Pubmed du 03/01/22
1. Camuso S, La Rosa P, Fiorenza MT, Canterini S. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022; 163: 105606.
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the mammalian brain, essential not only to the development of the central nervous system but also to synaptic plasticity. BDNF is present in various brain areas, but highest levels of expression are seen in the cerebellum and hippocampus. After birth, BDNF acts in the cerebellum as a mitogenic and chemotactic factor, stimulating the cerebellar granule cell precursors to proliferate, migrate and maturate, while in the hippocampus BDNF plays a fundamental role in synaptic transmission and plasticity, representing a key regulator for the long-term potentiation, learning and memory. Furthermore, the expression of BDNF is highly regulated and changes of its expression are associated with both physiological and pathological conditions. The purpose of this review is to provide an overview of the current state of knowledge on the BDNF biology and its neurotrophic role in the proper development and functioning of neurons and synapses in two important brain areas of postnatal neurogenesis, the cerebellum and hippocampus. Dysregulation of BDNF expression and signaling, resulting in alterations in neuronal maturation and plasticity in both systems, is a common hallmark of several neurodevelopmental diseases, such as autism spectrum disorder, suggesting that neuronal malfunction present in these disorders is the result of excessive or reduced of BDNF support. We believe that the more the relevance of the pathophysiological actions of BDNF, and its downstream signals, in early postnatal development will be highlighted, the more likely it is that new neuroprotective therapeutic strategies will be identified in the treatment of various neurodevelopmental disorders.
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2. Yeung MK. A systematic review and meta-analysis of facial emotion recognition in autism spectrum disorder: The specificity of deficits and the role of task characteristics. Neuroscience and biobehavioral reviews. 2022; 133: 104518.
This review assessed the specificity of facial emotion recognition impairment and the role of task characteristics in facial emotion recognition in autism spectrum disorder (ASD). Based on subsets of 148 studies identified in PubMed and PsycINFO, random-effects meta-analyses showed significant impairment in recognizing all basic facial emotions in ASD. Additionally, ASD involves poorer facial emotion recognition than other clinical conditions and has similar impairment in recognizing emotional and nonemotional facial attributes, as well as in recognizing emotion in faces and other modalities. Furthermore, there are significant moderating effects for emotion complexity and holistic processing, a statistical trend for task type, and no significant effect for motion, social relevance, or stimulus salience on facial emotion recognition in ASD. Altogether, this review suggests nonselective facial emotion recognition impairment in ASD. Such impairment is relatively specific to ASD but is not specific to the recognition of emotional facial attributes or emotion recognition in the face modality. Identifying the role of task characteristics improves our understanding of the mechanisms underlying facial emotion recognition in ASD.
