1. Amodeo L, Nijhof AD, Williams DM, Wiersema JR. Self-Bias and Self-Related Mentalizing are Unaltered in Adolescents with Autism. J Autism Dev Disord. 2025.

PURPOSE: The self is a multidimensional concept that can be represented at a pre-reflective (first-order) level, at a deeper, reflective level (second-order), or even at a meta-level (representing one’s own thoughts, i.e. self-related mentalizing). Since self-related processing and mentalizing are crucial for social cognition, both constructs have been researched in individuals with autism, who experience persistent socio-communicative difficulties. Some studies suggested autism-related reductions of the self-bias, i.e. tendency to preferentially process self-related content; while others observed a decreased ability to mentalize on one’s own thoughts in autism. However, prior research examined distinct levels of self-related processing in isolation, in the context of separate studies. METHODS: In this investigation, we directly compared self-bias, self- and other-related mentalizing within the same sample of adolescents with and without autism, to identify which of these are altered in this condition. Thirty adolescents with autism and 26 age- and IQ-matched controls performed a visual search task (first-order self-bias), a trait adjectives task (second-order self-bias), a feeling-of-knowing task (self-related mentalizing) and the Frith-Happé animations task (other-related mentalizing). Parents also completed two questionnaires (i.e. SRS, SCQ) assessing the adolescent’s degree of autism traits. RESULTS: Our findings replicated previous research showing reduced other-related mentalizing in autism. However, we did not find any difference between adolescents with and without autism in terms of first- or second-order self-bias, nor in the ability to mentalize on one’s own thoughts. CONCLUSION: In line with recent investigations, our results do not support earlier claims of altered self-related information processing in autism.

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2. Baker JK, Fenning RM, McElvain P. Differential Relations Between Parenting and Emotion Regulation in Children with ASD Across Dyadic and Independent Contexts. J Autism Dev Disord. 2025.

Many children with ASD exhibit difficulties with emotion regulation that greatly impair functioning. Certain intrinsic correlates of dysregulation have been identified in this population, but the search for potential environmental influences has been less fruitful. The current study examined several aspects of parenting as correlates of observed regulation in Autistic children, as measured in both parent-child and independent regulatory contexts. A diverse sample of 76 children with ASD aged 6 to 10 years participated in frustrating laboratory tasks with and without their primary caregivers, and the caregivers completed a parenting questionnaire. Emotion regulation, parental scaffolding, and gentle guidance were coded from videotaped interaction, and scores of parental involvement, positive parenting, and inconsistent discipline were obtained through parent report. Differential relations were observed between parenting and children’s regulation when considered across contexts, with parental scaffolding associated with children’s dyadic regulation and parents’ reports of their involvement and discipline associated with children’s independent regulation. Findings support previous evidence identifying a potential delay in the internalization of parental co-regulatory support in Autistic children, and highlight parental involvement as a previously unidentified unique correlate of independent regulation in this population. Implications for conceptualizations of emotion regulation in autism are discussed as is the importance of extending findings through further longitudinal research.

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3. Belteki Z, Ward EK, Begum-Ali J, van den Boomen C, Bölte S, Buitelaar J, Charman T, Demurie E, Falck-Ytter T, Hunnius S, Johnson MH, Jones EJH, Oosterling I, Pasco G, Pijl MKJ, Radkowska A, Rudling M, Tomalski P, Warreyn P, Junge C, Haman E. A Concurrent Validity Study of the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI) in Infants with an Elevated Likelihood or Diagnosis of Autism. J Autism Dev Disord. 2025.

Infants at elevated likelihood for or later diagnosed with autism typically have smaller vocabularies than their peers, as shown by the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI). However, the extent to which MSEL and CDI scores align remains unclear, especially across clinical and non-clinical populations. This study examined whether the concurrent validity of the MSEL and CDI differs based on autism likelihood and diagnosis. Data from 720 14-month-old infants were analysed, grouped by likelihood (elevated vs. typical) and diagnosis at 36 months (diagnosed vs. not diagnosed). Vocabulary scores were compared across both likelihood and diagnostic groups. Moderate correlations were observed between the MSEL and CDI in most groups (r(s) range = [.34-.58]). One exception was that the expressive scores of elevated likelihood infants on the MSEL and CDI were more closely associated than the expressive scores of typical likelihood infants. Diagnosed infants had lower vocabulary scores than non-diagnosed peers on both the MSEL and CDI. The elevated likelihood group showed lower scores on the MSEL but not the CDI compared to typical likelihood infants. The moderate correlations suggest that the MSEL and CDI assess different aspects of language in infancy. These associations were weaker than previously reported in autistic children. Differences in vocabulary scores across likelihood and diagnostic groups highlight the need for further research to understand the association between these measures.

