1. Akkermans SEA, Rheinheimer N, Bruchhage MMK, Durston S, Brandeis D, Banaschewski T, Boecker-Schlier R, Wolf I, Williams SCR, Buitelaar JK, van Rooij D, Oldehinkel M. {{Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder}}. {Psychological medicine}. 2018: 1-9.
BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are neurodevelopmental disorders with considerable overlap in terms of their defining symptoms of compulsivity/repetitive behaviour. Little is known about the extent to which ASD and OCD have common versus distinct neural correlates of compulsivity. Previous research points to potentially common dysfunction in frontostriatal connectivity, but direct comparisons in one study are lacking. Here, we assessed frontostriatal resting-state functional connectivity in youth with ASD or OCD, and healthy controls. In addition, we applied a cross-disorder approach to examine whether repetitive behaviour across ASD and OCD has common neural substrates. METHODS: A sample of 78 children and adolescents aged 8-16 years was used (ASD n = 24; OCD n = 25; healthy controls n = 29), originating from the multicentre study COMPULS. We tested whether diagnostic group, repetitive behaviour (measured with the Repetitive Behavior Scale-Revised) or their interaction was associated with resting-state functional connectivity of striatal seed regions. RESULTS: No diagnosis-specific differences were detected. The cross-disorder analysis, on the other hand, showed that increased functional connectivity between the left nucleus accumbens (NAcc) and a cluster in the right premotor cortex/middle frontal gyrus was related to more severe symptoms of repetitive behaviour. CONCLUSIONS: We demonstrate the fruitfulness of applying a cross-disorder approach to investigate the neural underpinnings of compulsivity/repetitive behaviour, by revealing a shared alteration in functional connectivity in ASD and OCD. We argue that this alteration might reflect aberrant reward or motivational processing of the NAcc with excessive connectivity to the premotor cortex implementing learned action patterns.
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2. Arony DA, Gazda S, Kitara DL. {{Could nodding syndrome in Northern Uganda be a form of autism spectrum disorder? an observational study design}}. {The Pan African medical journal}. 2018; 30: 115.
Introduction: Nodding syndrome (NS) is associated with high anion gap, biotinidase and acetyl carnitine deficiency, vitamin B6 and D deficiency and internal displacement. The objective of this study was to conduct a metabolic analysis on NS children and review literature on its similarities with ASD. Methods: We conducted biochemical analysis on blood and urine of NS children at Hope for HumaNs (HfH) centre in 2014 and reviewed literature on its similarities with ASD. Ethical approval was obtained from an IRB. Data analysis was conducted using STATA version 12 and a p-value less than 0.05 was considered significant. Results: We found biotinidase deficiency in NS with a mean 1.98 95% CI(1.61, 2.34; p < 0.001); Acetyl carnitine deficiency 16.92 95% CI(16.10,17.75; p<0.001); Low BMI-for-age 16.92 95% CI(16.10,17.75; p = 0.42); Age 14.08 95% CI(0.78,4.660; p = 0.007); IDP duration 4.82 95% CI(4.48, 5.21; p = 0.92); Age at NS onset 8.02 95% CI(7.03, 9.01; p = 0.001); NS associated with multiple nodding episodes (chi(2))=22.15, p=0.005; NS siblings with NS (chi(2)) = 9.68, p = 0.004; NS were in IDPs (chi(2)) = 22.15, p = 0.005. Conclusion: These findings are indicative that NS is associated with biotinidase and acetyl carnitine deficiency, IDPs, and environmental exposures. There are no new cases of NS reported by Ugandan MOH and WHO since 2012 when the IDP camps were disbanded and communities resettled in their own communities and feed on their own grown foods. Perhaps NS may be akin to Autism Spectrum Disorder (ASD). This finding will help support all efforts towards the treatment and rehabilitation of NS children. Lien vers le texte intégral (Open Access ou abonnement)
3. Courchesne V, Girard D, Jacques C, Soulieres I. {{Assessing intelligence at autism diagnosis: mission impossible? Testability and cognitive profile of autistic preschoolers}}. {Journal of autism and developmental disorders}. 2018.
