1. Akabogu J, Nnamani A, Otu MS, Uloh-Bethels AC, Ukoha E, Iyekekpolor OM, Omile JC, Obiezu MN, Dike AE, Ike CV. {{Effects of a language education intervention on social participation among emerging adults with autism}}. {The Journal of international medical research}. 2019: 300060519839510.
OBJECTIVE: This study aimed to examine the effects of a language education intervention (LEI) on social participation among emerging adults with autism. METHODS: This randomized clinical trial involved 86 emerging adults who had low social participation, as assessed by the Social Participation Questionnaire. Participants completed an LEI comprising cognitive, adaptive and rational thinking training to improve their ability to take part in social events. Repeated measures analysis of variance was used to analyse the data. RESULTS: The results indicated a significant increase in social participation among emerging adults who were exposed to the LEI compared with their counterparts in a wait list control group. CONCLUSION: Language and speech institutions and hospitals should adopt the LEI procedures discussed in this research to help their autistic patients increase their participation in social activities.
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2. Benevides TW, Lee J, Nwosu NAO, Franks J. {{Correction to: Understanding the Family Impact of Autism Spectrum Disorder in a Racially and Ethnically Diverse Sample: Findings from the National Survey of Children with Special Health Care Needs}}. {Maternal and child health journal}. 2019.
The original version of this article unfortunately contained a mistake. The copyright permission below in Table 2 was inadvertently not published in the article.
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3. Bossu JL, Roux S. {{[The valproate model of autism]}}. {Medecine sciences : M/S}. 2019; 35(3): 236-43.
Autism is a neuro-developmental pathology affecting 1 out of 100 children worldwide. The trauma and social consequences induced by autism are a real public health issue. Clinically, autism is characterized primarily by communications and social interactions deficits associated with repetitive behaviors and restricted interests. The term of autism spectrum disorders (ASD) is used to account for the diversity of symptoms that characterize this pathology. Based on observations made in humans, a rodent (rats and mice) model of autism was obtained and validated by prenatal exposure to sodium valproate. Using this model, mechanisms that concern both the functioning of neural networks and the properties of neurons have been proposed to account for some disorders that characterize autism. This model is also widely used in pre-clinical studies to evaluate new therapies against ASD.
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4. Canigueral R, Hamilton AFC. {{The Role of Eye Gaze During Natural Social Interactions in Typical and Autistic People}}. {Front Psychol}. 2019; 10: 560.
Social interactions involve complex exchanges of a variety of social signals, such as gaze, facial expressions, speech and gestures. Focusing on the dual function of eye gaze, this review explores how the presence of an audience, communicative purpose and temporal dynamics of gaze allow interacting partners to achieve successful communication. First, we focus on how being watched modulates social cognition and behavior. We then show that the study of interpersonal gaze processing, particularly gaze temporal dynamics, can provide valuable understanding of social behavior in real interactions. We propose that the Interpersonal Gaze Processing model, which combines both sensing and signaling functions of eye gaze, provides a framework to make sense of gaze patterns in live interactions. Finally, we discuss how autistic individuals process the belief in being watched and interpersonal dynamics of gaze, and suggest that systematic manipulation of factors modulating gaze signaling can reveal which aspects of social eye gaze are challenging in autism.
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5. Deutsch SI, Burket JA, Urbano MR. {{Autism Spectrum disorders: Biological insights into these descriptively heterogeneous disorders and opportunities for pharmacotherapy}}. {Prog Neuropsychopharmacol Biol Psychiatry}. 2019.
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6. Dovgan K, Mazurek MO. {{Impact of multiple co-occurring emotional and behavioural conditions on children with autism and their families}}. {J Appl Res Intellect Disabil}. 2019.
BACKGROUND: Comorbid conditions are very common in children and adults with autism spectrum disorder (ASD) and can affect school performance, adaptive skills and peer relationships. Comorbid conditions place strain on the family as well as the individual with ASD. This project aimed to determine the affect of comorbid conditions over and above child and family characteristics. METHODS: The present authors examined 3,055 cases of children with ASD who had varying numbers of comorbid conditions (i.e., ADHD, depression, anxiety or behaviour problems). RESULTS: Multiple comorbid conditions did have a unique impact on difficulties accessing services. A greater number of comorbid conditions impacted daily activity participation, but not a family’s receipt of mental health care or respite, work changes or number of weekly hours dedicated to caring for a child with ASD. CONCLUSIONS: Families, practitioners, paraprofessionals and educators of children with autism should address comorbid conditions to ensure both child and family well-being.
