4 recherche sur le mot-clé 'Sleep/physiology'

Evaluation of electroencephalography biomarkers for Angelman syndrome during overnight sleep / Yuval LEVIN in Autism Research, 15-6 (June 2022)  

Public ISBD [article]  inAutism Research > 15-6 (June 2022) . - p.1031-1042 Titre : Evaluation of electroencephalography biomarkers for Angelman syndrome during overnight sleep Type de document : Texte imprimé et/ou numérique Auteurs : Yuval LEVIN, Auteur ; Nishitha S. HOSAMANE, Auteur ; Taylor E. MCNAIR, Auteur ; Shrujana S. KUNNAM, Auteur ; Benjamin D. PHILPOT, Auteur ; Zheng FAN, Auteur ; Michael S. SIDOROV, Auteur Article en page(s) : p.1031-1042 Langues : Anglais (eng) Mots-clés : Angelman Syndrome/complications/diagnosis/genetics  Autism Spectrum Disorder  Biomarkers  Electroencephalography  Humans  Retrospective Studies  Sleep/physiology  Angelman syndrome  Eeg  biomarker  delta  sleep  spindle  Medpace, Inc. for EEG analysis. Index. décimale : PER Périodiques Résumé : Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss-of-function mutations in the maternal copy of the UBE3A gene. AS is characterized by intellectual disability, impaired speech and motor skills, epilepsy, and sleep disruptions. Multiple treatment strategies to re-express functional neuronal UBE3A from the dormant paternal allele were successful in rodent models of AS and have now moved to early phase clinical trials in children. Developing reliable and objective AS biomarkers is essential to guide the design and execution of current and future clinical trials. Our prior work quantified short daytime electroencephalograms (EEGs) to define promising biomarkers for AS. Here, we asked whether overnight sleep is better suited to detect AS EEG biomarkers. We retrospectively analyzed EEGs from 12 overnight sleep studies from individuals with AS with age and sex-matched Down syndrome and neurotypical controls, focusing on low frequency (2-4?Hz) delta rhythms and sleep spindles. Delta EEG rhythms were increased in individuals with AS during all stages of overnight sleep, but overnight sleep did not provide additional benefit over wake in the ability to detect increased delta. Abnormal sleep spindles were not reliably detected in EEGs from individuals with AS during overnight sleep, suggesting that delta rhythms represent a more reliable biomarker. Overall, we conclude that periods of wakefulness are sufficient, and perhaps ideal, to quantify delta EEG rhythms for use as AS biomarkers. LAY SUMMARY: Electroencephalography (EEG) is a safe and reliable way of measuring abnormal brain activity in Angelman syndrome. We found that low-frequency "delta" EEG rhythms are increased in individuals with Angelman syndrome during all stages of overnight sleep. Delta rhythms can be used as a tool to measure improvement in future clinical trials. En ligne : http://dx.doi.org/10.1002/aur.2709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Evaluation of electroencephalography biomarkers for Angelman syndrome during overnight sleep [Texte imprimé et/ou numérique] / Yuval LEVIN, Auteur ; Nishitha S. HOSAMANE, Auteur ; Taylor E. MCNAIR, Auteur ; Shrujana S. KUNNAM, Auteur ; Benjamin D. PHILPOT, Auteur ; Zheng FAN, Auteur ; Michael S. SIDOROV, Auteur . - p.1031-1042. Langues : Anglais (eng) in Autism Research > 15-6 (June 2022) . - p.1031-1042 Mots-clés : Angelman Syndrome/complications/diagnosis/genetics  Autism Spectrum Disorder  Biomarkers  Electroencephalography  Humans  Retrospective Studies  Sleep/physiology  Angelman syndrome  Eeg  biomarker  delta  sleep  spindle  Medpace, Inc. for EEG analysis. Index. décimale : PER Périodiques Résumé : Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss-of-function mutations in the maternal copy of the UBE3A gene. AS is characterized by intellectual disability, impaired speech and motor skills, epilepsy, and sleep disruptions. Multiple treatment strategies to re-express functional neuronal UBE3A from the dormant paternal allele were successful in rodent models of AS and have now moved to early phase clinical trials in children. Developing reliable and objective AS biomarkers is essential to guide the design and execution of current and future clinical trials. Our prior work quantified short daytime electroencephalograms (EEGs) to define promising biomarkers for AS. Here, we asked whether overnight sleep is better suited to detect AS EEG biomarkers. We retrospectively analyzed EEGs from 12 overnight sleep studies from individuals with AS with age and sex-matched Down syndrome and neurotypical controls, focusing on low frequency (2-4?Hz) delta rhythms and sleep spindles. Delta EEG rhythms were increased in individuals with AS during all stages of overnight sleep, but overnight sleep did not provide additional benefit over wake in the ability to detect increased delta. Abnormal sleep spindles were not reliably detected in EEGs from individuals with AS during overnight sleep, suggesting that delta rhythms represent a more reliable biomarker. Overall, we conclude that periods of