Intelligence in minimally verbal children on the autism spectrum (AS) is at risk of being underestimated. The present study investigated testability and cognitive profile of preschool autistic children using conventional tools and strength-informed tools. Fifty-two AS children and fifty-four typical children matched on age (31-77 months) were assessed. Testability increased with age in both groups, was generally lower in AS children, but not related to their test performance. Typical children performed significantly better than AS children on conventional tools, but performance of both groups was similar on strength-informed tools. Differences of performance across tests were much greater in the AS group. These results emphasize the heterogenous, yet characteristic, cognitive profile in preschool children, and introduce the usefulness of flexible testing.
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4. Crutcher J, Martin A, Wallace GL. {{Dissociations in the neural substrates of language and social functioning in autism spectrum disorder}}. {Autism research : official journal of the International Society for Autism Research}. 2018; 11(8): 1175-86.
Impairments in social communication (coupled with intact nonsocial language skills) are common in autism spectrum disorder (ASD). However, the neural correlates of these social communication deficits in adolescents and young adults with ASD are not fully understood. The communication checklist self-report (CC-SR) was administered to adolescents and young adults with ASD (n = 52) and typically developing (TD) controls (n = 64) to assess structural-language, pragmatic-language, and social-engagement. One high-resolution T1-weighted structural image was obtained from each participant. FreeSurfer was used to quantify cortical thickness. A main effect of diagnosis, with the ASD group performing worse than the TD group on all three CC-SR scales, and a diagnosis by scale interaction, driven by low social-engagement self-ratings in the ASD group, were found. There were also group differences in the relationship between scores on two of the three CC-SR scales and cortical thickness in multiple regions (pragmatic-language: left rostral frontal; social-engagement: left medial prefrontal). These interactions were driven by poorer self-ratings of language/social skills associated with decreased cortical thickness in the ASD group, while in the TD group worse self-ratings were associated with thicker cortex. Self-ratings of language/social-communication were lower in the ASD than the TD group. Moreover, language/social-communication self-ratings showed a different relationship with cortical thickness for the ASD and TD groups in the left inferior frontal region for pragmatic language ratings and the left medial prefrontal cortex for social engagement ratings. These findings suggest thinner cortex is associated with more impaired pragmatic language and social communication abilities in ASD. Autism Res 2018, 11: 1175-1186. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The present study examines the associations between brain structure and language/social communication ability in adolescents and young adults with autism spectrum disorder (ASD) as compared to neurotypical adolescents and young adults. We utilized thickness of the cerebral cortex as a measure of brain structure, and we found different correlations between language or social communication ability and cortical thickness in distinct regions for the ASD and TD groups. These findings suggest that for regions implicated in language/social communication ability, decreased cortical thickness is associated with more impaired pragmatic language and social communication abilities in ASD.
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5. Delbruck E, Yang M, Yassine A, Grossman ED. {{Functional connectivity in ASD: Atypical pathways in brain networks supporting action observation and joint attention}}. {Brain research}. 2018.
Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social communication, including attending to and interpreting social cues, initiating and responding to joint attention, and engaging in abstract social cognitive reasoning. Current studies emphasize a underconnectivity in ASD, particularly for brain systems that support abstract social reasoning and introspective thought. Here, we evaluate intrinsic connectivity in children with ASD, targeting brain systems that support the developmental precursors to social reasoning, namely perception of social cues and joint attention. Using resting state fMRI made available through the Autism Brain Imaging Data Exchange (ABIDE), we compute functional connectivity within and between nodes in the action observation, attention and social cognitive networks in children and adolescents with ASD. We also compare connectivity strength to observational assessments that explicitly evaluate severity of ASD on two distinct subdomains using the ADOS-Revised schedule: social affective (SA) and restricted, repetitive behaviors (RRB). Compared to age-matched controls, children with ASD have decreased functional connectivity in a number of connections in the action observation network, particularly in the lateral occipital cortex (LOTC) and fusiform gyrus (FG). Distinct patterns of connections were also correlated with symptom severity on the two subdomains of the ADOS. ADOS-SA severity most strongly correlated with connectivity to the left TPJ, while ADOS-RRB severity correlated with connectivity to the dMPFC. We conclude that atypical connectivity in the action observation system may underlie some of the more complex deficits in social cognitive systems in ASD.
