1. Alexiou GA, Siozos G, Stefanaki K, Vlachakis E, Sfakianos G, Prodromou N, Moschovi M. {{Medulloblastoma in a Child with Fragile X Syndrome}}. {Neuropediatrics};2012 (May 17)
Fragile X syndrome is the most common cause of inherited intellectual impairment and has been associated with decreased incidence of cancer. We present the case of an 11-year-old boy with a diagnosis of fragile X syndrome who presented with gait imbalance, headache, and episodes of vomiting. Radiological investigation revealed the presence of a posterior fossa tumor. The patient was operated upon and the tumor proved to be a medulloblastoma (MB). To the best of our knowledge this is the first reported case of MB in a child with fragile X syndrome.
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2. Budden S. {{Clinical variability in early speech-language development in females with Rett syndrome}}. {Dev Med Child Neurol};2012 (May);54(5):392-393.
3. Creten C, van der Zwaan S, Blankespoor RJ, Maatkamp A, Klinkenberg S, van Kranen-Mastenbroek VH, Nicolai J, Dhossche DM, van Os J, Schieveld JN. {{[Anti-NMDA-receptor encephalitis: a new axis-III disorder in the differential diagnosisof childhood disintegrative disorder, early onset schizophrenia and late onset autism]}}. {Tijdschr Psychiatr};2012;54(5):475-479.
<span class= »subtitle »>Summary</span> Childhood disintegrative disorder (<span class= »abbreviation »>cdd</span>), early onset schizophrenia (<span class= »abbreviation »>eos)</span>, and late onset autism <span class= »abbreviation »>(loa</span>) often follow a similar course: initially, development is normal, then there is a sudden neuropsychiatric deterioration of social interaction and communication skills, which is combined with a decline in intelligence and reduction in daily activities. A 9-year-old boy was admitted to the paediatric ward with acute onset of secondary epileptic seizures. It was not long until the boy’s symptoms resembled that of patients with <span class= »abbreviation »>cdd, eos </span>and <span class= »abbreviation »>loa</span>. Intensive tests led to the diagnosis of anti-<span class= »abbreviation »>nmda</span>-receptor encephalitis. Anti-<span class= »abbreviation »>nmda-</span>receptor encephalitis should be regarded as a possible organic cause underlying the syndromal presentation of <span class= »abbreviation »>cdd, eos</span> and<span class= »abbreviation »> loa</span>.
4. Hahn JE. {{Minimizing Health Risks Among Older Adults With Intellectual and/or Developmental Disabilities: Clinical Considerations to Promote Quality of Life}}. {J Gerontol Nurs};2012 (May 18):1-6.
The number of individuals aging with lifelong intellectual and/or developmental disabilities (I/DD) is increasing and is expected to double by 2030. People with I/DD have faced a number of health disparities, including health care professionals unprepared to meet their health needs. This article will review age- and health-related clinical considerations among individuals aging with I/DD. The aim is to provide nurses with suggested interventions that promote health, prevent secondary conditions, and foster person-centered care among individuals aging with I/DD to help them live healthy and meaningful lives in their later years.
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5. Khan NZ, Gallo LA, Arghir A, Budisteanu B, Budisteanu M, Dobrescu I, Donald K, El-Tabari S, Hoogenhout M, Kalambayi F, Kawa R, Espinoza IL, Lowenthal R, Malcolm-Smith S, Montiel-Nava C, Odeh J, de Paula CS, Rad F, Tarpan AK, Thomas KG, Wang C, Patel V, Baron-Cohen S, Elsabbagh M. {{Autism and the Grand Challenges in Global Mental Health}}. {Autism Res};2012 (May 17)
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6. McNally Keehn RH, Lincoln AJ, Brown MZ, Chavira DA. {{The Coping Cat Program for Children with Anxiety and Autism Spectrum Disorder: A Pilot Randomized Controlled Trial}}. {J Autism Dev Disord};2012 (May 17)
The purpose of this pilot study was to evaluate whether a modified version of the Coping Cat program could be effective in reducing anxiety in children with autism spectrum disorder (ASD). Twenty-two children (ages 8-14; IQ >/= 70) with ASD and clinically significant anxiety were randomly assigned to 16 sessions of the Coping Cat program (cognitive-behavioral therapy; CBT) or a 16-week waitlist. Children in the CBT condition evidenced significantly larger reductions in anxiety than those in the waitlist. Treatment gains were largely maintained at two-month follow-up. Results provide preliminary evidence that a modified version of the Coping Cat program may be a feasible and effective program for reducing clinically significant levels of anxiety in children with high-functioning ASD.
