1. Burns CO, Matson JL. {{An evaluation of the clinical application of the DSM-5 for the diagnosis of autism spectrum disorder}}. {Expert Rev Neurother};2017 (Jul 10):1-9.
INTRODUCTION: The changes to the diagnostic criteria for autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) were met with much controversy by researchers, clinicians, and families of individuals with ASD. The goal of this paper is to review the literature on the impact of these changes. Areas covered: This paper reviews the major changes to diagnostic criteria from DSM-IV-TR to DSM-5. It emphasizes how these changes are hypothesized to impact prevalence rates, as well as trends in characteristics of individuals who would have met previous criteria for ASD but no longer qualify for a diagnosis under DSM-5. Policy issues such as access to services and research considerations are also briefly reviewed. Expert commentary: Researchers have found that the DSM-5 diagnostic criteria for ASD may significantly impact which children receive diagnoses, which in turn affects access to services that address impairments characteristic of this disorder. Despite the fact that the DSM-5 has now been in use for four years, fewer recent studies were identified than was expected. Future research should continue to focus on the impact of changes in criteria, as well as on translational scientific advances across disciplines.
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2. DeGuzman PB, Altrui P, Allen M, Deagle CR, Keim-Malpass J. {{Mapping Geospatial Gaps in Early Identification of Children With Autism Spectrum Disorder}}. {J Pediatr Health Care};2017 (Jul 06)
Despite the known developmental benefits of early intervention for autism spectrum disorder (ASD), diagnosis before age 5 years is often not achieved. Research suggests that lack of health insurance and living in rural areas and areas of severe provider shortages contribute significantly to these delays. The purpose of this project was to conduct a geospatial evaluation of potential gaps in early ASD diagnosis of uninsured children in Virginia. A secondary purpose was to show the use of geospatial analysis by pediatric nurse practitioners for policy advocacy. We mapped data from a statewide provider of ASD evaluative services associated with the Virginia Department of Health and found several communities with high numbers of uninsured children where children may not be receiving early diagnostic services. Pediatric nurse practitioners can help address community-level gaps in early identification of ASD for uninsured young children living in rural areas by conducting outreach programs to providers and families within rural communities and concurrently partnering with nurse-scientists to develop visually impactful geospatial analyses to educate legislators and further advocate for policy positions.
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3. Esler AN, Hall-Lande J, Hewitt A. {{Phenotypic Characteristics of Autism Spectrum Disorder in a Diverse Sample of Somali and Other Children}}. {J Autism Dev Disord};2017 (Jul 08)
The potential for culture to impact diagnosis of autism spectrum disorder (ASD) is high, yet remains largely unstudied. This study examined differences across racial/ethnic groups in ASD symptoms, cognitive and adaptive skills, and related behaviors in children with ASD that included a unique subgroup, children from the Somali diaspora. Somali children were more likely to have ASD with intellectual disability than children from all other racial/ethnic groups. Few differences were found in the presence of specific symptoms and behaviors across groups once IQ was controlled. Results lend support to previous studies that found higher rates of ASD intellectual disability in children of immigrants from low human resource index countries compared to other groups. Implications for future research are discussed.
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4. Hancock GIP, Stokes MA, Mesibov GB. {{Socio-sexual functioning in autism spectrum disorder: A systematic review and meta-analyses of existing literature}}. {Autism Res};2017 (Jul 10)
Socio-sexual functioning encompasses an individual’s interests, behaviors, and knowledge with respect to sexual, romantic, and social aspects of life. An individual’s understanding of these domains is developed through a range of informal and formal avenues of sexual health education. The current model demonstrated this and proposed that, compared to typically developing individuals, those with ASD develop socio-sexual functioning differently due to having less peer engagement, less relationship experience, more parental guidance, greater use of online materials, receive less school-based sexual health education, and more support from wellbeing services. Systematic review and meta-analysis of existing literature revealed that individuals with ASD have greater difficultly adhering to privacy norms, engage in less social behavior, are described as engaging in less appropriate sexual behavior, have greater concerns about themselves, and receive less sexual health education. Having fewer opportunities for appropriate informal and formal sexual health education leaves them at a double disadvantage from others who are receiving this information from both of these avenues. Some of the current meta-analytic results are cautioned by large l-square statistics which suggest that a degree of variance is being caused by extraneous factors. Further empirical research in this area is needed to overcome current design and sample limitations. Finally, the Sexual Behavior Scale was the most commonly utilized tool in the meta-analyzed studies, thus comprehensive evaluation of its functioning is warranted. The importance of work in this area is highlighted by the central role of social and sexual wellbeing on one’s quality of life. Autism Res 2017. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc.
