1. Barbaro J, Dissanayake C. {{Autism spectrum disorders in infancy and toddlerhood: a review of the evidence on early signs, early identification tools, and early diagnosis}}. {J Dev Behav Pediatr};2009 (Oct);30(5):447-459.
To date, the biological basis of autism spectrum disorders (ASDs) remains unknown. Thus, identification and diagnosis are reliant on behavioral presentation and developmental history. There have been significant advances in our knowledge of the early signs of ASD through the use of retrospective videotape analysis, parental report, screening studies, and more recently, studies on high-risk infant siblings. Despite behavioral markers being identified within the first year of life, the current average age of diagnosis for ASD remains at approximately 3 years or older. Consequently, these children are not receiving intervention in their early years, which is increasingly recognized as an important time to begin intervention. There remains little research on the prospective identification of these children in a community-based sample before 18 months. It is recommended that future prospective studies monitor behavior repeatedly over time, thereby increasing the opportunity to identify early manifestations of ASD and facilitating the charting of subtle behavioral changes that occur in the development of infants and toddlers with ASD.
2. Larsson M, Weiss B, Janson S, Sundell J, Bornehag CG. {{Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age}}. {Neurotoxicology};2009 (Sep);30(5):822-831.
Potential contributions of environmental chemicals and conditions to the etiology of Autism Spectrum Disorders are the subject of considerable current research and speculation. The present paper describes the results of a study undertaken as part of a larger project devoted to the connection between properties of the indoor environment and asthma and allergy in young Swedish children. The larger project, The Dampness in Buildings and Health (DBH) Study, began in the year 2000 with a questionnaire distributed to parents of all children 1-6 years of age in one Swedish county (DBH-I). A second, follow-up questionnaire (DBH-III) was distributed in 2005. The original survey collected information about the child, the family situation, practices such as smoking, allergic symptoms, type of residence, moisture-related problems, and type of flooring material, which included polyvinyl chloride (PVC). The 2005 survey, based on the same children, now 6-8 years of age, also asked if, during the intervening period, the child had been diagnosed with Autism, Asperger’s syndrome, or Tourette’s syndrome. From a total of 4779 eligible children, 72 (60 boys, 12 girls) were identified with parentally reported autism spectrum disorder. A random sample of 10 such families confirmed that the diagnoses had been made by medical professionals, in accordance with the Swedish system for monitoring children’s health. An analysis of the associations between indoor environmental variables in 2000 as well as other background factors and the ASD diagnosis indicated five statistically significant variables: (1) maternal smoking; (2) male sex; (3) economic problems in the family; (4) condensation on windows, a proxy for low ventilation rate in the home; (5) PVC flooring, especially in the parents’ bedroom. In addition, airway symptoms of wheezing and physician-diagnosed asthma in the baseline investigation (2000) were associated with ASD 5 years later. Results from the second phase of the DBH-study (DBH-II) indicate PVC flooring to be one important source of airborne phthalates indoors, and that asthma and allergy prevalence are associated with phthalate concentrations in settled dust in the children’s bedroom. Because these associations are among the few linking ASD with environmental variables, they warrant further and more extensive exploration.
3. Warren Z, Stone W, Humberd Q. {{A training model for the diagnosis of autism in community pediatric practice}}. {J Dev Behav Pediatr};2009 (Oct);30(5):442-446.
OBJECTIVE: Early diagnosis of autism spectrum disorders (ASD) currently represents a critical public health and clinical practice issue. Waits for diagnostic services are quite lengthy and hinder the start of early intervention services thought to be crucial for optimizing functional developmental outcomes for children and their families. In this study, we present data from a newly developed training program (Screening Tools and Referral Training-Evaluation and Diagnosis training) designed to help pediatricians diagnose young children with ASD in the context of traditional community practice settings. METHODS: A small, targeted group of community pediatricians participated in an intensive training, conducted specialized ASD evaluations within their own practices, and then referred a consecutive series of children to a medical center diagnostic clinic for an independent assessment of ASD. CONCLUSION: Results of this small pilot study indicate good agreement (71%) between pediatrician judgments and independent diagnostic ASD evaluations, but a significant trend toward overidentification when a diagnostic decision is forced. We discuss the implications of this study with regard to revisiting traditional service models of diagnostic assessment for young children with ASD.