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4. Ganany-Dagan O. Parents’ initiative in community-based support for children with intellectual and developmental disabilities: The Ahada non-profit model. J Intellect Dev Disabil. 2025: 1-12.

BACKGROUND: The birth of a child with an intellectual or developmental disability inherently presents challenges to parents regarding the child’s long-term future. This qualitative study examined the perceptions of parents who are kibbutz members, focusing on the non-profit organisation they established and the socioeconomic model they developed to ensure the future wellbeing of their children with intellectual and developmental disabilities. METHOD: In-depth interviews were conducted with 12 participants and used a thematic analysis based on case study methodology. RESULTS: The socioeconomic model developed by kibbutz parents helps alleviate their concerns, but also gave rise to challenges related to kibbutz privatisation and the requirement for programs to be tailored to individual needs. The study highlighted how cooperation among families, the community, and government institutions can contribute to individual and collective solutions for people with disabilities. CONCLUSION: These insights expand our understanding of parental social entrepreneurship within intentional communities and other contexts.

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5. Griffen B, Lorah E, Caldwell NS, Holyfield C. Effects of AAC Intervention on School Readiness Skills from Young Children with Intellectual and Developmental Disabilities. Folia Phoniatr Logop. 2025: 1-19.

Introduction Young children with intellectual and developmental disabilities (IDD) who have limited speech and language require access to augmentative and alternative communication (AAC) intervention, including technology and instruction. While research shows that AAC intervention can effectively support communication from children with IDD, research on its impact on school readiness skills is limited. Methods Two preschool aged children with IDD participated in this study. Using a single case, multiple baseline across responses design for each participant, this study evaluated the effectiveness of an AAC intervention, including a high-tech AAC with a personalized color photo visual scene display with modeling, time delay, prompting, and social praise. The targeted responses were three questions from the participants’ state kindergarten readiness standards, including: « What is your first name? »; « What is your last name? »; and « How old are you? ». Results In baseline, both participants demonstrated little success communicating answers to questions. During intervention, both participants mastered the school readiness skill of responding accurately and independently to the targeted questions. Conclusion The current study shows that with early access to AAC intervention, children with IDD may begin to build communication skills that align with school readiness standards, providing them increased opportunity to participate fully and meaningfully in general education curricula, upon entering kindergarten. Keywords: school readiness, augmentative and alternative communication, intellectual and developmental disability.

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6. Gupta N, Srinivasan S, Gupta M. Rethinking Psychometric Testing in Autism: Overcoming the Challenges of Comorbidity and Diagnostic Overshadowing. CNS Spectr. 2025: 1-28.

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7. Hsu YH, Wu CY, Lee HL, Hsieh RL, Huang YL, Shiue HS, Lin YC, Chen MC, Hsueh YM. Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children. Environ Health. 2025; 24(1): 2.

DNA methylation is a critical step in brain development, 5-Methyl-2′-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers. Additionally, we assessed whether 5mdC modified the impacts of blood lead and total urinary arsenic levels on DD. We analyzed the concentrations of 5mdC, blood cadmium and lead, and total urinary arsenic in 174 children with DD and 88 healthy children. Global DNA methylation levels are expressed as the ratio 5mdC/2′-dexyguanosine (dG), called 5mdC (%). In our findings, elevated levels of blood lead and total urinary arsenic were significantly associated with DD risk among preschoolers. Furthermore, high 5mdC (%) was related with reduced risk of DD, with an odds ratio (OR) and 95% confidence interval (CI) of 0.14 (0.06 – 0.32). A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 – 21.64). The findings provide evidence of the combined effects of reduced 5mdC (%) and high blood lead concentrations, increasing the OR of DD.

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8. Hur A, Chung S, Jeon H, Lee H, Shin YW, Son JW. Investigating Disembodiment-related Brain Activation by Interaction between Perspective-shifting and the Experience of Agency in Autism Spectrum Disorder: A Possible Relationship with Interoceptive Abilities. Clin Psychopharmacol Neurosci. 2025; 23(1): 86-99.