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6. DeSouza AA, Fisher WW, Rodriguez NM. {{Facilitating the emergence of convergent intraverbals in children with autism}}. {Journal of applied behavior analysis}. 2018.
Convergent intraverbals represent a specific type of intraverbal in which multiple components of one speaker’s verbal behavior control a specific verbal response from another speaker (e.g., Speaker 1: What wooly, horned animal lives in the high country? Speaker 2: Bighorn sheep). To foster the development of advanced language, Sunderbeg and Sundberg (2011) proposed prerequisite skills that may engender the emergence of novel, convergent intraverbals. We used a multiple-probe design with both nonconcurrent (across participants) and concurrent (across stimulus sets) components to evaluate the effects of training these prerequisite skills on the emergence of convergent intraverbals with four children with autism. Participants showed the emergence of convergent intraverbals at mastery levels after they displayed mastery performance on all of the prerequisite skills identified by Sundberg and Sundberg, lending support to their characterization as prerequisites. We discuss these findings in terms of operant mechanisms that may facilitate the development of generative language.
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7. Diaz-Roman A, Zhang J, Delorme R, Beggiato A, Cortese S. {{Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies}}. {Evidence-based mental health}. 2018; 21(4): 146-54.
BACKGROUND: Sleep problems are common and impairing in individuals with autism spectrum disorders (ASD). Evidence synthesis including both subjective (ie, measured with questionnaires) and objective (ie, quantified with neurophysiological tools) sleep alterations in youth with ASD is currently lacking. OBJECTIVE: We conducted a systematic review and meta-analysis of subjective and objective studies sleep studies in youth with ASD. METHODS: We searched the following electronic databases with no language, date or type of document restriction up to 23 May 2018: PubMed, PsycInfo, Embase+Embase Classic, Ovid Medline and Web of Knowledge. Random-effects models were used. Heterogeneity was assessed with Cochran’s Q and I(2) statistics. Publication (small studies) bias was assessed with final plots and the Egger’s test. Study quality was evaluated with the Newcastle Ottawa Scale. Analyses were conducted using Review Manager and Comprehensive Meta-Analysis. FINDINGS: From a pool of 3359 non-duplicate potentially relevant references, 47 datasets were included in the meta-analyses. Subjective and objective sleep outcome measures were extracted from 37 and 15 studies, respectively. Only five studies were based on comorbidity free, medication-naive participants. Compared with typically developing controls, youth with ASD significantly differed in 10/14 subjective parameters and in 7/14 objective sleep parameters. The average quality score in the Newcastle-Ottawa Scale was 5.9/9. DISCUSSION AND CLINICAL IMPLICATIONS: A number of subjective and, to a less extent, objective sleep alterations might characterise youth with ASD, but future studies should assess the impact of pharmacological treatment and psychiatric comorbidities.
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8. Dyson MW, Chlebowski C, Brookman-Frazee L. {{Therapists’ Adaptations to an Intervention to Reduce Challenging Behaviors in Children with Autism Spectrum Disorder in Publicly Funded Mental Health Services}}. {Journal of autism and developmental disorders}. 2018.
