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Functional Evaluation of Hidden Figures Object Analysis in Children with Autistic Disorder / Krisztina L. MALISZA in Journal of Autism and Developmental Disorders, 41-1 (January 2011)
[article]
Titre : Functional Evaluation of Hidden Figures Object Analysis in Children with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Krisztina L. MALISZA, Auteur ; Christine CLANCY, Auteur ; Deborah SHILOFF, Auteur ; Derek FOREMAN, Auteur ; Jeanette J. A. HOLDEN, Auteur ; Cheryl JONES, Auteur ; K. PAULSON, Auteur ; Randy SUMMERS, Auteur ; C.T. YU, Auteur ; Albert E. CHUDLEY, Auteur Année de publication : 2011 Article en page(s) : p.13-22 Langues : Anglais (eng) Mots-clés : Autism Disorder (AD) Attention Deficit Hyperactivity Disorder (ADHD) Embedded Figures Task (EFT) Hidden Figures Task (HFT) Functional Magnetic Resonance Imaging (fMRI) Index. décimale : PER Périodiques Résumé : Functional magnetic resonance imaging (fMRI) during performance of a hidden figures task (HFT) was used to compare differences in brain function in children diagnosed with autism disorder (AD) compared to children with attention-deficit/hyperactivity disorder (ADHD) and typical controls (TC). Overall greater functional MRI activity was observed in the two control groups compared to children with AD. Laterality differences were also evident, with AD subjects preferentially showing activity in the right medial temporal region while controls tended to activate the left medial temporal cortex. Reduced fMRI activity was observed in the parietal, ventral-temporal and hippocampal regions in the AD group, suggesting differences in the way that children with AD process the HFT. En ligne : http://dx.doi.org/10.1007/s10803-010-1013-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.13-22[article] Functional Evaluation of Hidden Figures Object Analysis in Children with Autistic Disorder [Texte imprimé et/ou numérique] / Krisztina L. MALISZA, Auteur ; Christine CLANCY, Auteur ; Deborah SHILOFF, Auteur ; Derek FOREMAN, Auteur ; Jeanette J. A. HOLDEN, Auteur ; Cheryl JONES, Auteur ; K. PAULSON, Auteur ; Randy SUMMERS, Auteur ; C.T. YU, Auteur ; Albert E. CHUDLEY, Auteur . - 2011 . - p.13-22.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.13-22
Mots-clés : Autism Disorder (AD) Attention Deficit Hyperactivity Disorder (ADHD) Embedded Figures Task (EFT) Hidden Figures Task (HFT) Functional Magnetic Resonance Imaging (fMRI) Index. décimale : PER Périodiques Résumé : Functional magnetic resonance imaging (fMRI) during performance of a hidden figures task (HFT) was used to compare differences in brain function in children diagnosed with autism disorder (AD) compared to children with attention-deficit/hyperactivity disorder (ADHD) and typical controls (TC). Overall greater functional MRI activity was observed in the two control groups compared to children with AD. Laterality differences were also evident, with AD subjects preferentially showing activity in the right medial temporal region while controls tended to activate the left medial temporal cortex. Reduced fMRI activity was observed in the parietal, ventral-temporal and hippocampal regions in the AD group, suggesting differences in the way that children with AD process the HFT. En ligne : http://dx.doi.org/10.1007/s10803-010-1013-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD / C. R. O'CONAILL in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD Type de document : Texte imprimé et/ou numérique Auteurs : C. R. O'CONAILL, Auteur ; K. L. MALISZA, Auteur ; J. L. BUSS, Auteur ; R. B. BOLSTER, Auteur ; C. CLANCY, Auteur ; P. D. DE GERVAI, Auteur ; A. E. CHUDLEY, Auteur ; S. LONGSTAFFE, Auteur Article en page(s) : p.10 Langues : Anglais (eng) Mots-clés : Alcohol-related neurodevelopmental disorder (ARND) Attention Attention-deficit/hyperactivity