1. Almeida TS, Yang F, Zhang H, Lamb ME. The Narrative Coherence of Autistic Children’s Accounts of an Experienced Event in Response to Different Interviewer Prompts: A Longitudinal Study. J Autism Dev Disord. 2024.

PURPOSE: This study explored the narrative coherence of the accounts of an experienced event produced by autistic and neurotypical children (ages 6-15 years) after delays of two weeks and two months. METHODS: The sample comprised 27 autistic children and 32 neurotypical peers, who were interviewed about the event using the Revised National Institute of Child Health and Human Development (NICHD) Investigative Interview Protocol. The study focused on assessing the narrative coherence of children’s reports, emphasizing key story grammar elements and temporal features in their narratives. RESULTS: Results revealed that, over time, both autistic and neurotypical children showed a decrease in narrative coherence. Autistic children, particularly those who were cognitively and verbally able, demonstrated the ability to convey their experiences coherently, with performances comparable to those of their neurotypical peers. Interviewer prompts differentially influenced the narrative coherence of autistic and non-autistic children’s accounts. CONCLUSION: This research showed that, when questioned appropriately, cognitively and verbally able autistic children can effectively communicate their personal experiences, even after significant delays.

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2. Ayele A, Edin A, Dingeta T, Gudeta R, Beka J, Shore H. Developmental delay and associated factors among HIV-infected under-five children in public health facilities, Southern Ethiopia. Sci Rep. 2024; 14(1): 30763.

Delays in development that occur during early childhood can have long-lasting consequences, potentially leading to poor academic achievement. Research has shown that the human immunodeficiency virus can have neurotropic effects, which may impact the development of the brain in infected children. However, there is a scarcity of evidence regarding developmental delays among children with human immunodeficiency virus in the study area. This study aimed to determine the prevalence of developmental delay and associated factors among children with the human immunodeficiency virus in southern Ethiopia. A cross-sectional study was undertaken among 422 children aged below five during October 30 to December 30, 2021, who acquired the human immunodeficiency virus at public hospitals. A pretested tool anthropometric measurements were utilized. To examine developmental delay, the age and stage questionnaires (version 3) were used. Descriptive statistics were performed. Bivariable and multivariable binary logistic regression models were fitted to identify potential factors associated with delays in child development. The analysis was performed using STATA version 14.2. Adjusted odds ratios with 95% confidence intervals and variables with p-values less than 0.05 were considered to be significantly associated with global developmental delay. A total of 413 under-five children with human immune virus participated, with a 97.9% response rate. Of all children, 222 (53.75%) were male, and the mean age of children was 3.5 ± 1 (± SD) years. Overall global developmental delay was 41.89% [95% CI 37-47%]. Maternal age 35 and older [AOR 2.2; 95% CI (1.11-4.3)], maternal educational status [AOR 0.47; 95% CI (0.23-0.96)], higher birth order [AOR 3; 95% CI (1.5-4)], and stunting [AOR 2.2; 95% CI (1.4-3.42)] were significant factors associated with global developmental delay. Half of the children examined demonstrated delayed development across domains. The global developmental delay constitutes a significant public health concern, underscoring the necessity for early detection initiatives including developmental screening, diagnostic evaluations, and therapeutic interventions. We found significant associations between the developmental status of the children and the maternal age, educational level of mothers, higher birth order, and stunting of under-five children. Policies should aim to enhance mother and child health services, expand access to early intervention programs, and incorporate developmental surveillance into routine pediatric care. Additional research may be necessary to elucidate the underlying causes of the high prevalence of Global developmental delay, evaluate the efficacy of current interventions, and investigate innovative approaches to mitigate developmental delays.