Publicly funded mental health services play an important role in serving children with autism spectrum disorder (ASD). Previous research indicates a high likelihood of adaptations when therapists deliver evidence based practices to non-ASD populations, though less is known about therapists’ use of adaptations for children with ASD receiving mental health services. The current study uses a mixed quantitative and qualitative approach to characterize the types and reasons therapists adapted a clinical intervention [An Individualized Mental Health Intervention for Children with ASD (AIM HI)] for delivery with clinically complex children with ASD served in publicly funded mental health settings and identify therapist characteristics that predict use of adaptations. The most common adaptations were characterized as augmenting AIM HI and were done to individualize the intervention to fit with therapeutic style, increase caregiver participation, and address clients’ and caregivers’ needs and functioning. No therapist characteristics emerged as significant predictors of adaptations. Results suggest that therapists’ adaptations were largely consistent with the AIM HI protocol while individualizing the model to address the complex needs of youth with ASD.
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9. English MS, Tenenbaum EJ, Levine TP, Lester BM, Sheinkopf SJ. {{Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder}}. {Journal of autism and developmental disorders}. 2018.
This study investigates parental perceptions of cries of 1-month-old infants later diagnosed with autism spectrum disorder (ASD) and non-ASD controls. Parents of children with and without ASD listened to cry recordings of infants later diagnosed with ASD and comparison infants and rated them on cry perception scales. Parents completed the Broad Autism Phenotype Questionnaire (BAPQ) to assess the potential relations between traits associated with autism and cry perception. Across parents, ASD infant cries were rated as more distressed, less typical, and reflecting greater pain, with no significant differences between parent groups. Parents of children with ASD scored higher on the BAPQ compared to parents of children without ASD. Follow up analyses explored the relations between BAPQ score and cry ratings.
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10. Gantois I, Popic J, Khoutorsky A, Sonenberg N. {{Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders}}. {Annual review of medicine}. 2018.
Fragile X syndrome (FXS) is the most frequent inherited form of intellectual disability and autism spectrum disorder. Loss of the fragile X mental retardation protein, FMRP, engenders molecular, behavioral, and cognitive deficits in FXS patients. Experiments using different animal models advanced our knowledge of the pathophysiology of FXS and led to the discovery of many targets for drug treatments. In this review, we discuss the potential of metformin, an antidiabetic drug approved by the US Food and Drug Administration, to correct core symptoms of FXS and other neurological disorders in humans. We summarize its mechanisms of action in different animal and cellular models and human diseases. Expected final online publication date for the Annual Review of Medicine Volume 70 is January 27, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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11. Greenspan NS. {{Autism, evolution, and the inadequacy of ‘spectrum’}}. {Evolution, medicine, and public health}. 2018; 2018(1): 213-6.
Lay Summary: Individuals diagnosed with autism display variation in many traits, such as interest and ability in social interaction or resistance to change. Referring to this variation as a ‘spectrum’, defined as a range of values along an axis, understates the extent of such variation and can foster incorrect inferences. In psychiatry, the currently accepted term for a developmental disability characterized by variably impaired social and communicative skills, repetitive behaviors, and restricted interests is « autism spectrum disorder. » « Spectrum, » typically refers to values of a variable distributed along a single dimension, incorrectly suggesting people with autism can be simply ranked as more or less ‘autistic.’ In fact, there are multiple traits that pertain to autism and that can vary somewhat independently, in part due to the evolutionary mechanisms that give rise to risk alleles. Therefore, a new and more accurate clinical descriptor should be adopted. I propose: autism-related disorders (ARD).
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12. Guo X, Duan X, Suckling J, Chen H, Liao W, Cui Q, Chen H. {{Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder}}. {Human brain mapping}. 2018.
