1. Bakheet D, Maharatna K. Linear and nonlinear analysis of intrinsic mode function after facial stimuli presentation in children with autism spectrum disorder. Computers in biology and medicine. 2021; 133: 104376.

In this work, a method for classifying Autism Spectrum Disorders (ASD) from typically developing (TD) children is presented using the linear and nonlinear Event-Related Potential (ERP) analysis of the Electro-encephalogram (EEG) signals. The signals were acquired during the presentation of three types of face expression stimuli -happy, fearful and neutral faces. EEGs are first decomposed using the Multivariate Empirical Mode Decomposition (MEMD) method to extract its Intrinsic Mode Functions (IMFs), which provide information about the underlying activities of ERP components. The nonlinear sample entropy (SampEn) features, as well as the standard linear measurements utilizing maximum (Max.), minimum (Min), and standard deviation (Std.), are then extracted from each set of IMFs. These features are then evaluated by the statistical analysis tests and used to construct the input vectors for the Discriminant analysis (DA), Support vector machine (SVM), and k-Nearest Neighbors (kNN) classifiers. Experimental results show that the proposed features can differentiate the ASD and TD children using the happy stimulus dataset with high classification performance for all classifiers that reached 100% accuracy. This result suggests a general deficit in recognizing the positive expression in ASD children. Additionally, we found that the SampEn measurements computed from the alpha and theta bands and the linear features extracted from the delta band can be considered biomarkers for disturbances in Emotional Facial Expression (EFE) processing in ASD children.

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2. Buzzell GA, Thomas HR, Choi YB, Kim SH. Atypical Mediofrontal Theta Oscillations Underlying Cognitive Control in Kindergarteners With Autism Spectrum Disorder. Biological psychiatry Cognitive neuroscience and neuroimaging. 2021.

BACKGROUND: Children with autism spectrum disorder (ASD) often exhibit deficits in cognitive control. Neuroimaging approaches have implicated disruptions to mediofrontal cortex structure and function. However, previous work is limited in testing whether young children with ASD exhibit disruptions to task-related theta oscillations thought to arise from the mediofrontal cortex. METHODS: Children with ASD (n = 43) and age- and sex-matched typically developing peers (n = 24) at kindergarten entry performed a child-friendly Go/NoGo task while 64-channel electroencephalography was recorded. Time-frequency approaches were employed to assess the magnitude of mediofrontal theta oscillations immediately after error (vs. correct) responses (early theta) as well as later emerging theta oscillations (late theta). We tested whether error-related mediofrontal theta oscillations differed as a function of diagnosis (ASD/typical) and timing (early/late theta). In addition, links to social and academic outcomes were tested. RESULTS: Overall, children showed increased theta power after error versus correct responses. Compared with typically developing children, children with ASD exhibited a selective reduction in error-related mediofrontal theta power during the late time window. There were no significant group differences for early theta power. Moreover, reduced error-related theta power during the late, but not early, time window significantly predicted poorer academic and social skills. CONCLUSIONS: Kindergarteners with ASD demonstrated a selective reduction in error-related mediofrontal theta power during a relatively late time window, which is consistent with impairments in specific cognitive processes that recruit top-down control. Targeting these particular cognitive control processes via intervention prior to school entry may promote more successful functional outcomes for children with ASD.

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3. Ding Y, Wang J, Zhou H, Li T, Zhou S, Wang Y. Assessment of tuberous sclerosis-associated neuropsychiatric disorders using the MINI-KID tool: a pediatric case-control study. Orphanet journal of rare diseases. 2021; 16(1): 181.