wakefulness are sufficient, and perhaps ideal, to quantify delta EEG rhythms for use as AS biomarkers. LAY SUMMARY: Electroencephalography (EEG) is a safe and reliable way of measuring abnormal brain activity in Angelman syndrome. We found that low-frequency "delta" EEG rhythms are increased in individuals with Angelman syndrome during all stages of overnight sleep. Delta rhythms can be used as a tool to measure improvement in future clinical trials. En ligne : http://dx.doi.org/10.1002/aur.2709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice / Tanya LEDUC in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 13p. Titre : Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice Type de document : Texte imprimé et/ou numérique Auteurs : Tanya LEDUC, Auteur ; Hiba EL ALAMI, Auteur ; Khadija BOUGADIR, Auteur ; Erika BÉLANGER-NELSON, Auteur ; Valérie MONGRAIN, Auteur Article en page(s) : 13p. Langues : Anglais (eng) Mots-clés : Animals  Humans  Mice  Electroencephalography  Neuroligins  Quality of Life  Sleep/physiology  Sleep Deprivation/metabolism  Sleep, Slow-Wave  Cerebral cortex  GABAergic neurotransmission  Gene expression  Sleep deprivation  Sleep-wake regulation  Slow waves  Synaptic adhesion molecules Index. décimale : PER Périodiques Résumé : BACKGROUND: Sleep disturbances are a common comorbidity to most neurodevelopmental disorders and tend to worsen disease symptomatology. It is thus crucial to understand mechanisms underlying sleep disturbances to improve patients' quality of life. Neuroligin-2 (NLGN2) is a synaptic adhesion protein regulating GABAergic transmission. It has been linked to autism spectrum disorders and schizophrenia in humans, and deregulations of its expression were shown to cause epileptic-like hypersynchronized cerebral activity in rodents. Importantly, the absence of Nlgn2 (knockout: KO) was previously shown to alter sleep-wake duration and quality in mice, notably increasing slow-wave sleep (SWS) delta activity (1-4 Hz) and altering its 24-h dynamics. This type of brain oscillation is involved in memory consolidation, and is also a marker of homeostatic sleep pressure. Sleep deprivation (SD) is notably known to impair cognition and the physiological response to sleep loss involves GABAergic transmission. METHODS: Using electrocorticographic (ECoG) recordings, we here first aimed to verify how individual slow wave (SW; 0.5-4 Hz) density and properties (e.g., amplitude, slope, frequency) contribute to the higher SWS delta activity and altered 24-h dynamics observed in Nlgn2 KO mice. We further investigated the response of these animals to SD. Finally, we tested whether sleep loss affects the gene expression of Nlgn2 and related GABAergic transcripts in the cerebral cortex of wild-type mice using RNA sequencing. RESULTS: Our results show that Nlgn2 KO mice have both greater SW amplitude and density, and that SW density is the main property contributing to the altered 24-h dynamics. We also found the absence of Nlgn2 to accelerate paradoxical sleep recovery following SD, together with profound alterations in ECoG activity across vigilance states. Sleep loss, however, did not modify the 24-h distribution of the hypersynchronized ECoG events observed in these mice. Finally, RNA sequencing confirmed an overall decrease in cortical expression of Nlgn2 and related GABAergic transcripts following SD in wild-type mice. CONCLUSIONS: This work brings further insight into potential mechanisms of sleep duration and quality deregulation in neurodevelopmental disorders, notably involving NLGN2 and GABAergic neurotransmission. En ligne : https://dx.doi.org/10.1186/s13229-024-00594-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice [Texte imprimé et/ou numérique] / Tanya LEDUC, Auteur ; Hiba EL ALAMI, Auteur ; Khadija BOUGADIR, Auteur ; Erika BÉLANGER-NELSON, Auteur ; Valérie MONGRAIN, Auteur . - 13p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 13p. Mots-clés : Animals  Humans  Mice  Electroencephalography  Neuroligins  Quality of Life  Sleep/physiology  Sleep Deprivation/metabolism  Sleep, Slow-Wave  Cerebral cortex  GABAergic neurotransmission  Gene expression  Sleep deprivation  Sleep-wake regulation  Slow waves  Synaptic adhesion molecules Index. décimale : PER Périodiques Résumé : BACKGROUND: Sleep disturbances are a common comorbidity to most neurodevelopmental disorders and tend to worsen disease symptomatology. It is thus crucial to understand mechanisms underlying sleep disturbances to improve patients' quality of life. Neuroligin-2 (NLGN2) is a synaptic adhesion protein regulating GABAergic transmission. It has been linked to autism spectrum disorders and schizophrenia in humans, and deregulations of its expression were shown to cause epileptic-like hypersynchronized cerebral activity in rodents. Importantly, the absence of Nlgn2 (knockout: KO) was previously shown to alter sleep-wake duration and quality in mice, notably increasing slow-wave sleep (SWS) delta activity (1-4 Hz) and altering its 24-h dynamics. This type of brain