Time-invariant resting-state functional connectivity studies have illuminated the crucial role of the right anterior insula (rAI) in prominent social impairments of autism spectrum disorder (ASD). However, a recent dynamic connectivity study demonstrated that rather than being stationary, functional connectivity patterns of the rAI vary significantly across time. The present study aimed to explore the differences in functional connectivity in dynamic states of the rAI between individuals with ASD and typically developing controls (TD). Resting-state functional magnetic resonance imaging data obtained from a publicly available database were analyzed in 209 individuals with ASD and 298 demographically matched controls. A k-means clustering algorithm was utilized to obtain five dynamic states of functional connectivity of the rAI. The temporal properties, frequency properties, and meta-analytic decoding were first identified in TD group to obtain the characteristics of each rAI dynamic state. Multivariate analysis of variance was then performed to compare the functional connectivity patterns of the rAI between ASD and TD groups in obtained states. Significantly impaired connectivity was observed in ASD in the ventral medial prefrontal cortex and posterior cingulate cortex, which are two critical hubs of the default mode network (DMN). States in which ASD showed decreased connectivity between the rAI and these regions were those more relevant to socio-cognitive processing. From a dynamic perspective, these findings demonstrate partially impaired resting-state functional connectivity patterns between the rAI and DMN across states in ASD, and provide novel insights into the neural mechanisms underlying social impairments in individuals with ASD.
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13. Hull L, Mandy W, Lai MC, Baron-Cohen S, Allison C, Smith P, Petrides KV. {{Development and Validation of the Camouflaging Autistic Traits Questionnaire (CAT-Q)}}. {Journal of autism and developmental disorders}. 2018.
There currently exist no self-report measures of social camouflaging behaviours (strategies used to compensate for or mask autistic characteristics during social interactions). The Camouflaging Autistic Traits Questionnaire (CAT-Q) was developed from autistic adults’ experiences of camouflaging, and was administered online to 354 autistic and 478 non-autistic adults. Exploratory factor analysis suggested three factors, comprising of 25 items in total. Good model fit was demonstrated through confirmatory factor analysis, with measurement invariance analyses demonstrating equivalent factor structures across gender and diagnostic group. Internal consistency (alpha = 0.94) and preliminary test-retest reliability (r = 0.77) were acceptable. Convergent validity was demonstrated through comparison with measures of autistic traits, wellbeing, anxiety, and depression. The present study provides robust psychometric support for the CAT-Q.
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14. Millin R, Kolodny T, Flevaris AV, Kale AM, Schallmo MP, Gerdts J, Bernier RA, Murray S. {{Reduced auditory cortical adaptation in autism spectrum disorder}}. {eLife}. 2018; 7.
Adaptation is a fundamental property of cortical neurons and has been suggested to be altered in individuals with autism spectrum disorder (ASD). We used fMRI to measure adaptation induced by repeated audio-visual stimulation in early sensory cortical areas in individuals with ASD and neurotypical (NT) controls. The initial transient responses were equivalent between groups in both visual and auditory cortices and when stimulation occurred with fixed-interval and randomized-interval timing. However, in auditory but not visual cortex, the post-transient sustained response was greater in individuals with ASD than NT controls in the fixed-interval timing condition, reflecting reduced adaptation. Further, individual differences in the sustained response in auditory cortex correlated with ASD symptom severity. These findings are consistent with hypotheses that ASD is associated with increased neural responsiveness but that responsiveness differences only manifest after repeated stimulation, are specific to the temporal pattern of stimulation, and are confined to specific cortical regions.
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15. Mirza R, Sharma B. {{Selective modulator of peroxisome proliferator-activated receptor-alpha protects propionic acid induced autism-like phenotypes in rats}}. {Life sciences}. 2018.
