Pubmed (TDAH) du 13/01/26
1. Kauppinen I, Miettunen J, Nordström T, Halt AH, Hurtig T. Do ADHD symptoms in adolescence predict psychiatric disorders later in life? A longitudinal study of the Northern Finland birth cohort 1986. Soc Psychiatry Psychiatr Epidemiol;2026 (Jan 13)
PURPOSE: Attention Deficit Hyperactivity Disorder (ADHD) and concurrent psychiatric comorbidities have been thoroughly investigated but less is known on how ADHD symptoms predict subsequent psychiatric disorders. The aim of this study is to examine whether ADHD symptoms in adolescence predict adult psychiatric disorders in a longitudinal unselected population-based cohort. METHODS: The study is based on the Northern Finland Birth Cohort 1986 (N = 9432), in which ADHD symptoms had been measured with the parent-filled Strengths and Weaknesses of ADHD Symptoms and Normal Behaviours (SWAN) questionnaire at the age of 16 years. Adult psychiatric disorders were retrieved from the nationwide registers up to age 35 years. The population was divided into tertiles based on ADHD symptoms and the correlations between middle and highest tertiles and certain later psychiatric disorders were examined with logistic regression analyses, taking family type, parents’ education and adolescent-reported psychiatric symptoms as covariates. RESULTS: Among females, ADHD symptoms in adolescence predicted later anxiety and depressive disorders in both the crude and adjusted models for the middle and highest tertiles and substance use disorders in the highest tertile. The highest risk was associated with substance use disorders. In males, only anxiety disorders could be predicted for the middle and highest tertiles in all the analyses. CONCLUSIONS: ADHD symptoms in adolescence predict multiple psychiatric disorders among females and anxiety disorders among males. ADHD symptoms should be addressed as soon as they appear even if they do not fulfil the diagnostic criteria for ADHD. More research needs to be done into this question.
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2. Tarlacı S, Çolak A. Relationship Between MOXO-D-CPT Results and Volumetric Brain MR in Attention Deficit Hyperactivity Disorder. Int J Dev Neurosci;2026 (Feb);86(1):e70093.
OBJECTIVE: This study aimed to examine the multidimensional relationships between MOXO-d-CPT performance and severity profiles-attention, timing, impulsivity and hyperactivity-and regional brain volumetric and cortical thickness measures in individuals with ADHD. METHODS: Thirty-eight adults with ADHD underwent MOXO-d-CPT assessment and high-resolution structural brain MRI. MOXO-d-CPT performance and severity levels were analysed in relation to 155 regional brain volumes and 110 cortical thickness measures using group-wise statistical comparisons. RESULTS: Attention performance and severity were associated with volumetric and cortical thickness differences primarily in frontal, temporal and cerebellar regions. Timing performance was related to cerebellar and frontal volumetric measures, whereas timing severity showed limited volumetric differences without cortical involvement. Impulsivity performance demonstrated no volumetric differences but was associated with cortical thickness variations in frontal and temporal regions. Hyperactivity performance was linked to both volumetric and cortical alterations, whereas hyperactivity severity was associated exclusively with cortical thickness differences, predominantly in occipital regions (p < 0.05). CONCLUSION: These findings highlight distinct structural brain correlates underlying MOXO-d-CPT performance and symptom severity dimensions in ADHD, supporting a multidimensional neurobiological framework that extends beyond categorical diagnostic approaches.
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3. Wang Y, Jiang W, Zhang X, Li Y. Complex ADHD in a Transgender Adolescent: Case Study and Clinical Implications. Clin Child Psychol Psychiatry;2026 (Jan 13):13591045261417379.
BackgroundAdolescents have increasingly been reported as identifying as transgender or gender-diverse and seeking gender-affirming care. Nonetheless, the proportion receiving gender-affirming medical treatment remains low; in the United States, fewer than 100 out of every 100,000 17-year-old adolescents assigned male at birth receive gender-affirming medical treatment. Attention-deficit hyperactivity disorder (ADHD), the most common childhood neurodevelopmental disorder, is a major public health concern and shows elevated prevalence among transgender and gender-diverse adolescents.Case PresentationThis case presents a 15-year-old adolescent with ADHD and co-morbidities, including gender dysphoria, harmful use of substances, and childhood mood disorders. After antipsychotic and antidepressant pharmacotherapy combined with psychological interventions, the patient demonstrated improved emotional regulation and diminished impulsive behaviors.ConclusionThis case underscores the need for life course-oriented care that addresses transgender-specific stressors and incorporates preventive substance abuse strategies. It also emphasises the urgent need for research into comorbidity-tailored pharmacotherapy to balance ADHD treatment efficacy with gender-affirming hormone safety. This report describes the case of a 15-year-old teenager who has both attention-deficit/hyperactivity disorder (ADHD) and gender dysphoria. The teen also struggled with mood problems and used several harmful substances. These challenges made daily life, emotions, and self-control difficult. The patient received a combination of medication and psychological support. This included treatment for mood issues, ADHD symptoms, and emotional outbursts. After a period of care, the teen showed better emotional control and fewer impulsive actions. This case highlights the special challenges that transgender youth may face, especially when they also have ADHD. Stress from gender-related issues and the risk of substance use can make treatment more complex. In this case, care needed to be carefully adjusted to support both the patient’s mental health and their gender identity. This case shows that treatment should not only focus on ADHD itself. It should also consider gender identity, emotional needs, and the risk of substance use. Support that looks at the whole person can help young people feel safer, more understood, and more stable in both body and mind. eng
