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Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD / Simona SPINELLI in Journal of Child Psychology and Psychiatry, 52-7 (July 2011)
[article]
Titre : Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Simona SPINELLI, Auteur ; Roma A. VASA, Auteur ; Suresh JOEL, Auteur ; Tess E. NELSON, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur Année de publication : 2011 Article en page(s) : p.808-816 Langues : Anglais (eng) Mots-clés : Error processing variability temporal cortex medial frontal cortex ADD/ADHD child fMRI brain imaging distractibility emotion regulation reaction time Index. décimale : PER Périodiques Résumé : Background: Error processing is reflected, behaviorally, by slower reaction times (RT) on trials immediately following an error (post-error). Children with attention-deficit hyperactivity disorder (ADHD) fail to show RT slowing and demonstrate increased intra-subject variability (ISV) on post-error trials. The neural correlates of these behavioral deficits remain unclear. The dorsal anterior cingulate cortex (ACC) and lateral prefrontal cortex (PFC) are key regions implicated in error processing and subsequent behavioral adjustment. We hypothesized that children with ADHD, compared to typically developing (TD) controls, would exhibit reduced PFC activation during post-error (versus post-correct inhibition) trials and reduced dACC activation during error (versus correct inhibition) trials.
Methods: Using functional Magnetic Resonance Imaging (fMRI) and a Go/No-Go task, we analyzed the neural correlates of error processing in 13 children with ADHD and 17 TD children.
Results: Behaviorally, children with ADHD showed similar RT slowing but increased ISV compared to controls. The post-error contrast revealed a relative increase in blood-oxygen-level dependent (BOLD) signal in the middle/inferior temporal cortex (TempC), the ACC/supplementary motor area (SMA) and the somatosensory/auditory cortex (AudC) in children with ADHD compared to controls. Importantly, in the ADHD group, increased post-error temporal cortex activity was associated with lower ISV. During error (versus correct inhibition) trials, no between-group differences were detected. However, in children with ADHD lower ISV was associated with decreased insula and increased precentral gyrus activity.
Conclusions: In children with ADHD, post-error neural activity suggests, first, a shift of attention towards task-irrelevant stimuli (AudC), and second, a recruitment of compensatory regions that resolve stimulus conflict (TempC) and improve response selection/execution (ACC/SMA). ADHD children with higher temporal cortex activation showed lower ISV, suggesting that functional abnormalities in the compensatory temporal regions contribute to increased variability. Moreover, increased ISV may be related to an over-sensitivity to negative outcomes during error trials in ADHD (insula correlation).En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02356.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126
in Journal of Child Psychology and Psychiatry > 52-7 (July 2011) . - p.808-816[article] Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD [Texte imprimé et/ou numérique] / Simona SPINELLI, Auteur ; Roma A. VASA, Auteur ; Suresh JOEL, Auteur ; Tess E. NELSON, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 2011 . - p.808-816.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-7 (July 2011) . - p.808-816
Mots-clés : Error processing variability temporal cortex medial frontal cortex ADD/ADHD child fMRI brain imaging distractibility emotion regulation reaction time Index. décimale : PER Périodiques Résumé : Background: Error processing is reflected, behaviorally, by slower reaction times (RT) on trials immediately following an error (post-error). Children with attention-deficit hyperactivity disorder (ADHD) fail to show RT slowing and demonstrate increased intra-subject variability (ISV) on post-error trials. The neural correlates of these behavioral deficits remain unclear. The dorsal anterior cingulate cortex (ACC) and lateral prefrontal cortex (PFC) are key regions implicated in error processing and subsequent behavioral adjustment. We hypothesized that children with ADHD, compared to typically developing (TD) controls, would exhibit reduced PFC activation during post-error (versus post-correct inhibition) trials and reduced dACC activation during error (versus correct inhibition) trials.
Methods: Using functional Magnetic Resonance Imaging (fMRI) and a Go/No-Go task, we analyzed the neural correlates of error processing in 13 children with ADHD and 17 TD children.
Results: Behaviorally, children with ADHD showed similar RT slowing but increased ISV compared to controls. The post-error contrast revealed a relative increase in blood-oxygen-level dependent (BOLD) signal in the middle/inferior temporal cortex (TempC), the ACC/supplementary motor area (SMA) and the somatosensory/auditory cortex (AudC) in children with ADHD compared to controls. Importantly, in the ADHD group, increased post-error temporal cortex activity was associated with lower ISV. During error (versus correct inhibition) trials, no between-group differences were detected. However, in children with ADHD lower ISV was associated with decreased insula and increased precentral gyrus activity.
