1. Adrien JL, Blanc R, Thiébaut E. Profile and development of adaptive behavior in adults with autism spectrum disorder and severe intellectual disability. Front Psychiatry. 2024; 15: 1470466.

BACKGROUND: This study examined the profiles of adaptive behavior development in adults with autism spectrum disorder (ASD) and severe intellectual disability (ID), and the relationships between the levels of the different domains and subdomains of adaptive development and the intensity of autistic symptomatology. PARTICIPANTS: This study involved 71 adults (44 men and 27 women with average ages of 39 years 7 months and 36 years 2 months, respectively) living in medico-social institutions and having a level of adaptive development corresponding to age below 3 years 4 months and a level of cognitive development corresponding to ages between 12 and 24 months. METHODS: ASD was diagnosed using Pervasive Development Disorder-Mental Retardation Scale (PDD-MRS) and Childhood Autistic Rating Scale (CARS), ID and its severity were determined based on the Diagnostic Statistical Manual-5 (DSM-5) criteria, and the very low cognitive developmental level was assessed using the Socio-emotional Cognitive Evaluation Battery (Adrien, Pearson-ECPA, 2007), adapted for adults (SCEB-A). Adaptive development was assessed using the Vineland-II tool. RESULTS: The adaptive developmental profile was heterogeneous: the median levels of the three domains of socio-adaptive development differed significantly from each other, and the domain of Daily Living was the most developed. Among the nine subdomains, the weakest developmental levels corresponded to Expressive Language, Interpersonal Relationships, and Play/Leisure. By contrast, the highest levels corresponded to Writing and Personal and Domestic Autonomy. Significant and negative relationships were noted between the intensity of autism severity and the levels of development in Communication and Daily Living but not Socialization. These results are discussed to highlight the best-developed adaptive domains and those to be improved.

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2. Bitsika V, Sharpley CF, Evans ID, Watson CB, Williams RJ, Vessey KA. Low-Level Social Demand Is Associated with Anxiety-Related Gamma Wave Responses in Autistic Male Youth. Brain Sci. 2025; 15(1).

BACKGROUND: The Autism Spectrum Disorder (ASD) characteristic of difficulties in social communication and interaction has been previously associated with elevated anxiety and the degree of mental effort required to understand and respond to social cues. These associations have implications for the mental health of autistic youth, but they are usually based on correlational statistics between measures of anxiety and social interaction demands that are collected in formal psychological testing settings. Another index of mental effort that has been found to correlate with anxious arousal is gamma wave activity, which is measured via EEG. METHODS: To compare data from both of these indicators of mental effort and anxiety, a two-stage study was conducted using (1) standardized test data and (2) in vivo EEG data in a low-demand social setting. RESULTS: As well as significant associations between social cognition and anxiety from standardized scales, there were also meaningful relationships between social cognition and gamma wave activity. CONCLUSIONS: Because gamma wave activity represents the highest level of cognitive complexity for brain activity, is an index of hypervigilance under threatening conditions, and has been associated with anxiety in autistic youth, these findings suggest that even low-level demand social interaction settings may initiate high-level anxiety-related behaviour in autistic youth.

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3. Braverman Y, Surmacz M, Schnur G, Sheikhi N, Faja S. Piloting a battery to evaluate parasympathetic reactivity and externalizing behaviours during early childhood in autism spectrum disorder. Infant Child Dev. 2024; 33(6).

BACKGROUND: Respiratory Sinus Arrhythmia Reactivity (RSA-R) correlates both positively and negatively with externalizing behavior in autistic individuals. These inconsistencies may result from task-based differences. This pilot study measured RSA-R in 4-to 6-year-olds, across two time-points, using four validated tasks with matched baseline and challenge periods. Social, cognitive, sensory, and emotional tasks were employed to evaluate the use of a domain-specific approach in measuring RSA-R in young autistic children. METHODS: RSA and parent-reported externalizing behavior were collected from 16 children (M(age)=5.60 years; 13 male; 12 white/caucasian; 15 non-hispanic/latine). RSA-R was measured by the difference score of the challenge task minus its corresponding comparison task. Correlations were computed to evaluate associations between RSA-R and behavior. RESULTS: RSA was reliably measured for 3/4 tasks (.694 ≤ ICCs ≤ .896). Only RSA-R during a social task correlated with externalizing behavior. These results support using a battery that measures a range of challenges, differing in social demands, to characterize how arousal contributes to emotion regulation demands among young autistic children.

