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Auteur S. GOLDMAN |
Documents disponibles écrits par cet auteur (2)
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Quantitative gait assessment in children with 16p11.2 syndrome / S. GOLDMAN in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)
[article]
Titre : Quantitative gait assessment in children with 16p11.2 syndrome Type de document : Texte imprimé et/ou numérique Auteurs : S. GOLDMAN, Auteur ; A. K. MCCULLOUGH, Auteur ; S. D. YOUNG, Auteur ; C. MUELLER, Auteur ; A. STAHL, Auteur ; A. ZOELLER, Auteur ; L. D. ABBRUZZESE, Auteur ; A. K. RAO, Auteur ; J. MONTES, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : 16p11.2 Autism spectrum disorder Children Gait Motor function Neurodevelopment disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurodevelopmental disorders such as 16p11.2 syndrome are frequently associated with motor impairments including locomotion. The lack of precise measures of gait, combined with the challenges inherent in studying children with neurodevelopmental disorders, hinders quantitative motor assessments. Gait and balance are quantifiable measures that may help to refine the motor phenotype in 16p11.2. The characterization of motor profile is useful to study the trajectories of locomotion performance of children with genetic variants and may provide insights into neural pathway dysfunction based on genotype/phenotype model. METHODS: Thirty-six children (21 probands with 16p11.2 deletion and duplication mutation and 15 unaffected siblings), with a mean age of 8.5 years (range 3.2-15.4) and 55% male, were enrolled. Of the probands, 23% (n = 6) had a confirmed diagnosis of autism spectrum disorder (ASD) and were all male. Gait assessments included 6-min walk test (6MWT), 10-m walk/run test (10MWR), timed-up-and-go test (TUG), and spatio-temporal measurements of preferred- and fast-paced walking. The Pediatric Evaluation of Disability Inventory-Computer Adaptive Tests (PEDI-CAT), a caregiver-reported functional assessment, was administered. Measures of balance were calculated using percent time in double support and base of support. Analyses of the six children with ASD were described separately. RESULTS: Thirty-six participants completed the protocol. Compared with sibling controls, probands had significantly lower scores on the 6MWT (p = 0.04), 10MWR (p = 0.01), and TUG (p = 0.005). Group differences were also identified in base of support (p = 0.003). Probands had significantly lower PEDI-CAT scores in all domains including the mobility scale (p < 0.001). Using age-matched subsamples, the ASD and non-ASD genetic variant groups had larger base of support compared to the controls. In the fast-paced condition, all participants increased their velocity, and there was a corresponding decrease in percent time in double support compared to the preferred-pace condition in all participants. Only the ASD group presented with upper limb arm/hand stereotypies. CONCLUSIONS: Children with 16p11.2, with and without ASD, present with balance impairment during locomotion activities. Probands performed worse on functional assessments, and quantitative measures revealed differences in base of support. These results highlight the importance of using precise measures to differentiate motor dysfunction in children with neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1186/s11689-019-9286-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 26 p.[article] Quantitative gait assessment in children with 16p11.2 syndrome [Texte imprimé et/ou numérique] / S. GOLDMAN, Auteur ; A. K. MCCULLOUGH, Auteur ; S. D. YOUNG, Auteur ; C. MUELLER, Auteur ; A. STAHL, Auteur ; A. ZOELLER, Auteur ; L. D. ABBRUZZESE, Auteur ; A. K. RAO, Auteur ; J. MONTES, Auteur . - 26 p.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 26 p.
Mots-clés : 16p11.2 Autism spectrum disorder Children Gait Motor function Neurodevelopment disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurodevelopmental disorders such as 16p11.2 syndrome are frequently associated with motor impairments including locomotion. The lack of precise measures of gait, combined with the challenges inherent in studying children with neurodevelopmental disorders, hinders quantitative motor assessments. Gait and balance are quantifiable measures that may help to refine the motor phenotype in 16p11.2. The characterization of motor profile is useful to study the trajectories of locomotion performance of children with genetic variants and may provide insights into neural pathway dysfunction based on genotype/phenotype model. METHODS: Thirty-six children (21 probands with 16p11.2 deletion and duplication mutation and 15 unaffected siblings), with a mean age of 8.5 years (range 3.2-15.4) and 55% male, were enrolled. Of the probands, 23% (n = 6) had a confirmed diagnosis of autism spectrum disorder (ASD) and were all male. Gait assessments included 6-min walk test (6MWT), 10-m walk/run test (10MWR), timed-up-and-go test (TUG), and spatio-temporal measurements of preferred- and fast-paced walking. The Pediatric Evaluation of Disability Inventory-Computer Adaptive Tests (PEDI-CAT), a caregiver-reported functional assessment, was administered. Measures of balance were calculated using percent time in double support and base of support. Analyses of the six children with ASD were described separately. RESULTS: Thirty-six participants completed the protocol. Compared with sibling controls, probands had significantly lower scores on the 6MWT (p = 0.04), 10MWR (p = 0.01), and TUG (p = 0.005). Group differences were also identified in base of support (p = 0.003). Probands had significantly lower PEDI-CAT scores in all domains including the mobility scale (p < 0.001). Using age-matched subsamples, the ASD and non-ASD genetic variant groups had larger base of support compared to the controls. In the