Conclusions: In children with ADHD, post-error neural activity suggests, first, a shift of attention towards task-irrelevant stimuli (AudC), and second, a recruitment of compensatory regions that resolve stimulus conflict (TempC) and improve response selection/execution (ACC/SMA). ADHD children with higher temporal cortex activation showed lower ISV, suggesting that functional abnormalities in the compensatory temporal regions contribute to increased variability. Moreover, increased ISV may be related to an over-sensitivity to negative outcomes during error trials in ADHD (insula correlation).En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02356.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 An examination of response variability in children with autism and the relationship to restricted repetitive behavior subtypes / Clodagh MURRAY in Research in Autism Spectrum Disorders, 11 (March 2015)
[article]
Titre : An examination of response variability in children with autism and the relationship to restricted repetitive behavior subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Clodagh MURRAY, Auteur ; Olive HEALY, Auteur Article en page(s) : p.13-19 Langues : Anglais (eng) Mots-clés : Autism Restricted repetitive Behaviors Variability Index. décimale : PER Périodiques Résumé : The current study investigated response variability in children with autism and its relationship to restricted repetitive behaviors, one of the core symptoms of the disorder. The “Penny-Hiding Game” (Baron-Cohen, 1992) was used as a measure of response variability. Variability was compared for children with autism (n = 65) and typically developing children (n = 65) and patterns of response variability were categorized from least variable to most variable for both groups. For the participants with a diagnosis of autism, these patterns were examined relative to their scores on the Repetitive Behavior Scale-Revised (RBS-R; Bodfish, Symons, & Lewis, 1999). Results showed that children with autism demonstrated significantly lower variability in their responding in the “Penny-Hiding Game” than their typically developing peers. Variability was significantly negatively correlated with total RBS-R scores and with the Stereotypy subscale and the self-injurious behavior subscale, indicating that lower variability in responding was related to higher rates of these types of restricted and repetitive behaviors. No significant correlations were observed between variability and the Compulsion subscale, the Ritualistic/Sameness behaviors subscale or the Restricted Interests subscale. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 11 (March 2015) . - p.13-19[article] An examination of response variability in children with autism and the relationship to restricted repetitive behavior subtypes [Texte imprimé et/ou numérique] / Clodagh MURRAY, Auteur ; Olive HEALY, Auteur . - p.13-19.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 11 (March 2015) . - p.13-19
Mots-clés : Autism Restricted repetitive Behaviors Variability Index. décimale : PER Périodiques Résumé : The current study investigated response variability in children with autism and its relationship to restricted repetitive behaviors, one of the core symptoms of the disorder. The “Penny-Hiding Game” (Baron-Cohen, 1992) was used as a measure of response variability. Variability was compared for children with autism (n = 65) and typically developing children (n = 65) and patterns of response variability were categorized from least variable to most variable for both groups. For the participants with a diagnosis of autism, these patterns were examined relative to their scores on the Repetitive Behavior Scale-Revised (RBS-R; Bodfish, Symons, & Lewis, 1999). Results showed that children with autism demonstrated significantly lower variability in their responding in the “Penny-Hiding Game” than their typically developing peers. Variability was significantly negatively correlated with total RBS-R scores and with the Stereotypy subscale and the self-injurious behavior subscale, indicating that lower variability in responding was related to higher rates of these types of restricted and repetitive behaviors. No significant correlations were observed between variability and the Compulsion subscale, the Ritualistic/Sameness behaviors subscale or the Restricted Interests subscale. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Cortical Variability in the Sensory-Evoked Response in Autism / Sarah M. HAIGH in Journal of Autism and Developmental Disorders, 45-5 (May 2015)
[article]
Titre : Cortical Variability in the Sensory-Evoked Response in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarah M. HAIGH, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Nancy MINSHEW, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.1176-1190 Langues : Anglais (eng) Mots-clés : Autism fMRI Sensory-evoked Variability Index. décimale : PER Périodiques Résumé : Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2276-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1176-1190[article] Cortical Variability in the Sensory-Evoked Response in Autism [Texte imprimé et/ou numérique] / Sarah M. HAIGH, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Nancy MINSHEW, Auteur ; Marlene BEHRMANN, Auteur . - p.1176-1190.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1176-1190
Mots-clés : Autism fMRI Sensory-evoked Variability Index. décimale : PER Périodiques Résumé : Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2276-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder / Elizabeth S. HELLER MURRAY in Research in Autism Spectrum Disorders, 94 (June 2022)
[article]