AIMS: The present study investigated the neuropharmacological role of PPAR-alpha modulator, fenofibrate in postnatal-propionic acid induced symptomatology related with autism spectrum disorders (ASD) in Wistar rats. MAIN METHODS: The propionic acid (250mg/kg, p.o.) was administered to rats from postnatal 21st day to 23rd day to induce autism-related neurobehavioral and neurobiochemical alterations in rats. Then, rats were treated with fenofibrate (100mg/kg and 200mg/kg, orally) from postnatal 24th day till 48th day. The social behavior (three chambers social testing apparatus), repetitive behavior (Y-maze), locomotor activity (actophotometer), anxiety (elevated plus maze) and exploratory behavior (hole board test) were assessed. Biochemically, oxidative stress (thiobarbituric acid reactive species and reduced glutathione level) and neuroinflammation (interleukin-6, tumor necrosis factor-alpha and interleukin-10) were evaluated in the cerebellum, brainstem and prefrontal cortex of rats. KEY FINDINGS: Propionic acid-treated rats showed social impairment, repetitive behavior, hyperlocomotion, anxiety and low exploratory activity. Also, these animals showed higher levels of oxidative stress (increased in thiobarbituric acid reactive species and decreased in reduced glutathione level) as well as inflammation (increased in interleukin-6, tumor necrosis factor-alpha and decreased in interleukin-10) and inflammation in aforementioned brain-regions. Treatment with fenofibrate significantly attenuated the propionic acid induced-social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity. Furthermore, fenofibrate also reduced the oxidative stress and neuroinflammation in propionic acid-treated rats. SIGNIFICANCE: A selective PPAR-alpha agonist, fenofibrate provides neurobehavioral and neurobiochemical benefits in postnatal-propionic acid induced autism-related phenotype in rats. Thus, fenofibrate may further be studied for its possible benefits in ASD symptoms.
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16. Roman-Oyola R, Figueroa-Feliciano V, Torres-Martinez Y, Torres-Velez J, Encarnacion-Pizarro K, Fragoso-Pagan S, Torres-Colon L. {{Play, Playfulness, and Self-Efficacy: Parental Experiences with Children on the Autism Spectrum}}. {Occupational therapy international}. 2018; 2018: 4636780.
Background: Play serves as an essential medium for parent-child interaction; however, engaging children with ASD through play can be a challenge for parents. Purpose: The purpose of this phenomenological study was to explore the perspectives of parents with children on the autism spectrum regarding play experiences and self-efficacy during play encounters. Method: Semistructured interviews were administered to 8 parents of children 3-7 years of age with ASD. The analysis was guided by the constant comparison method. Findings: Parental narratives denoted playful experiences reflecting components of Skard and Bundy’s model of playfulness. The facilitation of framing and suspension of reality were generally more challenging than facilitating intrinsic motivation and internal control. Participants associated self-efficacy during play with their perceived ability to interact with their child and with positive emotions experienced during play. Fathers generally derived a greater sense of self-efficacy from play encounters than mothers, and this was explained by differences in fathers’ and mothers’ motivations for playing. Mothers were motivated to play for outcome-oriented reasons (e.g., promote the child’s progress) whereas fathers’ motivations depicted greater emotional emphasis, reflecting a better match between motivation and perceived indicators of efficacy during play. Conclusion: The results suggest that a good match between motivation for playing and perceived indicators of efficacy during play is important for a parental sense of self-efficacy. Occupational therapists should utilize coaching strategies to increase parents’ understanding of play and playfulness and how they can affect a sense of parental self-efficacy.
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17. Rossi LP, Lovisi GM, Abelha L, Gomide M. {{[Virtual Paths and Autism: access to health services from the perspective of Social Network Analysis]}}. {Ciencia & saude coletiva}. 2018; 23(10): 3319-26.
The prevalence of Autism Spectrum Disorder in the world population and in Brazil is increasing. The Internet has become an important source of information regarding access to health services, including mental health. It remains to be seen if the virtual paths in search of information are related to the outcomes of the line of care for mental disorders advocated by the SUS, such as Autism. Therefore, this article sets out to analyze the virtual network of access to information about care for Autism in the municipality of Rio de Janeiro in 2017 through the perspective of Social Network Analysis. In this regard, virtual data were collected, such as: virtual information sources; care services cited by the virtual sources and type of service (Public, Private or NGOs). Through the use of Gephi software, a sociogram was generated and analyzed. The results point to a predominance of NGO services in the network, greater centrality of degree and power of intermediation in NGO services, in addition to the isolation of public health services. The result implies that the information system about access to public health services for the treatment of ASD is expanded to the general population by contributing to improved access to these services.
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18. Safar K, Wong SM, Leung RC, Dunkley BT, Taylor MJ. {{Increased Functional Connectivity During Emotional Face Processing in Children With Autism Spectrum Disorder}}. {Frontiers in human neuroscience}. 2018; 12: 408.