OBJECTIVE: Many studies have explored sense of self in individuals with autism spectrum disorder (ASD); however, few have reported on their experience of « disembodiment. » This study aimed to investigate the differences in brain activity between patients with ASD and neurotypicals (NTs) under conditions causing disembodiment and to examine the correlation between their interoceptive abilities and disembodiment-related brain activity. METHODS: 18 Participants with ASD and 21 NTs completed psychological evaluations, interoceptive abilities measurement, and functional magnetic resonance imaging (fMRI). The fMRI images were taken while the participants performed tasks involving ball-throwing animations. The task focused on either self-agency related to ball-throwing (Agency Task) or the spatial location of a ball (Location Task). The animations were presented from constantly changing perspective (Changing View) or fixed perspective (Fixed View). The disembodiment-related condition was the interaction between the Agency Task and Changing View. RESULTS: Participants with ASD exhibited higher activation than NTs in regions near the left parieto-temporo-occipital junction, left precuneus, left hippocampus, and other brain areas. Furthermore, interoceptive accuracy was negatively correlated with the activity of the left superior parietal and posterior midcingulate areas, whereas interoceptive trait prediction error was positively correlated with the activity of the left hippocampus, mid-temporal area, and left posterior cingulate area in participants with ASD. CONCLUSION: These results suggest that disembodiment-related brain activation might be easily manifested by the interaction between perspective-shifting and the experience of agency, and that interoceptive abilities might be related to disembodiment-related brain activation in individuals with ASD.

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9. Kaur K, Saini RS, Quadri SA, Fernandes GVO, Avetisyan A, Mosaddad SA, Heboyan A. Bibliometric analysis of trends in dental management of the children with Autism Spectrum Disorder (ASD). Discov Ment Health. 2025; 5(1): 2.

This study aimed to present a complete overview of the trends, difficulties, and improvements in dental treatment for children diagnosed with autism spectrum disorder through rigorous bibliometric analysis. The dimensional database field was chosen to enable the inclusion and recall of the greatest number of relevant entries. All peer-reviewed international journals published between 2004 and 2023 were included in this study. The sophisticated search keywords’ Autistic Disorder » OR « Autism Spectrum Disorder » AND « Dental management » were used. Studies that examined patterns and difficulties in the dental care of children with ASD were included in the inclusion and exclusion criteria for this analysis. Among the listed countries, The United States had the highest number of documents and citations. Barbara Sheller is the most cited author, followed closely by Arthur H.Friedlander, Michael E.Mahler, and John A.Yagiela. This study also revealed that most articles involved multinational collaborations, highlighting the global scope of dental research. The United States leads in terms of research output and citations, followed by India and China. Research on autism spectrum disorder has grown substantially over the past few years, and the authors recommend that future research concentrate on creating effective behavioral techniques that will assist children with autism spectrum disorder in coping with dental treatment.

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10. Kristensen RK, Andersen PT, Bilenberg N, Milling ED, Dalgaard Guldager J. Mapping the landscape and evidence of cross-sectoral collaboration models targeting individuals referred for assessment of attention-deficit hyperactivity disorder or autism spectrum disorder: protocol for a scoping review. BMJ Open. 2025; 15(1): e088850.

INTRODUCTION: Neurodevelopmental disorders, notably attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), present substantial challenges in mental health. Individuals referred for assessment in a psychiatric unit experience complex needs. This implies that their needs necessitate coordination across multiple sectors. Cross-sectoral collaboration models have emerged as essential strategies for addressing the complexities of these disorders. However, evidence of their existence, implementation and success remains limited. This protocol aims to outline a scoping review where we will explore existing collaboration models, evaluate their implementation and gain an understanding of how cross-sectoral collaboration models can be developed to ultimately benefit individuals referred for assessment of ADHD or ASD. METHODS AND ANALYSIS: This proposed scoping review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. A comprehensive search will be conducted across PubMed, CINAHL, Embase, PsycINFO and Google Scholar, as well as grey literature sources, between 1 December 2024 and 1 January 2025. Inclusion criteria will encompass studies focusing on cross-sectoral collaboration for individuals referred for assessment of ADHD or ASD, published in English, Danish, Norwegian or Swedish. The search will use a three-block search string, with iterative refinement guided by familiarity with the evidence base. Data extraction will involve study characteristics and implementation details, using the Consolidated Framework for Implementation Research in combination with Proctor et al’s implementation outcomes framework. Results will be synthesised into descriptive tables, providing a comprehensive mapping of existing models and emphasising implementation feasibility. ETHICS AND DISSEMINATION: Ethical approval is not required for this protocol since it involves the review of existing literature without the involvement of human participants or personal data. Findings will be disseminated at national and international conferences and will be integrated into future efforts to develop cross-sectoral collaboration models in Denmark.