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4. Bridi MCD, Luo N, Kim G, Menarchek BJ, Lee RA, Rodriguez B, Severin D, Wesselborg C, O’Ferrall C, Patel R, Bertrand S, Kannan S, Kirkwood A, Moreno C, Contreras A. Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism. iScience. 2025; 28(1): 111494.

Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. Therefore, we tested whether E/I regulation, rather than the overall E/I ratio, is disrupted in two ASD-related mouse lines: Fmr1 KO and BTBR, models of syndromic and idiopathic ASD, respectively. The E/I ratio is dysregulated in both models, but in different ways: the oscillation is lost in Fmr1 KO and reversed in BTBR mice. Phenotypes in both models associate with differences the timing of excitatory and inhibitory synaptic transmission and endocannabinoid signaling compared to wild type mice, but not with altered sleep. These findings raise the possibility that ASD-related phenotypes may be produced by a mismatch between E/I and behavioral state, rather than alterations to overall E/I levels per se.

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5. Camerino C. The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder. Curr Issues Mol Biol. 2025; 47(1).

Sensory processing abnormalities have been noted since the first clinical description of autism in 1940. However, it was not until the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013 that sensory challenges were considered as symptoms of autism spectrum disorder (ASD). Multisensory processing is of paramount importance in building a perceptual and cognitive representation of reality. For this reason, deficits in multisensory integration may be a characteristic of ASD. The neurohormone oxytocin (Oxt) is involved in the etiology of ASD, and there are several ongoing clinical trials regarding Oxt administration in ASD patients. Recent studies indicate that Oxt triggers muscle contraction modulating thermogenesis, while abnormal thermoregulation results in sensory deficits, as in ASD. Activation of the Oxt system through exposure to cold stress regulates the expression of oxytocin receptor (Oxtr) in the brain and circulating Oxt, and if this mechanism is pathologically disrupted, it can lead to sensory processing abnormalities since Oxt acts as a master gene that regulates thermogenesis. This review will describe the sensory deficits characteristic of ASD together with the recent theories regarding how the modulation of Oxt/Oxtr in the brain influences sensory processing in ASD.

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6. Campbell K, Neul JL, Lieberman DN, Berry-Kravis E, Benke TA, Fu C, Percy A, Suter B, Morris D, Carpenter RL, Marsh ED, von Hehn J. A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome. J Neurodev Disord. 2025; 17(1): 4.

BACKGROUND: Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy. DESIGN: This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence, cross-over study of oral ketamine in 6-12-year-old girls with RTT to evaluate short-term safety and tolerability and explore efficacy. METHODS: Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite treatment. Ketamine was dosed twice daily at 0.75 mg/kg/dose (Cohort 1) or 1.5 mg/kg/dose (Cohort 2). An independent safety monitoring committee evaluated safety and approved proceeding to the next dose cohort. Caregivers, participants, outcome assessors, and study staff except pharmacists were blinded to allocation. The primary endpoint was safety and tolerability. Exploratory efficacy endpoints included change in clinician- and caregiver-rated measures of RTT features, brain activity on electroencephalography, and wearable biosensors to measure respiration, heart rate, sleep, and activity. RESULTS: Twenty-three participants enrolled (11 in Cohort 1, 12 in Cohort 2) from 3/12/2019-11/22/2021. One participant was excluded from analysis due to not meeting inclusion criteria on blinded review prior to analysis. One participant was withdrawn from the study due to an adverse event (vomiting) after the first dose of ketamine. Although planned for four dose cohorts, the trial was stopped after Cohort 2 due to enrollment challenges associated with the COVID-19 pandemic. Ketamine was safe and tolerated in both cohorts, with 1 related treatment emergent adverse event of vomiting. No difference was observed in efficacy between ketamine and placebo. Electroencephalography showed the expected increase in high frequency power with ketamine. CONCLUSIONS: Short-term, low-dose oral ketamine was safe and well tolerated in girls with RTT. No clinical efficacy of ketamine in treating symptoms of RTT was observed with 5 days of treatment, despite electroencephalography evidence of ketamine target engagement during the first dose. Further studies are needed to evaluate safety and efficacy of higher dose and longer exposure to ketamine in RTT. TRIAL REGISTRATION: Registered at clinicaltrials.gov NCT03633058.

