1. Dunst CJ, Hamby DW. {{Guide for calculating and interpreting effect sizes and confidence intervals in intellectual and developmental disability research studies}}. {J Intellect Dev Disabil};2012 (Apr 25)
This paper includes a nontechnical description of methods for calculating effect sizes in intellectual and developmental disability studies. Different hypothetical studies are used to illustrate how null hypothesis significance testing (NHST) and effect size findings can result in quite different outcomes and therefore conflicting results. Whereas NHST uses probability levels (e.g., p < .05) to evaluate the results of studies, effect size analyses focus on the magnitude of differences between groups or contrasting conditions and the strength of the relationship among variables of interest to report and interpret study results. Two families of effect sizes are described (mean difference, correlation coefficients) that are likely to be applicable to most intellectual and developmental disability studies. Sources of information on effect size calculators are included to provide researchers ready-available data analysis procedures for computing effect sizes and confidence intervals for different types of research designs and studies.
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2. El-Ansary AK, Ben Bacha A, Kotb M. {{Etiology of autistic features: the persisting neurotoxic effects of propionic acid}}. {J Neuroinflammation};2012 (Apr 24);9(1):74.
ABSTRACT: BACKGROUND: Recent clinical observations suggest that certain gut and dietary factors may transiently worsen symptoms in autism. Propionic acid (PA) is a short chain fatty acid and an important intermediate of cellular metabolism. Although PA has several beneficial biological effects, its accumulation is neurotoxic. METHODS: Two groups of young Western albino male rats weighing about 45 to 60 grams (approximately 21 days old) were used in the present study. The first group consisted of oral buffered PA-treated rats that were given a neurotoxic dose of 250 mg/kg body weight/day for three days, n = eight; the second group of rats were given only phosphate buffered saline and used as a control. Biochemical parameters representing oxidative stress, energy metabolism, neuroinflammation, neurotransmission, and apoptosis were investigated in brain homogenates of both groups. RESULTS: Biochemical analyses of brain homogenates from PA-treated rats showed an increase in oxidative stress markers (for example, lipid peroxidation), coupled with a decrease in glutathione (GSH) and glutathione peroxidase (GPX) and catalase activities. Impaired energy metabolism was ascertained through the decrease of lactate dehydrogenase and activation of creatine kinase (CK). Elevated IL-6, TNFalpha, IFNgamma and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. Moreover, elevation of caspase3 and DNA fragmentation proved the pro-apoptotic and neurotoxic effect of PA to rat pups CONCLUSION: By comparing the results obtained with those from animal models of autism or with clinical data on the biochemical profile of autistic patients, this study showed that the neurotoxicity of PA as an environmental factor could play a central role in the etiology of autistic biochemical features.
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3. Freitag CM. {{[Autistic disorders – the state of the art and recent findings: epidemiology, aetiology, diagnostic criteria, and therapeutic interventions]}}. {Z Kinder Jugendpsychiatr Psychother};2012 (May);40(3):139-149.
This review article is based on a state-of-the-art lecture given at the 32nd meeting of the German Child Psychiatry Association in March 2011. It summarizes recent findings from epidemiological studies (comorbid disorders, risk factors), early diagnosis, classification, and evidence-based therapeutic interventions (psychopharmacology, early intervention, group-based behavioural interventions). Intensive research over the last years has led to a better understanding of, and improved therapeutic options for, autism spectrum disorders.
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4. Jordan I, Robertson D, Catani M, Craig M, Murphy D. {{Aripiprazole in the treatment of challenging behaviour in adults with autism spectrum disorder}}. {Psychopharmacology (Berl)};2012 (Apr 26)
BACKGROUND: Autism spectrum disorders (ASD) are associated with repetitive behaviours and often also with hyperactivity, aggression, self-injurious behaviour, irritability and lability of mood. There is emerging evidence that aripiprazole, an antipsychotic with partial agonist dopaminergic effect, may be effective in the treatment of these challenging behaviours. Nevertheless, there is little evidence for their efficacy in adults with ASD. OBJECTIVES: The aim of this article is to present preliminary data on the use of aripiprazole in the treatment of challenging behaviour in the setting of ASD. METHODS: We present a consecutive series of five inpatients of normal intelligence with challenging behaviour associated with ASD, diagnosed according to ICD-10 criteria, which was resistant to treatment with other medical and behavioural interventions and which was treated with aripiprazole. RESULTS: Four out of five patients were classified as « much improved » or « very much improved » according to the Clinical Global Impression-Improvement scale. Aripiprazole caused akathisia, at a dose of 30 mg in the one patient who was not classified as a responder but was otherwise well tolerated. CONCLUSIONS: This is the first case series of adults with ASD presenting with challenging behaviour who have been treated with aripiprazole. While the results are promising, controlled trials are required to confirm the findings.
