1. Blatt J. {{Association of Autism with Cancer}}. {J Pediatr};2015 (Jul);167(1):208-211.
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2. Cooper RA, Plaisted-Grant KC, Hannula DE, Ranganath C, Baron-Cohen S, Simons JS. {{Impaired Recollection of Visual Scene Details in Adults With Autism Spectrum Conditions}}. {J Abnorm Psychol};2015 (Jun 29)
Subtle memory deficits observed in autism spectrum conditions (ASC) have often been characterized as reflecting impaired recollection and it has been proposed that a relational binding deficit may underlie the recollection impairment. However, subjective recollection and relational binding have not been measured within the same task in ASC to date and it is unclear whether a relational binding deficit can provide a full account of recollection impairments in ASC. Relational memory has also not been compared with item memory when the demands of the 2 tasks are comparable. To assess recollection, relational memory, and item memory within a single task in ASC, 24 adults with ASC and 24 typically developed adults undertook a change detection memory task that assessed recollection of item-specific and spatial details. Participants studied rendered indoor and outdoor scenes and, in a subsequent recognition memory test, distinguished scenes that had not changed from those that had either undergone an item change (a different item exemplar) or a relational (spatial) change, which was followed by a subjective recollection judgment. The ASC group identified fewer item changes and spatial changes, to a similar degree, which was attributable to a specific reduction in recollection-based recognition relative to the control group. These findings provide evidence that recollection deficits in ASC may not be driven entirely by a relational binding deficit. (PsycINFO Database Record
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3. Fleva E, Khan A. {{An examination of the leftward cradling bias among typically developing adults high on autistic traits}}. {Laterality};2015 (Jun 29):1-12.
The leftward cradling bias is the tendency to cradle infants on the left side of the body and it has been linked with hemispheric asymmetry for emotional processing. This study examines this phenomenon using a real-size infant doll in typically developing adults who score high in the Reading the Mind in the Eyes, the Autistic Spectrum Quotient and the Empathy Quotient, measures that assess autistic traits among typically developing individuals. Results revealed that this group showed a reduced tendency to cradle on the left compared to participants who score within the normal range on the above measurements. This study provides further support for the justification of the leftward cradling bias upon brain lateralization on emotional processing. Study limitations and suggestions for future research are discussed.
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4. Lee MS, Kim YJ, Kim EJ, Lee MJ. {{Overlap of autism spectrum disorder and glucose transporter 1 deficiency syndrome associated with a heterozygous deletion at the 1p34.2 region}}. {J Neurol Sci};2015 (Jun 24)
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5. Scremin OU, Roch M, Norman KM, Djazayeri S, Liu YY. {{Brain acetylcholine and choline concentrations and dynamics in a murine model of the fragile x syndrome: age, sex and region specific changes}}. {Neuroscience};2015 (Jun 24)
Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5′ untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation. We used a murine model of this condition, Fmr1 knock-out mice (KO) to study the acetylcholine (ACh) metabolism and compared it to that of wild type control mice (WT). Brain endogenous ACh (D0ACh), free choline (D0Ch), their deuterated variants D4ACh and D4Ch and mole ratios (AChMR and ChMR) were measured by gas chromatography-mass spectrometry in the cerebral hemisphere, cerebral cortex, hippocampus and cerebellum, following D4Ch administration. Regression analysis indicated a significant decrease with age (negative slope) of D4ACh, AChMR, D4Ch and ChMR in WT mice. Age dependence was only present for D4ACh and AChMR in KO mice. Analysis of variance with age as covariate indicated a significant greater D4Ch in the cerebral cortex of KO females when compared to WT females. Contrasts between sexes within genotypes indicated lower D0Ch in cortex and cerebellum of female KO mice but not in WT and lower D4Ch in hippocampus of female KO and WT mice. In conclusion, after adjusting for age, endogenous ACh concentrations and synthesis from deuterium labeled Ch were similar in KO and control WT mice in all brain regions. In contrast, significant changes in Ch dynamics were found in hippocampus and cerebral cortex of KO mice that might contribute to the pathogenesis of FXS.
