Pubmed du 27/02/21
1. Bennett HJ, Ringleb SI, Bobzien J, Haegele JA. Walking lower extremity biomechanics of adolescents with autism spectrum disorder. Journal of biomechanics. 2021 ; 119 : 110332.
Although the literature indicates children with autism spectrum disorder (ASD) walk at slower speeds and altered kinematics compared to neurotypical controls, no research has examined walking at matched speeds. This study examined biomechanical differences between adolescents with ASD and matched (age, sex, and body mass index) neurotypical controls. Lower extremity biomechanics of seventeen adolescents with ASD and seventeen controls were compared at matched speeds : self-selected and a standardized 1.3 m/s. Controls exhibited greater eversion angles and hip abduction moments compared to those with ASD. This study found adolescents, which may have a more mature gait than young children, walk with a similar pattern in the propulsive plane (i.e. sagittal) as neurotypical controls, but with alterations in the supportive plane (i.e. frontal).
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2. Błeszyński JJ. Self – Regard of Individuals with Autism – How People from the Autism Spectrum Perceive Autism. A Netnographic Research. Integrative psychological & behavioral science. 2021.
This research on adults with a diagnosis of autism is a multidirectional and multistage analysis. It is aimed at reviewing the current knowledge about the disorder as well as taking optimal actions towards social inclusion for people with ASD (autistic spectrum disorder). The research and analysis was facilitated by selecting subjects who have sufficient communication and social skills to be able to participate in the study. The new DSM 5, which now has descriptors of CTS (Conflict Tactics Scale) degrees, was useful for this purpose. Data was gathered by means of personalized forms and methods, with in-depth netnographic (rather than face-to-face) interviews conducted. As no similar research using the netnographic method could be found, a pilot study was initiated, which was then gradually expanded to include a larger number of respondents. This research made it possible to record the views of people with ASD regarding autism and their functioning in society.
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3. Brasher S, Middour-Oxler B, Chambers R, Calamaro C. Caring for Adults With Autism Spectrum Disorder in the Emergency Department : Lessons Learned From Pediatric Emergency Colleagues. Journal of emergency nursing. 2021.
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4. Dindar K, Loukusa S, Helminen TM, Mäkinen L, Siipo A, Laukka S, Rantanen A, Mattila ML, Hurtig T, Ebeling H. Social-Pragmatic Inferencing, Visual Social Attention and Physiological Reactivity to Complex Social Scenes in Autistic Young Adults. J Autism Dev Disord. 2021.
This study examined social-pragmatic inferencing, visual social attention and physiological reactivity to complex social scenes. Participants were autistic young adults (n = 14) and a control group of young adults (n = 14) without intellectual disability. Results indicate between-group differences in social-pragmatic inferencing, moment-level social attention and heart rate variability (HRV) reactivity. A key finding suggests associations between increased moment-level social attention to facial emotion expressions, better social-pragmatic inferencing and greater HRV suppression in autistic young adults. Supporting previous research, better social-pragmatic inferencing was found associated with less autistic traits.
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5. Siper PM, Layton C, Levy T, Lurie S, Benrey N, Zweifach J, Rowe M, Tang L, Guillory S, Halpern D, Giserman-Kiss I, Del Pilar Trelles M, Foss-Feig JH, De Rubeis S, Tavassoli T, Buxbaum JD, Kolevzon A. Sensory Reactivity Symptoms Are a Core Feature of ADNP Syndrome Irrespective of Autism Diagnosis. Genes. 2021 ; 12(3).
Background : Activity dependent neuroprotective protein (ADNP) syndrome is one of the most common single-gene causes of autism spectrum disorder (ASD) and intellectual disability, however, the phenotypes remain poorly described. Here we examine the sensory reactivity phenotype in children and adolescents with ADNP syndrome. Methods : Twenty-two individuals with ADNP syndrome received comprehensive clinical evaluations including standardized observations, caregiver interviews, and questionnaires to assess sensory reactivity symptoms. Relationships between sensory symptoms and age, sex, ASD, IQ, and adaptive behavior were examined. Genotype-phenotype correlations with the recurrent p.Tyr719* variant were also explored. Results : Sensory reactivity symptoms were observed and reported in all participants. A syndrome-specific phenotype was identified, characterized by high levels of sensory seeking across tactile, auditory, and visual domains. Tactile hyporeactivity, characterized by pain insensitivity, was reported in the majority of participants. Sensory symptoms were identified across individuals regardless of age, sex, IQ, adaptive ability, genetic variant, and most importantly, ASD status. No significant differences were identified between participants with and without the recurrent p.Tyr719* variant on any sensory measure. Conclusions : Sensory reactivity symptoms are a common clinical feature of ADNP syndrome. Quantifying sensory reactivity using existing standardized measures will enhance understanding of sensory reactivity in individuals with ADNP syndrome and will aid in clinical care. The sensory domain may also represent a promising target for treatment in clinical trials.