Individuals with autism spectrum disorder (ASD) demonstrate poor social functioning, which may be related to atypical emotional face processing. Altered functional connectivity among brain regions, particularly involving limbic structures may be implicated. The current magnetoencephalography (MEG) study investigated whole-brain functional connectivity of eight a priori identified brain regions during the implicit presentation of happy and angry faces in 20 7 to 10-year-old children with ASD and 22 typically developing controls. Findings revealed a network of increased alpha-band phase synchronization during the first 400 ms of happy face processing in children with ASD compared to controls. This network of increased alpha-band phase synchronization involved the left fusiform gyrus, right insula, and frontal regions critical for emotional face processing. In addition, greater connectivity strength of the left fusiform gyrus (maximal 85 to 208 ms) and right insula (maximal 73 to 270 ms) following happy face presentation in children with ASD compared to typically developing controls was found. These findings reflect altered neuronal communication in children with ASD only to happy faces during implicit emotional face processing.
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19. Shui AM, Katz T, Malow BA, Mazurek MO. {{Predicting sleep problems in children with autism spectrum disorders}}. {Research in developmental disabilities}. 2018; 83: 270-9.
BACKGROUND: Sleep difficulties in children with autism spectrum disorders (ASD) have been well-established. AIMS: To develop a model to predict sleep problems in children with ASD. METHODS AND PROCEDURES: A sample of children in the Autism Speaks-Autism Treatment Network (ATN) registry without parent-reported sleep problems at baseline and with sleep problem (yes/no) data at first annual followup was randomly split into training (n = 527) and test (n = 518) samples. Model predictors were selected using the training sample, and a threshold for classifying children at risk was determined. Comparison of the predicted and true sleep problem status of the test sample yielded model performance measures. OUTCOMES AND RESULTS: In a multivariable model aggressive behavior among children with no sleep problems reported at baseline was associated with having more sleep problems at the first annual follow-up visit. This model performed in the test sample with high sensitivity and accurate prediction of low risk. CONCLUSIONS AND IMPLICATIONS: Among children with ASD aggressive behavior independently predicts sleep problems. The model’s high sensitivity for identifying children at risk and its accurate prediction of low risk can help with treatment and prevention of sleep problems. Further data collection may provide better prediction through methods requiring larger samples.
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20. Tran CV, Weiss B. {{Characteristics of Agencies Providing Support Services for Children with Autism Spectrum Disorders in Vietnam}}. {International journal of social science and humanity : IJSSH}. 2018; 8(4): 116-21.
As in virtually all countries, in Vietnam there has been a general trend towards apparent increased rates of Autism Spectrum Disorder (ASD). To address the needs of families and children with ASD, many agencies providing support services have been opened throughout Vietnam over the last two decades. Although agencies in general appear to strive to provide good quality service, the actual quality of operations is unknown. The present article collected and analyzed secondary data from 68 agencies across Vietnam from different information sources, using the nine criteria published by Tran, Weiss, and Pham (in press) [1] and Nguyen, Hoang, Nguyen, Pham, and Tran (2017) [2] to evaluate agency quality. Results of this review suggest that a significant number of centers do not have appropriate legal status, are not following basic ethical standards, are using non-evidence based intervention methods, and are unclear in regards to the intervention procedures or intervention plans they use. Although the current study has a number of limitations, it provides important initial information regarding the current status of ASD services in Vietnam.
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21. Vogan VM, Leung RC, Safar K, Martinussen R, Smith ML, Taylor MJ. {{Longitudinal Examination of Everyday Executive Functioning in Children With ASD: Relations With Social, Emotional, and Behavioral Functioning Over Time}}. {Frontiers in psychology}. 2018; 9: 1774.