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3. Cao C, Li J, Cui W, Dai J, Guan Z, Wang D, Zhao X. Metalomics Revealed that Changes of Serum Elements were Associated with Oxidative Stress-Induced Inflammation of Cortex in a Mouse Model of Autism. Biol Trace Elem Res. 2024.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder emerging during early childhood. However, the mechanism underlying the pathogenesis of ASD remains unclear. This study investigated the alterations of elements in serum and prefrontal cortex of BTBR T + tf/J (BTBR) mice and potential mechanisms. The male BTBR mice were used for experimental group and C57BL/6 J (C57) mice were used for control group (n = 15). After behavioral tests were monitored, serum and prefrontal cortex of mice were analyzed by ICP-MS. The results demonstrated that the level of copper (Cu) was increased, and the levels of calcium (Ca), magnesium (Mg), selenium (Se), cobalt (Co), iron (Fe) and zinc (Zn) were decreased in BTBR mice compared to C57 mice (p < 0.01). The levels of above differential elements in serum demonstrated positive correlations with those in prefrontal cortex. Meanwhile, differential elements in prefrontal cortex had correlations with the total distance traveled (open field test) and the number of marbles buried (marble burying test) in BTBR mice (p < 0.05 or p < 0.01). The abnormally changed elements in serum might cross blood-brain-barrier into the brain and lead to oxidative stress, causing inflammation. Furtherly, the levels of inflammation-related indicators including tumor necrosis factor-alpha (TNF-α), nuclear factor kappa-B (NF-κB), interleukin-6 (IL-6) and interleukin-1β (IL-1β) were increased in prefrontal cortex of BTBR mice (p < 0.01), which were consistent with the aforementioned results. Our study suggested that the abnormal elements in the serum of BTBR mice may cause oxidative stress and inflammation in prefrontal cortex, which might contribute to increase the understanding of ASD pathogenesis.

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4. Dobrescu SR, Dahlin K, Karjalainen L, Montonen AB, Klint H, Stenberg I, Karlsson GP, Wentz E. The Cognitive Profile in Adolescents With Anorexia Nervosa and the Relationship With Autism and ADHD: A Pilot Study. Eur Eat Disord Rev. 2024.

OBJECTIVE: We aimed to examine the cognitive profile in adolescents with anorexia nervosa (AN) and its association with traits of autism spectrum disorder (ASD) and ADHD. In addition, resemblance in the cognitive profile between youths with AN and their parents was explored. METHODS: Adolescent females with acute AN (n = 20) and a healthy comparison group (n = 28) completed neuropsychological tasks of set-shifting (Trail making test, Wisconsin Card Sorting Test) and central coherence (Rey Complex Figures Task, Group Embedded Figures Test, object assembly subtest). In the AN group, mothers and fathers (n = 31) also completed the neuropsychological tasks. Traits of ASD and ADHD were assessed. The AN group was reassessed after weight gain. RESULTS: Weight-restored AN adolescents scored higher on the Group Embedded Figures Test than a comparison group (p < 0.001). No other set-shifting and central coherence differences were found across groups. A father-child correlation emerged in the object assembly subtest (r = 0.53, p = 0.035). ASD and ADHD traits were common in the AN group and not only related to starvation. No associations were found between neuropsychological deficits and traits of ASD and ADHD. CONCLUSIONS: Scant support was found for weaker central coherence in weight-recovered adolescents with AN. Set-shifting impairments could not be observed in young females with acute AN or after weight recovery.

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5. Elangovan G, Kumar NJ, Shobana J, Ramprasath M, Joshi GP, Cho W. Fusion of transfer learning with nature-inspired dandelion algorithm for autism spectrum disorder detection and classification using facial features. Sci Rep. 2024; 14(1): 31104.