disorder (ADHD) Diffusion tensor imaging (DTI) Fetal alcohol spectrum disorder (FASD) Functional magnetic resonance imaging (fMRI) Gray matter Inferior longitudinal fasciculus (ILF) Tract-based spatial statistics (TBSS) White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Alcohol-related neurodevelopmental disorder (ARND) falls under the umbrella of fetal alcohol spectrum disorder (FASD). Diagnosis of ARND is difficult because individuals do not demonstrate the characteristic facial features associated with fetal alcohol syndrome (FAS). While attentional problems in ARND are similar to those found in attention-deficit/hyperactivity disorder (ADHD), the underlying impairment in attention pathways may be different. METHODS: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was conducted at 3 T. Sixty-three children aged 10 to 14 years diagnosed with ARND, ADHD, and typically developing (TD) controls performed a single-feature and a feature-conjunction visual search task. RESULTS: Dorsal and ventral attention pathways were activated during both attention tasks in all groups. Significantly greater activation was observed in ARND subjects during a single-feature search as compared to TD and ADHD groups, suggesting ARND subjects require greater neural recruitment to perform this simple task. ARND subjects appear unable to effectively use the very efficient automatic perceptual 'pop-out' mechanism employed by TD and ADHD groups during presentation of the disjunction array. By comparison, activation was lower in ARND compared to TD and ADHD subjects during the more difficult conjunction search task as compared to the single-feature search. Analysis of DTI data using tract-based spatial statistics (TBSS) showed areas of significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) in the right inferior longitudinal fasciculus (ILF) in ARND compared to TD subjects. Damage to the white matter of the ILF may compromise the ventral attention pathway and may require subjects to use the dorsal attention pathway, which is associated with effortful top-down processing, for tasks that should be automatic. Decreased functional activity in the right temporoparietal junction (TPJ) of ARND subjects may be due to a reduction in the white matter tract's ability to efficiently convey information critical to performance of the attention tasks. CONCLUSIONS: Limited activation patterns in ARND suggest problems in information processing along the ventral frontoparietal attention pathway. Poor integrity of the ILF, which connects the functional components of the ventral attention network, in ARND subjects may contribute to the attention deficits characteristic of the disorder. En ligne : http://dx.doi.org/10.1186/s11689-015-9106-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.10[article] Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD [Texte imprimé et/ou numérique] / C. R. O'CONAILL, Auteur ; K. L. MALISZA, Auteur ; J. L. BUSS, Auteur ; R. B. BOLSTER, Auteur ; C. CLANCY, Auteur ; P. D. DE GERVAI, Auteur ; A. E. CHUDLEY, Auteur ; S. LONGSTAFFE, Auteur . - p.10.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.10
Mots-clés : Alcohol-related neurodevelopmental disorder (ARND) Attention Attention-deficit/hyperactivity disorder (ADHD) Diffusion tensor imaging (DTI) Fetal alcohol spectrum disorder (FASD) Functional magnetic resonance imaging (fMRI) Gray matter Inferior longitudinal fasciculus (ILF) Tract-based spatial statistics (TBSS) White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Alcohol-related neurodevelopmental disorder (ARND) falls under the umbrella of fetal alcohol spectrum disorder (FASD). Diagnosis of ARND is difficult because individuals do not demonstrate the characteristic facial features associated with fetal alcohol syndrome (FAS). While attentional problems in ARND are similar to those found in