oscillation is involved in memory consolidation, and is also a marker of homeostatic sleep pressure. Sleep deprivation (SD) is notably known to impair cognition and the physiological response to sleep loss involves GABAergic transmission. METHODS: Using electrocorticographic (ECoG) recordings, we here first aimed to verify how individual slow wave (SW; 0.5-4 Hz) density and properties (e.g., amplitude, slope, frequency) contribute to the higher SWS delta activity and altered 24-h dynamics observed in Nlgn2 KO mice. We further investigated the response of these animals to SD. Finally, we tested whether sleep loss affects the gene expression of Nlgn2 and related GABAergic transcripts in the cerebral cortex of wild-type mice using RNA sequencing. RESULTS: Our results show that Nlgn2 KO mice have both greater SW amplitude and density, and that SW density is the main property contributing to the altered 24-h dynamics. We also found the absence of Nlgn2 to accelerate paradoxical sleep recovery following SD, together with profound alterations in ECoG activity across vigilance states. Sleep loss, however, did not modify the 24-h distribution of the hypersynchronized ECoG events observed in these mice. Finally, RNA sequencing confirmed an overall decrease in cortical expression of Nlgn2 and related GABAergic transcripts following SD in wild-type mice. CONCLUSIONS: This work brings further insight into potential mechanisms of sleep duration and quality deregulation in neurodevelopmental disorders, notably involving NLGN2 and GABAergic neurotransmission. En ligne : https://dx.doi.org/10.1186/s13229-024-00594-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Sleep patterns, sluggish cognitive tempo, and daytime sleepiness - a commentary on Fredrick et al. (2022) / Dena SADEGHI-BAHMANI in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1668-1670 Titre : Sleep patterns, sluggish cognitive tempo, and daytime sleepiness - a commentary on Fredrick et al. (2022) Type de document : Texte imprimé et/ou numérique Auteurs : Dena SADEGHI-BAHMANI, Auteur ; Serge BRAND, Auteur Article en page(s) : p.1668-1670 Langues : Anglais (eng) Mots-clés : Adolescent  Child  Humans  Attention Deficit Disorder with Hyperactivity/complications  Cross-Sectional Studies  Sluggish Cognitive Tempo  Sleep/physiology  Disorders of Excessive Somnolence  Cognition/physiology Index. décimale : PER Périodiques Résumé : Fredrick et al. (Journal of Child Psychology and Psychiatry, 2022) showed in their cross-sectional and observational study that higher Sluggish Cognitive Tempo (SCT) traits were associated with more impaired subjective and objective sleep parameters. Importantly, data were gathered from adolescents and their parents, thus, enhancing the validity of the findings. In addition, the observed pattern of associations was unrelated to ADHD traits, age, sex, medication, or pubertal development. In the present commentary, we acknowledge the scientific value and practical and clinical implications of these findings. For future studies, we propose seven research avenues, which might help to further clarify the neurophysiological, psychological, and behavioral associations between SCT traits and sleep patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Sleep patterns, sluggish cognitive tempo, and daytime sleepiness - a commentary on Fredrick et al. (2022) [Texte imprimé et/ou numérique] / Dena SADEGHI-BAHMANI, Auteur ; Serge BRAND, Auteur . - p.1668-1670. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1668-1670 Mots-clés : Adolescent  Child  Humans  Attention Deficit Disorder with Hyperactivity/complications  Cross-Sectional Studies  Sluggish Cognitive Tempo  Sleep/physiology  Disorders of Excessive Somnolence  Cognition/physiology Index. décimale : PER Périodiques Résumé : Fredrick et al. (Journal of Child Psychology and Psychiatry, 2022) showed in their cross-sectional and observational study that higher Sluggish Cognitive Tempo (SCT) traits were associated with more impaired subjective and objective sleep parameters. Importantly, data were gathered from adolescents and their parents, thus, enhancing the validity of the findings. In addition, the observed pattern of associations was unrelated to ADHD traits, age, sex, medication, or pubertal development. In the present commentary, we acknowledge the scientific value and practical and clinical implications of these findings. For future studies, we propose seven research avenues, which might help to further clarify the neurophysiological, psychological, and behavioral associations between SCT traits and sleep patterns. En ligne : http://dx.doi.org/10.1111/jcpp.13693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