Autism spectrum disorder (ASD) is a neurologic disorder considered to cause discrepancies in physical activities, social skills, and cognition. There is no specific medicine for treating this disorder; early intervention is critical to improving brain function. Additionally, the lack of a clinical test for detecting ASD makes diagnosis challenging. To regulate identification, physicians entertain the children’s activities and growing histories. The human face is employed as a biological signature as it has the potential reflections of the brain. It is utilized as a simpler and more helpful tool for early detection. Artificial intelligence (AI) algorithms in medicinal rehabilitation and diagnosis can help specialists identify various illnesses more successfully. However, owing to its particular heterogeneous symptoms and complex nature, diagnosis of ASD remains to be challenging for investigators. This work presents a Fusion of Transfer Learning (TL) with the Dandelion Algorithm for Accurate Autism Spectrum Disorder Detection and Classification (FTLDA-AASDDC) method. The FTLDA-AASDDC technique detects and classifies autism and non-autism samples using facial images. To accomplish this, the FTLDA-AASDDC technique utilizes a bilateral filter (BF) approach for noise elimination. Next, the FTLDA-AASDDC technique employs a fusion-based TL process comprising three models, namely MobileNetV2, DenseNet201, and ResNet50. Moreover, the attention-based bi-directional long short-term memory (A-BiLSTM) method is used to classify and recognize ASD. Finally, the Dandelion Algorithm (DA) is employed to optimize the parameter tuning process, improving the efficacy of the A-BiLSTM technique. A wide range of simulation analyses is performed to highlight the ASD classification performance of the FTLDA-AASDDC technique. The experimental validation of the FTLDA-AASDDC technique portrayed a superior accuracy value of 97.50% over existing techniques.

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6. Elemo AS, Can E. Depression and psychological help-seeking attitude among Turkish mothers of children with autism: problem-focused coping as a mediator. Psychol Health Med. 2024: 1-15.

Studies demonstrate that mothers of children with autism spectrum disorder (ASD) experience depression and are less likely to seek professional psychological help. This study examined the roles of coping strategies in predicting psychological help-seeking attitudes among mothers of children with ASD. A total of 250 Turkish mothers of children with autism were recruited using purposive sampling during their training at the autism center in Istanbul. The results showed that depression was positively associated with problem-focused coping and negatively associated with psychological help-seeking attitudes. Psychological help-seeking attitudes and problem-focused coping were positively correlated with avoidant coping. Mediation analysis demonstrated that problem-solving plays a mediating role in the relationship between depression and psychological help-seeking attitudes. When addressing the psychological help-seeking attitudes of mothers of children with autism, future prevention and intervention programs may have to take into account mothers’ depressive symptoms, and how they view and cope with depression and challenges related to parenting their child with autism.

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7. Frederick RM, Smárason O, Boedeker PJ, Spencer SD, Guzick AG, Storch EA. An Exploratory Analysis of Child Characteristics Predicting Clinical Outcomes in Parent-Led Cognitive Behavioral Teletherapy for Anxiety in Autistic Children. J Autism Dev Disord. 2024.

Parent-led cognitive behavioral therapy (CBT) is an efficient, promising form of therapy that may be well suited for autistic youth with anxiety disorders. A recent clinical trial found that parent-led CBT – in which parents led their child through a guided CBT workbook with varying degrees of therapist support – was efficacious for reducing anxiety and associated functional impairment. While such findings demonstrate promise for future intervention development and dissemination efforts with this population, more work is needed to elucidate clinical factors that impact response to treatment as well as drop-out. Using data from the aforementioned clinical trial (N = 87), the present exploratory study examined pre-treatment patient characteristics, including family accommodation (FA), anxiety severity, autism features, and externalizing psychopathology, and their relationship with relevant treatment outcomes (i.e., anxiety severity and functional impairment) at both post-treatment and three-month follow-up and drop-out/completer status. Our findings did not reveal any consistent relations between pre-treatment patient characteristics and clinical outcomes, with several isolated exceptions: (a) baseline autism features were associated with greater post-treatment functional impairment; (b) non-male (vs. male) gender was associated with greater functional impairment at 3-month follow-up; and (c) Hispanic ethnicity (vs. non-Hispanic) was associated with greater likelihood of premature treatment drop-out. Findings are discussed in the context of the importance of continuing to elucidate unique patient characteristics predictive of optimal clinical outcomes for autistic youth with anxiety disorders.