attention-deficit/hyperactivity disorder (ADHD), the underlying impairment in attention pathways may be different. METHODS: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was conducted at 3 T. Sixty-three children aged 10 to 14 years diagnosed with ARND, ADHD, and typically developing (TD) controls performed a single-feature and a feature-conjunction visual search task. RESULTS: Dorsal and ventral attention pathways were activated during both attention tasks in all groups. Significantly greater activation was observed in ARND subjects during a single-feature search as compared to TD and ADHD groups, suggesting ARND subjects require greater neural recruitment to perform this simple task. ARND subjects appear unable to effectively use the very efficient automatic perceptual 'pop-out' mechanism employed by TD and ADHD groups during presentation of the disjunction array. By comparison, activation was lower in ARND compared to TD and ADHD subjects during the more difficult conjunction search task as compared to the single-feature search. Analysis of DTI data using tract-based spatial statistics (TBSS) showed areas of significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) in the right inferior longitudinal fasciculus (ILF) in ARND compared to TD subjects. Damage to the white matter of the ILF may compromise the ventral attention pathway and may require subjects to use the dorsal attention pathway, which is associated with effortful top-down processing, for tasks that should be automatic. Decreased functional activity in the right temporoparietal junction (TPJ) of ARND subjects may be due to a reduction in the white matter tract's ability to efficiently convey information critical to performance of the attention tasks. CONCLUSIONS: Limited activation patterns in ARND suggest problems in information processing along the ventral frontoparietal attention pathway. Poor integrity of the ILF, which connects the functional components of the ventral attention network, in ARND subjects may contribute to the attention deficits characteristic of the disorder. En ligne : http://dx.doi.org/10.1186/s11689-015-9106-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study / Ariel KARTEN in Journal of Autism and Developmental Disorders, 45-6 (June 2015)
[article]
Titre : Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study Type de document : Texte imprimé et/ou numérique Auteurs : Ariel KARTEN, Auteur ; Joy HIRSCH, Auteur Article en page(s) : p.1905-1914 Langues : Anglais (eng) Mots-clés : Functional magnetic resonance imaging (fMRI) Functional connectivity Psychophysiological interactions (PPI) Negative BOLD response (NBR) Neural inhibition Autism Receptive language processing Index. décimale : PER Périodiques Résumé : Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes. En ligne : http://dx.doi.org/10.1007/s10803-014-2344-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1905-1914[article] Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study [Texte imprimé et/ou numérique] / Ariel KARTEN, Auteur ; Joy HIRSCH, Auteur . - p.1905-1914.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1905-1914
Mots-clés : Functional magnetic resonance imaging (fMRI) Functional connectivity Psychophysiological interactions (PPI) Negative BOLD response (NBR) Neural inhibition Autism Receptive language processing Index. décimale : PER Périodiques Résumé : Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes. En ligne : http://dx.doi.org/10.1007/s10803-014-2344-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 Neurogenetic analysis of childhood disintegrative disorder / A. R. GUPTA in Molecular Autism, 8 (2017)
[article]