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7. Camussi D, Marchese M, Nicoletti F, Santorelli FM, Ogi A. Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review. Cells. 2025; 14(2).

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social skills and the presence of repetitive and restricted behaviors and interests. The social behavior of the zebrafish (Danio rerio) makes this organism a valuable tool for modeling ASD in order to explore the social impairment typical of this disorder. In addition to transgenic models, exposure of zebrafish embryos to valproic acid (VPA) has been found to produce ASD-like symptoms. This review first sets out to examine the existing literature on adult social behavior in the zebrafish VPA-induced model of autism, and the authors also aim to identify the ideal VPA dosage able to induce a persistent and long-lasting ASD-like phenotype while minimizing the suffering and distress of research animals in compliance with the principles of replacement, refinement, and reduction (3Rs).

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8. Forbes EJ, Tiego J, Langmead J, Unruh KE, Mosconi MW, Finlay A, Kallady K, Maclachlan L, Moses M, Cappel K, Knott R, Chau T, Sindhu VPM, Bellato A, Groom MJ, Kerestes R, Bellgrove MA, Johnson BP. Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD. J Autism Dev Disord. 2025.

Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism.

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9. He C, Miyamoto S, Lin Y. Narratives of Chinese kindergarteners with Autism spectrum disorder: Comparison with typically developing children. Clin Linguist Phon. 2025: 1-25.

Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder characterised by highly heterogeneous language abilities. These variations necessitate sensitive and comprehensive assessments, with narrative analysis being an effective method. This study aimed to examine the micro- and macrostructural aspects of narratives of Mandarin-speaking children with ASD. 19 children with ASD (mean age = 5.57 years; standard deviation [SD] = 1.09) and 19 age-matched typically developing (TD) children (mean age = 5.14 years; SD = 0.09) were enrolled in this study. The Narrative Assessment Protocol (NAP-2) was used to obtain the children’s narrative samples. Children’s wordless picture book-based narrations were analysed for story length (total number of words and utterances), linguistic abilities (mean length of utterances, mean length of the five longest utterances, number of different words, and vocabulary diversity), and NAP-2 scores (total scores, story grammar, storytelling convention, simple sentence structure, complex sentence structure, word and phrase). After applying Bonferroni’s adjustment (α = 0.0042), no significant differences were observed in linguistic performance or story length between the two groups. However, children with ASD showed significantly lower total scores (t = 3.25, p = 0.002), story grammar scores (t = 3.17, p = 0.003), and storytelling convention scores (t = 3.04, p = 0.004). These findings suggest that young Chinese children with ASD may exhibit comparable microstructural narrative abilities but face significant challenges in macrostructural narrative skills, such as organising episodic structures. This underscores the need for targeted interventions to enhance the macro-narrative skills in this population.

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10. He Y, He Y, Cheng B. Identification of Bacterial Lipopolysaccharide-Associated Genes and Molecular Subtypes in Autism Spectrum Disorder. Pharmgenomics Pers Med. 2025; 18: 1-18.

BACKGROUND: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition marked by diverse symptoms affecting social interaction, communication, and behavior. This research aims to explore bacterial lipopolysaccharide (LPS)- and immune-related (BLI) molecular subgroups in ASD to enhance understanding of the disorder. METHODS: We analyzed 89 control samples and 157 ASD samples from the GEO database, identifying BLI signatures using least absolute shrinkage and selection operator regression (LASSO) and logistic regression machine learning algorithms. A nomogram prediction model was developed based on these signatures, and we performed Gene Set Enrichment Analysis (GSEA), Gene Set Variation Analysis (GSVA), and immune cell infiltration analysis to assess the impact of BLI subtypes and their underlying mechanisms. RESULTS: Our findings revealed 17 differentially expressed BLI genes in children with ASD, with BLNK, MAPK8, PRKCQ, and TNFSF12 identified as potential biomarkers. The nomogram demonstrated high diagnostic accuracy for ASD. We delineated two distinct molecular subtypes (Cluster 1 and Cluster 2), with GSVA indicating that Cluster 2 showed upregulation of immune- and inflammation-related pathways. This cluster exhibited increased levels of antimicrobial agents, chemokines, cytokines, and TNF family cytokines, alongside activation of bacterial lipoprotein-related pathways. A significant correlation was found between these pathways and distinct immune cell subtypes, suggesting a potential mechanism for neuroinflammation and immune cell infiltration in ASD. CONCLUSION: Our research highlights the role of BLI-associated genes in the immune responses of individuals with ASD, indicating their contribution to the disorder’s typification. The interplay between bacterial components, genetic predisposition, and immune dysregulation offers new insights for understanding ASD and developing personalized interventions.