Titre : Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth S. HELLER MURRAY, Auteur ; Jennifer SEGAWA, Auteur ; F. Isik KARAHANOGLU, Auteur ; Catherine TOCCI, Auteur ; Jason A. TOURVILLE, Auteur ; Alfonso NIETO-CASTANON, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Dara S. MANOACH, Auteur ; Frank H. GUENTHER, Auteur Article en page(s) : 101955 Langues : Anglais (eng) Mots-clés : Speech Functional magnetic resonance imaging Communication Variability Index. décimale : PER Périodiques Résumé : Background Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. Results There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions These findings highlight the importance of understanding intra-subject neural variability in participants with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101955 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101955[article] Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder [Texte imprimé et/ou numérique] / Elizabeth S. HELLER MURRAY, Auteur ; Jennifer SEGAWA, Auteur ; F. Isik KARAHANOGLU, Auteur ; Catherine TOCCI, Auteur ; Jason A. TOURVILLE, Auteur ; Alfonso NIETO-CASTANON, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Dara S. MANOACH, Auteur ; Frank H. GUENTHER, Auteur . - 101955.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101955
Mots-clés : Speech Functional magnetic resonance imaging Communication Variability Index. décimale : PER Périodiques Résumé : Background Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. Results There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions These findings highlight the importance of understanding intra-subject neural variability in participants with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101955 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Over-Responsiveness and Greater Variability in Roughness Perception in Autism / Sarah M. HAIGH in Autism Research, 9-3 (March 2016)
[article]
Titre : Over-Responsiveness and Greater Variability in Roughness Perception in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Sarah M. HAIGH, Auteur ; Nancy MINSHEW, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Marlene BEHRMANN, Auteur Article en page(s) : p.393-402 Langues : Anglais (eng) Mots-clés : autism tactile variability sensory hypersensitivity Index. décimale : PER Périodiques Résumé : Although sensory problems, including tactile hypersensitivity and hyposensitivity (DSM-5) are commonly associated with autism, there is a dearth of systematic and rigorous research in this domain. Here, we report findings from a psychophysical experiment that explored differences in tactile perception between individuals with autism and typically developing control participants, who, using their index finger, rated a series of surfaces on the extent of their roughness. Each surface was rated multiple times and we calculated both the average rating and the variability across trials. Relative to controls, the individuals with autism perceived the surfaces as rougher overall and exhibited greater variability in their ratings across trials. These findings characterize altered tactile perception in autism and suggest that sensory problems in autism may be the product of overly responsive and variable sensory processing. Autism Res 2016, 9: 393–402. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Autism Research > 9-3 (March 2016) . - p.393-402[article] Over-Responsiveness and Greater Variability in Roughness Perception in Autism [Texte imprimé et/ou numérique] / Sarah M. HAIGH, Auteur ; Nancy MINSHEW, Auteur ; David J. HEEGER, Auteur ; Ilan DINSTEIN, Auteur ; Marlene BEHRMANN, Auteur . - p.393-402.
Langues : Anglais (eng)
in Autism Research > 9-3 (March 2016) . - p.393-402
Mots-clés : autism tactile variability sensory hypersensitivity Index. décimale : PER Périodiques Résumé : Although sensory problems, including tactile hypersensitivity and hyposensitivity (DSM-5) are commonly associated with autism, there is a dearth of systematic and rigorous research in this domain. Here, we report findings from a psychophysical experiment that explored differences in tactile perception between individuals with autism and typically developing control participants, who, using their index finger, rated a series of surfaces on the extent of their roughness. Each surface was rated multiple times and we calculated both the average rating and the variability across trials. Relative to controls, the individuals with autism perceived the surfaces as rougher overall and exhibited greater variability in their ratings across trials. These findings characterize altered tactile perception in autism and suggest that sensory problems in autism may be the product of overly responsive and variable sensory processing. Autism Res 2016, 9: 393–402. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1505 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 Promoting Behavioral Variability in Individuals With Autism Spectrum Disorders: A Literature Review / Katie WOLFE in Focus on Autism and Other Developmental Disabilities, 29-3 (September 2014)
PermalinkVocal stereotypy in children with autism: Structural characteristics, variability, and effects of auditory stimulation / Marc J. LANOVAZ in Research in Autism Spectrum Disorders, 5-3 (July-September 2011)
PermalinkChildren with autism observe social interactions in an idiosyncratic manner / Inbar AVNI in Autism Research, 13-6 (June 2020)
PermalinkDaytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children / Sharon A. KIDD in Journal of Autism and Developmental Disorders, 42-12 (December 2012)
PermalinkExploring individual trajectories of social communicative development in toddlers at risk for autism spectrum disorders / Mieke DEREU in Research in Autism Spectrum Disorders, 6-3 (July-September 2012)
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