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8. Gao L, Zhang T, Zhang Y, Liu J, Guo X. Sex Differences in Spatiotemporal Consistency and Effective Connectivity of the Precuneus in Autism Spectrum Disorder. J Autism Dev Disord. 2024.

Autism spectrum disorder (ASD) has been reported to exhibit altered local functional consistency. However, previous studies mainly focused on male samples and explored the temporal consistency in the ASD brain ignoring the spatial consistency. In this study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the sex differences of local spatiotemporal consistency of spontaneous brain activity in ASD. This study used resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database, including 64 males/64 females with ASD and 64 male/64 female neurotypical controls (NCs). Two-way analysis of variance was performed to ascertain diagnosis-by-sex interaction effects on whole brain FOCA maps. Moreover, granger causal analysis was used to investigate effective connectivity between the brain regions with interaction effects and the whole-brain in ASD. Significant diagnosis-by-sex interaction effects on FOCA were observed in the bilateral precuneus (PCUN), bilateral medial prefrontal cortex and right dorsolateral superior frontal gyrus. Specifically, FOCA was significantly increased in males with ASD but decreased in females with ASD in the PCUN compared with the sex-matched NC group. In addition, the lack of sex differences in the causal influences from the bilateral anterior cingulate cortex/medial prefrontal cortex to the PCUN was observed in ASD. Our results reveal altered sex differences in the spatiotemporal consistency of spontaneous brain activity and functional interaction of the anterior and posterior default mode network (DMN) in ASD, highlighting the critical role of the DMN in the sex heterogeneity of ASD.

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9. Levy L, Ambaw A, Ben-Itzchak E, Holdengreber E. A real-time environmental translator for emotion recognition in autism spectrum disorder. Sci Rep. 2024; 14(1): 31527.

Autism spectrum disorder (ASD) involves challenges in communication and social interaction, including challenges in recognizing emotions. Existing technological solutions aim to improve social behaviors in individuals with ASD by providing learning aids. This paper presents a real-time environmental translator designed to enhance social behaviors in individuals with ASD using sensory substitution. Our system utilizes vibrotactile and visual feedback to interpret and convey emotional states through vibration patterns emitted from small vibration motors on the user’s temple, complemented by color-coded displays of emotional intensity. It can detect seven emotions: neutral, sad, happy, angry, disgust, surprise, and fear. Testing with adults with ASD showed they could adapt to the system in about 19 min, enabling them to intuitively and immediately recognize others’ emotions. This innovative approach presents a promising advancement in emotion recognition technology for individuals with ASD, offering potential benefits in enhancing their social interactions and communication skills.

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10. McDonnell CG, Kaya RA, Andrzejewski T, Batista SG. Autistic Adults Experience Higher PTSD Symptoms Relating to Motor Vehicle Accidents than Non-Autistic Adults. J Autism Dev Disord. 2024.

PURPOSE: Autistic adults experience high rates of traumatic events and PTSD. However, little work has evaluated motor vehicle accident (MVA) related trauma symptoms. The goal of this brief report was to provide pilot data characterizing MVA-related peritraumatic reactions, trauma symptoms, and rates of PTSD diagnosis and mental health service use among Autistic compared to non-autistic adults. METHOD: Participants were 637 adults in the United States (276 Autistic, 361 non-autistic) who completed an online survey assessing MVA experiences. Participants provided information about peritraumatic reactions to the accident, and whether they were diagnosed with PTSD or sought mental health services relating to the MVA. Participants also completed the Posttraumatic Symptom Checklist for DSM-5 (PCL-5) in relation to the worst MVA experienced. RESULTS: 48.7% of Autistic adults had experienced an MVA relative to 64.5% of non-autistic adults. Of those who experienced an MVA, Autistic adults reported higher peritraumatic dissociative reactions, and higher MVA-related total, negative mood/cognition, and hypervigilance PTSD symptoms than non-autistic adults, when adjusting for covariates. Autistic adults were significantly more likely to have sought mental health treatment relating to the MVA (11.9% compared to 0.9% of non-autistic adults), and to have received a PTSD diagnosis relating to the MVA (5.9% compared to 0.4% of non-autistic adults). CONCLUSION: Autistic adults reported higher levels of trauma-related sequalae in response to MVAs than non-autistic adults. Future research should examine MVA-related trauma in more diverse samples, and develop assessment and support strategies to better identify, prevent, and reduce trauma-related symptoms post MVAs for Autistic people.

