocial/behavioural  school-age children Index. décimale : PER Périodiques Résumé : Mental health difficulties are prevalent in autistic people with ~14%-50% having experienced depression and ~40%-80% having experienced anxiety disorders. Identifying interventions that improve autistic people’s mental health is a top priority. However, at present, there is no high-quality network meta-analysis of benefits and harms of different interventions. We conducted a systematic review and network meta-analysis of randomised controlled trials, searching MEDLINE, EMBASE, other databases, and trial registers until 17 October 2020. We included randomised controlled trials reporting anxiety or depression in a suitable format. We calculated effect estimates and 95% credible intervals using Bayesian network meta-analysis. Our search identified 13,794 reports, of which 71 randomised controlled trials (3630 participants) were eligible for inclusion. All trials had high risk of bias. The follow-up period ranged from 1 to 24 months. Evidence indicates uncertainty about the effects of different interventions, with more high-quality evidence needed. Available evidence suggests that some forms of cognitive behavioural therapy may decrease anxiety and depression scores in autistic children and adults; mindfulness therapy may decrease anxiety and depression scores in autistic adults with previous mental health conditions; and behavioural interventions may provide some benefit for depression in autistic children. We recommend that autistic people are given access to mental health interventions available to non-autistic people, following principles of person-centred care. PROSPERO registration ID: CRD42019136093 Lay Abstract Nearly three out of four autistic people experience mental health problems such as stress, anxiety or depression. The research already done does not guide us on how best to prevent or treat mental health problems for autistic people. Our aim was to look at the benefits and harms of different interventions on mental health outcomes in autistic people. We searched all the published randomised controlled trials (RCTs) about interventions for mental health conditions in autistic people until 17 October 2020. We also searched for RCTs that were not published in peer-reviewed journals. These were obtained from registers of clinical trials online. We then combined the information from all these trials using advanced statistical methods to analyse how good the interventions are. Seventy-one studies (3630 participants) provided information for this research. The studies reported how participants were responding to the intervention for only a short period of time. The trials did not report which interventions worked for people with intellectual disability. In people without intellectual disability, some forms of cognitive behavioural therapy and mindfulness therapy may be helpful. However, further research is necessary. Many trials used medications to target core features of autism rather than targeting mental health conditions, but these medications did not help autistic people. Until we have more evidence, treatment of mental health conditions in autistic people should follow the evidence available for non-autistic people. We plan to widely disseminate the findings to healthcare professionals through medical journals and conferences and contact other groups representing autistic people. En ligne : http://dx.doi.org/10.1177/13623613221117931 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Benefits and harms of interventions to improve anxiety, depression, and other mental health outcomes for autistic people: A systematic review and network meta-analysis of randomised controlled trials [Texte imprimé et/ou numérique] / Audrey LINDEN, Auteur ; Lawrence BEST, Auteur ; Freya ELISE, Auteur ; Danielle ROBERTS, Auteur ; Aoife BRANAGAN, Auteur ; Yong Boon Ernest TAY, Auteur ; Laura CRANE, Auteur ; James CUSACK, Auteur ; Brian DAVIDSON, Auteur ; Ian DAVIDSON, Auteur ; Caroline HEARST, Auteur ; William MANDY, Auteur ; Dheeraj RAI, Auteur ; Edward SMITH, Auteur ; Kurinchi GURUSAMY, Auteur . - p.7-30. Langues : Anglais (eng) in Autism > 27-1 (January 2023) . - p.7-30 Mots-clés : adolescents  adults  anxiety  autism spectrum disorders  depression  interventions - pharmacologic  interventions - psychosocial/behavioural  school-age children Index. décimale : PER Périodiques Résumé : Mental health difficulties are prevalent in autistic people with ~14%-50% having experienced depression and ~40%-80% having experienced anxiety disorders. Identifying interventions that improve autistic people’s mental health is a top priority. However, at present, there is no high-quality network meta-analysis of benefits and harms of different interventions. We conducted a systematic review and network meta-analysis of randomised controlled trials, searching MEDLINE, EMBASE, other databases, and trial registers until 17 October 2020. We included randomised controlled trials reporting anxiety or depression in a suitable format. We calculated effect estimates and 95% credible intervals using Bayesian network meta-analysis. Our search identified 13,794 reports, of which 71 randomised controlled trials (3630 participants) were eligible for inclusion. All trials had high risk of bias. The follow-up period ranged from 1 to 24 months. Evidence indicates uncertainty about the effects of different interventions, with more high-quality evidence needed. Available evidence suggests that some forms of cognitive behavioural therapy may decrease anxiety and depression scores in autistic children and adults; mindfulness therapy may decrease anxiety and depression scores in autistic adults with previous mental health conditions; and behavioural interventions may provide some benefit for depression in autistic children. We recommend that autistic people are given access to mental health interventions available to non-autistic people, following principles of person-centred care. PROSPERO registration ID: CRD42019136093 Lay Abstract Nearly three out of four autistic people experience mental health problems such as stress, anxiety or depression. The research already done does not guide us on how best to prevent or treat mental health problems for autistic people. Our aim was to look at the benefits and harms of different interventions on mental health outcomes in autistic people. We searched all the published randomised controlled trials (RCTs) about interventions for mental health conditions in autistic people until 17 October 2020. We also searched for RCTs that were not published in peer-reviewed journals. These were obtained from registers of clinical trials online. We then combined the information from all these trials using advanced statistical methods to analyse how good the interventions are. Seventy-one studies (3630 participants) provided information for this research. The studies reported how participants were responding to the intervention for only a short period of time. The trials did not report which interventions worked for people with intellectual disability. In people without intellectual disability, some forms of cognitive behavioural therapy and mindfulness therapy may be helpful. However, further research is necessary. Many trials used medications to target core features of autism rather than targeting mental health conditions, but these medications did not help autistic people. Until we have more evidence, treatment of mental health conditions in autistic people should follow the evidence available for non-autistic people. We plan to widely disseminate the findings to healthcare professionals through medical journals and conferences and contact other groups representing autistic people. En ligne : http://dx.doi.org/10.1177/13623613221117931 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy / Aine RODDY ; Martin KNAPP ; Celso ARANGO ; Maria Andreina MENDEZ ; James CUSACK ; Declan MURPHY ; Roberto CANITANO ; Bethany OAKLEY ; Vinciane QUOIDBACH in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741 Titre : Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy Type de document : Texte imprimé et/ou numérique Auteurs : Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; Maria Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur Article en page(s) : p.2733-2741 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children?s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy [Texte imprimé et/ou numérique] / Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; Maria Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur . - p.2733-2741. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741 Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children?s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Participation and the gradual path to a better life for autistic people / James CUSACK in Autism, 21-2 (February 2017)  