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7. Flax J, Gwin C, Wilson S, Fradkin Y, Buyske S, Brzustowicz L. {{Social (Pragmatic) Communication Disorder: Another name for the Broad Autism Phenotype?}}. {Autism}. 2019: 1362361318822503.
The Diagnostic and Statistical Manual of Mental Disorders’ (5th ed.) Social (Pragmatic) Communication Disorder is meant to capture the social elements of communication dysfunction in children who do not meet autism spectrum disorder criteria. It is unclear whether Social (Pragmatic) Communication Disorder captures these elements without overlapping with Autism Spectrum Disorder or the Diagnostic and Statistical Manual of Mental Disorders’ (5th ed.) Language Disorder. Standardized behavioral assessments administered during a family genetics study were used to evaluate the social communication impairment and the restricted interests and repetitive behaviors in persons with autism spectrum disorder, language impairment, or neither. Social communication impairment and restricted interests and repetitive behavior were significantly correlated in all family members regardless of affection status. Rates of social communication impairment and restricted interests and repetitive behavior were highest in individuals with autism spectrum disorder. One-third of family members with language impairment presented with at least mild/moderate levels of social communication impairment (36.6%) and restricted interests and repetitive behavior (43.3%). A subset of unaffected members also presented with mild/moderate levels of social communication impairment (parents = 10.1%, siblings 11.6%) and restricted interests and repetitive behavior (parents = 14.0%, siblings = 22.1%). The majority of child family members with mild/moderate levels of social communication impairment had similar restricted interest and repetitive behavior levels reflecting criteria representing the Broad Autism Phenotype. These data suggest that social pragmatic communication disorder does not capture the profiles of children who have both social communication impairment and restricted interests and repetitive behavior but are in need of clinical services.
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8. Garcia-Molina I, Clemente-Estevan RA. {{Autism and Faux Pas. Influences of Presentation Modality and Working Memory}}. {The Spanish journal of psychology}. 2019; 22: E13.
People diagnosed with an autism spectrum disorder (ASD) often have difficulties on Theory of Mind (ToM) tasks involving social situations, such as ‘faux pas’. The objective of this study was to find the modality of presentation (visual, verbal, or mixed) that yields the best understanding of a ‘faux pas’, and the possible influence of other variables, including intelligence (IQ), age, and working memory. Thirty autistic children and 30 neurotypical children, all aged 7 to 12 years old and comparable in age and IQ, participated in this study. They were asked to resolve nine ‘faux pas’ stories (three per modality). Significant between-groups differences were found in the visual (t = 2.99, p = .004) and verbal modalities (t = 2.64, p = .011), such that the neurotypical (NT) group had higher scores than the ASD group. The ASD group’s comprehension was better via the mixed modality than the verbal modality (t = 2.48, p = .019). In addition, working memory had a bigger impact on Faux Pas understanding in cases of autism than in typical development (R2 explained between .19 and .28 of variance in Faux Pas test outcomes), and could therefore explain some of the difficulties previously reported in this area. Future research should include a measure of working memory and a control among the stimuli presented to test for group differences in faux pas understanding.
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9. Gavin J, Rees-Evans D, Brosnan M. {{Shy Geek, Likes Music, Technology, and Gaming: An Examination of Autistic Males’ Online Dating Profiles}}. {Cyberpsychology, behavior and social networking}. 2019.
Dating involves a range of complex social skills that autistic adults can often find challenging. Many autistic adults have turned to online dating, which in theory may ameliorate these social difficulties. The aim of this study was to explore, for the first time, how autistic males describe themselves in online dating profiles. The online dating profiles of 52 self-identified autistic males were analyzed using a combination of frequency and thematic analyses. A common pattern of self-description was identified, involving a combination of both desirable and undesirable characteristics. Themes included interests, negative descriptions of personality, ideal match, and autism. Findings are discussed in terms of desirability, the norms of online dating, and the benefits and costs of computer-mediated communication for autistic male online daters.
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10. Hau J, Aljawad S, Baggett N, Fishman I, Carper RA, Muller RA. {{The cingulum and cingulate U-fibers in children and adolescents with autism spectrum disorders}}. {Hum Brain Mapp}. 2019.