What time do you plan to sleep tonight? An intense longitudinal study of adolescent daily sleep self-regulation via planning and its associations with sleep opportunity / Svetlana MASKEVICH in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.900-911 Titre : What time do you plan to sleep tonight? An intense longitudinal study of adolescent daily sleep self-regulation via planning and its associations with sleep opportunity Type de document : Texte imprimé et/ou numérique Auteurs : Svetlana MASKEVICH, Auteur ; Lin SHEN, Auteur ; Sean P. A. DRUMMOND, Auteur ; Bei BEI, Auteur Article en page(s) : p.900-911 Langues : Anglais (eng) Mots-clés : Actigraphy  Adolescent  Female  Humans  Longitudinal Studies  Male  Schools  Self-Control  Sleep/physiology  Adolescents  planning  sleep restriction  sleep self-regulation  teenagers  unconstrained sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: Most adolescents are sleep deprived on school days, yet how they self-regulate their sleep-wake behaviours is poorly understood. Using ecological momentary assessment, this intense longitudinal study explored patterns of adolescents' daily bedtime and risetime planning and execution, and whether these behaviours predicted sleep opportunity. METHODS: Every afternoon, for 2 school weeks and the subsequent 2 vacation weeks, 205 (54.1% female, 64.4% non-White) adolescents from year 10 to 12 (MÂ+SD(age) =16.9Â+0.9) reported their plans for bedtime (BT) that evening, and for risetimes (RT) the following day. Actual daily sleep was measured via actigraphy and sleep diary. RESULTS: Some adolescents never planned bedtime (school 19.5%, non-school 53.2%) or risetime (school 1.5%, non-school 24.4%). More adolescents planned consistently (â¥75% of days) on school (BT=29.9%, RT=61.3%) compared to non-school nights (BT=3.5%, RT=2.5%). On average, adolescents went to bed later than planned, with longer delays on non-school (71min) compared to school nights (46min). Of those who executed their plans within 15min, more did it consistently (â¥75% of days) on school (BT=40.9%, RT=67.7%) than on non-school nights/days (BT=29.7%, RT=58.6%). Mixed effects models utilizing daily data, controlling for sex, race, and study day, showed that bedtime planning predicted longer time in bed (TIB; p<.01) on school and shorter TIB on non-school nights (p<.01); and greater delay in actual (compared to planned) BT predicted shorter TIB (p<.001). CONCLUSIONS: Adolescents may require support during the transition from parent-controlled to autonomous sleep self-regulation. Bedtime planning on school nights and going to bed as planned are two modifiable sleep regulatory behaviours that are protective and potential therapeutic targets for increasing sleep opportunity in adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] What time do you plan to sleep tonight? An intense longitudinal study of adolescent daily sleep self-regulation via planning and its associations with sleep opportunity [Texte imprimé et/ou numérique] / Svetlana MASKEVICH, Auteur ; Lin SHEN, Auteur ; Sean P. A. DRUMMOND, Auteur ; Bei BEI, Auteur . - p.900-911. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.900-911 Mots-clés : Actigraphy  Adolescent  Female  Humans  Longitudinal Studies  Male  Schools  Self-Control  Sleep/physiology  Adolescents  planning  sleep restriction  sleep self-regulation  teenagers  unconstrained sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: Most adolescents are sleep deprived on school days, yet how they self-regulate their sleep-wake behaviours is poorly understood. Using ecological momentary assessment, this intense longitudinal study explored patterns of adolescents' daily bedtime and risetime planning and execution, and whether these behaviours predicted sleep opportunity. METHODS: Every afternoon, for 2 school weeks and the subsequent 2 vacation weeks, 205 (54.1% female, 64.4% non-White) adolescents from year 10 to 12 (MÂ+SD(age) =16.9Â+0.9) reported their plans for bedtime (BT) that evening, and for risetimes (RT) the following day. Actual daily sleep was measured via actigraphy and sleep diary. RESULTS: Some adolescents never planned bedtime (school 19.5%, non-school 53.2%) or risetime (school 1.5%, non-school 24.4%). More adolescents planned consistently (â¥75% of days) on school (BT=29.9%, RT=61.3%) compared to non-school nights (BT=3.5%, RT=2.5%). On average, adolescents went to bed later than planned, with longer delays on non-school (71min) compared to school nights (46min). Of those who executed their plans within 15min, more did it consistently (â¥75% of days) on school (BT=40.9%, RT=67.7%) than on non-school nights/days (BT=29.7%, RT=58.6%). Mixed effects models utilizing daily data, controlling for sex, race, and study day, showed that bedtime planning predicted longer time in bed (TIB; p<.01) on school and shorter TIB on non-school nights (p<.01); and greater delay in actual (compared to planned) BT predicted shorter TIB (p<.001). CONCLUSIONS: Adolescents may require support during the transition from parent-controlled to autonomous sleep self-regulation. Bedtime planning on school nights and going to bed as planned are two modifiable sleep regulatory behaviours that are protective and potential therapeutic targets for increasing sleep opportunity in adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486