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11. Nicholson J, Faughnan K, Silverman AF, Lesser V, Andresen ML, Bahr M, Corey T, Benevides TW, Pham H. Diverse perspectives on supporting the health and wellness of people with intellectual and developmental disabilities. Disabil Health J. 2025: 101775.

BACKGROUND: Persons with intellectual and/or developmental disabilities (IDD) are a growing population, frequently living with complex health conditions and unmet healthcare needs. Traditional clinical practice and research methods and measures may require adaptation to reflect their preferences. OBJECTIVE: The perspectives of people with IDD, caregivers/partners, and clinicians were obtained to provide insight into factors contributing to the health and wellness of people with IDD. These, in turn, suggest opportunities for improvements in clinical training and care, and considerations for enhancing research methods and measures. METHODS: An exploratory design, participatory methods, abductive qualitative approach and thematic analysis were employed. Interview data were obtained in twelve focus groups with people with IDD (n = 25), caregivers/partners (n = 21), and clinicians (n = 27). Particular attention was paid to supporting attendees in focus group participation, with adaptations and accommodations made for communication preferences, and graphic illustrations were provided. RESULTS: Themes emerging across attendee categories that reflect factors contributing to health and wellness for people with IDD include: (1) making healthy choices; (2) participating in everyday activities; (3) benefitting from natural supports (e.g., family, friends, peers); and (4) accessing skilled professional supports (e.g., healthcare provision and payment). CONCLUSIONS: Study findings underscore factors related to supporting health and wellness for people with IDD and suggest the importance of autonomy, accessibility, healthy relationships, self-advocacy, and tailored clinical care. People with IDD can be actively engaged throughout the research enterprise to ensure the relevance, acceptability, and accessibility of research methods and measures; promote inclusiveness; and address health disparities.

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12. Pellegrini E, Scarpelli S, Alfonsi V, Gorgoni M, Pazzaglia M, De Gennaro L. Behind Closed Eyes: Understanding Nightmares in Children and Adolescents with Autism Spectrum Disorder – A Systematic Review. Neurosci Biobehav Rev. 2025: 106012.

INTRODUCTION: Brain and sleep development in childhood shapes emotional and cognitive growth, including the ability to recall dreams. In line with the continuity hypothesis of dreaming, several findings suggest a link between clinical symptoms and nightmare frequency. Sleep disorders and anxiety are among the most frequently co-occurring conditions in children and adolescents with autism spectrum disorder (ASD). However, their impact on nightmares has not yet been systematically explored. This review aims to address this research gap by investigating nightmares in autism and their influence on clinical symptoms and cognitive functioning. METHODS: The literature was searched utilizing the databases PubMed, PsycINFO, Web of Science, and Scopus, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The included studies were assessed for methodological quality. RESULTS: Twenty-nine papers were reviewed. The prevalence of nightmares occurring very frequently was below 5%, with no significant difference in nightmare prevalence between children with ASD and their healthy peers. Furthermore, several findings reported a relationship between nightmares and other sleep disturbances among individuals with ASD. DISCUSSION: The study of dreaming in ASD may provide valuable insights into the disorder. Although comorbid sleep disorders can influence nightmare frequency, the results of this review suggest that nightmares may not represent a distinctive feature of ASD. However, poor communication and introspection skills may explain the difficulties in reporting dream experiences. Given the preliminary nature of current research on nightmares in ASD, further studies are essential to overcome existing limitations and deepen our understanding.

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13. Shin Y, Park EJ, Lee A. Early Intervention for Children With Developmental Disabilities and Their Families via Telehealth: Systematic Review. J Med Internet Res. 2025; 27: e66442.