The cingulum is the major fiber system connecting the cingulate and surrounding medial cortex and medial temporal lobe internally and with other brain areas. It is important for social and emotional functions related to core symptomatology in autism spectrum disorders (ASDs). While the cingulum has been examined in autism, the extensive system of cingulate U-fibers has not been studied. Using probabilistic tractography, we investigated white matter fibers of the cingulate cortex by distinguishing its deep intra-cingulate bundle (cingulum proper) and short rostral anterior, caudal anterior, posterior, and isthmus cingulate U-fibers in 61 ASD and 54 typically developing children and adolescents. Increased mean and radial diffusivity of the left cingulum proper was observed in the ASD group, replicating previous findings on the cingulum. For cingulate U-fibers, an atypical age-related decline in right posterior cingulate U-fiber volume was found in the ASD group, which appeared to be driven by an abnormally large volume in younger children. History of repetitive and restrictive behavior was negatively associated with right caudal anterior cingulate U-fiber volume, linking cingulate motor areas with neighboring gyri. Aberrant development in U-fiber volume of the right posterior cingulate gyrus may underlie functional abnormalities found in this region, such as in the default mode network.
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11. Hauptman M, Stierman B, Woolf AD. {{Children With Autism Spectrum Disorder and Lead Poisoning: Diagnostic Challenges and Management Complexities}}. {Clinical pediatrics}. 2019: 9922819839237.
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12. Hisle-Gorman E, Landis CA, Susi A, Schvey NA, Gorman GH, Nylund CM, Klein DA. {{Gender Dysphoria in Children with Autism Spectrum Disorder}}. {LGBT health}. 2019.
PURPOSE: While gender dysphoria (GD) and autism spectrum disorder (ASD) are generally identified in isolation, research on individuals who are gender-referred or have autism suggests a possible overrepresentation of ASD in persons with GD and GD in persons with ASD. We investigated diagnosed GD in patients formally diagnosed with ASD and matched controls in the Military Health System. METHODS: We performed a retrospective case-cohort study of GD diagnoses in children aged 2-18 years with and without ASD utilizing health care records from 2000 to 2013. Cases were formally diagnosed with ASD and matched to five controls by date of birth, gender marker, and enrollment time. Outpatient visits for GD were identified by relevant International Classification of Diseases, Ninth Revision codes. Logistic regression analysis determined odds ratios (ORs) and 95% confidence intervals (95% CIs) of GD diagnoses by ASD. RESULTS: A total of 48,762 children with diagnosed ASD were identified, and each matched to five controls, for a total of 292,572 children. Cases and controls were each 80% assigned male at birth. The median end age of included children was 11.6 years. Of included children, 66 (0.02%) had diagnosed GD. Children with ASD were over four times as likely to be diagnosed with a condition indicating GD (OR 4.38 [95% CI 2.64-7.27], p < 0.001) compared with matched controls. CONCLUSION: This study corroborates previous research indicating an overrepresentation of GD in children with ASD. Further research is needed to understand the association and to demonstrate approaches to providing optimal care to these children. Lien vers le texte intégral (Open Access ou abonnement)
13. Kato Y, Kagitani-Shimono K, Matsuzaki J, Hanaie R, Yamamoto T, Tominaga K, Watanabe Y, Mohri I, Taniike M. {{White Matter Tract-Cognitive Relationships in Children with High-Functioning Autism Spectrum Disorder}}. {Psychiatry investigation}. 2019; 16(3): 220-33.
OBJECTIVE: The purpose of the present study was to clarify the relationship between white matter tracts and cognitive symptoms in children with high-functioning autism spectrum disorder (ASD). METHODS: We examined the cognitive functions of 17 children with high-functioning ASD and 18 typically developing (TD) controls and performed diffusion tensor imaging (DTI) tractography. We compared the results between the groups and investigated the correlations between the cognitive scores and DTI parameters within each group. RESULTS: The Comprehension scores in the ASD group exhibited a positive correlation with mean diffusivity (MD) in the forceps minor (F minor). In the TD group, the Comprehension scores were positively correlated with fractional anisotropy (FA) in the right inferior fronto-occipital fasciculus (IFO) and left anterior thalamic radiation (ATR), and negatively correlated with MD in the left ATR, radial diffusivity (RD) in the right IFO, and RD in the left ATR. Additionally, a positive correlation was observed between the Matching Numbers scores and MD in the left uncinate fasciculus and F minor, and RD in the F minor. Furthermore, the Sentence Questions scores exhibited a positive correlation with RD in the right inferior longitudinal fasciculus. Relative to TD controls, the specific tract showing a strong correlation with the cognitive scores was reduced in the ASD group. CONCLUSION: Our findings indicate that white matter tracts connecting specific brain areas may exhibit a weaker relationship with cognitive functions in children with ASD, resulting in less efficient cognitive pathways than those observed in TD children.
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14. Levman J, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda A, Takahashi E. {{Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults}}. {Front Hum Neurosci}. 2019; 13: 75.
Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988 control subjects (aged 0-32 years), and extracted regionally distributed cortical thickness measurements, including average measurements as well as standard deviations which supports the assessment of intra-regional cortical thickness variability. The youngest autistic participants (<2.5 years) were diagnosed after imaging and were identified retrospectively. The largest effect sizes and the most common findings not previously published in the scientific literature involve abnormal intra-regional variability in cortical thickness affecting many (but not all) regions of the autistic brain, suggesting irregular gray matter development in autism that can be detected with MRI. Atypical developmental patterns have been detected as early as 0 years old in individuals who would later be diagnosed with autism. Lien vers le texte intégral (Open Access ou abonnement)
15. Lora CC, Kisamore AN, Reeve KF, Townsend DB. {{Effects of a problem-solving strategy on the independent completion of vocational tasks by adolescents with autism spectrum disorder}}. {Journal of applied behavior analysis}. 2019.
Individuals with autism spectrum disorder (ASD) often have few employment opportunities and a lower job quality than individuals of typical development. Social deficits and lack of independence may contribute to underemployment and unemployment of individuals with ASD. The ability to solve problems might ameliorate some of these barriers. We taught four adolescents with ASD a problem-solving strategy (i.e., use of a textual activity schedule) to assist with independent completion of vocational tasks in the face of three types of problems (e.g., missing or broken items) and nonproblem situations. Following introduction of the problem-solving strategy, all four participants independently completed the tasks when a problem was presented and responding generalized to untaught vocational tasks.
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16. Millward C, Ferriter M, Calver SJ, Connell-Jones GG. {{WITHDRAWN: Gluten- and casein-free diets for autistic spectrum disorder}}. {Cochrane Database Syst Rev}. 2019; 4: Cd003498.
BACKGROUND: It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid of people with autism. OBJECTIVES: To determine the efficacy of gluten and/or casein free diets as an intervention to improve behaviour, cognitive and social functioning in individuals with autism. SEARCH METHODS: The following electronic databases were searched: CENTRAL(The Cochrane Library Issue 2, 2007), MEDLINE (1966 to April 2007), PsycINFO (1971 to April 2007), EMBASE (1974 to April 2007), CINAHL (1982 to April 2007), ERIC (1965 to 2007), LILACS (1982 to April 2007), and the National Research register 2007 (Issue1). Review bibliographies were also examined to identify potential trials. SELECTION CRITERIA: All randomised controlled trials (RCT) involving programmes which eliminated gluten, casein or both gluten and casein from the diets of individuals diagnosed with an autistic spectrum disorder. DATA COLLECTION AND ANALYSIS: Abstracts of studies identified in searches of electronic databases were assessed to determine inclusion by two independent authors The included trials did not share common outcome measures and therefore no meta-analysis was possible. Data are presented in narrative form. MAIN RESULTS: Two small RCTs were identified (n = 35). No meta-analysis was possible. There were only three significant treatment effects in favour of the diet intervention: overall autistic traits, mean difference (MD) = -5.60 (95% CI -9.02 to -2.18), z = 3.21, p=0.001 (Knivsberg 2002) ; social isolation, MD = -3.20 (95% CI -5.20 to 1.20), z = 3.14, p = 0.002) and overall ability to communicate and interact, MD = 1.70 (95% CI 0.50 to 2.90), z = 2.77, p = 0.006) (Knivsberg 2003). In addition three outcomes showed no significant difference between the treatment and control group and we were unable to calculate mean differences for ten outcomes because the data were skewed. No outcomes were reported for disbenefits including harms. AUTHORS’ CONCLUSIONS: Research has shown of high rates of use of complementary and alternative therapies (CAM) for children with autism including gluten and/or casein exclusion diets. Current evidence for efficacy of these diets is poor. Large scale, good quality randomised controlled trials are needed.
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17. Novakovic N, Milovancevic MP, Dejanovic SD, Aleksic B. {{Effects of Snoezelen-Multisensory environment on CARS scale in adolescents and adults with autism spectrum disorder}}. {Res Dev Disabil}. 2019; 89: 51-8.