Public ISBD [article]  inAutism > 21-2 (February 2017) . - p.131-132 Titre : Participation and the gradual path to a better life for autistic people Type de document : Texte imprimé et/ou numérique Auteurs : James CUSACK, Auteur Article en page(s) : p.131-132 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361316680155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Participation and the gradual path to a better life for autistic people [Texte imprimé et/ou numérique] / James CUSACK, Auteur . - p.131-132. Langues : Anglais (eng) in Autism > 21-2 (February 2017) . - p.131-132 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361316680155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

The National Autism Project (NAP) Legacy Forum 2018: what's happened since the publication of the NAP report in 2017? / Ian RAGAN in Good Autism Practice - GAP, 20-2 (October 2019)

Public ISBD [article]  inGood Autism Practice - GAP > 20-2 (October 2019) . - p.5-12 Titre : The National Autism Project (NAP) Legacy Forum 2018: what's happened since the publication of the NAP report in 2017? Type de document : Texte imprimé et/ou numérique Auteurs : Ian RAGAN, Auteur ; James CUSACK, Auteur ; Hilary GILFOY, Auteur ; Elizabeth VALLANCE, Auteur Article en page(s) : p.5-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] The National Autism Project (NAP) Legacy Forum 2018: what's happened since the publication of the NAP report in 2017? [Texte imprimé et/ou numérique] / Ian RAGAN, Auteur ; James CUSACK, Auteur ; Hilary GILFOY, Auteur ; Elizabeth VALLANCE, Auteur . - p.5-12. Langues : Anglais (eng) in Good Autism Practice - GAP > 20-2 (October 2019) . - p.5-12 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

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