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11. Hendry A, Hulks V, Murphy S, Radford H, Smith S, Charman T, Mathers S, Rhodes S, Scerif G. Learning from the community: iterative co-production of a programme to support the development of attention, regulation and thinking skills in toddlers at elevated likelihood of autism or ADHD. Res Involv Engagem. 2025; 11(1): 7.

Programmes designed to support children with known, or increased likelihood of, autism or ADHD often focus on reducing behaviours central to a clinical diagnosis. However, supporting children to pursue their own goals and cope with everyday life through fostering executive function (EF) development, without enforcing neuro-normative assumptions, may be more acceptable to neurodivergent people, and more beneficial. The co-production process for this neurodiversity-affirming programme involved: Review of research priorities identified during published public-and-clinician consultations; iterative programme development through two pilot rounds with a general community sample; and consultation with stakeholders (parents with a connection to autism or ADHD, alongside early years specialists, psychologists and therapists) to check acceptability of the proposal, and refine the logic model and materials. The logic model for the resultant programme-Supporting Toddlers with a connection to autism or ADHD to develop strong Attention, Regulation and Thinking skills (START)-involves three mechanisms of change: The child has appropriate play-based opportunities to practise EF skills; Parenting behaviours linked to strong EFs are encouraged; Parents are empowered to improve environmental-fit for their child so that EF stressors are reduced. Children showing many autistic traits, or who have a close family member on the autism spectrum or having ADHD, are more likely than average to struggle with attention, regulation and thinking skills. This may lead to difficulties with mental health and independent living in later life. We aimed to create a parent-toddler programme that would help children with a connection to autism or ADHD to thrive, without pressuring them to act in a certain way. To do this we first reviewed the results of previous studies and community consultations, and identified how we could build on an existing parent support programme structure to meet the project goals. Next, we tried out our ideas with 18 families. Then, we asked nine parents with a connection to autism or ADHD (because they are neurodivergent themselves, and/or raising a neurodivergent child), and five professionals to help us improve the materials further. The end result is a programme called START (Supporting Toddlers with a connection to autism or ADHD to develop strong Attention, Regulation and Thinking skills). This 12-week group-based parent-toddler programme aims to foster children’s development in three ways: (1) Giving children opportunities to practise their skills through play and everyday activities (2) Creating a welcoming, accessible and non-judgemental space for parents to hear about and share ideas (3) Helping parents to identify ways to help their child feel calm, safe and supported. eng.

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12. Hildebrandt T, Simpson K, Adams D. Anxiety During Employment-Seeking for Autistic Adults. Brain Sci. 2024; 15(1).

BACKGROUND/OBJECTIVES: Autistic adults are more likely to be unemployed compared to neurotypical adults and those with disability. To address these poorer employment outcomes, it is important to consider factors that may be impacting on autistic adults’ employment outcomes. Anxiety is a common co-occurring condition for autistic adults; however, there is little research on how anxiety affects or influences autistic people’s experience across the employment-seeking process. The aim of this study was to explore whether anxiety is perceived to affect autistic adults’ ability to engage in employment-seeking tasks. METHODS: Online, semi-structured interviews were conducted with 12 autistic adults (22-52 years) who were actively seeking employment or had sought employment in the last 18 months. Interview transcripts were analysed using thematic analysis. RESULTS: Three themes were generated from the data analysis. Theme 1, Finding the « sweet spot », identified some level of anxiety-but not too much-was helpful in performing the employment-seeking tasks and this « spot » could vary depending on the person and the task. Theme 2, Anxiety affects the ability to perform and function, encapsulates the autistic person’s experience when anxiety is too high. The third theme, The « vicious cycle » of anxiety and employment-seeking behaviours, explores participants’ ongoing experience of anxiety on their employment-seeking behaviours. CONCLUSIONS: The findings suggest that autistic job candidates would benefit from tailored accommodations and adjustments offered throughout the recruitment process, to reduce anxiety and improve employment-seeking outcomes for autistic candidates.

