Pubmed du 31/08/13

Pubmed du jour

2013-08-31 12:03:50

1. {{Secrets to Success for Professionals in the Autism Field – An Insider’s Guide to Understanding the Autism Spectrum, the Environment and Your RoleSecrets to Success for Professionals in the Autism Field – An Insider’s Guide to Understanding the Autism Spectrum, the Environment and Your Role}}. {Nursing standard (Royal College of Nursing (Great Britain) : 1987)}. 2013 Jun 26-Jul 2;27(43):28.

Who could not be drawn to a book with chapter titles such as ‘How it can be a constructive action to smash a window’, ‘Good aids that no one uses’ and ‘CRAP’ – thoughts on the use of confirmation or rewards, the idea of being affirmative, and why punishments do not work.

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2. Gabard-Durnam L, Tierney AL, Vogel-Farley V, Tager-Flusberg H, Nelson CA. {{Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders}}. {J Autism Dev Disord}. 2013 Aug 30.

An emerging focus of research on autism spectrum disorder (ASD) targets the identification of early-developing ASD endophenotypes using infant siblings of affected children. One potential neural endophenotype is resting frontal electroencephalogram (EEG) alpha asymmetry, a metric of hemispheric organization. Here, we examined the development of frontal EEG alpha asymmetry in ASD high-risk and low-risk infant populations. Our findings demonstrate that low and high-risk infants show different patterns of alpha asymmetry at 6 months of age and opposite growth trajectories in asymmetry over the following 12 months. These results support the candidacy of alpha asymmetry as an early neural ASD endophenotype.

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3. Granovetter M. {{Let’s talk therapy: treatments for children with autism}}. {Lancet}. 2013 Aug 31;382(9894):753.

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4. Grodberg D, Weinger PM, Halpern D, Parides M, Kolevzon A, Buxbaum JD. {{The Autism Mental Status Exam: Sensitivity and Specificity Using DSM-5 Criteria for Autism Spectrum Disorder in Verbally Fluent Adults}}. {J Autism Dev Disord}. 2013 Aug 29.

The phenotypic heterogeneity of adults suspected of autism spectrum disorder (ASD) requires a standardized diagnostic approach that is feasible in all clinical settings. The autism mental status exam (AMSE) is an eight-item observational assessment that structures the observation and documentation of social, communicative and behavioral signs and symptoms of ASD. Previous findings indicate high classification accuracy when compared to the autism diagnostic observation schedule in a non-stratified population of high-risk patients suspected of having ASD. This protocol investigates the sensitivity and specificity of AMSE scores using DSM-5 criteria for ASD in a sample of high-risk verbally fluent adults. Findings indicate an optimized sensitivity of 0.91 and a specificity of 0.93 for this group. Because of its high clinical utility, the AMSE holds promise as a diagnostic assessment tool that can support one’s clinical diagnosis of ASD in high-risk adults.

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5. Schaaf RC, Benevides TW, Leiby BE, Sendecki JA. {{Autonomic Dysregulation During Sensory Stimulation in Children with Autism Spectrum Disorder}}. {J Autism Dev Disord}. 2013 Aug 31.

Autonomic nervous system (ANS) activity during sensory stimulation was measured in 59 children with autism spectrum disorder (ASD) ages 6-9 in comparison to 30 typically developing controls. Multivariate comparisons revealed significant differences between groups in the respiratory sinus arrhythmia (parasympathetic measure) vector of means across sensory stimuli (p = 0.02) and in change from domain to domain (p = 0.01). Sympathetic activity, measured by pre-ejection period, did not differ significantly between groups, although it was higher in ASD participants. Findings suggest that participants with ASD demonstrated a different pattern of parasympathetic activity during sensory stimulation. Findings are discussed in relation to the biological mechanisms of sensory processing in autism, insight into the autism phenotype, and the utility of ANS activity as an outcomes marker.

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6. Van Wijngaarden-Cremers PJ, van Eeten E, Groen WB, Van Deurzen PA, Oosterling IJ, Van der Gaag RJ. {{Gender and Age Differences in the Core Triad of Impairments in Autism Spectrum Disorders: A Systematic Review and Meta-analysis}}. {J Autism Dev Disord}. 2013 Aug 30.

Autism is an extensively studied disorder in which the gender disparity in prevalence has received much attention. In contrast, only a few studies examine gender differences in symptomatology. This systematic review and meta-analysis of 22 peer reviewed original publications examines gender differences in the core triad of impairments in autism. Gender differences were transformed and concatenated using standardized mean differences, and analyses were stratified in five age categories (toddlerhood, preschool children, childhood, adolescence, young adulthood). Boys showed more repetitive and stereotyped behavior as from the age of six, but not below the age of six. Males and females did not differ in the domain of social behavior and communication. There is an underrepresentation of females with ASD an average to high intelligence. Females could present another autistic phenotype than males. As ASD is now defined according to the male phenotype this could imply that there is an ascertainment bias. More research is needed into the female phenotype of ASD with development of appropriate instruments to detect and ascertain them.

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7. Virues-Ortega J, Julio FM, Pastor-Barriuso R. {{The TEACCH program for children and adults with autism: A meta-analysis of intervention studies}}. {Clinical psychology review}. 2013 Jul 24;33(8):940-53.

The intervention program for autism known as Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) is considered an emerging practice for autism. In the present study we used state-of-the-art meta-analytical procedures to examine the pooled clinical effects of TEACCH in a variety of outcomes. A total of 13 studies were selected for meta-analysis totaling 172 individuals with autism exposed to TEACCH. Standardized measures of perceptual, motor, adaptive, verbal and cognitive skills were identified as treatment outcomes. We used inverse-variance weighted random effects meta-analysis supplemented with quality assessment, sensitivity analysis, meta-regression, and heterogeneity and publication bias tests. The results suggested that TEACCH effects on perceptual, motor, verbal and cognitive skills were of small magnitude in the meta-analyzed studies. Effects over adaptive behavioral repertoires including communication, activities of daily living, and motor functioning were within the negligible to small range. There were moderate to large gains in social behavior and maladaptive behavior. The effects of the TEACCH program were not moderated by aspects of the intervention such as duration (total weeks), intensity (hours per week), and setting (home-based vs. center-based). While the present meta-analysis provided limited support for the TEACCH program as a comprehensive intervention, our results should be considered exploratory owing to the limited pool of studies available.

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