Executive functioning (EF) deficits are well-documented in Autism Spectrum Disorder (ASD), yet little is known about the longitudinal trajectory of « everyday » EF and links to social, emotional and behavioral outcomes in ASD. This study examined the profile of everyday EF utilizing parent-reported measures over 2 years, and explored whether prior estimates of EF were related to later co-morbid psychopathology and social functioning in 39 children with ASD and 34 typically developing (TD) children (ages 7-14 years). According to parent reports, children with ASD had impaired scores of EF in all domains at both time points, and showed no significant improvement across 2 years, compared to controls. Regression analyses showed that prior estimates of behavior regulation difficulties at time 1 uniquely predicted later emotional (i.e., symptoms of anxiety/depression) and behavioral (i.e., oppositionality/aggressiveness) problems in children with ASD 2 years later. Furthermore, an improvement of metacognitive skills predicted a reduction of social difficulties over 2 years in ASD. These results imply that EF may be a potential target of intervention for preventing and reducing co-morbid psychopathology and promoting social competence in youth with ASD. Furthermore, the findings that EF related to behavior is more critical for later emotional and behavioral functioning, whereas EF related to cognition is more critical for social functioning, indicates that it may be beneficial to tailor treatment. Future studies investigating the effectiveness of EF-based interventions in improving the cognitive, psychological and social outcomes in ASD are of high priority.
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22. Wang M, Zhou J, He F, Cai C, Wang H, Wang Y, Lin Y, Rong H, Cheng G, Xu R, Zhou W. {{Alteration of gut microbiota-associated epitopes in children with autism spectrum disorders}}. {Brain, behavior, and immunity}. 2018.
BACKGROUND: Autism spectrum disorder (ASD) affects 1% of children and has no cure. Gastrointestinal (GI) problems are common in children with ASD, and although gut microbiota is known to play an important role in ASD through the gut-brain axis, the specific mechanism is unknown. Recent evidence suggests that gut microbiota may participate in the pathogenesis of ASD through immune- and inflammation-mediated pathways. Here, we identified potentially immunogenic epitopes derived from gut microbiota in stool samples from ASD children with and without GI problems and typically developing (TD) children. METHODS: Candidate gut microbiota-associated epitopes (MEs) were identified by blast shotgun metagenomic sequencing of fecal samples from 43 ASD children (19 with and 24 without GI involvement) and 31 sex- and age-matched typically developing (TD) children. Potentially immunogenic epitopes were screened against a predictive human Immune Epitope Database. The composition and abundance of candidate MEs were compared between the three groups of children. RESULTS: MEs identified in ASD children with GI problems were significantly more diverse than those in TD children. ME composition could discriminate between the three groups of children. We identified 34 MEs that were significantly more or less abundant in ASD children than TD children, most (29/34) of the differences in MEs were reduced in ASD and associated with abnormal gut IgA level and altered gut microbiota composition, these MEs were limited effected by clinical factors such as age, gender, and GI problems, of which eleven MEs were pathogenic microorganisms peptides with strong T or B cell response, nine MEs showed high homology to peptides from human self proteins associated with autoimmune disease occurrence, eliciting immune attack against hematopoietic stem cells and inhibition antigen binding. We also found that the abundance of five MEs were increased in ASD, including three human self proteins, gap junction alpha-1 (GJA1), paired box protein Pax-3 (PAX3) and eyes absent homolog 1 isoform 4 (EYA1) which associated with cancer, and a ME with homology to a Listeriolysin O peptide from the pathogenic bacterium Listeria monocytogenes was significantly increased in ASD children compared with TD children. CONCLUSIONS: Our findings demonstrate the abnormal of MEs composition in the gut of children with ASD, moreover, the abnormality in MEs composition was associated with abnormal gut IgA levels and altered gut microbiota composition, this abnormality also suggests that there may be abnormalities in intestinal immunity in children with ASD; In all, thirty-four MEs identified were potential biomarker of ASD, andalterations in MEs may contribute to abnormalities in gut immunity and/or homeostasis in ASD children. Further study of the MEs identified here may advance our understanding of the pathogenesis of ASD.