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13. Kikuchi Y, Uddin M, Veltman JA, Wells S, Morris C, Woodbury-Smith M. Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes. Mol Autism. 2025; 16(1): 5.

BACKGROUND: Significant progress has been made in elucidating the genetic underpinnings of Autism Spectrum Disorder (ASD). However, there are still significant gaps in our understanding of the link between genomics, neurobiology and clinical phenotype in scientific discovery. New models are therefore needed to address these gaps. Rhesus macaques (Macaca mulatta) have been extensively used for preclinical neurobiological research because of remarkable similarities to humans across biology and behaviour that cannot be captured by other experimental animals. METHODS: We used the macaque Genotype and Phenotype (mGAP) resource consisting of 2,054 macaque genomes to examine patterns of evolutionary constraint in known human neurodevelopmental genes. Residual variation intolerance scores (RVIS) were calculated for all annotated autosomal genes (N = 18,168) and Gene Set Enrichment Analysis (GSEA) was used to examine patterns of constraint across ASD genes and related neurodevelopmental genes. RESULTS: We demonstrated that patterns of constraint across autosomal genes are correlated in humans and macaques, and that ASD-associated genes exhibit significant constraint in macaques (p = 9.4 × 10(- 27)). Among macaques, many key ASD-implicated genes were observed to harbour predicted damaging mutations. A small number of key ASD-implicated genes that are highly intolerant to mutation in humans, however, showed no evidence of similar intolerance in macaques (CACNA1D, MBD5, AUTS2 and NRXN1). Constraint was also observed across genes associated with intellectual disability (p = 1.1 × 10(- 46)), epilepsy (p = 2.1 × 10(- 33)) and schizophrenia (p = 4.2 × 10(- 45)), and for an overlapping neurodevelopmental gene set (p = 4.0 × 10(- 10)). LIMITATIONS: The lack of behavioural phenotypes among the macaques whose genotypes were studied means that we are unable to further investigate whether genetic variants have similar phenotypic consequences among nonhuman primates. CONCLUSION: The presence of pathological mutations in ASD genes among macaques, along with evidence of similar genetic constraints to those in humans, provides a strong rationale for further investigation of genotype-phenotype relationships in macaques. This highlights the importance of developing primate models of ASD to elucidate the neurobiological underpinnings and advance approaches for precision medicine and therapeutic interventions.

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14. Li X, Wu S, Yang W, Jiang C, Zhao Z, Wang H, Lin F. Abnormal resting-state brain network dynamics in toddlers with autism spectrum disorder. Eur Child Adolesc Psychiatry. 2025.

Emerging evidence suggests aberrant functional connectivity (FC) of brain networks in children, adolescents, and adults with autism spectrum disorder (ASD). However, little is known about alterations of dynamic FC in toddlers with ASD. The aim of this study was to investigate the characteristics of brain network dynamics in ASD toddlers. We analyzed resting-state functional magnetic resonance imaging data of 41 ASD and 23 typically-developing (TD) toddlers aged 15-45 months using leading eigenvector dynamics analysis. The between-group differences in the temporal properties of state were evaluated, followed by correlation analysis of these differences with autistic factors in ASD. Compared with TD subjects, ASD toddlers had a lower occurrence rate and mean dwell time in the global state. The mean dwell time of this state was negatively correlated with the body and object use of the autism behavior checklist (ABC) score. The ASD group presented a higher occurrence probability in the state related to the visual network, and the dwell time of this state was positively correlated with the relationship building of the ABC score. Moreover, the occurrence probability of the state related to the dorsal attention network and default mode network was positively correlated with the body and object use of the ABC score. Our findings indicate that there are differences in the developmental patterns of large-scale brain functional networks in ASD toddlers, which may contribute to the early identification of ASD and provide meaningful insights into its potential neural mechanisms.

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15. MacDonald-Prégent A, McGuinness L, Nadig A. Value Added by Assessing Nonspoken Vocabulary in Minimally Speaking Autistic Children. Am J Speech Lang Pathol. 2025: 1-13.

