Pubmed (TDAH) du 03/02/26
1. Altunok Ünlü N, Çatal S, Özdemir Çelik DS. Mandibular bone changes in children with ADHD: evaluation using fractal analysis and mandibular indices. BMC Oral Health;2026 (Feb 3)
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2. Cleare S, O’Connor RC. Exploring the relationship between ADHD symptoms and suicide risk through the lens of the Integrated Motivational-Volitional Model of suicidal behaviour. J Psychiatr Res;2026 (Jan 27);195:142-152.
INTRODUCTION: Attention Deficit-Hyperactivity Disorder (ADHD) is associated with increased vulnerability to suicide. However, understanding of the psychological factors associated with increased risk is limited. Therefore, we investigated the extent to which psychological factors from the Integrated Motivational-Volitional (IMV) model of suicidal behaviour were associated with suicide risk. METHODS: 696 adults who were recruited to a study on ADHD, mental health and suicide risk completed validated measures that assessed components of the IMV model, ADHD symptoms and mental health history. RESULTS: 642 (92.2 %) participants scored 4 or more on the Adult ADHD Self-Report screener (ASRS; Kessler et al., 2005), indicating recent ADHD symptoms. Analyses of IMV model factors were conducted in this subgroup. More than nine out of ten (93 %) participants reported lifetime suicidal thoughts (n = 597), and 41.7 % (n = 268) reported a history of suicide attempts. Multivariable analyses showed higher defeat, internal entrapment and perceived burdensomeness were associated with recent suicidal thoughts, while mental imagery distinguished those with suicide attempt from suicidal thought histories. Perceived burdensomeness moderated the entrapment-to-suicidal thoughts relationship. Exploratory mediation analysis indicated entrapment may mediate the defeat-to-suicidal thoughts relationship. CONCLUSIONS: This is the first study to apply the IMV model to understanding the ADHD-suicide risk relationship. Psychological factors from the IMV model warrant investigation longitudinally as potentially targets for suicide prevention in people with ADHD.
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3. Dan O, Haimov I, Harel A, Asraf K, Saveliev J, Raz S, Cohen A. Sleep deprivation alters early event-related potentials during emotional face processing in adults with ADHD. Sci Rep;2026 (Feb 2)
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4. Estrada-Araoz EG. [Teacher training and the perception of ADHD in the school setting]. Aten Primaria;2026 (Feb 3);58(4):103451.
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5. Mitchell S. Treatment of disruptive mood dysregulation disorder with autism spectrum disorder and attention-deficit/hyperactivity disorder. Ment Health Clin;2026 (Feb);16(1):1-6.
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6. Smith C, Walker H, Parlatini V, Cortese S. Tolerance and Tachyphylaxis to Medications for Attention-Deficit/Hyperactivity Disorder (ADHD): A Systematic Review of Empirical Studies. CNS Drugs;2026 (Feb 2)
BACKGROUND AND OBJECTIVE: Individuals with attention-deficit/hyperactivity disorder, their families and clinicians may report worsening symptoms despite compliant use of medication, suggesting potential tolerance, but evidence remains conflicting. Some studies have also suggested tachyphylaxis, or acute tolerance, though research is limited. We conducted the first systematic review of empirical studies focussing on tolerance/tachyphylaxis to attention-deficit/hyperactivity disorder medication to clarify their potential clinical relevance. METHODS: As registered on PROSPERO (CRD42024594759), we searched PubMed, OVID (including PsychInfo and MEDLINE) and Web of Knowledge up to 1 September, 2024, and assessed the risk of bias using National Institutes of Health quality assessment tools. RESULTS: The identified 17 studies were either interventional or observational, and varied greatly in design and duration. Four investigated tachyphylaxis, nine tolerance to the subjective and behavioural effects, and four tolerance to cardiovascular effects. We found preliminary evidence of tachyphylaxis to the affective or behavioural effects of stimulants, as well as tolerance to the subjective effects of d-amphetamine, such as drug liking and excitation, in neurotypical volunteers in the short term. Conversely, there was little or no evidence for tolerance to the therapeutic or cardiovascular effects of attention-deficit/hyperactivity disorder medication in clinical settings in the longer term. Quality was rated as low in most studies because of small sample sizes and methodological limitations. CONCLUSIONS: Overall, these results do not support the hypothesis that tolerance commonly develops to the therapeutic effects of attention-deficit/hyperactivity disorder medication, although robustly designed longitudinal studies are needed to provide more conclusive evidence. Clinicians may consider other potential explanations for reduced therapeutic effects over time, including natural fluctuations of symptoms, limited compliance, life events and co-occurrent mental health conditions.
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7. Teke H, Artik A, Gunduz BO, Azizagaoglu C, Kutluturk K, Erden N, Atas E, Congologlu MA. Fibromyalgia and its psychosocial determinants in mothers of children with attention-deficit/hyperactivity disorder: A controlled cross-sectional study. J Psychosom Res;2026 (Feb 3);203:112561.
OBJECTIVE: To investigate the prevalence of fibromyalgia (FM) and its psychosocial correlates in mothers of children diagnosed with attention-deficit/hyperactivity disorder (ADHD), compared with mothers of healthy peers. METHODS: This controlled cross-sectional study included 81 mothers of children with ADHD and 80 mothers of typically developing peers. FM was evaluated according to the American College of Rheumatology 2016 criteria. Psychometric evaluations included the Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Autism-Spectrum Quotient (AQ), along with a structured sociodemographic form. Group comparisons and multivariable logistic regression analyses were conducted to identify independent predictors of FM. RESULTS: FM prevalence was significantly higher in mothers of children with ADHD compared with controls (38.3% vs. 7.5%, p < 0.001). Mothers in the ADHD group also reported markedly elevated anxiety and depressive symptoms. In univariate analyses, higher maternal anxiety, depressive symptoms, autistic traits, and a history of psychiatric disorder were associated with FM. In the fully adjusted model, however, only higher maternal anxiety and older child age remained independent predictors of FM in the ADHD group. When the full sample was analyzed, having a child with ADHD was also independently associated with maternal FM. FM severity demonstrated moderate positive correlations with anxiety and depression. CONCLUSION: Mothers of children with ADHD constitute a high-risk group for FM, likely driven by chronic caregiving stress and associated psychological burden. Routine screening and early psychosocial support interventions targeting parental mental health may help prevent or mitigate FM-related disability in this vulnerable population.
