Pubmed du 25/04/22
1. Bird F, Shah R, Williams S, Shlesinger A, Luiselli JK, Wachtel LE. Multiyear Evaluation of Maintenance Electroconvulsive Therapy in an Adult With Autism Spectrum Disorder, Catatonia, and Challenging Behavior. The journal of ECT. 2022.
We report the case of a 30-year-old man diagnosed with autism spectrum disorder who received electroconvulsive therapy (ECT) over a 4-year period to treat catatonia associated with life-threatening self-injury, aggression, major depression, and associated self-care, daily living, and communication skills deficits. A systematic schedule of maintenance ECT (m-ECT) was associated with elimination of challenging behavior, catatonic and depressive symptom remission, removal of protective equipment, and reduced dosages of psychotropic medications.
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2. Gehdu BK, Gray KLH, Cook R. Impaired grouping of ambient facial images in autism. Scientific reports. 2022; 12(1): 6665.
Ambient facial images depict individuals from a variety of viewing angles, with a range of poses and expressions, under different lighting conditions. Exposure to ambient images is thought to help observers form robust representations of the individuals depicted. Previous results suggest that autistic people may derive less benefit from exposure to this exemplar variation than non-autistic people. To date, however, it remains unclear why. One possibility is that autistic individuals possess atypical perceptual learning mechanisms. Alternatively, however, the learning mechanisms may be intact, but receive low-quality perceptual input from face encoding processes. To examine this second possibility, we investigated whether autistic people are less able to group ambient images of unfamiliar individuals based on their identity. Participants were asked to identify which of four ambient images depicted an oddball identity. Each trial assessed the grouping of different facial identities, thereby preventing face learning across trials. As such, the task assessed participants’ ability to group ambient images of unfamiliar people. In two experiments we found that matched non-autistic controls correctly identified the oddball identities more often than our autistic participants. These results imply that poor face learning from variation by autistic individuals may well be attributable to low-quality perceptual input, not aberrant learning mechanisms.
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3. Graves WW, Levinson H, Coulanges L, Cahalan S, Cruz D, Sancimino C, Bal VH, Rosenberg-Lee M. Neural differences in social and figurative language processing on the autism spectrum. Neuropsychologia. 2022; 171: 108240.
Individuals on the autism spectrum often have trouble with social and figurative language. As social language is often figurative, it can be challenging to disentangle the cognitive and neural sources of these difficulties. Neural systems for social cognition and language comprehension overlap in areas involved in retrieving linguistic meaning (semantics), such as the anterior temporal lobe (ATL), ventro-medial prefrontal cortex (vmPFC), posterior cingulate cortex (PCC), and posterior middle temporal gyrus (pMTG). Using adjective-noun phrases, we manipulated social/nonsocial and figurative/literal dimensions, which we expected to activate distinct but overlapping regions. We hypothesized that activation differences in the group with autism (AUT) would be greater for more social and figurative stimuli. During fMRI, participants in the AUT group (N = 19) and those in the non-autistic comparison (NAC) group (N = 22) made familiarity judgments to 192 phrases in a balanced 2 × 2 (social/nonsocial x figurative/literal) design. Social phrases activated the PCC in all participants, but only the NAC group activated the vmPFC. Figurative phrases were rated as more literal by the AUT group, with the figurative-literal phrase contrast showing no activation in the AUT group, but activating the PCC and right pMTG in the NAC group. The one significant group-level neural difference was for the social-figurative condition predicted to be most different between groups: greater activation for the AUT group in the right ATL. Differences in the right ATL and pMTG in the AUT group suggest altered engagement of right homologues of the canonical semantic network being recruited for processing combined social and figurative language.
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4. Simón C, Martínez-Rico G, McWilliam RA, Cañadas M. Attitudes Toward Inclusion and Benefits Perceived by Families in Schools with Students with Autism Spectrum Disorders. Journal of autism and developmental disorders. 2022.
The aim of this study was to find out about attitudes toward inclusion and benefits perceived by families with children enrolled in schools attended by students with ASD at different educational stages (from kindergarten to high school). 323 families of classmates of students with ASD from different educational stages of 16 mainstream schools participated. The analysis of the attitudes, perceived benefits, relationship with the teacher, and relationship with the school was carried out through questionnaires. The results show positive attitudes toward the inclusive education of students with ASD in all families, but especially among families of children with SEN. All the families identified the benefit of inclusion. Attitudes are related to collaboration with the school and satisfaction with teachers.