BACKGROUND: The tuberous sclerosis-associated neuropsychiatric disorders (TAND) have not previously been studied in China. We aimed to assess the psychiatric level of individuals with TAND using the Mini International Neuropsychiatric Interview for Children (MINI-KID) in China. RESULTS: A total of 83.16% of individuals (79/95) had at least one TAND, and 70.53% (67/95) had an intellectual disability. The MINI-KID tool diagnosed 16 neuropsychiatric diseases, the most common of which were attention-deficit/hyperactivity disorder (ADHD) (51.58%, 49/95) and social anxiety disorder (30.53%, 29/95). The number of children with psychiatric diseases in the tuberous sclerosis complex (TSC) group was significantly greater than the number in the typically developing group (P < 0.0001). Notably, 69.47% (66/95) had two or more psychiatric disorders. Pervasive developmental disorder (PDD) was often co-morbid with other psychiatric disorders. CONCLUSIONS: This study used the structured and systematic MINI-KID scale to determine the diagnosis of psychiatric co-morbidities in a relatively large sample, suggesting a higher rate. By comparing the status of individuals with TSC with typically developing children, the results suggests that neuropsychiatric co-morbidities are significantly higher in individuals with TSC. Research has revealed the frequent presence of two, three or more neuropsychiatric diseases in individuals with TSC.

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4. Mazzoni N, Ricciardelli P, Actis-Grosso R, Venuti P. Difficulties in Recognising Dynamic but not Static Emotional Body Movements in Autism Spectrum Disorder. Journal of autism and developmental disorders. 2022; 52(3): 1092-105.

In this study, we investigated whether the difficulties in body motion (BM) perception may led to deficit in emotion recognition in Autism spectrum disorder (ASD). To this aim, individuals with high-functioning ASD were asked to recognise fearful, happy, and neutral BM depicted as static images or dynamic point-light and full-light displays. Results showed slower response times in participants with ASD only in recognising dynamic stimuli, but no group differences in accuracy. This suggests that i) a deficit in action chaining mechanism in ASD may prevent the recognition of dynamic BM automatically and rapidly, ii) individuals with ASD and high cognitive resources can develop alternative-but equally successful-strategies to recognise emotional body expressions. Implications for treatment are discussed.

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5. Nair A, Jalal R, Liu J, Tsang T, McDonald NM, Jackson L, Ponting C, Jeste SS, Bookheimer SY, Dapretto M. Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder. Cerebral cortex (New York, NY : 1991). 2021; 31(9): 4191-205.

Converging evidence from neuroimaging studies has revealed altered connectivity in cortical-subcortical networks in youth and adults with autism spectrum disorder (ASD). Comparatively little is known about the development of cortical-subcortical connectivity in infancy, before the emergence of overt ASD symptomatology. Here, we examined early functional and structural connectivity of thalamocortical networks in infants at high familial risk for ASD (HR) and low-risk controls (LR). Resting-state functional connectivity and diffusion tensor imaging data were acquired in 52 6-week-old infants. Functional connectivity was examined between 6 cortical seeds-prefrontal, motor, somatosensory, temporal, parietal, and occipital regions-and bilateral thalamus. We found significant thalamic-prefrontal underconnectivity, as well as thalamic-occipital and thalamic-motor overconnectivity in HR infants, relative to LR infants. Subsequent structural connectivity analyses also revealed atypical white matter integrity in thalamic-occipital tracts in HR infants, compared with LR infants. Notably, aberrant connectivity indices at 6 weeks predicted atypical social development between 9 and 36 months of age, as assessed with eye-tracking and diagnostic measures. These findings indicate that thalamocortical connectivity is disrupted at both the functional and structural level in HR infants as early as 6 weeks of age, providing a possible early marker of risk for ASD.

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6. Nakata Y, Kanahara N, Kimura A, Niitsu T, Komatsu H, Oda Y, Nakamura M, Ishikawa M, Hasegawa T, Kamata Y, Yamauchi A, Inazumi K, Kimura H, Shiko Y, Kawasaki Y, Iyo M. Oxytocin system dysfunction in patients with treatment-resistant schizophrenia: Alterations of blood oxytocin levels and effect of a genetic variant of OXTR. Journal of psychiatric research. 2021; 138: 219-27.