BACKGROUND: Early intervention during the first 3 years of life is crucial for children with developmental disabilities to optimize developmental outcomes. However, access to such services is often limited by geographical distance and resource constraints. Telehealth can be part of a solution for overcoming these barriers, enabling the delivery of early intervention services. However, a comprehensive understanding of the efficacy and implementation of telehealth in early interventions remains elusive, particularly for children aged 0-3 years. OBJECTIVE: This systematic review aims to synthesize existing research on the effectiveness and implementation of telehealth interventions in infants and toddlers (aged 0-3 years) who are at risk of or diagnosed with developmental disabilities. The primary objective of the study is to evaluate the ways that telehealth compares to conventional in-person interventions in improving developmental outcomes for children and supporting family well-being. METHODS: A systematic search was conducted of 4 electronic databases (PubMed, Embase, CINAHL, and Web of Science), focusing on studies published between 2010 and 2024. The inclusion criteria were studies involving telehealth interventions for children aged 0-3 years who were at high risk or had developmental disabilities, which involved active interactions between the providers and the families. Study quality was assessed using the mixed methods appraisal tool, and a narrative synthesis was used to analyze the data. RESULTS: Eighteen studies met the inclusion criteria: 12 single-case designs, 4 randomized controlled trials, and 2 nonequivalent control group designs. All studies involved caregiver-child dyads, with child ages ranging from 5 to 37 months and having or at risk of autistic spectrum disorder (n=10, 56%), cerebral palsy (n=4, 22%), and other conditions (n=4, 22%). Synchronous videoconferencing was the primary modality for caregiver training and coaching (n=17, 94%) while 1 intervention used an Internet of Things system. Outcomes were identified in child communication (n=9, 50%), physical (n=6, 33%), social or emotional (n=6, 33%), and adaptive behavior (n=4, 22%), as well as caregiver implementation (n=12, 66%). Telehealth demonstrated comparable or superior effectiveness to traditional in-person methods in 2 studies. However, the focus on specific conditions and limited research on cognitive development were notable gaps. CONCLUSIONS: Telehealth can be a viable alternative to traditional in-person early interventions for young children who have developmental disabilities and their families. It enhances accessibility and interactions between families and providers at a distance while promoting family-centered care. Challenges exist, including those of technological literacy, and the lack of research on cognitive outcomes must be addressed. Future work should explore more comprehensive interventions, including multidisciplinary approaches and expanded family outcomes, to solidify the role that telehealth plays in early intervention. TRIAL REGISTRATION: PROSPERO CRD42024551286; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=551286.

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14. Singh JS, Brasher S, Sarrett J, Barger B, Guerra K, Dilly LJ, Rubin IL, Stapel-Wax JL, Benevides T, Fernandez-Carriba S. Structural, Institutional, and Interpersonal Racism: Calling for Equity in Autism Research and Practice. J Racial Ethn Health Disparities. 2025.

Disparities in autism research and practices based on race and ethnicity are evident across many outcomes and life course stages. However, most of the research has focused on outlining differences and not the underlying systemic inequities driving these disparities. In this conceptual paper, we aim to shift the focus by outlining mechanisms of structural racism within the institutions of science, healthcare, and residential segregation and educational systems in the United States (U.S.). We argue that these and other forms of institutional racism constitute structural racism that are influencing the racial and ethnic disparities we see in autism services and care. For each of these institutions, we identify institutional racism related to autism and offer an example of how it shapes interpersonal racism and adverse outcomes, including misdiagnosis, delayed diagnosis, unequal access to educational services, and differential treatment in clinical encounters. We then provide anti-racism approaches in autism research and practice for each of these institutions that addresses institutional and interpersonal racism shaping autism inequities among racial and ethnic minorities. We conclude with a call to action to clinicians, researchers, and others to prioritize and disrupt the impacts of structural, institutional, and interpersonal racism through targeted anti-racism approaches.

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15. Sumiya M, Katahira K, Akechi H, Senju A. The preference for surprise in reinforcement learning underlies the differences in developmental changes in risk preference between autistic and neurotypical youth. Mol Autism. 2025; 16(1): 3.

BACKGROUND: Risk preference changes nonlinearly across development. Although extensive developmental research on the neurotypical (NTP) population has shown that risk preference is highest during adolescence, developmental changes in risk preference in autistic (AUT) people, who tend to prefer predictable behaviors, have not been investigated. Here, we aimed to investigate these changes and underlying computational mechanisms. METHOD: We ran a game-like risk-sensitive reinforcement learning task on 75 participants aged 6-30 years (AUT group, n = 31; NTP group, n = 44). Focusing on choices between alternatives with the same objective value but different risks, we calculated the risk preference and stay probability of a risky choice after a rewarding or non-rewarding outcome. Analyses using t-tests and multiple regression analyses were conducted. Using the choice-related data of each participant, we fit four reinforcement learning models and compared the fit of each model to the data. Furthermore, we validated the results of model fitting with multiple methods, model recovery, parameter recovery, and posterior predictive check. RESULTS: We found a significant difference in nonlinear developmental changes in risk preference between the AUT and NTP groups. The computational modeling approach with reinforcement learning models revealed that individual preferences for surprise modulated such preferences. CONCLUSIONS: These findings indicate that for NTP people, adolescence is a developmental period involving risk preference, possibly due to lower surprise aversion. Conversely, for AUT people, who show opposite developmental change of risk preference, adolescence could be a developmental period involving risk avoidance because of low surprise preference.