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5. Herrington JD, Maddox BB, Kerns CM, Rump K, Worley JA, Bush JC, McVey AJ, Schultz RT, Miller JS. {{Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety}}. {J Autism Dev Disord};2017 (Jul 08)
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.
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6. Li Y, Fang H, Zheng W, Qian L, Xiao Y, Wu Q, Chang C, Xiao C, Chu K, Ke X. {{A Fiber Tractography Study of Social-Emotional Related Fiber Tracts in Children and Adolescents with Autism Spectrum Disorder}}. {Neurosci Bull};2017 (Jul 10)
The symptoms of autism spectrum disorder (ASD) have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the « disconnectivity » hypothesis has been used to explain characteristic impairments in « socio-emotional » function. Therefore, in this study we compared the facial emotional recognition (FER) feature and the integrity of social-emotional-related white-matter tracts between children and adolescents with high-functioning ASD (HFA) and their typically developing (TD) counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group, FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group (P < 0.01). In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities. Lien vers le texte intégral (Open Access ou abonnement)
7. Marzolf AL, Peterseim MM, Forcina BD, Papa C, Wilson ME, Cheeseman EW, Trivedi RH. {{Use of the Spot Vision Screener for patients with developmental disability}}. {J aapos};2017 (Jul 05)
PURPOSE: To determine whether the Spot Vision Screener effectively detects amblyopia risk factors (ARF) in patients with developmental disability using the 2013 guidelines of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS). METHODS: Children with developmental disability presenting for complete pediatric ophthalmologic examination were prospectively enrolled between June 2012 and March 2016. The following data were analyzed: presence of ARF according to the AAPOS guidelines, refraction, eye alignment, and other ocular pathology. RESULTS: A total of 100 children (average age, 5.7 years; range, 2.2- 9.2 years) were included. The prevalence of ARF in this cohort was 38%. The sensitivity of the Spot Vision Screener in detecting amblyopia risk factors was 84%; the specificity, 62%. The positive predictive value was 58%; the negative predictive value, 86%. CONCLUSIONS: In our study cohort the Spot Vision Screener provided good sensitivity and adequate specificity for a screening examination. Automated screeners may be useful in screening children with developmental disability.
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8. McPartland JC. {{Developing Clinically Practicable Biomarkers for Autism Spectrum Disorder}}. {J Autism Dev Disord};2017 (Jul 10)
Despite significant advances in understanding the biological bases of autism spectrum disorder (ASD), the field remains primarily reliant on observational and parent report measures of behavior to guide clinical practice, conduct research, and evaluate intervention outcomes. There is a critical need for objective measures to more sensitively and validly quantify risk for ASD, ASD symptomatology, and its change in clinical trials. To maximize public health impact, such biomarkers must be cost effective and utilize accessible and scalable technologies. This letter describes concerns specific to the development of clinically practicable biomarkers for ASD and approaches to optimize understanding of these biomarkers through development of large-scale consortia and clinical networks.
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9. Parker KJ, Oztan O, Libove RA, Sumiyoshi RD, Jackson LP, Karhson DS, Summers JE, Hinman KE, Motonaga KS, Phillips JM, Carson DS, Garner JP, Hardan AY. {{Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism}}. {Proc Natl Acad Sci U S A};2017 (Jul 10)
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in part, because existing medications target only associated ASD features. Emerging evidence suggests that the neuropeptide oxytocin (OXT) may be a blood-based biomarker of social functioning and a possible treatment for ASD. However, prior OXT treatment trials have produced equivocal results, perhaps because of variability in patients’ underlying neuropeptide biology, but this hypothesis has not been tested. Using a double-blind, randomized, placebo-controlled, parallel design, we tested the efficacy and tolerability of 4-wk intranasal OXT treatment (24 International Units, twice daily) in 32 children with ASD, aged 6-12 y. When pretreatment neuropeptide measures were included in the statistical model, OXT compared with placebo treatment significantly enhanced social abilities in children with ASD [as measured by the trial’s primary outcome measure, the Social Responsiveness Scale (SRS)]. Importantly, pretreatment blood OXT concentrations also predicted treatment response, such that individuals with the lowest pretreatment OXT concentrations showed the greatest social improvement. OXT was well tolerated, and its effects were specific to social functioning, with no observed decrease in repetitive behaviors or anxiety. Finally, as with many trials, some placebo-treated participants showed improvement on the SRS. This enhanced social functioning was mirrored by a posttreatment increase in their blood OXT concentrations, suggesting that increased endogenous OXT secretion may underlie this improvement. These findings indicate that OXT treatment enhances social abilities in children with ASD and that individuals with pretreatment OXT signaling deficits may stand to benefit the most from OXT treatment.
