1. Bahi A. {{Hippocampal BDNF overexpression or microR124a silencing reduces anxiety- and autism-like behaviors in rats}}. {Behav Brain Res};2017 (Mar 08)
MicroRNA124a (miR124a) has emerged recently as a key player for multiple neuropsychiatric disorders including depression, anxiety, alcoholism, and cocaine addiction. Although we have previously reported that miR124a and its target the brain-derived neutrophic factor (BDNF) play an important role in autism-like behaviors, the molecular and behavioral dysfunctions remain unknown. The aim of this study was to understand the effects of sustained decreases in miR124a and increases of BDNF in the dentate gyrus (DG) on neonatal isolation-induced anxiety-and autism like behaviors in rats. Here we report that lentiviral-mediated silencing of miR124a in the adult DG attenuated neonatal isolation-induced anxiety-like behavior in the elevated plus maze (EPM) and open-field (OF) tests. Also, miR124a silencing decreased autism-like phenotype in the marble burying test (MBT), self-grooming (SG), and social interaction tests. Pearson’s correlations demonstrated that high levels of BDNF, a direct target of miR124a, were negatively correlated with miR124a expression. Interestingly, viral-mediated BDNF overexpression in the DG also reversed the neonatal isolation-induced anxiety-and autism like phenotypes. Collectively, these findings suggest that miR124a, through its target BDNF, may influence neonatal isolation-induced anxiety-and autism like behaviors. In conclusion, these results do support the hypothesis that miR124a in discrete hippocampal areas contributes to anxiety- and autism-like behaviors and may be involved in the neuroadaptations underlying the development of autism spectrum disorders as a persistent and lasting condition, and therefore provide a clearer mechanistic framework for understanding the physiopathology of such psychiatric illnesses.
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2. Green SA, Hernandez LM, Bowman HC, Bookheimer SY, Dapretto M. {{Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues}}. {Dev Cogn Neurosci};2017 (Feb 21)
Sensory over-responsivity (SOR) is a common condition in autism spectrum disorders (ASD) that is associated with greater social impairment. However, the mechanisms through which sensory stimuli may affect social functioning are not well understood. This study used fMRI to examine brain activity while interpreting communicative intent in 15 high-functioning youth with ASD and 16 age- and IQ-matched typically-developing (TD) controls. Participants completed the task with and without a tactile sensory distracter, and with and without instructions directing their attention to relevant social cues. When completing the task in the presence of the sensory distracter, TD youth showed increased activity in auditory language and frontal regions whereas ASD youth showed decreased activation in these areas. Instructions mitigated this effect such that ASD youth did not decrease activation during tactile stimulation; instead, the ASD group showed increased medial prefrontal activity. SOR severity modulated the effect of the tactile stimulus on social processing. Results demonstrate for the first time a neural mechanism through which sensory stimuli cause disruption of social cognition, and that attentional modulation can restore neural processing of social cues through prefrontal regulation. Findings have implications for novel, integrative interventions that incorporate attentional directives to target both sensory and social symptoms.
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3. Hasan CZ, Jailani R, Md Tahir N, Ilias S. {{The analysis of three-dimensional ground reaction forces during gait in children with autism spectrum disorders}}. {Res Dev Disabil};2017 (Mar 09)
Minimal information is known about the three-dimensional (3D) ground reaction forces (GRF) on the gait patterns of individuals with autism spectrum disorders (ASD). The purpose of this study was to investigate whether the 3D GRF components differ significantly between children with ASD and the peer controls. 15 children with ASD and 25 typically developing (TD) children had participated in the study. Two force plates were used to measure the 3D GRF data during walking. Time-series parameterization techniques were employed to extract 17 discrete features from the 3D GRF waveforms. By using independent t-test and Mann-Whitney U test, significant differences (p<0.05) between the ASD and TD groups were found for four GRF features. Children with ASD demonstrated higher maximum braking force, lower relative time to maximum braking force, and lower relative time to zero force during mid-stance. Children with ASD were also found to have reduced the second peak of vertical GRF in the terminal stance. These major findings suggest that children with ASD experience significant difficulties in supporting their body weight and endure gait instability during the stance phase. The findings of this research are useful to both clinicians and parents who wish to provide these children with appropriate treatments and rehabilitation programs. Lien vers le texte intégral (Open Access ou abonnement)
4. Lunsky Y, Durbin A, Brown HK, Bansal S, Heifetz M, Antoniou T. {{Health profiles and associated service use among adults with HIV and intellectual and developmental disabilities}}. {AIDS};2017 (Mar 13);31(5):697-705.
