Pubmed du 16/01/21
1. Behzadpoor S, Pouretemad H. Some comments on cognitive behavioral therapy for anxiety in children with autism. Asian J Psychiatr ;2021 (Jan 11) ;56:102553.
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2. Halstead EJ, Jones A, Esposito G, Dimitriou D. The Moderating Role of Parental Sleep Knowledge on Children with Developmental Disabilities and Their Parents’ Sleep. Int J Environ Res Public Health ;2021 (Jan 16) ;18(2)
BACKGROUND : Children with intellectual and developmental difficulties often experience sleep problems, which in turn may impact parental sleep patterns. This study explored the role of parental sleep knowledge as a moderator on the relationship between child sleep and parental sleep impairment. METHODS : 582 parents or caregivers (92.6% mothers) of children with different developmental disabilities (Age M = 9.34, 29.5% females) such as Down’s syndrome, participated in an online survey. Multiple regression analysis was conducted. RESULTS : Parental sleep knowledge of child sleep was a moderating variable in the relationship between child sleep nocturnal duration and parental sleep impairment. Although overall, sleep knowledge was high in this sample, two specific knowledge gaps were identified namely child sleep duration requirements, and the recognition of signs of a well-rested child. CONCLUSION : This study has provided evidence that increased parental sleep knowledge can positively impact both child and parental sleep outcomes.
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3. Kanemura H, Sano F, Hoshino H, Aihara M. Efficacy of perampanel in epilepsy patients with autism spectrum disorder. Epilepsy Res ;2021 (Jan 6) ;170:106550.
AIM : The aim of this study was to assess the usefulness of perampanel (PER), and to identify the relationship between behavioral impairments and electroencephalogram (EEG) findings in epilepsy patients with autism spectrum disorder (ASD). METHODS : Participants were ASD patients with epilepsy recruited between June 1, 2016 and June 30, 2018. Inclusion criteria were : seizures refractory to two appropriate antiseizure medications (ASMs) ; presence of neuropsychological impairments ; and ≥12 months of monitoring. PER was administered once daily, starting at a dose of 2 mg/day, increased to 12 mg/day. Seizure/EEG responders were identified as participants showing a >50 % reduction in seizure/interictal epileptiform discharge (IED) frequency (indicated as complete disappearance and response). Behavioral responders were identified as participants with a ≥50 % reduction in scores of the Japanese manuals for the Aberrant Behavior Checklist (ABC-J). RESULTS : Eleven (64.7 %) of 17 patients were considered to be both seizure and EEG responders. Five (45.5 %) of these 11 patients with seizure/EEG response were considered as behavioral responders. Mean ABC-J scores were significantly decreased at 12 months after PER administration (p = 0.0002). A correlation between decreased IED frequency and ABC-J score was evident in frontal IEDs, but not in non-frontal IEDs. Participants presenting with frontal IEDs showed a significantly higher correlation between seizures/EEG and behavioral improvements (p = 0.023). Moreover, 2 of 6 patients without seizure/EEG improvement were considered as behavioral responders. No patients discontinued PER. CONCLUSIONS : The results from this study suggest the utility of PER treatment in reducing clinical seizures and IEDs for ASD patients with intractable epilepsy, at least in some patients. Moreover, the present results also indicate the usefulness of PER in improving neuropsychiatric impairments, including behavioral disturbances in ASD related to improvement of clinical seizures/frontal IEDs, but also unrelated to seizure/EEG improvement in at least some ASD patients.
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4. Kawamoto A, Kajiume A, Yoshida H, Toshima T, Kobayashi M. Individual Differences in Autistic Traits are Associated with Serotonin Transporter Gene Polymorphism Through Medial Prefrontal Function : A Study Using NIRS. Neuroscience ;2021 (Jan 16)
Autism spectrum disorder (ASD) is a heritable neurodevelopmental disorder that can vary considerably in severity. Autistic traits are distributed continuously across populations, even in sub-clinical individuals. Serotonin transporter-gene polymorphic region (5-HTTLPR) has been studied as a candidate genetic factor related to ASD, however results have been inconsistent. 5-HTTLPR is implicated in the function of medial prefrontal cortex (mPFC), a region associated with the social abnormalities found in ASD. Here we hypothesize that autistic traits are affected by the 5-HTTLPR genotype indirectly through mPFC mediation. Using near-infrared spectroscopy (NIRS), we first examined mPFC activation in people with ASD when they performed a facial affect-labeling task. Compared with a typical development group, the ASD group showed significantly lower mPFC activation during the task. Using the same task paradigm, we next investigated the relationship between autistic traits and 5-HTTLPR in sub-clinical participants, and whether associations were mediated by mPFC function. Correlation analyses indicated that participants with a large number of 5-HTTLPR L-alleles had high-level autistic traits related to social skills and low right mPFC activation. We also observed a significant negative correlation between autistic traits related to social skills and right mPFC activation. Structural equation analysis suggested a significant indirect effect of 5-HTTLPR on Autism-Spectrum Quotients, with right mPFC activation acting as a mediator. These results suggest that the diverse autistic traits related to social skills seen in the general population are associated with the 5-HTTLPR genotype, and that this association is mediated by right mPFC function.
