1. Boucher J. {{Putting theory of mind in its place: psychological explanations of the socio-emotional-communicative impairments in autistic spectrum disorder}}. {Autism};2012 (Feb 1)
In this review, the history of the theory of mind (ToM) theory of autistic spectrum disorder (ASD) is outlined (in which ToM is indexed by success on false belief tasks), and the explanatory power and psychological causes of impaired ToM in ASD are critically discussed. It is concluded that impaired ToM by itself has only limited explanatory power, but that explorations of the psychological precursors of impaired ToM have been fruitful in increasing understanding of mindreading impairments in ASD (where ‘mindreading’ refers those abilities that underlie triadic interaction as well as ToM). It is argued that early explanations of impaired mindreading are untenable for various reasons, but that impairments of dyadic interaction in ASD that could lead to impaired ability to represent others’ mental states may be the critical psychological cause, or causes, of impaired ToM. The complexity of causal routes to impaired ToM is emphasized.
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2. Danesh AA, Kaf WA. {{DPOAEs and contralateral acoustic stimulation and their link to sound hypersensitivity in children with autism}}. {Int J Audiol};2012 (Feb 3)
Objective: The hypersensitivity of children with autism to sound is a relatively unexplained behavior. The goal of the current study was to investigate the DPOAE characteristics of children with autism compared to a control group. Design: DPOAEs with and without contralateral stimuli were measured in two groups in three different conditions. Study sample: The study employed 14 children with autism and a control group with 28 age-matched participants. Results: In the without-contralateral stimulus condition, the overall S/N of DPOAEs was greater for the control group compared to the autism group (p < 0.0005). For both groups, the DPOAE S/N increased as a function of frequency in both ears. In the with contralateral stimulus condition, group and ear effects were noticed, however, no age, frequency, or contralateral stimulus type (BBN vs. 1000 Hz) effect could be detected. Conclusions: Presence of reduced DPOAEs in the autism group does not support the hypothesis that sound hypersensitivity in children with autism may be related to overactive outer hair cells function; rather it may be due to early cochlear dysfunction. Also, sound hypersensitivity in the autism group may be due to abnormality of the efferent auditory pathway as shown by lack of sufficient contralateral suppression.
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3. Danial-Saad A, Tamar Weiss PL, Schreuer N. {{Assessment of computer task performance (ACTP) of children and youth with intellectual and developmental disability}}. {Disabil Rehabil Assist Technol};2012 (Feb 3)
The aims of this study were to assess the reliability and validity of the Arabic translation of the Assessment of Computer Task Performance (ACTP) when used for children with Intellectual and Developmental Disabilities (IDD) and to determine the relationship between participants’ performance when using an adapted pointing device and the teacher’s satisfaction of their performance. Thirty boys and girls, Arabic speakers, 6- 21 years old, who had moderate IDD, participated in the study. Two expert occupational therapists used the ACTP to evaluate the performance of five standardized timed computer tasks. The Quebec User Evaluation of Satisfaction with Assistive Technology was used to evaluate the teachers’ satisfaction with the prescribed pointing device. The sample in the current study performed slower than typically developing children and youth, and slower than participants with motor impairments, examined in previous studies. Differences were found in performance time between girls and boys, and between three diagnostic subgroups. The participants’ success scores of computer performance correlated significantly with the teacher’s satisfaction with the prescribed pointing device. Demonstration of the validity and reliability of the Arabic version of the ACTP-Child enables wider use of this tool which is now available in four languages and diverse cultural settings and disability populations, including children and youth with significant IDD. [Box: see text].
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4. Goodman SJ, Glenwick DS. {{Correlates of Attachment Perceptions in Parents of Children with Autism Spectrum Disorders}}. {J Autism Dev Disord};2012 (Feb 2)
This study explored the relationship between parents’ perceptions of their child’s attachment to them and parents’ own affective attachment to their child, as well the relationship of these constructs to parenting stress, parent-rated child functional impairment, and parenting sense of competence. Mothers (n = 76) and fathers (n = 30) of children ages 2-10 with autism spectrum disorders participated. Overall, parents’ affective attachment to their child was more consistently related to other aspects of their parenting experiences than were their perceptions of their child’s attachment to them. Also, perceptions of child-to-parent attachment were related to other aspects of parenting for fathers more than for mothers. Implications for parenting interventions and future research, such as longitudinal investigations, are discussed.