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5. Okabe Y, Takahashi T, Mitsumasu C, Kosai K, Tanaka E, Matsuishi T. {{Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-Null Mouse Model of Rett Syndrome}}. {PLoS One};2012;7(4):e35354.
Rett syndrome (RTT) is a neurodevelopmetal disorder associated with mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. MeCP2-deficient mice recapitulate the neurological degeneration observed in RTT patients. Recent studies indicated a role of not only neurons but also glial cells in neuronal dysfunction in RTT. We cultured astrocytes from MeCP2-null mouse brain and examined astroglial gene expression, growth rate, cytotoxic effects, and glutamate (Glu) clearance. Semi-quantitative RT-PCR analysis revealed that expression of astroglial marker genes, including GFAP and S100beta, was significantly higher in MeCP2-null astrocytes than in control astrocytes. Loss of MeCP2 did not affect astroglial cell morphology, growth, or cytotoxic effects, but did alter Glu clearance in astrocytes. When high extracellular Glu was added to the astrocyte cultures and incubated, a time-dependent decrease of extracellular Glu concentration occurred due to Glu clearance by astrocytes. Although the shapes of the profiles of Glu concentration versus time for each strain of astrocytes were grossly similar, Glu concentration in the medium of MeCP2-null astrocytes were lower than those of control astrocytes at 12 and 18 h. In addition, MeCP2 deficiency impaired downregulation of excitatory amino acid transporter 1 and 2 (EAAT1/2) transcripts, but not induction of glutamine synthetase (GS) transcripts, upon high Glu exposure. In contrast, GS protein was significantly higher in MeCP2-null astrocytes than in control astrocytes. These findings suggest that MeCP2 affects astroglial genes expression in cultured astrocytes, and that abnormal Glu clearance in MeCP2-deficient astrocytes may influence the onset and progression of RTT.
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6. Walsh MB. {{The Top 10 Reasons Children With Autism Deserve ABA}}. {Behav Anal Pract};2011 (Summer);4(1):72-79.
We who advocate for applied behavior analysis (ABA) for children with autism spectrum disorders often construct our arguments based on the scientific evidence. However, the audience that most needs to hear this argument, that is, the parents of children, especially very young children, diagnosed with autism, may not be convinced by the science alone. This essay attempts to make the case for the multiple benefits of ABA intervention through the use of humor and anecdotes couched in a « Top Ten List, » and illustrating most points with stories of an engaging child with autism (my son, Ben).
7. Wang L, Christophersen CT, Sorich MJ, Gerber JP, Angley MT, Conlon MA. {{Elevated Fecal Short Chain Fatty Acid and Ammonia Concentrations in Children with Autism Spectrum Disorder}}. {Dig Dis Sci};2012 (Apr 26)
BACKGROUND AND AIM: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder where a high frequency of gastrointestinal disturbance (e.g., constipation and diarrhea) is reported. As large bowel fermentation products can have beneficial or detrimental effects on health, these were measured in feces of children with and without ASD to examine whether there is an underlying disturbance in fermentation processes in the disorder. METHODS: Fecal samples (48 h) were collected from children with ASD (n = 23), and without ASD (n = 31) of similar age. Concentrations of short chain fatty acids, phenols and ammonia were measured. RESULTS: Fecal total short chain fatty acid concentrations were significantly higher in children with ASD compared to controls (136.6 +/- 8.7 vs. 111.1 +/- 6.6 mmol/kg). Moreover, when concentrations of fecal acetic, butyric, isobutyric, valeric, isovaleric and caproic acids were measured, all were significantly higher in children with ASD compared with controls except for caproic acid. The concentration of fecal ammonia was also significantly greater in ASD participants than controls (42.7 +/- 3.3 vs. 32.3 +/- 1.9 mmol/kg). Fecal phenol levels and pH did not differ between groups. Macronutrient intake, as determined from dietary records kept by caregivers, also did not differ significantly between study groups. CONCLUSIONS: Our results suggest fermentation processes or utilization of fermentation products may be altered in children with ASD compared to children without ASD.
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8. White ER, Hoffmann B, Hoch H, Taylor BA. {{Teaching teamwork to adolescents with autism: the cooperative use of activity schedules}}. {Behav Anal Pract};2011 (Summer);4(1):27-35.
We used a multiple baseline design to assess the effects of prompting and reinforcement to teach three pairs of adolescents with autism to use photographic activity schedules to cooperatively complete a multistep vocational task (e.g., cleaning a kitchen). Baseline data indicated that despite being competent schedule followers, participants did not coordinate their actions to complete the schedule cooperatively. Following intervention, we observed an increase in cooperative schedule following. All prompts were removed and the schedule of reinforcement was thinned to the end of the task for two of the three pairs. We discuss the results in terms of increasing the collaborative work skills of individuals with autism.
