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A transdiagnostic study of theory of mind in children and youth with neurodevelopmental conditions / Kaela AMORIM in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 37 Titre : A transdiagnostic study of theory of mind in children and youth with neurodevelopmental conditions Type de document : texte imprimé Auteurs : Kaela AMORIM, Auteur ; Marlee M. VANDEWOUW, Auteur ; Nhu HUYNH, Auteur ; Kathrina DE VILLA, Auteur ; Celine SAFATI, Auteur ; Aurora ALMONTE, Auteur ; Rob NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Jennifer CROSBIE, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Margot J. TAYLOR, Auteur ; Julie SATO, Auteur ; Kaela AMORIM, Auteur ; Marlee M. VANDEWOUW, Auteur ; Nhu HUYNH, Auteur ; Kathrina DE VILLA, Auteur ; Celine SAFATI, Auteur ; Aurora ALMONTE, Auteur ; Rob NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Jennifer CROSBIE, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Margot J. TAYLOR, Auteur ; Julie SATO, Auteur Article en page(s) : 37 Langues : Anglais (eng) Mots-clés : Humans  Child  Theory of Mind  Male  Female  Adolescent  Child, Preschool  Young Adult  Neurodevelopmental Disorders/diagnosis/psychology  Attention Deficit Disorder with Hyperactivity/diagnosis/psychology  Case-Control Studies  Obsessive-Compulsive Disorder/diagnosis/psychology  Autistic Disorder/diagnosis/psychology  Development  Neurodevelopmental conditions  Social attribution task  Theory of mind  Transdiagnostic  human participants and was approved by Holland Bloorview Kids Rehabilitation  Hospital, Toronto (11–280)  The Hospital for Sick Children, Toronto (1000012230)  McMaster Children’s Hospital, Hamilton (12–050)  Lawson Health Research  Institute, London (103326)  and Queen’s University, Kingston (6005107). All  children and youth provided verbal assent, and parents gave written informed  consent in accordance with the Declaration of Helsinki. Consent for publication:  Not applicable. Competing interests: EA has received grants from Roche and  Anavex, served as a consultant to Roche, Quadrant Therapeutics, Ono, and Impel  Pharmaceuticals, has received in-kind support from AMO Pharma and CRA-Simons  Foundation, received royalties from APPI and Springer, received an editorial  honorarium from Wiley, and has a patent for hollyâ„¢ (formerly Anxiety Meter). All  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Theory of mind (ToM) is fundamental for social interactions, allowing individuals to appreciate that others have their own mental states. Children and youth with neurodevelopmental conditions (e.g., autism, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD)) often show differences in ToM abilities compared to their neurotypical (NT) peers. Given the phenotypic heterogeneity and overlap associated with these conditions, this motivates a transdiagnostic investigation of ToM across neurodevelopmental conditions. METHODS: Five hundred and fifty-five participants (5-22 years; 193 ADHD, 189 autism, 33 OCD, and 140 NT) were recruited via the Province of Ontario Neurodevelopmental Disorders network. To measure ToM, participants completed the Social Attribution Task (SAT), where participants attribute social stories to videos of moving shapes. The Animation Index (ability to attribute social stories to the videos) and Pertinence Index (how pertinent the attributions are) were calculated from the descriptions. Three analyses were performed: (1) a case-control analysis, comparing the SAT indices amongst the diagnostic groups, (2) a univariate dimensional analysis, examining associations with phenotypic variables (e.g., full-scale IQ, verbal IQ, and social communication difficulties), (3) and a multivariate analysis (partial least squares) that identifies a latent space that describes the associations between the SAT and phenotypic measures. RESULTS: There were no between-group differences in the Animation Index, but the Pertinence Index was significantly lower in autism compared to the other diagnostic categories. Phenotypic variables (full-scale IQ, verbal IQ, and social communication difficulties) were found to be significantly associated with SAT performance across groups, and explained more variance than the diagnostic categories. In the multivariate analysis, the phenotypic variables contributed more strongly to the identified latent component compared to the diagnostic categories. LIMITATIONS: The verbal requirement of the SAT limited the inclusion of non-verbal participants, while the overall cognitive demand limited the participation of those with lower IQs. Additionally, our OCD group was significantly smaller than the other groups, which may have limited our ability to detect OCD-specific effects. CONCLUSIONS: In a large sample, we found that transdiagnostic measures, such as IQ and social communication difficulties, are related to SAT abilities across neurodivergent and neurotypical children and youth and better describe differences in SAT performance compared to the individual diagnostic categories. Although poorer performance on ToM tasks has been classically associated with autism, this study highlights that transdiagnostic, phenotypic variables are a stronger predictor of SAT performance than diagnostic group. En ligne : https://dx.doi.org/10.1186/s13229-025-00671-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] A transdiagnostic study of theory of mind in children and youth with neurodevelopmental conditions [texte imprimé] / Kaela AMORIM, Auteur ; Marlee M. VANDEWOUW, Auteur ; Nhu HUYNH, Auteur ; Kathrina DE VILLA, Auteur ; Celine SAFATI, Auteur ; Aurora ALMONTE, Auteur ; Rob NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Jennifer CROSBIE, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Margot J. TAYLOR, Auteur ; Julie SATO, Auteur ; Kaela AMORIM, Auteur ; Marlee M. VANDEWOUW, Auteur ; Nhu HUYNH, Auteur ; Kathrina DE VILLA, Auteur ; Celine SAFATI, Auteur ; Aurora ALMONTE, Auteur ; Rob NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Jennifer CROSBIE, Auteur ; Jessica BRIAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Margot J. TAYLOR, Auteur ; Julie SATO, Auteur . - 37. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 37 Mots-clés : Humans  Child  Theory of Mind  Male  Female  Adolescent  Child, Preschool  Young Adult  Neurodevelopmental Disorders/diagnosis/psychology  Attention Deficit Disorder with Hyperactivity/diagnosis/psychology  Case-Control Studies  Obsessive-Compulsive Disorder/diagnosis/psychology  Autistic Disorder/diagnosis/psychology  Development  Neurodevelopmental conditions  Social attribution task  Theory of mind  Transdiagnostic  human participants and was approved by Holland Bloorview Kids Rehabilitation  Hospital, Toronto (11–280)  The Hospital for Sick Children, Toronto (1000012230)  McMaster Children’s Hospital, Hamilton (12–050)  Lawson Health Research  Institute, London (103326)  and Queen’s University, Kingston (6005107). All  children and youth provided verbal assent, and parents gave written informed  consent in accordance with the Declaration of Helsinki. Consent for publication:  Not applicable. Competing interests: EA has received grants from Roche and  Anavex, served as a consultant to Roche, Quadrant Therapeutics, Ono, and Impel  Pharmaceuticals, has received in-kind support from AMO Pharma and CRA-Simons  Foundation, received royalties from APPI and Springer, received an editorial  honorarium from Wiley, and has a patent for hollyâ„¢ (formerly Anxiety Meter). All  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Theory of mind (ToM) is fundamental for social interactions, allowing individuals to appreciate that others have their own mental states. Children and youth with neurodevelopmental conditions (e.g., autism, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD)) often show differences in ToM abilities compared to their neurotypical (NT) peers. Given the phenotypic heterogeneity and overlap associated with these conditions, this motivates a transdiagnostic investigation of ToM across neurodevelopmental conditions. METHODS: Five hundred and fifty-five participants (5-22 years; 193 ADHD, 189 autism, 33 OCD, and 140 NT) were recruited via the Province of Ontario Neurodevelopmental Disorders network. To measure ToM, participants completed the Social Attribution Task (SAT), where participants attribute social stories to videos of moving shapes. The Animation Index (ability to attribute social stories to the videos) and Pertinence Index (how pertinent the attributions are) were calculated from the descriptions. Three analyses were performed: (1) a case-control analysis, comparing the SAT indices amongst the diagnostic groups, (2) a univariate dimensional analysis, examining associations with phenotypic variables (e.g., full-scale IQ, verbal IQ, and social communication difficulties), (3) and a multivariate analysis (partial least squares) that identifies a latent space that describes the associations between the SAT and phenotypic measures. RESULTS: There were no between-group differences in the Animation Index, but the Pertinence Index was significantly lower in autism compared to the other diagnostic categories. Phenotypic variables (full-scale IQ, verbal IQ, and social communication difficulties) were found to be significantly associated with SAT performance across groups, and explained more variance than the diagnostic categories. In the multivariate analysis, the phenotypic variables contributed more strongly to the identified latent component compared to the diagnostic categories. LIMITATIONS: The verbal requirement of the SAT limited the inclusion of non-verbal participants, while the overall cognitive demand limited the participation of those with lower IQs. Additionally, our OCD group was significantly smaller than the other groups, which may have limited our ability to detect OCD-specific effects. CONCLUSIONS: In a large sample, we found that transdiagnostic measures, such as IQ and social communication difficulties, are related to SAT abilities across neurodivergent and neurotypical children and youth and better describe differences in SAT performance compared to the individual diagnostic categories. Although poorer performance on ToM tasks has been classically associated with autism, this study highlights that transdiagnostic, phenotypic variables are a stronger predictor of SAT performance than diagnostic group. En ligne : https://dx.doi.org/10.1186/s13229-025-00671-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Facial expression recognition is linked to clinical and neurofunctional differences in autism / Hannah MEYER-LINDENBERG in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 43 p. Titre : Facial expression recognition is linked to clinical and neurofunctional differences in autism Type de document : texte imprimé Auteurs : Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Hannah HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary J. HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G.M. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur Article en page(s) : 43 p. Langues : Anglais (eng) Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Facial expression recognition is linked to clinical and neurofunctional differences in autism [texte imprimé] / Hannah MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Bethany OAKLEY, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J.H. JONES, Auteur ; Hannah HAYWARD, Auteur ; Jennifer COOKE, Auteur ; Daisy CRAWLEY, Auteur ; Rosemary J. HOLT, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Simon BARON-COHEN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Christian F. BECKMANN, Auteur ; Heike TOST, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G.M. MURPHY, Auteur ; Michael BRAMMER, Auteur ; Eva LOTH, Auteur . - 43 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 43 p. Mots-clés : Humans  Facial Recognition  Autistic Disorder/diagnostic imaging  Emotions  Magnetic Resonance Imaging/methods  Biomarkers  Autism Spectrum Disorder  Facial Expression  Autism  Autism spectrum disorder  Clustering analysis  Development  Facial expression recognition  Multi-site  Social brain  Stratification biomarkers  fMRI  consultant to F. Hoffmann-La Roche Ltd. and Servier and has received royalties  from Sage Publications and Guilford Publications. TB served in an advisory or  consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH,  Takeda, and Infectopharm. He received conference support or speaker’s fee by  Lilly, Medice, and Takeda. He received royalties from Hogrefe, Kohlhammer, CIP  Medien, Oxford University Press  the present work is unrelated to these  relationships. AM-L has received consultant fees in the past two years from  Boehringer Ingelheim, Elsevier, Lundbeck Int. Neuroscience Foundation, Lundbeck  AS, The Wolfson Foundation, Thieme Verlag, Sage Therapeutics, von Behring  Stiftung, Fondation FondaMental, Janssen-Cilag GmbH, MedinCell, Brain Mind  Institute, CISSN. Furthermore, he has received speaker fees from Italian Society  of biological Psychiatry, Merz-Stiftung, Forum Werkstatt Karlsruhe, Lundbeck SAS  France, BAG Psychiatrie Oberbayern. JB has been in the past 3 years a consultant  to/member of advisory board of/and/or speaker for Takeda/Shire, Roche, Medice,  Angelini, Janssen, and Servier. He is not an employee of any of these companies,  and not a stock shareholder of any of these companies. He has no other financial  or material support, including expert testimony, patents, royalties. EL is an  Associate Editor at Molecular Autism. DM has been paid for advisory board work by  F. Hoffmann-La Roche Ltd. and Servier, and for editorial work by Springer. The  other authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. METHODS: Between 255 and 488 participants aged 6-30 years with autism, typical development and/or mild intellectual disability completed the Karolinska Directed Emotional Faces task, the Reading the Mind in the Eyes Task and/or the Films Expression Task. We first examined mean-group differences on each test. Then, we used a novel intersection approach that compares two centroid and connectivity-based clustering methods to derive subgroups based on the combined performance across the three tasks. Measures and subgroups were then related to clinical features and neurofunctional differences measured using fMRI during a fearful face-matching task. RESULTS: We found significant mean-group differences on each expression recognition test. However, cluster analyses showed that these were driven by a low-performing autistic subgroup (~ 30% of autistic individuals who performed below 2SDs of the neurotypical mean on at least one test), while a larger subgroup (~ 70%) performed within 1SD on at least 2 tests. The low-performing subgroup also had on average significantly more social communication difficulties and lower activation in the amygdala and fusiform gyrus than the high-performing subgroup. LIMITATIONS: Findings of autism expression recognition subgroups and their characteristics require independent replication. This is currently not possible, as there is no other existing dataset that includes all relevant measures. However, we demonstrated high internal robustness (91.6%) of findings between two clustering methods with fundamentally different assumptions, which is a critical pre-condition for independent replication. CONCLUSIONS: We identified a subgroup of autistic individuals with expression recognition difficulties and showed that this related to clinical and neurobiological characteristics. If replicated, expression recognition may serve as bio-behavioural stratification biomarker and aid in the development of targeted interventions for a subgroup of autistic individuals. En ligne : http://dx.doi.org/10.1186/s13229-022-00520-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491