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5. Heyer NJ, Echeverria D, Woods JS. {{Disordered Porphyrin Metabolism: A Potential Biological Marker for Autism Risk Assessment}}. {Autism Res};2012 (Feb 1)
Autism (AUT) is a complex neurodevelopmental disorder that, together with Asperger’s syndrome and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS), comprises the expanded classification of autistic spectrum disorder (ASD). The heterogeneity of ASD underlies the need to identify biomarkers or clinical features that can be employed to identify meaningful subtypes of ASD, define specific etiologies, and inform intervention and treatment options. Previous studies have shown that disordered porphyrin metabolism, manifested principally as significantly elevated urinary concentrations of pentacarboxyl (penta) and coproporphyrins, is commonly observed among some children with ASD. Here, we extend these observations by specifically evaluating penta and coproporphyrins as biological indicators of ASD among 76 male children comprising 30 with validated AUT, 14 with PDD-NOS, and 32 neurotypical (NT) controls. ASD children (AUT and PDD-NOS) had higher mean urinary penta (P < 0.006) and copro (P < 0.006) concentrations compared with same-aged NT children, each characterized by a number of extreme values. Using Receiver Operating Characteristic curve analysis, we evaluated the sensitivity and specificity of penta, copro, and their combined Z-scores in ASD detection. The penta sensitivity was 30% for AUT and 36% for PDD-NOS, with 94% specificity. The copro sensitivity was 33% and 14%, respectively, with 94% specificity. The combined Z-score measure had 33% and 21% sensitivity for AUT and PDD-NOS, respectively, with 100% specificity. These findings demonstrate that porphyrin measures are strong predictors of both AUT and PDD-NOS, and support the potential clinical utility of urinary porphyrin measures for identifying a subgroup of ASD subjects in whom disordered porphyrin metabolism may be a salient characteristic. Autism Res 2012,**: **-**. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
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6. Hume K, Plavnick J, Odom SL. {{Promoting Task Accuracy and Independence in Students with Autism Across Educational Setting Through the Use of Individual Work Systems}}. {J Autism Dev Disord};2012 (Feb 3)
Strategies that promote the independent demonstration of skills across educational settings are critical for improving the accessibility of general education settings for students with ASD. This research assessed the impact of an individual work system on the accuracy of task completion and level of adult prompting across educational setting. Student accuracy and adult prompting were measured in both special and general education settings during academic work periods. Work systems, an element of structured teaching developed by Division TEACCH, are organized sets of visual information that inform a student about participation in work areas. A multiple-probe-across-participants design was used to evaluate the effects of the individual work systems. All participants demonstrated increased accuracy yet required less adult support across special and general education settings. Results were maintained when measured during a 1-month follow-up probe.
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7. Lai G, Pantazatos SP, Schneider H, Hirsch J. {{Neural systems for speech and song in autism}}. {Brain};2012 (Feb 1)
Despite language disabilities in autism, music abilities are frequently preserved. Paradoxically, brain regions associated with these functions typically overlap, enabling investigation of neural organization supporting speech and song in autism. Neural systems sensitive to speech and song were compared in low-functioning autistic and age-matched control children using passive auditory stimulation during functional magnetic resonance and diffusion tensor imaging. Activation in left inferior frontal gyrus was reduced in autistic children relative to controls during speech stimulation, but was greater than controls during song stimulation. Functional connectivity for song relative to speech was also increased between left inferior frontal gyrus and superior temporal gyrus in autism, and large-scale connectivity showed increased frontal-posterior connections. Although fractional anisotropy of the left arcuate fasciculus was decreased in autistic children relative to controls, structural terminations of the arcuate fasciculus in inferior frontal gyrus were indistinguishable between autistic and control groups. Fractional anisotropy correlated with activity in left inferior frontal gyrus for both speech and song conditions. Together, these findings indicate that in autism, functional systems that process speech and song were more effectively engaged for song than for speech and projections of structural pathways associated with these functions were not distinguishable from controls.
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8. Lo SY. {{Diagnosis, Treatment and Prevention of Autism via Meridian Theory}}. {Am J Chin Med};2012;40(1):39-56.
A twelve-week pilot study was conducted on 11 male children, aged five to 19 years, who had ASD (autistic symptom disorder) of varying degrees of severity. These eleven subjects were each examined three times in the 12-week period: at the first week, 6th week, and 12th week. During each examination, two sets of full-body thermographs were taken of each child, before and fifteen minutes after drinking a solution of stable water clusters with a double helix configuration. This solution of stable water clusters is called double helix water (DHW). In the before thermographs, a consistent thermal pattern of six hot regions of body surface temperature were identified. They are: left and right upper forehead region of the face; left and right area in front of the center of the ear; left and right area of the inner extreme point of the eye; left and right collarbone region; left and right side neck region; and left and right armpit region. These areas may be interpreted as regions surrounding various acupoints along the GB, BL, ST, SI, SJ meridians. These meridians are yang meridians that on one end reach the head, and hence have branches reaching into the brain, and on the other end reach to the gastrointestinal tract and urinary bladder system. Thus, they can be considered to explain the major clinical symptoms of ASD. These thermal patterns, if confirmed in a larger clinical study, may lead to a new way to diagnose ASD, and to test the effectiveness of any treatment. When such a thermal pattern is discovered early, say around the age of 18 months, preventive action can be initiated before observation of any behavior disorder. We simultaneously studied the healing effect of stable water clusters with double helix configuration (DHW) on these subjects. The quantitative reduction of maximum temperature at these six regions was calculated. A consistent reduction was noted and suggests a positive healing effect taking place within a very short time period (fifteen minutes), and lasting over a long time period (12 weeks). Quantitative evaluation by the parents over the 12-week period showed that eight out of 11 children had physiological and behavioral improvement. Our findings with these small numbers suggest a reliable method of early diagnosis/detection and also an effective treatment of ASD. We therefore conclude that a study of larger numbers of children with ASD should be conducted.