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11. Petat H, Michelet I, Hassani A. Scurvy and autism. BMJ Case Rep. 2024; 17(12).

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12. Santos CLD, Barreto, II, Silva A, Soriano JFB, Castro JLS, Tristão LS, Bernardo WM. Behavioral therapies for the treatment of autism spectrum disorder: A systematic review. Clinics (Sao Paulo). 2024; 80: 100566.

INTRODUCTION: Autism Spectrum Disorder (ASD) is a neurodevelopment spectrum characterized by persistent deficits in social communication and interpersonal interaction, along with restricted and repetitive patterns of behavior, interest, or activities. The appropriate screening and diagnosis must be realized to improve the children’s prognosis. Moreover, appropriate treatments are necessary to promote better social integration and development. In this scenario, this systematic review aims to evaluate the impacts of behavioral therapies applied in healthcare settings for patients with ASD. METHODS: This systematic review followed the PRISMA guidelines. The databases MEDLINE, Embase, CENTRAL (Cochrane), and Lilacs were accessed, and gray and manual searches were performed. The search strategy was created with terms referring to autism and behavioral therapy. The studies were assessed qualitatively. RESULTS: Randomized clinical trials and observational studies demonstrated improvements in cognitive and verbal components of patients who received behavioral therapies in therapeutic settings. These results indicate a positive impact of both cognitive-behavioral therapy and ESDM on the development of patients’ skills. Among the cognitive-behavioral therapies, the one based on the MASSI protocol did not impact the reduction of anxious symptoms. As for cognitive-behavioral therapy, one study demonstrated that the Behavioral Intervention for Anxiety in Children with Autism (BIACA), when compared to the Coping Cat protocol, improves cognition and reduces anxiety symptoms. Despite these results, further randomized clinical trials comparing behavioral therapies with one another are needed. CONCLUSION: In the context of behavioral therapy within a healthcare setting, the Early Start Denver Model (ESDM) showed improvements in the cognitive, verbal, and social aspects of the evaluated patients. Improvement in scores sometimes is achieved independently of the group and related to the time of interventions.

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13. Sneed L, Pfingston B, Cook I, Taylor R, Samelson D, Fitchett B. Psychometric Properties of The Parental Stress Scale for Parents of Children with Intellectual and Developmental Disabilities. J Autism Dev Disord. 2024.

Parental stress can be debilitating for parents and their families. This is particularly true for parents who have a child with autism spectrum disorder (ASD) or other intellectual and developmental disability (I/DD). Effective screening and measurement of parental stress leads to accurate and effective intervention. The purpose of this study was to understand the psychometric properties of the Parental Stress Scale (PSS) for families who have a child with I/DD (ages ranging from 1 to 18 years old, with a mean of 5.28). Caregivers of 3220 families who have a child with I/DD (91% diagnosed with ASD) completed the scale. The psychometric properties including internal reliability and factor structure were completed as well as discriminant validity. Results of confirmatory factor analysis with the 18-item scale revealed a poor model fit with three items not meeting minimum factor loading threshold. Given this, the three items were removed, and confirmatory factor analysis was reconducted with 15 items of the PSS. Results revealed good internal consistency and discriminant validity, as well as a good model fit with all 15 items loading above the minimum threshold. The identified two-factor structure is consistent with the dichotomous (rewarding/burdensome) construct of parental stress that Berry and Jones (J Soc Pers Relationsh 12(3):463-472, 1995) originally designed the scale to index. Thus, the 15-item PSS has initial psychometric evidence in a large sample of families with a child with I/DD.

