1. Amorim K, Vandewouw MM, Huynh N, de Villa K, Safati C, Almonte A, Nicolson R, Kelley E, Crosbie J, Brian J, Anagnostou E, Taylor MJ, Sato J. A transdiagnostic study of theory of mind in children and youth with neurodevelopmental conditions. Mol Autism;2025 (Jul 20);16(1):37.

BACKGROUND: Theory of mind (ToM) is fundamental for social interactions, allowing individuals to appreciate that others have their own mental states. Children and youth with neurodevelopmental conditions (e.g., autism, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD)) often show differences in ToM abilities compared to their neurotypical (NT) peers. Given the phenotypic heterogeneity and overlap associated with these conditions, this motivates a transdiagnostic investigation of ToM across neurodevelopmental conditions. METHODS: Five hundred and fifty-five participants (5-22 years; 193 ADHD, 189 autism, 33 OCD, and 140 NT) were recruited via the Province of Ontario Neurodevelopmental Disorders network. To measure ToM, participants completed the Social Attribution Task (SAT), where participants attribute social stories to videos of moving shapes. The Animation Index (ability to attribute social stories to the videos) and Pertinence Index (how pertinent the attributions are) were calculated from the descriptions. Three analyses were performed: (1) a case-control analysis, comparing the SAT indices amongst the diagnostic groups, (2) a univariate dimensional analysis, examining associations with phenotypic variables (e.g., full-scale IQ, verbal IQ, and social communication difficulties), (3) and a multivariate analysis (partial least squares) that identifies a latent space that describes the associations between the SAT and phenotypic measures. RESULTS: There were no between-group differences in the Animation Index, but the Pertinence Index was significantly lower in autism compared to the other diagnostic categories. Phenotypic variables (full-scale IQ, verbal IQ, and social communication difficulties) were found to be significantly associated with SAT performance across groups, and explained more variance than the diagnostic categories. In the multivariate analysis, the phenotypic variables contributed more strongly to the identified latent component compared to the diagnostic categories. LIMITATIONS: The verbal requirement of the SAT limited the inclusion of non-verbal participants, while the overall cognitive demand limited the participation of those with lower IQs. Additionally, our OCD group was significantly smaller than the other groups, which may have limited our ability to detect OCD-specific effects. CONCLUSIONS: In a large sample, we found that transdiagnostic measures, such as IQ and social communication difficulties, are related to SAT abilities across neurodivergent and neurotypical children and youth and better describe differences in SAT performance compared to the individual diagnostic categories. Although poorer performance on ToM tasks has been classically associated with autism, this study highlights that transdiagnostic, phenotypic variables are a stronger predictor of SAT performance than diagnostic group.

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2. Erdogan MA, Gurbuz O, Bozkurt MF, Erbas O. Retraction Note: Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations. Neurochem Res;2025 (Jul 19);50(4):237.

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3. Harada N, Pellicano E, Kumagaya S, Ayaya S, Asada K, Senju A. ‘I don’t think they understand the reality of autism’: The lived experiences of autistic adults in Japan. Autism;2025 (Jul 20):13623613251355303.

Most autism research has been conducted in Western settings, which means that we know little about the lived experiences of autistic adults across a wide range of sociocultural contexts and countries. This study is, to our knowledge, the first to examine the lived experiences of autistic Japanese adults, eliciting their experiences of growing up autistic from their time at elementary school to the time of interview. We used semi-structured interviews with seven autistic Japanese adults, who had been clinically diagnosed in their 20s and 30s. Using reflexive thematic analysis, we identified four themes, including (1) people feeling different and misunderstood, (2) the books, doctors or other autistic people enabling the journey towards diagnosis, (3) the many and mixed emotions that emanated from the diagnosis and (4) a strong desire to be accepted. All interviewees experienced significant hardship throughout their lives, including a lack of acceptance of their diagnosis from their families. While this took its toll on the interviewees’ mental health, they desired to be understood by others and to address stigma. More efforts are needed to increase the knowledge, understanding and acceptance of autism in Japan through the lens of neurodiversity and with the input of the autistic community.Lay AbstractWe know more and more about what it’s like to be autistic and autistic people’s experiences at school and at work. But most studies are from Western cultures, especially the United Kingdom and the United States, which means we know little about what it’s like to be autistic in other cultures, including East Asian cultures. In this study, for the first time, we investigated the life experiences from school to employment of Japanese autistic adults. We asked seven Japanese autistic adults, who had received their clinical diagnosis in their 20s and 30s, about their experiences from their own perspective. We found four major ideas or ‘themes’: (1) people feeling different and misunderstood, (2) the books, doctors or other autistic people enabling the journey towards diagnosis, (3) the many, mixed emotions that came from getting an autism diagnosis and (4) a strong desire to be accepted. All participants experienced bullying and felt different from others around them from an early age. Some participants were happy to receive their autism diagnosis, which made them understand themselves better, while others had mixed feelings – such as feeling hopeless because autism has no cure. Our findings are consistent with previous Western research. We also found some distinctive experiences from Japanese participants, who faced a significant amount of stigma, potentially because of negative attitudes towards autism/disability and Japanese social expectations and rules. Future research should focus on the needs of autistic people in Japan and work with them to increase understanding, awareness and acceptance of autism.