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16. Surgent O, Andrews DS, Lee JK, Boyle J, Dakopolos A, Miller M, Ozonoff S, Rogers SJ, Solomon M, Amaral DG, Nordahl CW. Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children. Biol Psychiatry. 2025.

BACKGROUND: Fine motor challenges are prevalent in autistic populations. However, little is known about their neurobiological underpinnings or how their related neural mechanisms are influenced by sex. The dorsal striatum, comprised of the caudate nucleus and putamen, is associated with motor learning and control and may hold critical information. We investigated how autism diagnosis and sex assigned at birth influence associations between the dorsal striatum and fine motor development in autistic and non-autistic children. METHODS: We used multimodal assessment of striatal structures (volume and cortico-striatal white matter microstructure) and longitudinal assessment of fine motor skills, first at approximately 3 years of age (Time 1) and again 2-3 years later (Follow-up). Fine motor and magnetic resonance imaging (T1 and diffusion) data were collected at Time 1 from 356 children (234 autistic; 128 female) and at Follow-up from 195 children (113 autistic; 76 female). RESULTS: At Time 1, associations among fine motor skills, putamen volume, and sensorimotor-striatal fractional anisotropy (sensorimotor-affiliated dorsal striatal structures) were different in autistic boys compared to autistic girls and were not significant for non-autistic children. Further, Time 1 sensorimotor-striatal and prefrontal-striatal microstructure predicted fine motor development for autistic girls but not boys. CONCLUSIONS: Sensorimotor-affiliated dorsal striatum structures may contribute to concurrent motor ability and predict fine motor improvement during critical windows of development in a sex-specific and diagnosis-dependent way. Moreover, the dorsal striatum may play a key role in the distinct neural mechanisms underlying motor challenges in autistic males and females.

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17. Thomas JJ, McPherson IK. Elevating the Discourse on the Comorbidity and Treatment of Eating Disorders and Autism Spectrum Disorder: Commentary on Inal-Kaleli et al. and Nimbley et al. Int J Eat Disord. 2025.

Two recent review papers published in the International Journal of Eating Disorders have considerably elevated the rigor of scholarship on the comorbidity between autism spectrum disorder (ASD) and eating disorders. One paper reported that more than one-quarter of individuals with acute anorexia nervosa also have ASD, and that autistic traits are positively correlated with eating disorder psychopathology. The other paper reported that, compared to individuals with low autistic traits, those with high autistic traits report poorer experiences of eating disorder treatment, despite similar treatment outcomes. While both papers make excellent points, in this commentary we highlight important challenges in the assessment of ASD that may artificially inflate its prevalence in the context of disordered eating. We then caution the field against completely discarding evidence-based eating disorder treatments in the setting of comorbid ASD. Finally, we offer recommendations for future research to determine when and how eating disorder treatments should be modified to accommodate neurodiversity.

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18. Torres RF, Llontop N, Espinoza CS, Kerr B. Environmental Enrichment and Epigenetic Changes in the Brain: From the Outside to the Deep Inside. Subcell Biochem. 2025; 108: 217-30.

The brain plays a vital role in maintaining homeostasis and effective interaction with the environment, shaped by genetic and environmental factors throughout neurodevelopment and maturity. While genetic components dictate initial neurodevelopment stages, epigenetics-specifically neuroepigenetics-modulates gene expression in response to environmental influences, allowing for brain adaptability and plasticity. This interplay is particularly evident in neuropathologies like Rett syndrome and CDKL5 deficiency syndrome, where disruptions in neuroepigenetic processes underline significant cognitive and motor impairments. The environmental enrichment paradigm, introduced by Donald Hebb in the late 1940s, demonstrates how enriching stimuli-such as complex sensory, social, and cognitive inputs-affect brain structure and function. Despite methodological variability, evidence reveals that enriched environments catalyze beneficial changes in behavior and neuroanatomy, including increased synaptic plasticity, enhanced motor coordination, and improved cognitive performance in rodent models. Additionally, environmental enrichment induces epigenetic modifications that facilitate these outcomes, highlighting the necessity of understanding the mechanisms driving gene expression changes within the context of enriched experiences. Ultimately, this manifold relationship between environment, neuroepigenetic modulation, and brain function highlights the brain’s capacity for change, reinforcing the importance of considering environmental factors in studies of neurodevelopment and therapy for neurological disorders.