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14. Varley D, Southby K, Trigwell J, Brown SS, Lines N, Hearn A, Bagnall AM. Hybrid Service Delivery for voluntary, community and social enterprise organisations working with adults with learning disabilities and/or autism: a realist review protocol. Syst Rev. 2024; 13(1): 316.

BACKGROUND: Delivery of health and care services using a combination of remote and/or in-person channels and digital and/or traditional tools (Hybrid Service Delivery, HSD) is increasingly seen as a way of improving quality and affordability, improving access, personalisation and sustainability, and reducing inequalities. Across the voluntary, community and social enterprise sector (VCSE), using a combination of remote and/or in-person channels and digital and/or traditional tools (HSD) has enabled the essential provision of services for people who have learning disabilities and/or autistic (LDA). However, it is unclear how different tools and channels have been used, what worked well or not well, for whom, and in what circumstances. The aim of this realist review is to explore how VCSE organisations can effectively use digital technologies alongside or instead of in-person activity to provide social care services to adults with learning disabilities and/or autism. This review protocol is presented in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol (PRISMA-P). METHODS: We will conduct a participatory realist review. Following realist review methodology, and involving people with LDA and organisations who deliver services to them, we will define the scope of the review/theory development, search for and appraise evidence, extract and synthesise findings, and develop the narrative. Using a developed strategy, electronic databases (Academic Search Complete, CINAHL, MEDLINE, PsycInfo, SCOPUS, Social Science Citation Index and Social Policy and Practice) will be searched. A data extraction table will be used to assist in sifting, sorting and organising relevant information from identified studies. For each proposition statement, relevant data from the identified literature will be synthesised and compared with the proposed theory to develop an understanding of how, why and when hybrid delivery works in different settings with different populations. DISCUSSION: This review aims to collate and synthesise evidence relating to hybrid service delivery in VCSE organisations to provide social care services to LDA adults. By conducting a participatory realist review, we anticipate that the findings will lead to a greater understanding of contextual factors and therefore more relevant recommendations. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024457161.

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15. Yu L, Ban L, Yi A, Xin J, Li S, Wang S, Mottron L. Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children. Autism Res. 2024.

Child-directed speech (CDS), which amplifies acoustic and social features of speech during interactions with young children, promotes typical phonetic and language development. In autism, both behavioral and brain data indicate reduced sensitivity to human speech, which predicts absent, decreased, or atypical benefits of exaggerated speech signals such as CDS. This study investigates the impact of exaggerated fundamental frequency (F0) and voice-onset time on the neural processing of speech sounds in 22 Chinese-speaking autistic children aged 2-7 years old with a history of speech delays, compared with 25 typically developing (TD) peers. Electroencephalography (EEG) data were collected during passive listening to exaggerated and non-exaggerated syllables. A time-resolved multivariate pattern analysis (MVPA) was used to evaluate the potential effects of acoustic exaggeration on syllable discrimination in terms of neural decoding accuracy. For non-exaggerated syllables, neither the autism nor the TD group achieved above-chance decoding accuracy. In contrast, for exaggerated syllables, both groups achieved above-chance decoding, indicating significant syllable discrimination, with no difference in accuracy between the autism and TD groups. However, the temporal generalization patterns in the MVPA results revealed distinct neural mechanisms supporting syllable discrimination between the groups. Although the TD group demonstrated a left-hemisphere advantage for decoding and generalization, the autism group displayed similar decoding patterns between hemispheres. These findings highlight the potential of selective acoustic exaggeration to support speech learning in autistic children, underscoring the importance of tailored, sensory-based interventions.

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16. Zhang Y, Xie F, Li S, Li Y, Yang L, Wang Z, Lei J, Guo H. Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study. Autism Res. 2024.

Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case-control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges.

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