Pubmed du 06/08/10

Pubmed du jour

2010-08-06 12:03:50

1. Charnsil C. {{Efficacy of Atomoxetine in Children With Severe Autistic Disorders and Symptoms of ADHD: An Open-Label Study}}. {J Atten Disord} (Aug 4)

2. Lichtenstein P, Carlstrom E, Rastam M, Gillberg C, Anckarsater H. {{The Genetics of Autism Spectrum Disorders and Related Neuropsychiatric Disorders in Childhood}}. {Am J Psychiatry} (Aug 4)

3. Smith KR, Matson JL. {{Social skills: Differences among adults with intellectual disabilities, co-morbid autism spectrum disorders and epilepsy}}. {Res Dev Disabil} (Aug 6)

Assessing social skills is one of the most complex and challenging areas to study because behavioral repertoires vary depending on an individual’s culture and context. However, researchers have conclusively demonstrated that individuals with intellectual disabilities (ID) have impaired social skills as well as those with co-morbid autism spectrum disorders (ASD) and epilepsy. However, it is unknown how these groups differ. Assessment of social skills was made with the Matson Evaluation of Social Skills for Individuals with Severe Retardation. One hundred participants with ID were matched and compared across four equal groups comprising 25 participants with ID, 25 participants with epilepsy, 25 participants with ASD, and 25 participants with combined ASD and epilepsy. When controlling for age, gender, race, level of ID, and hearing and visual impairments, significant differences were found among the four groups on the MESSIER, Wilks’s Lambda=.58, F(18, 257)=3.05, p<.01. The multivariate eta(2) based on Wilks’s Lambda was .17. Significant differences were found on the Positive Verbal subscale, F(3, 96)=3.70, p<.01, eta(2)=.10, Positive Non-verbal subscale, F(3, 96)=8.95, p<.01, eta(2)=.22, General Positive subscale, F(3, 96)=7.30, p<.01, eta(2)=.19, Negative Non-verbal subscale, F(3, 96)=5.30, p<.01, eta(2)=.14, and General Negative subscale, F(3, 96)=3.16, p<.05, eta(2)=.09. Based on these results, individuals with ID expressing combined co-morbid ASD and epilepsy had significantly more impaired social skills than the ID only or groups containing only a single co-morbid factor with ID (ASD or epilepsy only). Implications of these findings are discussed.

4. Williams K, Wheeler DM, Silove N, Hazell P. {{Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)}}. {Cochrane Database Syst Rev};8:CD004677.