PURPOSE: There is a scarcity of language assessment tools properly adapted for use with minimally speaking autistic children. As these children often use nonspoken methods of communication (i.e., augmentative and alternative communication [AAC]), modification of traditional assessment tools is needed to capture the full range of their communicative repertoires. We modified the MacArthur-Bates Communicative Development Inventories (CDI) to explore how vocabulary size and composition are impacted by considering nonspoken, as well as spoken, expressive vocabulary (AAC-modified CDI: Words and Gestures). METHOD: Our initial sample consisted of 16 minimally speaking autistic children, 3-9 years old, whose caregivers completed our modified CDI after taking part in an AAC intervention. Our final sample included 15 participants, after removing an outlier. RESULTS: Accounting for both spoken and nonspoken communication significantly increased participants’ reported expressive vocabulary by an average of 14 words (z = -2.61, p = .009, r = .75). Verbs made up a sizable portion (13.3%) of vocabulary when accounting for all modalities, while nouns made up the majority (51.5%). CONCLUSIONS: We demonstrated the value of including both spoken and nonspoken modalities of communication when assessing the expressive vocabulary of minimally speaking autistic children. Prior work has shown that minimally speaking autistic children’s spoken vocabulary was prominent in verbs (i.e., contained proportionally more verbs than that of vocabulary-matched typically developing children). In our sample, which used a broader definition of minimally speaking, we found that the proportions of verbs and nouns were consistent with what has been reported for typically developing children with similar-sized productive vocabularies.

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16. Ricchiuti G, Tuerlinckx E, Taillieu A, Prinsen J, Steyaert J, Boets B, Alaerts K. Toward effective oxytocin interventions in autism: Overcoming challenges and harnessing opportunities. J Psychopharmacol. 2025: 2698811241309621.

Intranasal administration of oxytocin is emerging as a potential pharmacological option for mitigating social difficulties and regulating stress in autism spectrum disorder. However, initial single-dose and multiple-dose trials showed mixed results, with some demonstrating improvements in social and repetitive behavior and others showing no benefit over placebo. This perspective aims to elucidate factors contributing to this variability and to highlight pitfalls and opportunities in the field. We identified two major factors: design-related elements and individual participant characteristics. Pertaining to design-related elements, optimal dosing regimens have yet to be established, but appear to favor moderate intervention durations (i.e., 4-6 weeks) with intermittent and intermediate dosing (i.e., 24-32 IU every other day). Also, the context of the intervention seems crucial, as enhanced outcomes are mainly observed when oxytocin administration is paired with a socially stimulating and supporting environment. In addition, more adequate outcome measures have to be established to effectively assess oxytocin’s impact, including behavioral scales and objective biophysiological markers tapping into stress and neurophysiological regulation. Future research should also account for individual participant differences in biological sex, developmental stage and cognitive and adaptive functioning, and incorporate (epi)genetic screening to identify responders. Overall, refining study designs and personalizing intervention protocols are essential for optimizing oxytocin’s prosocial and anxiolytic effect in autism.

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17. Sarhani-Robles A, Guillot-Valdés M, Robles-Bello MA, Sánchez-Teruel D. Cognitive and Emotional Resilience in Parents with Children with Autism Spectrum Disorder During COVID-19: The Role of Promoting Variables. J Intell. 2025; 13(1).

The pandemic resulting from the coronavirus disease (COVID-19) has entailed social and psychological consequences for the Spanish population, with children with autism spectrum disorder (ASD) being particularly vulnerable due to their genetic characteristics. The present study focuses on the efforts of parents of children with autism spectrum disorder to improve their situation during the pandemic. In particular, the objective is to identify promoting variables (subjective well-being, positive mental health, social support, humour, cognitive reappraisal, and self-esteem) and sociodemographic variables that predict resilience, marking positive coping with this adverse situation. Furthermore, the study conceptually explores the potential role of emotional intelligence in resilience-building processes. We hypothesised that higher scores in these promoting variables would predict greater resilience, with emotional intelligence potentially serving as an underlying framework. The methodology employed in this study is as follows: A cross-sectional predictive study was conducted on a sample of 799 parents using an online questionnaire administered during the social confinement resulting from the SARS-CoV-2 pandemic. The information analysed is based on data provided by the parents. Statistical methods included Student’s t-tests, Pearson’s correlations, and stepwise multivariate regression analysis to identify predictors of resilience. The results of the study are presented below. Significant resilience scores and resilience prediction were identified in participants based on positive mental health, emotion regulation, sense of humour, social support, age, and employment status (self-employed). Relations with emotional intelligence were identified, particularly in the domains of emotion regulation, cognitive reappraisal, and positive mental health. Discussion: The necessity of an intervention that prioritises the empowerment of resilience in the target population is substantiated. Practical implications suggest leveraging emotional intelligence strategies to enhance resilience in this population. This study highlights the importance the aforementioned variables, in addition to potential strategies for enhancing the sociodemographic circumstances of the families.