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5. McDevitt SE. While quarantined : An online parent education and training model for families of children with autism in China. Res Dev Disabil ;2021 (Jan 16) ;109:103851.
PURPOSE : In the wake of the COVID-19 outbreak, already limited services and resources for families of children with autism spectrum disorder (ASD) in China became even more scarce. This qualitative case study highlights one online parent education and training (PET) program developed during the pandemic to offer home-intervention strategies to parents of children with ASD in mainland China. This exploratory study sought to examine the emic perspectives of the trainers and parents who participated in the 12-week intensive training program while considering the cultural context in China and the transnational, remote nature of the program. METHODS : The primary data focused on the experiences of the trainers and parents within PET program’s structure and strategies, which were adapted from the Training of Trainers model, and were collected from semi-structured, in-depth individual and focus group interviews conducted virtually with trainers (n = 4). Supplemental data sources included training session materials and feedback forms collected from parents (n = 294) at the midpoint and end of the program. After the collected data were sorted and condensed, a thematic analysis was performed using the data analysis spiral to further organize and code the data, and the codes were finally collapsed into themes. FINDINGS : Three overarching themes were identified : (1) training as modeling with resources, (2) dilemmas in cultural contexts and expectations, and (3) cultivating parent support networks. CONCLUSION : The online PET program became a hub of support networks and learning spaces for parents of children with ASD in different regions in China during the pandemic. Through the interactive virtual training sessions, parents were supported by continuous feedback on their home intervention and coached to cultivate support networks among themselves despite tensions arising from cultural differences and to implement effective intervention strategies that were individualized and authenticated to their specific familial needs.
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6. van Dijk MWG, Buruma ME, Blijd-Hoogewys EMA. Detecting Feeding Problems in Young Children with Autism Spectrum Disorder. J Autism Dev Disord ;2021 (Jan 16)
Feeding problems are prevalent in children with ASD. We investigated whether the Montreal Children’s Hospital Feeding Scale (MCH-FS, Ramsay et al. in Pediatrics and Child Health 16:147-151, 2011) can be used for young children with ASD. Participants (1-6 years) were selected from a clinical ASD sample (n = 80) and a general population sample (n = 1389). Internal consistency was good in both samples. In general, parents of children with ASD reported more feeding problems than those from the population sample. The response patterns on the individual items was highly similar. There was a slight increase in symptoms with age in the population sample, but not in the ASD sample. These results suggest that the MCH-FS can be used in populations that include children with ASD.
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7. Xu L, Sun Z, Xie J, Yu J, Li J, Wang J. Identification of autism spectrum disorder based on short-term spontaneous hemodynamic fluctuations using deep learning in a multi-layer neural network. Clin Neurophysiol ;2020 (Dec 30) ;132(2):457-468.
OBJECTIVE : To classify children with autism spectrum disorder (ASD) and typical development (TD) using short-term spontaneous hemodynamic fluctuations and to explore the abnormality of inferior frontal gyrus and temporal lobe in ASD. METHODS : 25 ASD children and 22 TD children were measured with functional near-infrared spectroscopy located on the inferior frontal gyrus and temporal lobe. To extract features used to classify ASD and TD, a multi-layer neural network was applied, combining with a three-layer convolutional neural network, a layer of long and short-term memory network (LSTM) and a layer of LSTM with Attention mechanism. In order to shorten the time of data collection and get more information from limited samples, a sliding window with 3.5 s width was utilized after comparisons, and numerous short (3.5 s) fNIRS time series were then obtained and used as the input of the multi-layer neural network. RESULTS : A good classification between ASD and TD was obtained with considerably high accuracy by using a multi-layer neural network in different brain regions, especially in the left temporal lobe, where sensitivity of 90.6% and specificity of 97.5% achieved. CONCLUSIONS : The « CLAttention » multi-layer neural network has the potential to excavate more meaningful features to distinguish between ASD and TD. Moreover, the temporal lobe may be worth further study. SIGNIFICANCE : The findings in this study may have implications for rapid diagnosis of children with ASD and provide a new perspective for future medical diagnosis.