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9. Ozsivadjian A, Knott F, Magiati I. {{Parent and Child Perspectives on the Nature of Anxiety in Children and Young People With Autism Spectrum Disorders: a Focus Group Study}}. {Autism};2012 (Feb 1)
Anxiety disorders are common among children and young people with autism spectrum disorders (ASD). Despite growing knowledge about the prevalence, phenomenology and treatment of anxiety disorders, relatively little is understood about the nature and impact of anxiety in this group and little is known about autism-specific factors that may have a role in the increased prevalence of anxiety disorders. In this exploratory study, we report on a series of five focus groups with 17 parents of children and adolescents with ASD and anxiety. Across groups, parents gave strikingly similar descriptions of the triggers and behavioural signs associated with anxiety. Another consistent finding was that many parents reported that their children had great difficulty expressing their worries verbally and most showed their anxiety through changes in their behaviour. The impact of anxiety was reported to often be more substantial than the impact of ASD itself. The implications of the focus group findings are discussed in relation to existing literature.
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10. Peterson CC, Wellman HM, Slaughter V. {{The Mind Behind the Message: Advancing Theory-of-Mind Scales for Typically Developing Children, and Those With Deafness, Autism, or Asperger Syndrome}}. {Child Dev};2012 (Feb 3)
Children aged 3-12 years (n = 184) with typical development, deafness, autism, or Asperger syndrome took a series of theory-of-mind (ToM) tasks to confirm and extend previous developmental scaling evidence. A new sarcasm task, in the format of H. M. Wellman and D. Liu’s (2004) 5-step ToM Scale, added a statistically reliable 6th step to the scale for all diagnostic groups. A key previous finding, divergence in task sequencing for children with autism, was confirmed. Comparisons among diagnostic groups, controlling age, and language ability, showed that typical developers mastered the 6 ToM steps ahead of each of the 3 disabled groups, with implications for ToM theories. The final (sarcasm) task challenged even nondisabled 9-year-olds, demonstrating the new scale’s sensitivity to post-preschool ToM growth.
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11. Qurashi A, Liu H, Ray L, Nelson DL, Duan R, Jin P. {{Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila}}. {Hum Mol Genet};2012 (Feb 1)
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder recognized in fragile X premutation carriers. Using Drosophila, we previously identified elongated noncoding CGG repeats in FMR1 allele as the pathogenic cause of FXTAS. Here we use this same FXTAS Drosophila model to conduct a chemical screen that reveals small molecules that can ameliorate the toxic effects of fragile X premutation rCGG repeats, among them several known phospholipase A(2) (PLA(2)) inhibitors. We show that specific inhibition of PLA(2) activity could mitigate the neuronal deficits caused by fragile X premutation rCGG repeats, including lethality and locomotion deficits. Furthermore, through a genetic screen, we identified a PLA(2) Drosophila ortholog that specifically modulates rCGG-repeat-mediated neuronal toxicity. Our results demonstrate the utility of Drosophila models for unbiased small molecule screens and point to PLA(2) as a possible therapeutic target to treat FXTAS.
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12. Samadi SA, McConkey R, Kelly G. {{Enhancing parental well-being and coping through a family-centred short course for Iranian parents of children with an autism spectrum disorder}}. {Autism};2012 (Feb 1)
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13. Sasaki R, Uchiyama H, Okamoto T, Fukada K, Ogiuchi H, Ando T. {{A toothbrush impalement injury of the floor of mouth in autism child}}. {Dent Traumatol};2012 (Feb 2)
Abstract – Penetrating injuries in the oral cavity are common in children. However, penetrating injuries with retained foreign bodies are rare. We report a case of a toothbrush impalement injury of the floor of the mouth in a child with autism. A 5-year-old boy with autism presented with an accidentally impaled toothbrush in the oral cavity. He was taken to the operation room and examined under general anesthesia. The handle of the toothbrush was cut off using rib scissors for mask ventilation, and intra-oral intubation was performed. The toothbrush was located approximately 2.5 cm into the floor of the mouth. The toothbrush was removed uneventfully. Intravenous antibiotic therapy was instituted during hospitalization, and discharge from the hospital occurred 4 days after the operation.
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14. Taylor LJ, Maybery MT, Whitehouse AJ. {{Do Children with Specific Language Impairment have a Cognitive Profile Reminiscent of Autism? A Review of the Literature}}. {J Autism Dev Disord};2012 (Feb 2)
There is debate regarding the relationship between autism and specific language impairment (SLI), with some researchers proposing aetiological overlap between the conditions and others maintaining their aetiological distinction. Although considerable research has investigated the language phenotypes of these disorders, the relationship between the cognitive phenotypes has been left relatively unexplored. This paper reviews relevant literature on whether individuals with SLI exhibit cognitive characteristics reminiscent of autism. Overall, findings are inconsistent and there is a lack of substantive evidence supporting overlapping cognitive phenotypes in autism and SLI. Better powered and more rigorous experimental designs, as well as studies directly comparing the cognitive phenotype of children with SLI and those with autism will further elucidate the aetiological relationship between these two conditions.