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18. Tuma J, Rana AN, Philip T, Park JB, Lee HY. Altered olfactory responses in Fmr1 KO mice. Sci Rep. 2025; 15(1): 2952.

Fragile X syndrome (FXS) is a neurodevelopmental disorder oftentimes associated with abnormal social behaviors and altered sensory responsiveness. It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS. However, previous studies investigating olfaction in animal models of FXS have shown inconsistent results. Here, we found that Fmr1 knock-out (KO) mice, a mouse model of FXS, showed increased sniffing duration for non-social odors during their first exposure. Additionally, while wild-type (WT) males demonstrated differences in behavioral patterns between non-social odors while Fmr1 KO males did not show such distinction. We also showed that Fmr1 KO males spent significantly less time sniffing female urine odor compared to WT males. Moreover, we found an increased volume of the olfactory bulb in Fmr1 KO males. Overall, our findings suggest that the Fmr1 KO mice demonstrate atypical olfactory behaviors as well as structural changes in the olfactory bulb.

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19. Wong MY, Carlton C, Paul S, Deutsch J, Sherman R, Milliron BJ, Farmer N, Hingst R, Richardson C, Shea L. Cooking with confidence for autistic youth: outcomes from a pilot program evaluation model. BMC Res Notes. 2025; 18(1): 35.

OBJECTIVE: This article outlines the evaluation model for the Cooking with Confidence (CWC) program, developed using Bandura’s Social Learning Theory as its conceptual framework. The evaluation aimed to: (1) Examine participant characteristics in the CWC program, (2) Assess changes in cooking knowledge, skill acquisition, self-efficacy, and confidence, and (3) Identify barriers and facilitators to participant engagement. CWC is a community-based educational program designed to help autistic young adults develop independent living skills and promote health through hands-on cooking classes. Recognizing the need for more opportunities for autistic individuals to practice these skills, the program was created through public and private partnerships. A pre-post study design was employed, with participants completing surveys before and after their involvement in the program. RESULTS: Participants reported high satisfaction with the program and showed improvements in cooking knowledge and self-efficacy. The analysis also highlighted participant characteristics, as well as key barriers and facilitators to cooking. Overall, the CWC program demonstrated positive outcomes, with findings offering valuable insights for future program development to enhance its impact.

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20. Yardımcı-Lokmanoğlu BN, Topal Y, Kınacı-Biber E, Arıkan Z, Sırtbaş-Işık G, Porsnok D, Çelik HT, Mutlu A. Is there a risk of developmental problems in infants born to mothers with gestational diabetes mellitus and/or pre-eclampsia?. PLoS One. 2025; 20(1): e0318003.

OBJECTIVE: The aims of this study were (i) to describe the early spontaneous movements in 3-to 5-month-old infants in groups of infants born to mothers with GDM and/or PE, (ii) to compare them, and (iii) to analyze the differences between infants with these risk factors and typically developing infants born to mothers without GDM and/or PE and other risk factors. METHODS: This cohort study included 255 infants in 4 groups: (i) 96 infants born to mothers with GDM, (ii) 78 infants born to mothers with PE, (iii) 31 infants born to mothers with GDM and PE, and (iv) 50 typically developing infants. Early spontaneous movements, including not only fidgety movements but also concurrent movement and postural patterns, were assessed using the General Movements Assessment (GMA), which determines the Motor Optimality Score-Revised (MOS-R). Comparisons were made using one-way ANOVA for normally distributed continuous variables, Kruskal-Wallis test for non-normally distributed data, and Pearson chi-squared for categorical variables. Univariate logistic regression analyses were used to determine the odds ratios (OR) with 95% confidence intervals (CI). RESULTS: There were no differences between the three groups, which included infants whose mothers had at least one of these risk factors (p>0.05). Infants born to mothers with GDM, infants born to mothers with PE, and infants born to mothers with both GDM and PE had more aberrant fidgety movements, reduced age-adequate movement repertoire, and more abnormal postural patterns than typically developing infants (p<0.05), in addition to lower MOS-R. When looking at those with ≤24 in MOS-R, the odds ratios were ≥2.74. CONCLUSION: Findings suggest that early spontaneous movements, GMA, may play a crucial role in understanding developmental outcomes of these infants and in determining infants who need early intervention.