fast-paced condition, all participants increased their velocity, and there was a corresponding decrease in percent time in double support compared to the preferred-pace condition in all participants. Only the ASD group presented with upper limb arm/hand stereotypies. CONCLUSIONS: Children with 16p11.2, with and without ASD, present with balance impairment during locomotion activities. Probands performed worse on functional assessments, and quantitative measures revealed differences in base of support. These results highlight the importance of using precise measures to differentiate motor dysfunction in children with neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1186/s11689-019-9286-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 Rethinking autism spectrum disorder assessment for children during COVID-19 and beyond / Lonnie ZWAIGENBAUM in Autism Research, 14-11 (November 2021)
[article]
Titre : Rethinking autism spectrum disorder assessment for children during COVID-19 and beyond Type de document : Texte imprimé et/ou numérique Auteurs : Lonnie ZWAIGENBAUM, Auteur ; Somer L. BISHOP, Auteur ; W. L. STONE, Auteur ; L. IBANEZ, Auteur ; Alycia K. HALLADAY, Auteur ; S. GOLDMAN, Auteur ; A. KELLY, Auteur ; C. KLAIMAN, Auteur ; Meng-Chuan LAI, Auteur ; M. MILLER, Auteur ; Celine A. SAULNIER, Auteur ; P. SIPER, Auteur ; K. SOHL, Auteur ; Zachary WARREN, Auteur ; Amy M. WETHERBY, Auteur Article en page(s) : p.2251-2259 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology Autistic Disorder Covid-19 Child Humans Pandemics SARS-CoV-2 assessment autism challenges children diagnosis disparities pandemic Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic has posed unique challenges for families and caregivers, as well as for autism-focused clinicians, who are faced with providing a thorough and accurate evaluation of children's specific needs and diagnoses in the absence of in-person assessment tools. The shift to telehealth assessments has challenged clinicians to reconsider approaches and assumptions that underlie the diagnostic assessment process, and to adopt new ways of individualizing standard assessments according to family and child needs. Mandates for physical distancing have uncovered deficiencies in diagnostic practices for suspected autism and have illuminated biases that have posed obstacles preventing children and families from receiving the services that they truly need. This Commentary outlines several considerations for improving diagnostic practices as we move forward from the current pandemic and continue to strive to build an adaptable, sustainable, equitable, and family-centered system of care. LAY SUMMARY: Physical distancing and the abrupt end to in-person services for many children on the autism spectrum has forced clinicians to examine the existing challenges with autism spectrum disorder (ASD) diagnostic assessment and consider things they want to keep and things that should be changed in the years ahead. New approaches such as telehealth both alleviated and exacerbated existing disparities, and brought into stark focus the importance of equitable and timely access to family-centered care. This commentary suggests ways of improving clinical practices related to ASD assessment to continue along this path. En ligne : http://dx.doi.org/10.1002/aur.2615 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2251-2259[article] Rethinking autism spectrum disorder assessment for children during COVID-19 and beyond [Texte imprimé et/ou numérique] / Lonnie ZWAIGENBAUM, Auteur ; Somer L. BISHOP, Auteur ; W. L. STONE, Auteur ; L. IBANEZ, Auteur ; Alycia K. HALLADAY, Auteur ; S. GOLDMAN, Auteur ; A. KELLY, Auteur ; C. KLAIMAN, Auteur ; Meng-Chuan LAI, Auteur ; M. MILLER, Auteur ; Celine A. SAULNIER, Auteur ; P. SIPER, Auteur ; K. SOHL, Auteur ; Zachary WARREN, Auteur ; Amy M. WETHERBY, Auteur . - p.2251-2259.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2251-2259
Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology Autistic Disorder Covid-19 Child Humans Pandemics SARS-CoV-2 assessment autism challenges children diagnosis disparities pandemic Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic has posed unique challenges for families and caregivers, as well as for autism-focused clinicians, who are faced with providing a thorough and accurate evaluation of children's specific needs and diagnoses in the absence of in-person assessment tools. The shift to telehealth assessments has challenged clinicians to reconsider approaches and assumptions that underlie the diagnostic assessment process, and to adopt new ways of individualizing standard assessments according to family and child needs. Mandates for physical distancing have uncovered deficiencies in diagnostic practices for suspected autism and have illuminated biases that have posed obstacles preventing children and families from receiving the services that they truly need. This Commentary outlines several considerations for improving diagnostic practices as we move forward from the current pandemic and continue to strive to build an adaptable, sustainable, equitable, and family-centered system of care. LAY SUMMARY: Physical distancing and the abrupt end to in-person services for many children on the autism spectrum has forced clinicians to examine the existing challenges with autism spectrum disorder (ASD) diagnostic assessment and consider things they want to keep and things that should be changed in the years ahead. New approaches such as telehealth both alleviated and exacerbated existing disparities, and brought into stark focus the importance of equitable and timely access to family-centered care. This commentary suggests ways of improving clinical practices related to ASD assessment to continue along this path. En ligne : http://dx.doi.org/10.1002/aur.2615 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450