Pubmed du 24/05/21
1. Ansari AMA, Janahi MI, AlTourah AJ, Jahrami HA, Rajab MB. Self-reported psychological disorders among the mothers of children with autism spectrum disorder, type 1 diabetes mellitus, and typically developed children. Journal of neurodevelopmental disorders. 2021; 13(1): 21.
BACKGROUND: To assess the prevalence of symptoms of depression, anxiety, and stress among mothers of children with autism spectrum disorders (ASD), type 1 diabetes (DM), and typical development (TD), in a geographical area where such data are lacking METHOD: A descriptive study with the three groups of parents of children with and without a condition was conducted (ASD n=126, group 1; DM n=43, group 2; and TD n= 116, comparative group). Measures of depression, anxiety, and stress were collected to examine the prevalence of factors, difference between groups, and their association with demographic characteristics. RESULTS: On the DASS-21, both groups 1 and 2 had higher mean scores for depression (37.86), anxiety (4.58), and stress (29.81) than the control group (P=0.015). On the PSS-14, the mean score was higher in group 2 (28.63) than in group 1 (27.61) and the comparison group (25.87) (P=0.004). On the DASS 21, group 1 scored higher in the depression domain (P=0.046), whereas group 2 scored higher in the anxiety domain (P=0.034) and stress domain (P=0.009) than the TD group. CONCLUSION: Mothers of children with ASD should be assessed for the presence of depression following diagnosis. Mothers of children with type 1 diabetes require careful monitoring for the effects of anxiety and stress on their mental health and therefore their ability to cope with diabetes management plans. TRIAL REGISTRATION: Not applicable.
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2. Farmer C, Thurm A. Inclusion of individuals with low IQ in drug development for autism spectrum disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2021; 48: 37-9.
Although individuals with intellectual disability (ID) and/or limited language ability make up a significant proportion of those with autism spectrum disorder (ASD), they are routinely excluded from ASD research. As a result, this vulnerable population is prevented from participating in and deriving full benefit from research. In this commentary, we expand upon points made by McCracken and colleagues (this issue), who describe several opportunities for improvement in drug development for ASD related to the inclusion of individuals with ID and/or limited language ability.
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3. Kiruthika DL, Tiwari S. Broad Autism Phenotype Traits in Parents of Children with Language Impairments: A Comparative Study. Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP). 2022; 74(1): 70-7.
INTRODUCTION: The broad autism phenotype (BAP) comprises milder language and cognitive deficits seen in the nonautistic relatives of individuals with autism. BAP represents the range of individuals with a higher number of these characteristics than average but a lower number than would point to a diagnosis of autism. The Broad Autism Phenotype Questionnaire (BAPQ) is one of the efficient and reliable tools to explore and measure BAP traits, namely, aloofness, pragmatic language, and rigid personality, which represent a few of the diagnostic features of autism. Against the background of positive familial history and common causes across the developmental disorders, this study aimed to compare BAP traits in the parents of children with autism spectrum disorder (ASD), specific language impairment (SLI), and social communication disorder (SCD) by means of the BAPQ. METHODS: A total of 120 parents (60 mothers and 60 fathers) of children with ASD, SCD, and SLI participated in the study. All mothers filled in the self-report version and fathers filled in the informant version of BAPQ simultaneously in the communication intervention setting. RESULTS: Obtained data was analyzed with the t test and ANOVA to compare self-ratings, informant ratings, and BAPQ scores across groups. The results of the study revealed no statistically significant difference for the overall BAPQ scores (except on the Pragmatic Language subscale). Furthermore, mothers in all 3 groups presented with BAP traits, with pragmatic language deficits being common. These observations point towards an overlap of BAP traits in the mothers of children with language disorders. CONCLUSION: These findings indicate the value of a detailed assessment of BAP in parents of children with developmental disorders.
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4. Lönnberg P, Pihko E, Lauronen L, Nurminen J, Andersson S, Metsäranta M, Lano A, Nevalainen P. Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2021; 132(7): 1572-83.