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7. Moss J, Richards C, Nelson L, Oliver C. {{Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome}}. {Autism};2012 (May 15)
We evaluated the proportion of individuals with Down syndrome (DS: N = 108) who met criteria for autism spectrum disorder (ASD) on the Social Communication Questionnaire and the severity of ASD-related symptomatology in this group. The proportions of individuals with DS meeting the cut-off for ASD and autism in this sample were 19% and 8%, respectively. We then evaluated the behavioural profile of individuals with DS who scored above cut-off for ASD (DS+ASD; N = 17) compared with those with DS-only (N = 17) and individuals with idiopathic ASD (N = 17), matched for adaptive behaviour skills and ASD symptom severity (ASD group only). Individuals in the DS+ASD and ASD-only groups showed more stereotyped behaviour, repetitive language, overactivity and self-injury than the DS-only group (p < .001). Individuals in the DS+ASD and DS-only groups appeared less withdrawn from their surroundings than those with ASD (p < .004). These findings indicate differences in the behavioural and cognitive profile of individuals with DS+ASD compared with those with DS-only, when controlling for adaptive behaviour skills. Individuals with DS+ASD show broad similarities with individuals with idiopathic ASD with regard to ASD and behavioural characteristics but may also show some areas of subtle difference from this group.
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8. Schaap-Jonker H, van Schothorst-van Roekel J, Sizoo B. {{[The God image in relation to autistic traits and religious denomination]}}. {Tijdschr Psychiatr};2012;54(5):419-428.
<span class= »subtitle »>Summary background </span>Estimates of the prevalence of autism spectrum disorders (<span class= »abbreviation »>asd</span>) range from 0.6 to 1.0 per cent of the general population. Among the characteristic traits of <span class= »abbreviation »>asd</span> are qualitative impairments in social reciprocity and in abstract imagination. Not surprisingly, these traits can affect the personal religion of <span class= »abbreviation »>asd</span> patients, in the same manner as religious background does. <span class= »subtitle »>aim</span> To determine to what extent the religiousness of religious patients is associated with autistic traits and religious background. <span class= »abbreviation subtitle »>method </span>78 Dutch adults attending a Protestant mental healthcare institution as outpatients were asked to complete the ‘Questionnaire God Image’ (<span class= »abbreviation »>qgi)</span> and the ‘Autism Quotiënt’ <span class= »abbreviation »>(aqnl</span>). In this cross-sectional study various aspects of the God image were related to autistic traits and religious background. <span class= »subtitle »>results</span> The more that respondents reported autistic traits, the greater was their fear of God and the less positive were their feelings. Respondents who were strict Calvinists experienced greater fear of God than did other respondents. <span class= »subtitle »>conclusion </span>Treatment of religious patients with asd needs to take into account these patients’ greater fear of God and their less positive feelings. Those patients who had had a strict Calvinist upbringing had a more pronounced fear of God.
9. Wallace S, Fein D, Rosanoff M, Dawson G, Hossain S, Brennan L, Como A, Shih A. {{A Global Public Health Strategy for Autism Spectrum Disorders}}. {Autism Res};2012 (May 17)
In recent years, there has been increasing awareness about autism spectrum disorders (ASD) around the world, including in low and middle income countries. Unlike countries in Western Europe and North America where infrastructure and capacity are available to help meet some of the needs of individuals with ASD, little expertise or capacity exists in most of the developing world. In 2008 Autism Speaks launched the Global Autism Public Health (GAPH) Initiative to facilitate the development of systematic and sustainable solutions for enhancing global autism awareness, research, training and service delivery. In the last 3 years Autism Speaks has established collaboration with stakeholders from over 20 countries who are working alongside dedicated local and international stakeholders to effect change. In this article, the GAPH framework is described, along with a few brief case examples that illustrate how the framework for implementation of the model can occur. GAPH is still in its infancy but has the potential to have significant impact through inclusive collaboration with local and international stakeholders to develop effective and sustainable public health solutions for disseminating best practices and delivering tangible benefits to individuals with ASD and their families. Autism Res 2012, **: **-**. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
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10. White SW, Kreiser NL, Pugliese C, Scarpa A. {{Social Anxiety Mediates the Effect of Autism Spectrum Disorder Characteristics on Hostility in Young Adults}}. {Autism};2012 (May 15)
Problems with social anxiety are frequently reported in people with autism spectrum disorders (ASD). It is possible that social anxiety, when present, exacerbates the experience of hostility and other forms of aggression in relation to ASD symptoms. This study sought to determine if social anxiety symptoms mediate the relationship between features of ASD and feelings of hostility in young adults. Self-report measures of social anxiety, ASD, and facets of aggression were collected in a non-clinical sample (n = 618) of college students. Social anxiety was found to partially mediate the relationship between ASD features and self-reported hostility. There was also evidence for inconsistent mediation, such that social anxiety dampened the strength of the relationship between ASD symptoms and verbal and physical aggression. Findings highlight the potential influence of associated psychiatric symptoms in people with ASD. In addition, dimensional conceptualization of ASD symptoms, as opposed to a categorical approach solely, may be a useful approach to studying complex personality processes.