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10. Reilly J, Gallagher L, Chen JL, Leader G, Shen S. {{Bio-collections in autism research}}. {Mol Autism};2017;8:34.
Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding the genetic basis for ASD, critically supported through the establishment of ASD bio-collections and application in research. Here, we summarise a selection of major ASD bio-collections and their associated findings. Collectively, these include mapping ASD candidate genes, assessing the nature and frequency of gene mutations and their association with ASD clinical subgroups, insights into related molecular pathways such as the synapses, chromatin remodelling, transcription and ASD-related brain regions. We also briefly review emerging studies on the use of induced pluripotent stem cells (iPSCs) to potentially model ASD in culture. These provide deeper insight into ASD progression during development and could generate human cell models for drug screening. Finally, we provide perspectives concerning the utilities of ASD bio-collections and limitations, and highlight considerations in setting up a new bio-collection for ASD research.
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11. Sher-Censor E, Dolev S, Said M, Baransi N, Amara K. {{Coherence of Representations Regarding the Child, Resolution of the Child’s Diagnosis and Emotional Availability: A Study of Arab-Israeli Mothers of Children with ASD}}. {J Autism Dev Disord};2017 (Jul 10)
This study examined the interplay of mothers’ coherent representations of their child (i.e., multidimensional and balanced view); resolution of the child’s ASD diagnosis (i.e., acceptance); and emotional availability to the child in the unique cultural context of Arab-Israeli families. Participants were 46 mothers and their 2-8 year old sons. Coherent representations and resolution of the diagnosis were assessed using narrative measures. Emotional availability (namely, sensitivity, structuring, and lack of intrusiveness and hostility) was observed during mother-child play interactions. Results suggested that coherent and resolved mothers were more emotionally available than incoherent and/or unresolved mothers. These findings highlight the importance of supporting mothers’ ability to accept the child’s diagnosis and see the unique characteristics of the child beyond his ASD symptoms.
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12. Singh P, Ghosh S, Nandi S. {{Subjective Burden and Depression in Mothers of Children with Autism Spectrum Disorder in India: Moderating Effect of Social Support}}. {J Autism Dev Disord};2017 (Jul 10)
The quantitative study assessed subjective burden, depression, and the moderating effect of social support in mothers of children with autism spectrum disorder (ASD) in India. Seventy mothers were interviewed using a structured interview schedule, which measured their subjective burden, depression, and social support from family, friends, and significant others. Data was analyzed using descriptive statistics and multiple regression analysis with interaction terms. Half of the mothers in the study reported depression of clinical significance. Higher subjective burden significantly predicted higher depression. Of the three sources of support, only medium/high family support had a direct impact on depression and also moderated the impact of the subjective burden of depression. Implications for practice and policy are discussed.
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13. van der Heijden KB, Stoffelsen RJ, Popma A, Swaab H. {{Sleep, chronotype, and sleep hygiene in children with attention-deficit/hyperactivity disorder, autism spectrum disorder, and controls}}. {Eur Child Adolesc Psychiatry};2017 (Jul 08)
Sleep problems are highly prevalent in ADHD and autism spectrum disorder (ASD). Better insight in the etiology is of clinical importance since intervention and prevention strategies of sleep problems are directed at underlying mechanisms. We evaluated the association of sleep problems and sleep patterns with sleep hygiene (behavioral/environmental practices that influence sleep quality, e.g. caffeine use), access to electronic media, chronotype, and anxiety/depression in children aged 6-12 years with ADHD, ASD, or typical development (TD) using parental questionnaires. ANOVA and linear regression analyses were adjusted for age and sex. Children with ADHD and ASD showed more sleep problems (63.6 and 64.7%, vs 25.1% in TD) and shorter sleep duration than controls, while differences between ADHD and ASD were not significant. Sleep hygiene was worse in ADHD and ASD compared to TD, however, the association of worse sleep hygiene with more sleep problems was only significant in ASD and TD. There was a significant association of access to electronic media with sleep problems only in typically developing controls. Chronotype did not differ significantly between groups, but evening types were associated with sleep problems in ADHD and TD. Associations of greater anxiety/depression with more sleep problems were shown in ADHD and TD; however, anxiety/depression did not moderate the effects of chronotype and sleep hygiene. We conclude that sleep problems are highly prevalent in ADHD and ASD, but are differentially related to chronotype and sleep hygiene. In ASD, sleep problems are related to inadequate sleep hygiene and in ADHD to evening chronotype, while in TD both factors are important. Clinical implications are discussed.