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4. Lieb RW, Kalb LG, Reetzke R, Ludwig NN, Love CE, Ng R, Wexler D, Gornik AE, Holingue C, Hong JS. Associations between emotion and behavior codes and ADOS-2 scores in a sample of children referred for autism evaluation. Autism;2025 (Jul 20):13623613251355231.

While the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) is considered a « reference standard » measure to observe symptoms of autism spectrum disorder (ASD), little is known about the utility of its Other Abnormal Behaviors or « E codes. » This study investigated the unique influence of each E code (overactivity, disruptive behavior, anxiety) on ADOS-2 scoring. Data from ADOS-2 administrations (Modules 1, 2, 3) were collected from 3364 children (mean age = 6.73 years) at an outpatient ASD clinic. For those with ASD, ADOS-2 Calibrated Severity Scores (CSS) were descriptively higher for those with overactivity and disruptive behavior, but lower for those with anxiety. For those without ASD, no patterns emerged when comparing means. After controlling for age, sex, and language level, multivariable linear models indicated the presence of overactivity was significantly associated with increased CSS for children with ASD compared to those without. No significant interaction was present for disruptive behavior. The presence of anxiety was significantly associated with increased Social Affect CSS only for those without ASD. All effect sizes were small. This is one of the first studies to evaluate the effect of each individual E code on ADOS-2 CSS. Unique differences emerged across diagnostic groups, suggesting implications for ADOS-2 interpretation.Lay SummaryThe Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) is a common assessment tool used during an autism evaluation. As part of the ADOS-2, the examiner rates « E codes, » which are levels of hyperactivity, disruptive behavior, and anxiety during testing. These codes are not part of the final ADOS-2 score. While there is a lot of research on the ADOS-2, less is known about these E codes. This study looked at how the E codes might affect the final ADOS-2 scoring. Information came from 3364 in-person autism assessments (average age = 6.73 years) who were evaluated at an autism specialty clinic. For autistic children, ADOS-2 scores were higher (i.e. more autism-related behaviors) for those with overactivity and disruptive behavior, but lower for those with anxiety. For those without autism, there was no pattern. After accounting for the child’s age, sex, and language level, there were unique results for each E code, depending on whether the child received an autism diagnosis. This study is important as it is one of the first to evaluate the effects of each E code on ADOS-2 scores and could impact how scores are interpreted when considering an autism diagnosis.

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5. Sterner EF, Greve A, Knolle F. Temporal stability of semantic predictions in subclinical autistic and schizotypal personality traits. Schizophrenia (Heidelb);2025 (Jul 19);11(1):103.

Language impairments are core symptoms of both schizophrenia and autism spectrum disorders and have been linked to deficits in predictive language processing. While altered use of semantic predictions have been reported in both conditions, little is known whether semantic predictions are stable over time. The goal of this study was therefore to investigate the temporal stability of semantic prior beliefs focusing on individuals with schizotypal and autistic traits. 115 participants, assessed for subclinical schizotypal (SPQ(5ls); mean = 77.99, SD = 39.31) and autistic traits (AQ; mean = 15.67, SD = 6.01), completed an auditory stability paradigm at two timepoints to investigate the temporal stability of semantic predictions. At timepoint one, consisting of one session, participants listened to 240 sentence beginnings varying in predictability (e.g., high: « The swimmer jumped into the… »; low: « The child hid the toy under the… ») and provided a prediction for each sentence-final word. Timepoint two, consisting of two sessions, each session comprising of 120 old and 120 new sentences. In addition to final-word predictions, sentence recall was assessed to examine the influence of memory on prediction stability. Generalized linear mixed models revealed that higher predictability led to greater temporal stability of semantic predictions. Importantly, increasing schizotypal and autistic traits were associated with reduced stability, particularly in highly predictable contexts where stable predictions typically facilitate efficient language processing. While poorer sentence recall was linked to greater instability, especially in medium- and low-predictability contexts, it did not account for the reduced stability observed in relation to schizotypal and autistic traits. These findings suggest that individuals with higher schizotypal and autistic traits struggle to form stable, lasting semantic predictions, which may contribute to difficulties in efficient language processing.

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