Titre : Neurogenetic analysis of childhood disintegrative disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. R. GUPTA, Auteur ; A. WESTPHAL, Auteur ; D. Y. J. YANG, Auteur ; C. A. W. SULLIVAN, Auteur ; J. EILBOTT, Auteur ; S. ZAIDI, Auteur ; A. VOOS, Auteur ; B. C. VANDER WYK, Auteur ; Pamela VENTOLA, Auteur ; Z. WAQAR, Auteur ; T. V. FERNANDEZ, Auteur ; A. G. ERCAN-SENCICEK, Auteur ; M. F. WALKER, Auteur ; M. CHOI, Auteur ; A. SCHNEIDER, Auteur ; T. HEDDERLY, Auteur ; Gillian BAIRD, Auteur ; H. FRIEDMAN, Auteur ; C. CORDEAUX, Auteur ; A. RISTOW, Auteur ; F. SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur Article en page(s) : 19p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD) Childhood disintegrative disorder (CDD) Eye tracking Functional magnetic resonance imaging (fMRI) Genetics Intellectual disability (ID) Regression Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) and severe autism. Although there are phenotypic differences between CDD and other forms of ASD, it is unclear if there are neurobiological differences. METHODS: We pursued a multidisciplinary study of CDD (n = 17) and three comparison groups: low-functioning ASD (n = 12), high-functioning ASD (n = 50), and typically developing (n = 26) individuals. We performed whole-exome sequencing (WES), copy number variant (CNV), and gene expression analyses of CDD and, on subsets of each cohort, non-sedated functional magnetic resonance imaging (fMRI) while viewing socioemotional (faces) and non-socioemotional (houses) stimuli and eye tracking while viewing emotional faces. RESULTS: We observed potential differences between CDD and other forms of ASD. WES and CNV analyses identified one or more rare de novo, homozygous, and/or hemizygous (mother-to-son transmission on chrX) variants for most probands that were not shared by unaffected sibling controls. There were no clearly deleterious variants or highly recurrent candidate genes. Candidate genes that were found to be most conserved at variant position and most intolerant of variation, such as TRRAP, ZNF236, and KIAA2018, play a role or may be involved in transcription. Using the human BrainSpan transcriptome dataset, CDD candidate genes were found to be more highly expressed in non-neocortical regions than neocortical regions. This expression profile was similar to that of an independent cohort of ASD probands with regression. The non-neocortical regions overlapped with those identified by fMRI as abnormally hyperactive in response to viewing faces, such as the thalamus, cerebellum, caudate, and hippocampus. Eye-tracking analysis showed that, among individuals with ASD, subjects with CDD focused on eyes the most when shown pictures of faces. CONCLUSIONS: Given that cohort sizes were limited by the rarity of CDD, and the challenges of conducting non-sedated fMRI and eye tracking in subjects with ASD and significant ID, this is an exploratory study designed to investigate the neurobiological features of CDD. In addition to reporting the first multimodal analysis of CDD, a combination of fMRI and eye-tracking analyses are being presented for the first time for low-functioning individuals with ASD. Our results suggest differences between CDD and other forms of ASD on the neurobiological as well as clinical level. En ligne : http://dx.doi.org/10.1186/s13229-017-0133-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 19p.[article] Neurogenetic analysis of childhood disintegrative disorder [Texte imprimé et/ou numérique] / A. R. GUPTA, Auteur ; A. WESTPHAL, Auteur ; D. Y. J. YANG, Auteur ; C. A. W. SULLIVAN, Auteur ; J. EILBOTT, Auteur ; S. ZAIDI, Auteur ; A. VOOS, Auteur ; B. C. VANDER WYK, Auteur ; Pamela VENTOLA, Auteur ; Z. WAQAR, Auteur ; T. V. FERNANDEZ, Auteur ; A. G. ERCAN-SENCICEK, Auteur ; M. F. WALKER, Auteur ; M. CHOI, Auteur ; A. SCHNEIDER, Auteur ; T. HEDDERLY, Auteur ; Gillian BAIRD, Auteur ; H. FRIEDMAN, Auteur ; C. CORDEAUX, Auteur ; A. RISTOW, Auteur ; F. SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur . - 19p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 19p.