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19. Tsujita M, Inada N, Saneyoshi AH, Hayakawa T, Kumagaya SI. Serial dependence in orientation is weak at the perceptual stage but intact at the response stage in autistic adults. J Vis. 2025; 25(1): 13.

Recent studies have suggested that autistic perception can be attributed to atypical Bayesian inference; however, it remains unclear whether the atypical Bayesian inference originates in the perceptual or post-perceptual stage or both. This study examined serial dependence in orientation at the perceptual and response stages in autistic and neurotypical adult groups. Participants comprised 17 autistic and 23 neurotypical adults. They reproduced the orientation of a Gabor stimulus in every odd trial or its mirror in every even trial. In the similar-stimulus session, a right-tilted Gabor stimulus was always presented; hence, serial dependence at the perceptual stage was presumed to occur because the perceived orientation was similar throughout the session. In the similar-response session, right- and left-tilted Gabor patches were alternately presented; thus serial dependence was presumed to occur because the response orientations were similar. Significant serial dependence was observed only in neurotypical adults for the similar-stimulus session, whereas it was observed in both groups for the similar-response session. Moreover, no significant correlation was observed between serial dependence and sensory profile. These findings suggest that autistic individuals possess atypical Bayesian inference at the perceptual stage and that sensory experiences in their daily lives are not attributable only to atypical Bayesian inference.

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20. Wang C, Liu JY, Su LD, Wang XT, Bian YP, Wang ZX, Ye LY, Lu XJ, Zhou L, Chen W, Yang W, Liu J, Wang L, Shen Y. GABAergic Progenitor Cell Graft Rescues Cognitive Deficits in Fragile X Syndrome Mice. Adv Sci (Weinh). 2025: e2411972.

Fragile X syndrome (FXS) is an inherited neurodevelopmental disorder characterized by a range of clinical manifestations with no effective treatment strategy to date. Here, transplantation of GABAergic precursor cells from the medial ganglionic eminence (MGE) is demonstrated to significantly improve cognitive performance in Fmr1 knockout (KO) mice. Within the hippocampus of Fmr1-KO mice, MGE-derived cells from wild-type donor mice survive, migrate, differentiate into functionally mature interneurons, and form inhibitory synaptic connections with host pyramidal neurons. MGE cell transplantation restores Ras-PKB signaling in pyramidal neurons, enhances AMPA receptor trafficking, rescues synaptic plasticity, and corrects abnormal hippocampal neural oscillations. These findings highlight the potential of GABAergic precursor cell transplantation as a promising therapeutic strategy for FXS.

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21. Williams PG, Sears L, Watson WH, Gunaratnam B, Feygin Y, Wright SP, Sullivan JE. Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study. J Dev Behav Pediatr. 2025.

OBJECTIVE: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy. METHODS: Glutathione and glutathione in combination with vitamin C and N-acetylcysteine (Trio) were tested. Both treatments were administered in double-blind placebo-controlled randomized crossover studies. In total, 24 children between the ages of 5 and 16 years with ASD and severe behavior disorders were randomized to receive weekly intravenous injections of either placebo or 1 of the 2 interventions (glutathione or Trio) for 8 weeks. After a 1-week washout period, participants were crossed over for the subsequent 8 weeks. Behavioral measures and plasma levels of glutathione were obtained at baseline, during the washout period, and at the end of the study. RESULTS: No differences between treatment groups in behavioral or biologic measures were found. No significant adverse side effects attributable to the treatments were observed. Small improvements in specific glutathione and behavioral measures occurred over the study period for all groups. CONCLUSION: Treatment with glutathione or glutathione in combination with vitamin C and N-acetylcysteine did not result in improvements in behavior or biologic measures. The positive trends over the course of the study were likely due to the placebo effect or decreased anxiety associated with the study routine.

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