1. Dammann O, Follett P. {{Toward multi-scale computational modeling in developmental disability research}}. {Neuropediatrics};2011 (Jun);42(3):90-96.
The field of theoretical neuroscience is gaining increasing recognition. Virtually all areas of neuroscience offer potential linkage points for computational work. In developmental neuroscience, main areas of research are neural development and connectivity, and connectionist modeling of cognitive development. In this paper, we suggest that computational models can be helpful tools for understanding the pathogenesis and consequences of perinatal brain damage and subsequent developmental disability. In particular, designing multi-scale computational models should be considered by developmental neuroscientists interested in helping reduce the risk for developmental disabilities.
Lien vers le texte intégral (Open Access ou abonnement)
2. Rao TS, Andrade C. {{The MMR vaccine and autism: Sensation, refutation, retraction, and fraud}}. {Indian J Psychiatry};2011 (Apr);53(2):95-96.
Lien vers le texte intégral (Open Access ou abonnement)
3. Welberg L. {{Autism: The importance of getting the dose right}}. {Nat Rev Neurosci};2011;12(8):429.
Lien vers le texte intégral (Open Access ou abonnement)
4. Yan X, Denman RB. {{Conformational-dependent and independent RNA binding to the fragile x mental retardation protein}}. {J Nucleic Acids};2011;2011:246127.
The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts produced by in vitro transcription contain a population of conformers, which can be modulated by preannealing. Accordingly, FMRP differentially binds to the annealed and unannealed conformer populations. Using partial RNase digestion, we demonstrate that annealed BC1 RNA contains a unique conformer that FMRP likely binds. We further demonstrate that this interaction is 100-fold weaker than that the binding of eEF-1A mRNA and FMRP, and that preannealing is not a general requirement for FMRP’s interaction with RNA. In addition, binding does not require the N-terminal 204 amino acids of FMRP, methylated arginine residues and can be recapitulated by both fragile X paralogs. Altogether, our data continue to support a model in which BC1 RNA functions independently of FMRP.