Treatment-resistant schizophrenia (TRS) has a quite complex pathophysiology that includes not only severe positive symptoms but also other symptom domains. Much attention has been devoted to the overlapping psychological and biological profiles of schizophrenia and autistic spectrum disorder (ASD). We compared TRS patients (n = 30) with schizophrenia patients in remission (RemSZ, n = 28) and ASD patients (n = 28), focusing on general cognitive and social cognitive impairment and oxytocin system dysfunction. Our analyses revealed that there was no difference in oxytocin concentration among the three groups. The TRS patients’ oxytocin blood concentrations were positively correlated with their processing speed and theory-of-mind scores, whereas the RemSZ and ASD groups had no significant relation with any measures. Rs53576, a single nucleotide polymorphism on the oxytocin receptor gene, affected social cognition abilities in the schizophrenia group. Although the overall findings are preliminary, they indicate that oxytocin system dysfunction could be involved in the serious cognitive deficits in TRS patients. Further, these results suggest that patients with TRS might have early neurodevelopmental abnormalities based on their shared biological features with ASD patients.

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7. Odom SL, Hall LJ, Morin KL, Kraemer BR, Hume KA, McIntyre NS, Nowell SW, Steinbrenner JR, Tomaszewski B, Sam AM, DaWalt L. Educational Interventions for Children and Youth with Autism: A 40-Year Perspective. Journal of autism and developmental disorders. 2021; 51(12): 4354-69.

Commemorating the 40 th anniversary of the Diagnostic and Statistical Manual (DSM) III, the purpose of this commentary is to describe school-based and school-relevant interventions and instructional approaches for children and youth with autism that have been developed and employed during that time period. The commentary begins with a brief description of foundational research that provides an historical context. Research themes shaped by science, ethics, social policy, and the changes in the DSM provide an organization for describing the evolution of intervention and instructional practices over the four previous decades. The commentary concludes with a discussion of school-contextual variables that influence implementation and the promise of the « iSciences » for closing the research to practice gap in the future.

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8. Perini I, Gustafsson PA, Igelström K, Jasiunaite-Jokubaviciene B, Kämpe R, Mayo LM, Molander J, Olausson H, Zetterqvist M, Heilig M. Altered relationship between subjective perception and central representation of touch hedonics in adolescents with autism-spectrum disorder. Translational psychiatry. 2021; 11(1): 224.

An impairment of social communication is a core symptom of autism-spectrum disorder (ASD). Affective touch is an important means of social interaction, and C-Tactile (CT) afferents are thought to play a key role in the peripheral detection and encoding of these stimuli. Exploring the neural and behavioral mechanisms for processing CT-optimal touch (~3 cm/s) may therefore provide useful insights into the pathophysiology of ASD. We examined the relationship between touch hedonics (i.e. the subjective pleasantness with which affective touch stimuli are perceived) and neural processing in the posterior superior temporal sulcus (pSTS). This region is less activated to affective touch in individuals with ASD, and, in typically developing individuals (TD), is correlated positively with touch pleasantness. TD and ASD participants received brushing stimuli at CT-optimal, and CT-non-optimal speeds during fMRI. Touch pleasantness and intensity ratings were collected, and affective touch awareness, a measure of general touch hedonics was calculated. As expected, slow touch was perceived as more pleasant and less intense than fast touch in both groups, whereas affective touch awareness was moderately higher in TD compared to ASD. There was a strong, positive correlation between right pSTS activation and affective touch awareness in TD, but not in ASD. Our findings suggest that altered neural coupling between right pSTS and touch hedonics in ASD may be associated with social touch avoidance in ASD.

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9. Sweetmore V. Mental health nursing and autism: I am a mental health nurse so why did it take me so long to realize I’m autistic?. Journal of psychiatric and mental health nursing. 2021.

WHAT IS KNOWN ON THE SUBJECT?: Women with autistic spectrum disorder are likely to be diagnosed with other mental health needs and to have experienced trauma. Mental health nurses are likely to encounter women who possibly fit the criteria for a autistic spectrum diagnosis, but who have not been offered appropriate support or signposting. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE: Using my own lived experience as a late diagnosed woman with autism and as a mental health nurse, I identify some of the gaps in training and knowledge that mental health nurses have. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Suggestions are made as to how improvements in mental health nurses’ knowledge of autistic spectrum disorder in women could enhance mental wellbeing for this group of people.

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