OBJECTIVE: We assessed in extremely preterm born (EPB) children whether secondary somatosensory cortex (SII) responses recorded with magnetoencephalography (MEG) at term-equivalent age (TEA) correlate with neurodevelopmental outcome at age 6 years. Secondly, we assessed whether SII responses differ between 6-year-old EPB and term-born (TB) children. METHODS: 39 EPB children underwent MEG with tactile stimulation at TEA. At age 6 years, 32 EPB and 26 TB children underwent MEG including a sensorimotor task requiring attention and motor inhibition. SII responses to tactile stimulation were modeled with equivalent current dipoles. Neurological outcome, motor competence, and general cognitive ability were prospectively evaluated at age 6 years. RESULTS: Unilaterally absent SII response at TEA was associated with abnormal motor competence in 6-year-old EPB children (p = 0.03). At age 6 years, SII responses were bilaterally detectable in most EPB (88%) and TB (92%) children (group comparison, p = 0.69). Motor inhibition was associated with decreased SII peak latencies in TB children, but EPB children lacked this effect (p = 0.02). CONCLUSIONS: Unilateral absence of an SII response at TEA predicted poorer motor outcome in EPB children. SIGNIFICANCE: Neurophysiological methods may provide new means for outcome prognostication in EPB children.
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5. Okajima J, Kato N, Nakamura M, Otani R, Yamamoto J, Sakuta R. A pilot study of combining social skills training and parenting training for children with autism spectrum disorders and their parents in Japan. Brain & development. 2021; 43(8): 815-25.
The purpose of this study is to investigate the effects of a program containing a combination of social skills training (SST) and parenting training (PT) for the enrichment of social interaction skills and reduction of parenting stress for children with high-functioning autism spectrum disorder (HFASD) and their parents in Japan. Twenty-two patients with HFASD from second to fourth grade and their parents were assigned to a training group (TG) or treatment as usual (TAU) and compared. The children with HFASD and their parents who were assigned to the TG participated in the manualized program for over a period of five to six months. Subjects provided demographic and medical information and completed teacher and parent-rating scales for social competence (Social Responsiveness Scale-2: SRS-2) and parent-rating of parenting stress (Parental Stress Index: PSI) and mental health (General Health Questionnaire-28: GHQ-28). The participants exhibited some improvements pre-, middle-, and post-treatment, particularly regarding the GHQ, PSI and SRS-2, as reported by parents. However, the social skills improvement reported by teachers was not significant. At the three-month follow-up, parent-rated GHQ and PSI maintained improvement, and SRS-2 achieved the greatest improvement from the baseline rating. Although some findings indicate that a program combination of SST and PT might be useful for enhancing social skills and improving parental stress and mental health, some subscales did not show a sufficient effect. Future research should consider program contents and provide longitudinal follow-up data to test the durability of the treatment.
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6. Saini AG, Sankhyan N, Malhi P, Ahuja C, Khandelwal N, Singhi P. Hyperbilirubinemia and Asphyxia in Children With Dyskinetic Cerebral Palsy. Pediatric neurology. 2021; 120: 80-5.
BACKGROUND: We aimed to study the clinical, etiologic, and radiological characteristics in children with dyskinetic cerebral palsy (DCP) and to compare the etiologic subtypes of hyperbilirubinemia and perinatal asphyxia. METHODS: This is a cross-sectional, observational study that enrolled consecutive children with DCP, aged one to 14 years. RESULTS: Sixty-five children with DCP were evaluated. Most children were boys (77%, n = 50), and term gestation (80%, n = 52). Presenting concerns were global developmental delay (97%, n = 63) and involuntary movements (60%, n = 39). Hyperbilirubinemia (66%, n = 43) and perinatal asphyxia (29%, n = 19) were the most important causes. The majority (83%, n = 54) of children were severely disabled (level V and IV). The hyperbilirubinemia group had significant motor delay (63% vs 37%, P = 0.03) and upward gaze palsy (69.7% vs 31.5%, P = 0.005) when compared with the perinatal asphyxia group. Hyperbilirubinemia significantly involved pallidi (86% vs 10% P = 0.0001) and subthalamic nucleus (26% vs none, P = 0.01), whereas asphyxia significantly involved the putamen (58% vs none, P = 0.0001), thalamus (63% vs none, P = 0.0001), and periventricular white matter (79% vs 19%, P = 0.0001). CONCLUSIONS: DCP is the dominant type of cerebral palsy seen in term-born babies with severe dystonia, developmental delay, and motor impairment. Hyperbilirubinemia is the major cause of DCP in the study. Hyperbilirubinemia is associated with motor delay, upward gaze palsy, prominent dystonia, and involvement of globus pallidi and subthalamic nuclei.
