1. Falahpour M, Thompson WK, Abbott AE, Jahedi A, Mulvey ME, Datko M, Liu T, Muller RA. {{‘Underconnected’, but not broken? Dynamic fcMRI shows underconnectivity in autism is linked to increased intra-individual variability across time}}. {Brain Connect};2016 (Mar 14)
Autism spectrum disorder (ASD) is characterized by core sociocommunicative impairments. Atypical intrinsic functional connectivity (iFC) has been reported in numerous studies of ASD. A majority of findings has indicated long-distance underconnectivity. However, fMRI studies have thus far exclusively examined static iFC across several minutes of scanning. We examined temporal variability of iFC, using sliding window analyses in selected high-quality (low-motion) consortium datasets from 76 ASD and 76 matched typically developing (TD) participants (Study 1) and in-house data from 32 ASD and 32 TD participants. Mean iFC and standard deviation across time (SD-iFC) were computed for regions of interest from default mode and salience networks, as well as amygdalae and thalami. In both studies, ROI pairings with significant underconnectivity (ASD
2. Kugelberg E. {{Neuroimmunology: IL-17A mediates a path to autism}}. {Nat Rev Immunol};2016 (Mar 14)
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3. Minichino A, Singh F, Pineda J, Friederich E, Cadenhead KS. {{Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD)}}. {Psychiatry Res};2016 (Jan 26)
There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and healthy subjects (HS). ASDs and EPs with « active » negative symptoms showed significant differences in mu suppression, in response to Biological Motion/point-light display animation, compared to HS. Preliminary findings suggest that similar neural network deficits in ASD and EP could be driven by the expression of negative symptoms in the latter group of patients. These findings may aid future studies on EP and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.
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4. Shtayermman O. {{Fred R. Volkmar; Sally J. Rogers, Rhea Paul; Kevin A. Pelphery: Handbook of Autism and Pervasive Developmental Disorders : 4th Edition, Volume 1 and 2, John Wiley and Sons, Inc, 2014, 1312 pp, ISBN: 978-1-118-14068-0, $300.00 (hardcover)}}. {J Autism Dev Disord};2016 (Mar 12)