Mots-clés : Autism spectrum disorder (ASD) Childhood disintegrative disorder (CDD) Eye tracking Functional magnetic resonance imaging (fMRI) Genetics Intellectual disability (ID) Regression Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) and severe autism. Although there are phenotypic differences between CDD and other forms of ASD, it is unclear if there are neurobiological differences. METHODS: We pursued a multidisciplinary study of CDD (n = 17) and three comparison groups: low-functioning ASD (n = 12), high-functioning ASD (n = 50), and typically developing (n = 26) individuals. We performed whole-exome sequencing (WES), copy number variant (CNV), and gene expression analyses of CDD and, on subsets of each cohort, non-sedated functional magnetic resonance imaging (fMRI) while viewing socioemotional (faces) and non-socioemotional (houses) stimuli and eye tracking while viewing emotional faces. RESULTS: We observed potential differences between CDD and other forms of ASD. WES and CNV analyses identified one or more rare de novo, homozygous, and/or hemizygous (mother-to-son transmission on chrX) variants for most probands that were not shared by unaffected sibling controls. There were no clearly deleterious variants or highly recurrent candidate genes. Candidate genes that were found to be most conserved at variant position and most intolerant of variation, such as TRRAP, ZNF236, and KIAA2018, play a role or may be involved in transcription. Using the human BrainSpan transcriptome dataset, CDD candidate genes were found to be more highly expressed in non-neocortical regions than neocortical regions. This expression profile was similar to that of an independent cohort of ASD probands with regression. The non-neocortical regions overlapped with those identified by fMRI as abnormally hyperactive in response to viewing faces, such as the thalamus, cerebellum, caudate, and hippocampus. Eye-tracking analysis showed that, among individuals with ASD, subjects with CDD focused on eyes the most when shown pictures of faces. CONCLUSIONS: Given that cohort sizes were limited by the rarity of CDD, and the challenges of conducting non-sedated fMRI and eye tracking in subjects with ASD and significant ID, this is an exploratory study designed to investigate the neurobiological features of CDD. In addition to reporting the first multimodal analysis of CDD, a combination of fMRI and eye-tracking analyses are being presented for the first time for low-functioning individuals with ASD. Our results suggest differences between CDD and other forms of ASD on the neurobiological as well as clinical level. En ligne : http://dx.doi.org/10.1186/s13229-017-0133-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis / L. PHAN in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
[article]
Titre : The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis Type de document : Texte imprimé et/ou numérique Auteurs : L. PHAN, Auteur ; A. TARIQ, Auteur ; G. LAM, Auteur ; Elizabeth W. PANG, Auteur ; C. ALAIN, Auteur Article en page(s) : p.3266-3279 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Brain/diagnostic imaging Brain Mapping Humans Likelihood Functions Magnetic Resonance Imaging Semantics Activation likelihood estimation Autism spectrum disorder Functional magnetic resonance imaging (fMRI) Left inferior frontal gyrus Semantic processing Index. décimale : PER Périodiques Résumé : Semantic processing impairments are present in a proportion of individuals with autism spectrum disorder (ASD). Despite the numerous imaging studies investigating this language domain in ASD, there is a lack of consensus regarding the brain structures showing abnormal pattern of activity. This meta-analysis aimed to identify neural activation patterns present during semantic processing in ASD. Findings reveal activation of areas associated with semantic processing and executive functions in ASD. However, the activation was less concise in comparison to controls and there was less activation in the right hemisphere and in areas associated with executive functions. This provides strong support for impaired semantic processing in ASD that is consistently associated with abnormal patterns of neural activity in the semantic network. En ligne : http://dx.doi.org/10.1007/s10803-020-04794-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3266-3279[article] The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis [Texte imprimé et/ou numérique] / L. PHAN, Auteur ; A. TARIQ, Auteur ; G. LAM, Auteur ; Elizabeth W. PANG, Auteur ; C. ALAIN, Auteur . - p.3266-3279.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3266-3279
Mots-clés : Autism Spectrum Disorder Brain/diagnostic imaging Brain Mapping Humans Likelihood Functions Magnetic Resonance Imaging Semantics Activation likelihood estimation Autism spectrum disorder Functional magnetic resonance imaging (fMRI) Left inferior frontal gyrus Semantic processing Index. décimale : PER Périodiques Résumé : Semantic processing impairments are present in a proportion of individuals with autism spectrum disorder (ASD). Despite the numerous imaging studies investigating this language domain in ASD, there is a lack of consensus regarding the brain structures showing abnormal pattern of activity. This meta-analysis aimed to identify neural activation patterns present during semantic processing in ASD. Findings reveal activation of areas associated with semantic processing and executive functions in ASD. However, the activation was less concise in comparison to controls and there was less activation in the right hemisphere and in areas associated with executive functions. This provides strong support for impaired semantic processing in ASD that is consistently associated with abnormal patterns of neural activity in the semantic network. En ligne : http://dx.doi.org/10.1007/s10803-020-04794-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453