OBJECTIVE(S): Owing to the commonly held notion that individuals with intellectual and developmental disabilities (IDD) have low risk of HIV acquisition, we compared the prevalence of HIV infection among people with and without IDD. We also examined health status and health service use among the HIV-infected group. DESIGN: Population-based cohort study using linked administrative health and social services databases. METHODS: We compared HIV prevalence between Ontario adults with IDD (n = 64 008) and a 20% random sample of Ontario adults without IDD. Among the HIV-infected group, we compared adults with and without IDD in terms of comorbid chronic physical conditions and mental health disorders, as well as use of overall health services, mental health services, and HIV-specific services. RESULTS: HIV prevalence per 100 000 population did not differ for adults with IDD [163.38 (95% confidence interval: 132.27, 199.6)] and without IDD [172.45 (95 confidence interval: 167.48, 177.53)]. Among the HIV-infected group, those with IDD had more comorbid chronic physical conditions and mental health disorders. They also had greater use of overall health services and mental health services. Likelihood of use of HIV-specific services also differed for those with and without IDD. DISCUSSION: A similar prevalence of HIV among adults with and without IDD accentuates a need for strategies for individuals with IDD to be included in HIV prevention efforts. High prevalence of chronic physical and mental health comorbidity and health service use among the HIV-infected group with IDD highlight a need for comprehensive and coordinated treatment plans to optimize outcomes for this complex patient group.
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5. Marler S, Ferguson BJ, Lee EB, Peters B, Williams KC, McDonnell E, Macklin EA, Levitt P, Margolis KG, Beversdorf DQ, Veenstra-VanderWeele J. {{Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder}}. {J Autism Dev Disord};2017 (Mar 13)
Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.
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6. Voorspoels W, Rutten I, Bartlema A, Tuerlinckx F, Vanpaemel W. {{Sensitivity to the prototype in children with high-functioning autism spectrum disorder: An example of Bayesian cognitive psychometrics}}. {Psychon Bull Rev};2017 (Mar 13)
We present a case study of hierarchical Bayesian explanatory cognitive psychometrics, examining information processing characteristics of individuals with high-functioning autism spectrum disorder (HFASD). On the basis of previously published data, we compare the classification behavior of a group of children with HFASD with that of typically developing (TD) controls using a computational model of categorization. The parameters in the model reflect characteristics of information processing that are theoretically related to HFASD. Because we expect individual differences in the model’s parameters, as well as differences between HFASD and TD children, we use a hierarchical explanatory approach. A first analysis suggests that children with HFASD are less sensitive to the prototype. A second analysis, involving a mixture component, reveals that the computational model is not appropriate for a subgroup of participants, which implies parameter estimates are not informative for these children. Focusing only on the children for whom the prototype model is appropriate, no clear difference in sensitivity between HFASD and TD children is inferred.
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7. Yu X, Qiu Z, Zhang D. {{Recent Research Progress in Autism Spectrum Disorder}}. {Neurosci Bull};2017 (Apr);33(2):125-129.
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8. Zamzow RM, Lit L, Hamilton S, Beversdorf DQ. {{Characterizing Autism-Relevant Social Behavior in Poodles via Owner Report}}. {J Comp Psychol};2017 (Mar 13)
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted, repetitive behaviors. It can be difficult to model the complex behavioral features of this disorder with rodent models, which have limited similarity to human behaviors. The domestic dog may be a promising model of complex human behavior, including core features of ASD. The present study examines ASD-relevant social behavior in Miniature and Standard Poodles using an owner-report questionnaire with questions adapted from the Autism Diagnostic Observation Schedule (Lord, Rutter, DiLavore, & Risi, 2000). A previous study identified 3 behavioral constructs examined by this questionnaire: initiation of reciprocal social behaviors, response to social interaction, and communication. In the present study, confirmatory and experimental factor analyses used to assess how collected data fit with the previous model revealed moderate model fit and a similar factorial structure. Between-breed comparisons across these factors and at the individual question level revealed differences between Miniature and Standard Poodles in showing behaviors. Cluster analyses used to group dogs within each breed according to social behavior identified smaller subgroups of dogs with less social behavior across all 3 factors compared with the average within each breed. Within- and between-breed differences in social behavior warrant investigation of genetic variation underlying this complex trait as it relates to ASD-relevant behavior. (PsycINFO Database Record
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9. Zare S, Mashayekhi F, Bidabadi E. {{The association of CNTNAP2 rs7794745 gene polymorphism and autism in Iranian population}}. {J Clin Neurosci};2017 (Mar 08)
Autism is a heterogeneous and multifactorial disease that results from the interaction between genetic vulnerability and environmental factors. Several studies showed that many of genes that play role in autism are component of signaling networks that regulate growth and synaptic plasticity, play an important role in the etiology of autism. Contactin associated-like 2 (CNTNAP2) gene is a member of the superfamily of synaptic adhesion proteins and encodes a scaffold protein called CASPR2 that is involved in the interaction of neuron-glia and clusters K+ channels in myelinated axons. CNTNAP2 is highly expressed during the nervous system development. In this study the association of rs7794745 CNTNAP2 gene polymorphism and autism was investigated. Two hundred patients with autism and 260 healthy individuals were included in this study. Genomic DNA was extracted from peripheral blood cells. Genotypes were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Statistical analysis was performed using the software MedCalc (12.1). The genotype frequencies of AA, AT, TT were 35.3%, 50.7% and 13.8% in controls and these values were 32% and 68% and 0% in patients with autism, respectively (P=0.0001) (OR=0.01, 95% CI 0.001-0.32). The frequency of A and T alleles were 66%, 34% in patients and 60%, 40% in controls, respectively (P=0.11). The results of this study showed that there is a significant association between rs7794745 CNTNAP2 gene polymorphism and autism in the studied population. However, to obtain a definitive conclusion larger studies with more patients and controls are needed to confirm the results.