BACKGROUND: New classification system Diagnostic and statistical manual of mental disorders. 5th ed.(DSM – 5) includes sensory problems as one of the symptoms in diagnostic profile of Autism Spectrum Disorder (ASD). Researching the effects of sensory integration treatment may improve new approaches to the individuals with ASD. The objective of this study is to determine the effects of Snoezelen, multisensory environment on the severity of ASD and stereotyped/repetitive behaviours in adolescents and adults using CARS scale. METHOD: The study involved 40 subjects with ASD associated with intellectual difficulties of both sexes, aged 15-35. The subjects were randomly divided into two groups: a control one (without treatment) and an experimental one (with treatment). The assessments were rated by CARS (Childhood Autism Rating Scale) before and after the three-month treatment. RESULTS: In the experimental group, there was a statistically significant difference of the total CARS score before and after the treatment (p < 0.0005). Comparing the results of both experimental and control groups, a statistically significant difference was found on total CARS score (p < 0.0005). Conslusion: The results in the present study indicate that the continual sessions in Snoezelen room had effects on reducing severity of ASD and repetitive and stereotyped behaviours on CARS scale. Lien vers le texte intégral (Open Access ou abonnement)
18. Rahbar MH, Samms-Vaughan M, Lee M, Christian MA, Bressler J, Hessabi M, Grove ML, Shakespeare-Pellington S, Desai CC, Reece JA, Loveland KA, Beecher C, McLaughlin W, Boerwinkle E. {{Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium}}. {Res Autism Spectr Disord}. 2018; 55: 50-63.
Background: We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children. In this paper, we investigate the same interactive association with ASD while adjusting for the mixture of four metals (lead, mercury, cadmium, and arsenic). Method: We used data from 163 case-control pairs of children 2-8 years of age from our autism project in Jamaica, in which we collected blood for heavy metals analysis at enrollment. To minimize potential multicollinearity between concentrations of the four metals, we generated a mixture index using generalized weighted quantile sum regression, which was used in conditional logistic regression models to control for the four metals while assessing the interactive association between GSTP1 and BMC with ASD. Results: Similar to the findings we reported previously, we found that in co-dominant and dominant models for GSTP1, among children with the Ile/Ile genotype, those with BMC > 12mug/L had 4.6 and 4.27 times higher odds of ASD compared to those with BMC < 12mug/L (adjusted Matched Odds Ratio (MOR) = 4.6, 95% CI: 1.21 - 17.42 and adjusted MOR = 4.27, 95% CI: 1.15 - 15.85, respectively). In the co-dominant model, for children with the Ile/Val and Val/Val genotypes, the adjusted MORs were 1.26 (95% CI: 0.32, 5.01) and 0.26 (95% CI: 0.05, 1.42), respectively. Conclusions: After adjusting for the mixture of four metals, the interactive association of BMC and GSTP1 with ASD remained significant with similar magnitude of associations. Results should be interpreted cautiously. Lien vers le texte intégral (Open Access ou abonnement)
19. Rim SJ, Park S, Lee Y, Kim CE. {{Mental Health Literacy of Autism Spectrum Disorder in Korea: Recognition, Etiology, Treatment}}. {Psychiatry investigation}. 2019; 16(3): 213-9.
OBJECTIVE: The objective of this study was to investigate the Korean public’s recognition of autism spectrum disorder (ASD), revealing underlying factors regarding perception relative to etiology and treatment of ASD, and examining variables related to those factors. METHODS: An online survey was held to investigate mental health literacy (MHL) on ASD of the general public in Korea. A total of 673 adults participated and completed questionnaires on socio-demographic characteristics and if they know someone with ASD. Next, participants were provided with a vignette describing a child with ASD. Only those that recognized there was a problem with the child moved to the next part which asked their perception regarding etiology and treatment of ASD. RESULTS: According to our study, approximately 25% of participants correctly recognized the child in the vignette as having ASD. Perception regarding etiology and treatment of ASD varied among socio-demographic characteristics. Participants acquainted with someone with ASD and correctly recognized ASD held mixed perception regarding cause and treatment. CONCLUSION: This study investigated MHL of ASD in Korea. The result reveals there is much room for improvement relative to raising awareness on MHL of ASD. Intervention considering socio-demographic characteristics and acquaintance with ASD are needed.
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20. Serati M, Delvecchio G, Orsenigo G, Mandolini GM, Lazzaretti M, Scola E, Triulzi F, Brambilla P. {{The Role of the Subplate in Schizophrenia and Autism: A Systematic Review}}. {Neuroscience}. 2019.
The subplate (SP) represents a transitory cytoarchitectural fetal compartment containing most subcortical and cortico-cortical afferents, and has a fundamental role in the structural development of the healthy adult brain. There is evidence that schizophrenia and autism may be determined by developmental defects in the cortex or cortical circuitry during the earliest stages of pregnancy. This article provides an overview on fetal SP development, considering its role in schizophrenia and autism, as supported by a systematic review of the main databases. The SP has been described as a cortical amplifier with a role in the coordination of cortical activity, and sensitive growth and migration windows have crucial consequences with respect to cognitive functioning. Although there are not enough studies to draw final conclusions, improved knowledge of the SP’s role in schizophrenia and autism spectrum disorders may help to elucidate and possibly prevent the onset of these two severe disorders.