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21. Ying J, Zhang MW, Wei KC, Wong SH, Subramaniam M. Influential articles in autism and gut microbiota: bibliometric profile and research trends. Front Microbiol. 2024; 15: 1401597.

OBJECTIVE: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Increasing evidence suggests that it is potentially related to gut microbiota, but no prior bibliometric analysis has been performed to explore the most influential works in the relationships between ASD and gut microbiota. In this study, we conducted an in-depth analysis of the most-cited articles in this field, aiming to provide insights to the existing body of research and guide future directions. METHODS: A search strategy was constructed and conducted in the Web of Science database to identify the 100 most-cited papers in ASD and gut microbiota. The Biblioshiny package in R was used to analyze and visualize the relevant information, including citation counts, country distributions, authors, journals, and thematic analysis. Correlation and comparison analyses were performed using SPSS software. RESULTS: The top 100 influential manuscripts were published between 2000 and 2021, with a total citation of 40,662. The average number of citations annually increased over the years and was significantly correlated to the year of publication (r = 0.481, p < 0.01, Spearman's rho test). The United States was involved in the highest number of publications (n = 42). The number of publications in the journal was not significantly related to the journal's latest impact factor (r = 0.016, p > 0.05, Spearman’s rho test). Co-occurrence network and thematic analysis identified several important areas, such as microbial metabolites of short-chain fatty acids and overlaps with irritable bowel syndrome. CONCLUSION: This bibliometric analysis provides the key information of the most influential studies in the area of ASD and gut microbiota, and suggests the hot topics and future directions. The findings of this study can serve as a valuable reference for researchers and policymakers, guiding the development and implementation of the scientific research strategies in this area.

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22. Zarokanellou V, Gryparis A, Papanikolaou K. Exploring Narrative Ability in Greek-Speaking Children with High-Functioning ASD: Associations with Memory and Attention. Brain Sci. 2025; 15(1).

Background/Objectives: Narration is a sensitive tool for the assessment of language in children with high-functioning autism spectrum disorder (HF-ASD) since mild language deficits beyond the sentential level are not always noticeable through the administration of standardized language tests targeting the lexical or sentential level. This study investigated the narrative ability of monolingual Greek-speaking HF-ASD children in comparison to that of their typically developing (TD) peers and explored the associations between narrative variables, ADHD symptomatology, and memory skills in the participants on the autistic spectrum. Methods: The participants were 39 children aged 7 to 12 years, 19 with HF-ASD and 20 age-matched, vocabulary-matched, and cognitively matched TD peers. Results: The two groups were similar in most microstructural and macrostructural variables but differed significantly in syntactic complexity (p = 0.024; d = 0.754) and subordination (p < 0.001; d = -1.576) indices, implying that the HF-ASD group presented syntactic delay in comparison to their TD peers. The HF-ASD participants showed significantly higher heterogeneity in the amount of information generated for the story's main character (p = 0.004; d = -0.093) in comparison to their TD peers. Significant associations were observed between verbal and visual memory, complex syntactic structures, and Theory of Mind-related internal state terms. ADHD symptomatology was negatively correlated with the generation of simple and coordinated clauses. Finally, complex syntax and delayed vSTM were correlated with retelling total scores, indicating that language ability and verbal memory compensate for narrative competence in HF-ASD children. Conclusions: The findings highlight the impact that language skills, memory ability, and ADHD symptomatology have on narrative competence in children with HF-ASD, as well as the importance of narrative use for assessing the language skills in populations with mild language impairment.

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